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P56278 (MTCP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein p13 MTCP-1

Short name=p13MTCP1
Alternative name(s):
Mature T-cell proliferation-1 type B1
Short name=MTCP-1 type B1
Gene names
Name:MTCP1
Synonyms:C6.1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length107 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Enhances the phosphorylation and activation of AKT1 and AKT2. Ref.4

Subunit structure

Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3. Ref.4 Ref.5

Tissue specificity

Not found at a significant level in any tissue.

Involvement in disease

Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.

Sequence similarities

Belongs to the TCL1 family.

Caution

MTCP1 and MTCP1NB are transcribed from the same promoter and could be considered the same gene.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Chromosomal rearrangement
   DiseaseProto-oncogene
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell proliferation

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 2 (identifier: P56278-1)

Also known as: Long; Type B1; p13 MTCP1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Shares a non-coding 5' exon with isoform 1 which is spliced to a different set of 3' exons encoding an unrelated protein.
Isoform 1 (identifier: P56277-1)

Also known as: Short; Type A; p8 MTCP1;

The sequence of this isoform can be found in the external entry P56277.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Shares a non-coding 5' exon with isoform 2 which is spliced to a different set of 3' exons encoding an unrelated protein.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 107107Protein p13 MTCP-1
PRO_0000184486

Secondary structure

................... 107
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 (Long) (Type B1) (p13 MTCP1) [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: C00967E1AECDDDCA

FASTA10712,600
        10         20         30         40         50         60 
MAGEDVGAPP DHLWVHQEGI YRDEYQRTWV AVVEEETSFL RARVQQIQVP LGDAARPSHL 

        70         80         90        100 
LTSQLPLMWQ LYPEERYMDN NSRLWQIQHH LMVRGVQELL LKLLPDD 

« Hide

Isoform 1 (Short) (Type A) (p8 MTCP1) [UniParc].

See P56277.

References

« Hide 'large scale' references
[1]"MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations."
Stern M.-H., Soulier J., Rosenzwajg M., Nakahara K., Canki-Klain N., Aurias A., Sigaux F., Kirsch I.R.
Oncogene 8:2475-2483(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
Tissue: T-cell.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The protooncogene TCL1 is an Akt kinase coactivator."
Laine J., Kuenstle G., Obata T., Sha M., Noguchi M.
Mol. Cell 6:395-407(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH AKT1 AND AKT2.
[5]"Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family."
Laine J., Kuenstle G., Obata T., Noguchi M.
J. Biol. Chem. 277:3743-3751(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: LACK OF INTERACTION WITH AKT3.
[6]"Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies."
Fu Z.Q., du Bois G.C., Song S.P., Kulikovskaya I., Virgilio L., Rothstein J.L., Croce C.M., Weber I.T., Harrison R.W.
Proc. Natl. Acad. Sci. U.S.A. 95:3413-3418(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
[7]"Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data."
Guignard L., Padilla A., Mispelter J., Yang Y.-S., Stern M.-H., Lhoste J.-M., Roumestand C.
J. Biomol. NMR 17:215-230(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z24459 Genomic DNA. Translation: CAA80828.1.
BX470111 Genomic DNA. Translation: CAI41656.1.
CH471172 Genomic DNA. Translation: EAW72642.1.
CCDSCCDS44027.1. [P56278-1]
PIRS78532.
RefSeqNP_001018025.1. NM_001018025.3. [P56278-1]
UniGeneHs.6917.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1A1XX-ray2.00A2-107[»]
1QTTNMR-A1-107[»]
1QTUNMR-A1-107[»]
ProteinModelPortalP56278.
SMRP56278. Positions 1-107.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110618. 5 interactions.
MINTMINT-1484922.
STRING9606.ENSP00000329343.

Proteomic databases

MaxQBP56278.
PRIDEP56278.

Protocols and materials databases

DNASU4515.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000362018; ENSP00000355058; ENSG00000214827. [P56278-1]
ENST00000369476; ENSP00000358488; ENSG00000214827. [P56278-1]
ENST00000596212; ENSP00000473214; ENSG00000268700. [P56278-1]
ENST00000597096; ENSP00000471992; ENSG00000268700. [P56278-1]
GeneID4515.
KEGGhsa:4515.
UCSCuc004fmz.2. human. [P56278-1]

Organism-specific databases

CTD4515.
GeneCardsGC0XM154290.
HGNCHGNC:7423. MTCP1.
MIM300116. gene.
neXtProtNX_P56278.
PharmGKBPA164742098.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG76642.
HOGENOMHOG000037945.
HOVERGENHBG052523.
InParanoidP56278.
KOK16837.
OMATWVAVLE.
PhylomeDBP56278.
TreeFamTF337903.

Gene expression databases

BgeeP56278.
CleanExHS_MTCP1.
GenevestigatorP56278.

Family and domain databases

Gene3D2.40.15.10. 1 hit.
InterProIPR004832. TCL1_MTCP1.
[Graphical view]
PfamPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF50904. SSF50904. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP56278.
GeneWikiMTCP1.
GenomeRNAi4515.
NextBio17437.
PROP56278.
SOURCESearch...

Entry information

Entry nameMTCP1_HUMAN
AccessionPrimary (citable) accession number: P56278
Secondary accession number(s): Q5HYP2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM