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P56278

- MTCP1_HUMAN

UniProt

P56278 - MTCP1_HUMAN

Protein

Protein p13 MTCP-1

Gene

MTCP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Enhances the phosphorylation and activation of AKT1 and AKT2.1 Publication

    GO - Biological processi

    1. cell proliferation Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein p13 MTCP-1
    Short name:
    p13MTCP1
    Alternative name(s):
    Mature T-cell proliferation-1 type B1
    Short name:
    MTCP-1 type B1
    Gene namesi
    Name:MTCP1
    Synonyms:C6.1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:7423. MTCP1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl

    Pathology & Biotechi

    Involvement in diseasei

    Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA164742098.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 107107Protein p13 MTCP-1PRO_0000184486Add
    BLAST

    Proteomic databases

    MaxQBiP56278.
    PRIDEiP56278.

    Expressioni

    Tissue specificityi

    Not found at a significant level in any tissue.

    Gene expression databases

    BgeeiP56278.
    CleanExiHS_MTCP1.
    GenevestigatoriP56278.

    Interactioni

    Subunit structurei

    Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3.1 Publication

    Protein-protein interaction databases

    BioGridi110618. 5 interactions.
    MINTiMINT-1484922.
    STRINGi9606.ENSP00000329343.

    Structurei

    Secondary structure

    1
    107
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi11 – 177
    Beta strandi20 – 234
    Beta strandi28 – 358
    Beta strandi40 – 456
    Helixi57 – 604
    Beta strandi67 – 726
    Turni73 – 753
    Beta strandi76 – 794
    Beta strandi84 – 9310
    Beta strandi96 – 1038

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A1XX-ray2.00A2-107[»]
    1QTTNMR-A1-107[»]
    1QTUNMR-A1-107[»]
    ProteinModelPortaliP56278.
    SMRiP56278. Positions 1-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP56278.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TCL1 family.Curated

    Phylogenomic databases

    eggNOGiNOG76642.
    HOGENOMiHOG000037945.
    HOVERGENiHBG052523.
    InParanoidiP56278.
    KOiK16837.
    OMAiTWVAVLE.
    PhylomeDBiP56278.
    TreeFamiTF337903.

    Family and domain databases

    Gene3Di2.40.15.10. 1 hit.
    InterProiIPR004832. TCL1_MTCP1.
    [Graphical view]
    PfamiPF01840. TCL1_MTCP1. 1 hit.
    [Graphical view]
    ProDomiPD015575. TCL1_MTCP1. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50904. SSF50904. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: P56278-1) [UniParc]FASTAAdd to Basket

    Also known as: Long, Type B1, p13 MTCP1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGEDVGAPP DHLWVHQEGI YRDEYQRTWV AVVEEETSFL RARVQQIQVP    50
    LGDAARPSHL LTSQLPLMWQ LYPEERYMDN NSRLWQIQHH LMVRGVQELL 100
    LKLLPDD 107

    Note: Shares a non-coding 5' exon with isoform 1 which is spliced to a different set of 3' exons encoding an unrelated protein.

    Length:107
    Mass (Da):12,600
    Last modified:July 15, 1998 - v1
    Checksum:iC00967E1AECDDDCA
    GO
    Isoform 1 (identifier: P56277-1) [UniParc]FASTAAdd to Basket

    Also known as: Short, Type A, p8 MTCP1

    The sequence of this isoform can be found in the external entry P56277.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Shares a non-coding 5' exon with isoform 2 which is spliced to a different set of 3' exons encoding an unrelated protein.

    Length:68
    Mass (Da):7,747
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z24459 Genomic DNA. Translation: CAA80828.1.
    BX470111 Genomic DNA. Translation: CAI41656.1.
    CH471172 Genomic DNA. Translation: EAW72642.1.
    CCDSiCCDS44027.1. [P56278-1]
    PIRiS78532.
    RefSeqiNP_001018025.1. NM_001018025.3. [P56278-1]
    UniGeneiHs.6917.

