P56278 (MTCP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein p13 MTCP-1
Short name=p13MTCP1

Alternative name(s):
Mature T-cell proliferation-1 type B1
Short name=MTCP-1 type B1

Gene names

Name:	MTCP1
Synonyms:	C6.1B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Enhances the phosphorylation and activation of AKT1 and AKT2. Ref.4
Subunit structure	Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3. Ref.4 Ref.5
Tissue specificity	Not found at a significant level in any tissue.
Involvement in disease	Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
Sequence similarities	Belongs to the TCL1 family.
Caution	MTCP1 and MTCP1NB are transcribed from the same promoter and could be considered the same gene.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Chromosomal rearrangement
Disease	Proto-oncogene
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Traceable author statement Ref.1. Source: ProtInc
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: P56278-1)

Also known as: Long; Type B1; p13 MTCP1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Shares a non-coding 5' exon with isoform 1 which is spliced to a different set of 3' exons encoding an unrelated protein.

Isoform 1 (identifier: P56277-1)

Also known as: Short; Type A; p8 MTCP1;

The sequence of this isoform can be found in the external entry P56277.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Shares a non-coding 5' exon with isoform 2 which is spliced to a different set of 3' exons encoding an unrelated protein.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 107

107

Protein p13 MTCP-1

PRO_0000184486

Secondary structure

1

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107

Helix Strand Turn

Details...

Beta strand

11 – 17

7

Beta strand

20 – 23

4

Beta strand

28 – 35

8

Beta strand

40 – 45

6

Helix

57 – 60

4

Beta strand

67 – 72

6

Turn

73 – 75

3

Beta strand

76 – 79

4

Beta strand

84 – 93

10

Beta strand

96 – 103

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 (Long) (Type B1) (p13 MTCP1) [UniParc]. Last modified July 15, 1998. Version 1. Checksum: C00967E1AECDDDCA	FASTA	107	12,600
	10 20 30 40 50 60 MAGEDVGAPP DHLWVHQEGI YRDEYQRTWV AVVEEETSFL RARVQQIQVP LGDAARPSHL 70 80 90 100 LTSQLPLMWQ LYPEERYMDN NSRLWQIQHH LMVRGVQELL LKLLPDD
	Isoform 1 (Short) (Type A) (p8 MTCP1) [UniParc]. See P56277.		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations." Stern M.-H., Soulier J., Rosenzwajg M., Nakahara K., Canki-Klain N., Aurias A., Sigaux F., Kirsch I.R. Oncogene 8:2475-2483(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2). Tissue: T-cell.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The protooncogene TCL1 is an Akt kinase coactivator." Laine J., Kuenstle G., Obata T., Sha M., Noguchi M. Mol. Cell 6:395-407(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AKT1 AND AKT2.
[5]	"Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family." Laine J., Kuenstle G., Obata T., Noguchi M. J. Biol. Chem. 277:3743-3751(2002) [PubMed] [Europe PMC] [Abstract] Cited for: LACK OF INTERACTION WITH AKT3.
[6]	"Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies." Fu Z.Q., du Bois G.C., Song S.P., Kulikovskaya I., Virgilio L., Rothstein J.L., Croce C.M., Weber I.T., Harrison R.W. Proc. Natl. Acad. Sci. U.S.A. 95:3413-3418(1998) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
[7]	"Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data." Guignard L., Padilla A., Mispelter J., Yang Y.-S., Stern M.-H., Lhoste J.-M., Roumestand C. J. Biomol. NMR 17:215-230(2000) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z24459 Genomic DNA. Translation: CAA80828.1.
BX470111 Genomic DNA. Translation: CAI41656.1.
CH471172 Genomic DNA. Translation: EAW72642.1.

IPI

IPI00447137.

PIR

S78532.

RefSeq

NP_001018025.1. NM_001018025.3.

UniGene

Hs.6917.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1A1X	X-ray	2.00	A	2-107	[»]
1QTT	NMR	-	A	1-107	[»]
1QTU	NMR	-	A	1-107	[»]

ProteinModelPortal

P56278.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-1484922.

STRING

9606.ENSP00000329343.

Polymorphism databases

DMDM

3024175.

Proteomic databases

PRIDE

P56278.

Protocols and materials databases

DNASU

4515.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000362018; ENSP00000355058; ENSG00000214827.
ENST00000369476; ENSP00000358488; ENSG00000214827.
ENST00000596212; ENSP00000473214; ENSG00000268700.
ENST00000597096; ENSP00000471992; ENSG00000268700.

GeneID

4515.

KEGG

hsa:4515.

UCSC

uc004fmz.2. human.

Organism-specific databases

CTD

4515.

GeneCards

GC0XM154290.

HGNC

HGNC:7423. MTCP1.

MIM

300116. gene.

neXtProt

NX_P56278.

PharmGKB

PA164742098.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG76642.

HOGENOM

HOG000037945.

HOVERGEN

HBG052523.

InParanoid

P56278.

KO

K16837.

OMA

QEGVYRD.

OrthoDB

EOG444KMS.

PhylomeDB

P56278.

Gene expression databases

Bgee

P56278.

CleanEx

HS_MTCP1.

Genevestigator

P56278.

GermOnline

ENSG00000182712. Homo sapiens.

Family and domain databases

Gene3D

2.40.15.10. 1 hit.

InterPro

IPR004832. TCL1_MTCP1.
[Graphical view]

Pfam

PF01840. TCL1_MTCP1. 1 hit.
[Graphical view]

ProDom

PD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF50904. TCL1_MTCP1. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P56278.

GenomeRNAi

4515.

NextBio

17437.

SOURCE

Search...

Entry information

Entry name

MTCP1_HUMAN

Accession

Primary (citable) accession number: P56278
Secondary accession number(s): Q5HYP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	May 1, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.