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Protein

Cx9C motif-containing protein 4

Gene

CMC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell proliferation Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cx9C motif-containing protein 4
Alternative name(s):
Mature T-cell proliferation 1 neighbor protein
Mature T-cell proliferation-1 type A
Short name:
MTCP-1 type A
Protein p8 MTCP-1
Short name:
p8MTCP1
Gene namesi
Name:CMC4
Synonyms:C6.1B, MTCP1, MTCP1NB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:35428. CMC4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Overexpressed in T-cell leukemia bearing a t(X;14) translocation.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA164723191.

Polymorphism and mutation databases

BioMutaiCMC4.
DMDMi3024174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6868Cx9C motif-containing protein 4PRO_0000096614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi7 ↔ 381 Publication
Disulfide bondi17 ↔ 281 Publication
Disulfide bondi39 ↔ 501 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP56277.
PaxDbiP56277.
PeptideAtlasiP56277.
PRIDEiP56277.

PTM databases

iPTMnetiP56277.
PhosphoSiteiP56277.

Expressioni

Tissue specificityi

Expressed in many tissues with a relatively high level in skeletal muscle.

Gene expression databases

CleanExiHS_MTCP1.
GenevisibleiP56277. HS.

Organism-specific databases

HPAiHPA045866.

Interactioni

Protein-protein interaction databases

IntActiP56277. 1 interaction.
MINTiMINT-3226168.
STRINGi9606.ENSP00000358491.

Structurei

Secondary structure

1
68
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 2013Combined sources
Turni21 – 233Combined sources
Helixi25 – 273Combined sources
Helixi29 – 4113Combined sources
Helixi44 – 463Combined sources
Helixi48 – 5912Combined sources
Turni60 – 634Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EI0NMR-A5-42[»]
1HP8NMR-A1-68[»]
2HP8NMR-A1-68[»]
ProteinModelPortaliP56277.
SMRiP56277. Positions 1-68.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56277.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi7 – 1711Cx9C motif 1Add
BLAST
Motifi28 – 3811Cx9C motif 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 596Poly-Glu

Domaini

The twin Cx9C motifs are involved in the recognition by the mitochondrial disulfide relay system.By similarity

Sequence similaritiesi

Belongs to the CMC4 family.Curated

Phylogenomic databases

eggNOGiENOG410J36V. Eukaryota.
ENOG410XV6I. LUCA.
GeneTreeiENSGT00390000012647.
HOGENOMiHOG000246949.
HOVERGENiHBG052522.
InParanoidiP56277.
OMAiEMRKCCA.
OrthoDBiEOG75B882.
PhylomeDBiP56277.
TreeFamiTF353119.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR009069. Cys_alpha_HP_mot_SF.
IPR027179. MTCP1.
[Graphical view]
PANTHERiPTHR15590:SF0. PTHR15590:SF0. 1 hit.
PfamiPF08991. MTCP1. 1 hit.
[Graphical view]
SUPFAMiSSF47072. SSF47072. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P56277-1) [UniParc]FASTAAdd to basket

Also known as: Short, Type A, p8 MTCP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQKDPCQKQ ACEIQKCLQA NSYMESKCQA VIQELRKCCA QYPKGRSVVC
60
SGFEKEEEEN LTRKSASK
Note: Shares a non-coding 5' exon with isoform 2 which is spliced to a different set of 3' exons encoding an unrelated protein.
Length:68
Mass (Da):7,747
Last modified:July 15, 1998 - v1
Checksum:i0646725C35A915D9
GO
Isoform 2 (identifier: P56278-1) [UniParc]FASTAAdd to basket

Also known as: Long, Type B1, p13 MTCP1

The sequence of this isoform can be found in the external entry P56278.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Shares a non-coding 5' exon with isoform 1 which is spliced to a different set of 3' exons encoding an unrelated protein.
Length:107
Mass (Da):12,600
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24459 Genomic DNA. Translation: CAA80829.1.
BT006749 mRNA. Translation: AAP35395.1.
BX470111 Genomic DNA. Translation: CAI41657.1.
CH471172 Genomic DNA. Translation: EAW72639.1.
BC002600 mRNA. Translation: AAH02600.1.
CCDSiCCDS14764.1. [P56277-1]
PIRiS70751.
RefSeqiNP_001018024.1. NM_001018024.2. [P56277-1]
UniGeneiHs.6917.