    Genome annotation databases

    EnsembliENST00000362018; ENSP00000355058; ENSG00000214827. [P56278-1]
    ENST00000369476; ENSP00000358488; ENSG00000214827. [P56278-1]
    GeneIDi4515.
    KEGGihsa:4515.
    UCSCiuc004fmz.2. human. [P56278-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z24459 Genomic DNA. Translation: CAA80828.1 .
    BX470111 Genomic DNA. Translation: CAI41656.1 .
    CH471172 Genomic DNA. Translation: EAW72642.1 .
    CCDSi CCDS44027.1. [P56278-1 ]
    PIRi S78532.
    RefSeqi NP_001018025.1. NM_001018025.3. [P56278-1 ]
    UniGenei Hs.6917.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A1X X-ray 2.00 A 2-107 [» ]
    1QTT NMR - A 1-107 [» ]
    1QTU NMR - A 1-107 [» ]
    ProteinModelPortali P56278.
    SMRi P56278. Positions 1-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110618. 5 interactions.
    MINTi MINT-1484922.
    STRINGi 9606.ENSP00000329343.

    Proteomic databases

    MaxQBi P56278.
    PRIDEi P56278.

    Protocols and materials databases

    DNASUi 4515.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000362018 ; ENSP00000355058 ; ENSG00000214827 . [P56278-1 ]
    ENST00000369476 ; ENSP00000358488 ; ENSG00000214827 . [P56278-1 ]
    GeneIDi 4515.
    KEGGi hsa:4515.
    UCSCi uc004fmz.2. human. [P56278-1 ]

    Organism-specific databases

    CTDi 4515.
    GeneCardsi GC0XM154290.
    HGNCi HGNC:7423. MTCP1.
    MIMi 300116. gene.
    neXtProti NX_P56278.
    PharmGKBi PA164742098.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG76642.
    HOGENOMi HOG000037945.
    HOVERGENi HBG052523.
    InParanoidi P56278.
    KOi K16837.
    OMAi TWVAVLE.
    PhylomeDBi P56278.
    TreeFami TF337903.

    Miscellaneous databases

    EvolutionaryTracei P56278.
    GeneWikii MTCP1.
    GenomeRNAii 4515.
    NextBioi 17437.
    PROi P56278.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56278.
    CleanExi HS_MTCP1.
    Genevestigatori P56278.

    Family and domain databases

    Gene3Di 2.40.15.10. 1 hit.
    InterProi IPR004832. TCL1_MTCP1.
    [Graphical view ]
    Pfami PF01840. TCL1_MTCP1. 1 hit.
    [Graphical view ]
    ProDomi PD015575. TCL1_MTCP1. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50904. SSF50904. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations."
      Stern M.-H., Soulier J., Rosenzwajg M., Nakahara K., Canki-Klain N., Aurias A., Sigaux F., Kirsch I.R.
      Oncogene 8:2475-2483(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
      Tissue: T-cell.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The protooncogene TCL1 is an Akt kinase coactivator."
      Laine J., Kuenstle G., Obata T., Sha M., Noguchi M.
      Mol. Cell 6:395-407(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH AKT1 AND AKT2.
    5. "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family."
      Laine J., Kuenstle G., Obata T., Noguchi M.
      J. Biol. Chem. 277:3743-3751(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF INTERACTION WITH AKT3.
    6. "Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies."
      Fu Z.Q., du Bois G.C., Song S.P., Kulikovskaya I., Virgilio L., Rothstein J.L., Croce C.M., Weber I.T., Harrison R.W.
      Proc. Natl. Acad. Sci. U.S.A. 95:3413-3418(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
    7. "Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data."
      Guignard L., Padilla A., Mispelter J., Yang Y.-S., Stern M.-H., Lhoste J.-M., Roumestand C.
      J. Biomol. NMR 17:215-230(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiMTCP1_HUMAN
    AccessioniPrimary (citable) accession number: P56278
    Secondary accession number(s): Q5HYP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3