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Protein

Cx9C motif-containing protein 4

Gene

CMC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell proliferation Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31460-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Cx9C motif-containing protein 4
Alternative name(s):
Mature T-cell proliferation 1 neighbor protein
Mature T-cell proliferation-1 type A
Short name:
MTCP-1 type A
Protein p8 MTCP-1
Short name:
p8MTCP1
Gene namesi
Name:CMC4
Synonyms:C6.1B, MTCP1, MTCP1NB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:35428. CMC4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Overexpressed in T-cell leukemia bearing a t(X;14) translocation.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi100272147.
OpenTargetsiENSG00000182712.
PharmGKBiPA164723191.

Polymorphism and mutation databases

BioMutaiCMC4.
DMDMi3024174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966141 – 68Cx9C motif-containing protein 4Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 38PROSITE-ProRule annotation1 Publication
Disulfide bondi17 ↔ 28PROSITE-ProRule annotation1 Publication
Disulfide bondi39 ↔ 501 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP56277.
PaxDbiP56277.
PeptideAtlasiP56277.
PRIDEiP56277.

PTM databases

iPTMnetiP56277.
PhosphoSitePlusiP56277.

Expressioni

Tissue specificityi

Expressed in many tissues with a relatively high level in skeletal muscle.

Gene expression databases

CleanExiHS_MTCP1.
GenevisibleiP56277. HS.

Organism-specific databases

HPAiHPA045866.

Interactioni

Protein-protein interaction databases

IntActiP56277. 1 interactor.
MINTiMINT-3226168.
STRINGi9606.ENSP00000358491.

Structurei

Secondary structure

168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 20Combined sources13
Turni21 – 23Combined sources3
Helixi25 – 27Combined sources3
Helixi29 – 41Combined sources13
Helixi44 – 46Combined sources3
Helixi48 – 59Combined sources12
Turni60 – 63Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EI0NMR-A5-42[»]
1HP8NMR-A1-68[»]
2HP8NMR-A1-68[»]
ProteinModelPortaliP56277.
SMRiP56277.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56277.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 46CHCHPROSITE-ProRule annotationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi7 – 17Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi28 – 38Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 59Poly-Glu6

Domaini

The twin Cx9C motifs are involved in the recognition by the mitochondrial disulfide relay system.By similarity

Sequence similaritiesi

Belongs to the CMC4 family.Curated
Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J36V. Eukaryota.
ENOG410XV6I. LUCA.
GeneTreeiENSGT00390000012647.
HOGENOMiHOG000246949.
HOVERGENiHBG052522.
InParanoidiP56277.
OMAiEMRKCCA.
OrthoDBiEOG091G1BZF.
PhylomeDBiP56277.
TreeFamiTF353119.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR009069. Cys_alpha_HP_mot_SF.
IPR027179. MTCP1.
[Graphical view]
PANTHERiPTHR15590:SF0. PTHR15590:SF0. 1 hit.
PfamiPF08991. MTCP1. 1 hit.
[Graphical view]
SUPFAMiSSF47072. SSF47072. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P56277-1) [UniParc]FASTAAdd to basket
Also known as: Short, Type A, p8 MTCP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQKDPCQKQ ACEIQKCLQA NSYMESKCQA VIQELRKCCA QYPKGRSVVC
60
SGFEKEEEEN LTRKSASK
Note: Shares a non-coding 5' exon with isoform 2 which is spliced to a different set of 3' exons encoding an unrelated protein.
Length:68
Mass (Da):7,747
Last modified:July 15, 1998 - v1
Checksum:i0646725C35A915D9
GO
Isoform 2 (identifier: P56278-1) [UniParc]FASTAAdd to basket
Also known as: Long, Type B1, p13 MTCP1
The sequence of this isoform can be found in the external entry P56278.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Shares a non-coding 5' exon with isoform 1 which is spliced to a different set of 3' exons encoding an unrelated protein.
Length:107
Mass (Da):12,600
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24459 Genomic DNA. Translation: CAA80829.1.
BT006749 mRNA. Translation: AAP35395.1.
BX470111 Genomic DNA. Translation: CAI41657.1.
CH471172 Genomic DNA. Translation: EAW72639.1.
BC002600 mRNA. Translation: AAH02600.1.
CCDSiCCDS14764.1. [P56277-1]
PIRiS70751.
RefSeqiNP_001018024.1. NM_001018024.2. [P56277-1]
UniGeneiHs.6917.

Genome annotation databases

EnsembliENST00000369479; ENSP00000358491; ENSG00000182712. [P56277-1]
ENST00000369484; ENSP00000358496; ENSG00000182712. [P56277-1]
GeneIDi100272147.
KEGGihsa:100272147.
UCSCiuc004fmy.4. human. [P56277-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24459 Genomic DNA. Translation: CAA80829.1.
BT006749 mRNA. Translation: AAP35395.1.
BX470111 Genomic DNA. Translation: CAI41657.1.
CH471172 Genomic DNA. Translation: EAW72639.1.
BC002600 mRNA. Translation: AAH02600.1.
CCDSiCCDS14764.1. [P56277-1]
PIRiS70751.
RefSeqiNP_001018024.1. NM_001018024.2. [P56277-1]
UniGeneiHs.6917.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EI0NMR-A5-42[»]
1HP8NMR-A1-68[»]
2HP8NMR-A1-68[»]
ProteinModelPortaliP56277.
SMRiP56277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56277. 1 interactor.
MINTiMINT-3226168.
STRINGi9606.ENSP00000358491.

PTM databases

iPTMnetiP56277.
PhosphoSitePlusiP56277.

Polymorphism and mutation databases

BioMutaiCMC4.
DMDMi3024174.

Proteomic databases

EPDiP56277.
PaxDbiP56277.
PeptideAtlasiP56277.
PRIDEiP56277.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369479; ENSP00000358491; ENSG00000182712. [P56277-1]
ENST00000369484; ENSP00000358496; ENSG00000182712. [P56277-1]
GeneIDi100272147.
KEGGihsa:100272147.
UCSCiuc004fmy.4. human. [P56277-1]

Organism-specific databases

CTDi100272147.
DisGeNETi100272147.
GeneCardsiCMC4.
HGNCiHGNC:35428. CMC4.
HPAiHPA045866.
neXtProtiNX_P56277.
OpenTargetsiENSG00000182712.
PharmGKBiPA164723191.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J36V. Eukaryota.
ENOG410XV6I. LUCA.
GeneTreeiENSGT00390000012647.
HOGENOMiHOG000246949.
HOVERGENiHBG052522.
InParanoidiP56277.
OMAiEMRKCCA.
OrthoDBiEOG091G1BZF.
PhylomeDBiP56277.
TreeFamiTF353119.

Enzyme and pathway databases

BioCyciZFISH:G66-31460-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Miscellaneous databases

EvolutionaryTraceiP56277.
GenomeRNAii100272147.
PROiP56277.

Gene expression databases

CleanExiHS_MTCP1.
GenevisibleiP56277. HS.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR009069. Cys_alpha_HP_mot_SF.
IPR027179. MTCP1.
[Graphical view]
PANTHERiPTHR15590:SF0. PTHR15590:SF0. 1 hit.
PfamiPF08991. MTCP1. 1 hit.
[Graphical view]
SUPFAMiSSF47072. SSF47072. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCMC4_HUMAN
AccessioniPrimary (citable) accession number: P56277
Secondary accession number(s): Q5HYP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

MTCP1 and MTCP1NB are transcribed from the same promoter and could be considered the same gene.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.