P56277 (MTCNB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mature T-cell proliferation 1 neighbor protein

Alternative name(s):
Mature T-cell proliferation-1 type A
Short name=MTCP-1 type A
Protein p8 MTCP-1
Short name=p8MTCP1

Gene names

Name:	MTCP1NB
Synonyms:	C6.1B, MTCP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	68 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion Ref.6.
Tissue specificity	Expressed in many tissues with a relatively high level in skeletal muscle.
Involvement in disease	Note=Overexpressed in T-cell leukemia bearing a t(X;14) translocation.
Caution	MTCP1 and MTCP1NB are transcribed from the same promoter and could be considered the same gene.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Chromosomal rearrangement
Disease	Proto-oncogene
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell proliferation Traceable author statement. Source: ProtInc
Cellular component	mitochondrion Inferred from direct assay. Source: HPA
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P56277-1)

Also known as: Short; Type A; p8 MTCP1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Shares a non-coding 5' exon with isoform 2 which is spliced to a different set of 3' exons encoding an unrelated protein.

Isoform 2 (identifier: P56278-1)

Also known as: Long; Type B1; p13 MTCP1;

The sequence of this isoform can be found in the external entry P56278.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Shares a non-coding 5' exon with isoform 1 which is spliced to a different set of 3' exons encoding an unrelated protein.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 68

68

Mature T-cell proliferation 1 neighbor protein

PRO_0000096614

Regions

Compositional bias

54 – 59

6

Poly-Glu

Amino acid modifications

Disulfide bond

7 ↔ 38

Ref.7

Disulfide bond

17 ↔ 28

Ref.7

Disulfide bond

39 ↔ 50

Ref.7

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

68

Helix Strand Turn

Details...

Helix

8 – 20

13

Turn

21 – 23

3

Helix

25 – 27

3

Helix

29 – 41

13

Helix

44 – 46

3

Helix

48 – 59

12

Turn

60 – 63

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Short) (Type A) (p8 MTCP1) [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 0646725C35A915D9	FASTA	68	7,747
	10 20 30 40 50 60 MPQKDPCQKQ ACEIQKCLQA NSYMESKCQA VIQELRKCCA QYPKGRSVVC SGFEKEEEEN LTRKSASK
	Isoform 2 (Long) (Type B1) (p13 MTCP1) [UniParc]. See P56278.		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations." Stern M.-H., Soulier J., Rosenzwajg M., Nakahara K., Canki-Klain N., Aurias A., Sigaux F., Kirsch I.R. Oncogene 8:2475-2483(1993) [PubMed: 8361760] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1). Tissue: T-cell.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[6]	"The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein." Madani A., Soulier J., Schmid M., Plichtova R., Lerme F., Gateau-Roesch O., Garnier J.-P., Pla M., Sigaux F., Stern M.-H. Oncogene 10:2259-2262(1995) [PubMed: 7784073] [Abstract] Cited for: SUBCELLULAR LOCATION.
[7]	"Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif." Barthe P., Yang Y.-S., Chiche L., Hoh F., Strub M.-P., Guignard L., Soulier J., Stern M.-H., van Tilbeurgh H., Lhoste J.-M., Roumestand C. J. Mol. Biol. 274:801-815(1997) [PubMed: 9405159] [Abstract] Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z24459 Genomic DNA. Translation: CAA80829.1.
BT006749 mRNA. Translation: AAP35395.1.
BX470111 Genomic DNA. Translation: CAI41657.1.
CH471172 Genomic DNA. Translation: EAW72639.1.
BC002600 mRNA. Translation: AAH02600.1.

IPI

IPI00446798.

PIR

S70751.

RefSeq

NP_001018024.1. NM_001018024.2.

UniGene

Hs.6917.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EI0	NMR	-	A	5-42	[»]
1HP8	NMR	-	A	1-68	[»]
2HP8	NMR	-	A	1-68	[»]

ProteinModelPortal

P56277.

SMR

P56277. Positions 1-68.

ModBase

Search...

Protein-protein interaction databases

IntAct

P56277. 1 interaction.

STRING

P56277.

Polymorphism databases

DMDM

3024174.

Proteomic databases

PeptideAtlas

P56277.

PRIDE

P56277.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000369479; ENSP00000358491; ENSG00000182712.
ENST00000369480; ENSP00000358492; ENSG00000182712.
ENST00000369484; ENSP00000358496; ENSG00000182712.

GeneID

100272147.

KEGG

hsa:100272147.

UCSC

uc004fmy.1. human.

Organism-specific databases

CTD

100272147.

GeneCards

GC0XM154289.

HGNC

HGNC:35428. MTCP1NB.

HPA

HPA045866.

neXtProt

NX_P56277.

PharmGKB

PA164723191.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG20280.

GeneTree

ENSGT00390000012647.

HOGENOM

HBG283638.

HOVERGEN

HBG052522.

InParanoid

P56277.

OMA

CEIQKCL.

OrthoDB

EOG4MCX20.

PhylomeDB

P56277.

Gene expression databases

CleanEx

HS_MTCP1.

Genevestigator

P56277.

GermOnline

ENSG00000182712. Homo sapiens.

Family and domain databases

InterPro

IPR009069. MTCP1.
[Graphical view]

Gene3D

G3DSA:1.10.810.10. pMTCP1. 1 hit.

Pfam

PF08991. DUF1903. 1 hit.
[Graphical view]

SUPFAM

SSF47072. MTCP1. 1 hit.

ProtoNet

Search...

Other

NextBio

17437.

Entry information

Entry name

MTCNB_HUMAN

Accession

Primary (citable) accession number: P56277
Secondary accession number(s): Q5HYP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	January 25, 2012
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.