Reviewed, UniProtKB/Swiss-Prot P56278 (MTCPB_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein p13 MTCP-1
Alternative name(s):
    Mature T-cell proliferation-1 type B1
      Short name=MTCP-1 type B1
    P13MTCP1

Gene names

Name:	MTCP1
Synonyms:	C6.1B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Enhances the phosphorylation and activation of AKT1 and AKT2. Ref.4
Subunit structure	Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3. Ref.4 Ref.5
Tissue specificity	Not found at a significant level in any tissue.
Involvement in disease	Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
Sequence similarities	Belongs to the TCL1 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Chromosomal rearrangement
Disease	Proto-oncogene
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	cell proliferation Ref.1 Traceable author statement. Source: ProtInc
Molecular function	protein binding Ref.4 Inferred from physical interaction. Source: GDB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: P56278-1)

Also known as: Type B1; p13 MTCP1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Short (identifier: P56277-1)

Also known as: Type A; p8 MTCP1;

The sequence of this isoform can be found in the external entry P56277-1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 107

107

Protein p13 MTCP-1

PRO_0000184486

Secondary structure

1

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107

Helix Strand Turn

Details...

Beta strand

11 – 17

7

Beta strand

20 – 23

4

Beta strand

28 – 35

8

Beta strand

40 – 45

6

Helix

57 – 60

4

Beta strand

67 – 72

6

Turn

73 – 75

3

Beta strand

76 – 79

4

Beta strand

84 – 93

10

Beta strand

96 – 103

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform Long (Type B1) (p13 MTCP1) [UniParc]. Last modified July 15, 1998. Version 1. Checksum: C00967E1AECDDDCA	FASTA	107	12,600
	10 20 30 40 50 60 MAGEDVGAPP DHLWVHQEGI YRDEYQRTWV AVVEEETSFL RARVQQIQVP LGDAARPSHL 70 80 90 100 LTSQLPLMWQ LYPEERYMDN NSRLWQIQHH LMVRGVQELL LKLLPDD
	Isoform Short (Type A) (p8 MTCP1). See P56277.	FASTA	–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations." Stern M.-H., Soulier J., Rosenzwajg M., Nakahara K., Canki-Klain N., Aurias A., Sigaux F., Kirsch I.R. Oncogene 8:2475-2483(1993) [PubMed: 8361760] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: T-cell.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The protooncogene TCL1 is an Akt kinase coactivator." Laine J., Kuenstle G., Obata T., Sha M., Noguchi M. Mol. Cell 6:395-407(2000) [PubMed: 10983986] [Abstract] Cited for: FUNCTION, INTERACTION WITH AKT1 AND AKT2.
[5]	"Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family." Laine J., Kuenstle G., Obata T., Noguchi M. J. Biol. Chem. 277:3743-3751(2002) [PubMed: 11707444] [Abstract] Cited for: LACK OF INTERACTION WITH AKT3.
[6]	"Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies." Fu Z.Q., du Bois G.C., Song S.P., Kulikovskaya I., Virgilio L., Rothstein J.L., Croce C.M., Weber I.T., Harrison R.W. Proc. Natl. Acad. Sci. U.S.A. 95:3413-3418(1998) [PubMed: 9520380] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
[7]	"Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data." Guignard L., Padilla A., Mispelter J., Yang Y.-S., Stern M.-H., Lhoste J.-M., Roumestand C. J. Biomol. NMR 17:215-230(2000) [PubMed: 10959629] [Abstract] Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z24459 Genomic DNA. Translation: CAA80828.1.
BX470111 Genomic DNA. Translation: CAI41656.1.
CH471172 Genomic DNA. Translation: EAW72642.1.

IPI

IPI00447137.

PIR

S78532.

RefSeq

NP_001018025.1.

UniGene

Hs.6917

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1A1X	X-ray	2.00	A	2-107	[»]
1QTT	NMR	-	A	1-107	[»]
1QTU	NMR	-	A	1-107	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

P56278.

Proteomic databases

PRIDE

P56278.

Genome annotation databases

Ensembl

ENST00000330425; ENSP00000329343; ENSG00000214827; Homo sapiens. [Genome view]
ENST00000362018; ENSP00000355058; ENSG00000214827; Homo sapiens. [Genome view]
ENST00000369476; ENSP00000358488; ENSG00000214827; Homo sapiens. [Genome view]

GeneID

4515.

KEGG

hsa:4515.

UCSC

uc004fmx.1. human.

Organism-specific databases

CTD

4515.

GeneCards

GC0XM153853.
GC0XM153944.

H-InvDB

HIX0021833.

HGNC

HGNC:7423. MTCP1.

MIM

300116. gene.

Orphanet

86871. Leukemia, T-cell prolymphocytic.

PharmGKB

PA31230.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

HBG279858.

HOVERGEN

P56278.

InParanoid

P56278.

OMA

QEGVYRD.

OrthoDB

EOG9T7BPB.

PhylomeDB

P56278.

Gene expression databases

ArrayExpress

P56278.

Bgee

P56278.

CleanEx

HS_MTCP1.

Genevestigator

P56278.

GermOnline

ENSG00000182712. Homo sapiens.

Family and domain databases

InterPro

IPR004832. TCL1_MTCP1.
[Graphical view]

Gene3D

G3DSA:2.40.15.10. TCL1_MTCP1. 1 hit.

Pfam

PF01840. TCL1_MTCP1. 1 hit.
[Graphical view]

ProDom

PD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

Search...

Other Resources

SOURCE

Search...

Entry information

Entry name

MTCPB_HUMAN

Accession

Primary (citable) accession number: P56278
Secondary accession number(s): Q5HYP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	January 19, 2010
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.