Genome annotation databases

EnsembliENST00000369479; ENSP00000358491; ENSG00000182712. [P56277-1]
ENST00000369484; ENSP00000358496; ENSG00000182712. [P56277-1]
GeneIDi100272147.
KEGGihsa:100272147.
UCSCiuc004fmy.4. human. [P56277-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24459 Genomic DNA. Translation: CAA80829.1.
BT006749 mRNA. Translation: AAP35395.1.
BX470111 Genomic DNA. Translation: CAI41657.1.
CH471172 Genomic DNA. Translation: EAW72639.1.
BC002600 mRNA. Translation: AAH02600.1.
CCDSiCCDS14764.1. [P56277-1]
PIRiS70751.
RefSeqiNP_001018024.1. NM_001018024.2. [P56277-1]
UniGeneiHs.6917.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EI0NMR-A5-42[»]
1HP8NMR-A1-68[»]
2HP8NMR-A1-68[»]
ProteinModelPortaliP56277.
SMRiP56277. Positions 1-68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56277. 1 interaction.
MINTiMINT-3226168.
STRINGi9606.ENSP00000358491.

PTM databases

iPTMnetiP56277.
PhosphoSiteiP56277.

Polymorphism and mutation databases

BioMutaiCMC4.
DMDMi3024174.

Proteomic databases

EPDiP56277.
PaxDbiP56277.
PeptideAtlasiP56277.
PRIDEiP56277.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369479; ENSP00000358491; ENSG00000182712. [P56277-1]
ENST00000369484; ENSP00000358496; ENSG00000182712. [P56277-1]
GeneIDi100272147.
KEGGihsa:100272147.
UCSCiuc004fmy.4. human. [P56277-1]

Organism-specific databases

CTDi100272147.
GeneCardsiCMC4.
HGNCiHGNC:35428. CMC4.
HPAiHPA045866.
neXtProtiNX_P56277.
PharmGKBiPA164723191.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J36V. Eukaryota.
ENOG410XV6I. LUCA.
GeneTreeiENSGT00390000012647.
HOGENOMiHOG000246949.
HOVERGENiHBG052522.
InParanoidiP56277.
OMAiEMRKCCA.
OrthoDBiEOG75B882.
PhylomeDBiP56277.
TreeFamiTF353119.

Miscellaneous databases

EvolutionaryTraceiP56277.
GenomeRNAii100272147.
PROiP56277.

Gene expression databases

CleanExiHS_MTCP1.
GenevisibleiP56277. HS.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR009069. Cys_alpha_HP_mot_SF.
IPR027179. MTCP1.
[Graphical view]
PANTHERiPTHR15590:SF0. PTHR15590:SF0. 1 hit.
PfamiPF08991. MTCP1. 1 hit.
[Graphical view]
SUPFAMiSSF47072. SSF47072. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations."
    Stern M.-H., Soulier J., Rosenzwajg M., Nakahara K., Canki-Klain N., Aurias A., Sigaux F., Kirsch I.R.
    Oncogene 8:2475-2483(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), OVEREXPRESSION IN T-CELL.
    Tissue: T-cell.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. "The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein."
    Madani A., Soulier J., Schmid M., Plichtova R., Lerme F., Gateau-Roesch O., Garnier J.-P., Pla M., Sigaux F., Stern M.-H.
    Oncogene 10:2259-2262(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif."
    Barthe P., Yang Y.-S., Chiche L., Hoh F., Strub M.-P., Guignard L., Soulier J., Stern M.-H., van Tilbeurgh H., Lhoste J.-M., Roumestand C.
    J. Mol. Biol. 274:801-815(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

Entry informationi

Entry nameiCMC4_HUMAN
AccessioniPrimary (citable) accession number: P56277
Secondary accession number(s): Q5HYP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: June 8, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

MTCP1 and MTCP1NB are transcribed from the same promoter and could be considered the same gene.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.