Reviewed, UniProtKB/Swiss-Prot P56277 (MTCPA_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein p8 MTCP-1
      Short name=p8MTCP1
Alternative name(s):
    Mature T-cell proliferation-1 type A
      Short name=MTCP-1 type A

Gene names

Name:	MTCP1
Synonyms:	C6.1B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	68 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Mitochondrion. Ref.4
Tissue specificity	Expressed in many tissues with a relatively high level in skeletal muscle.
Involvement in disease	Overexpressed in T-cell leukemia bearing a t(X;14) translocation.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Chromosomal rearrangement
Disease	Proto-oncogene
PTM	Disulfide bond
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cell proliferation Ref.1 Traceable author statement. Source: ProtInc
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Short (identifier: P56277-1)

Also known as: Type A; p8 MTCP1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Long (identifier: P56278-1)

Also known as: Type B1; p13 MTCP1;

The sequence of this isoform can be found in the external entry P56278-1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 68

68

Protein p8 MTCP-1

PRO_0000096614

Regions

Compositional bias

54 – 59

6

Poly-Glu

Amino acid modifications

Disulfide bond

7 ↔ 38

Ref.5

Disulfide bond

17 ↔ 28

Ref.5

Disulfide bond

39 ↔ 50

Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

68

Helix Strand Turn

Details...

Helix

8 – 20

13

Turn

21 – 23

3

Helix

25 – 27

3

Helix

29 – 41

13

Helix

44 – 46

3

Helix

48 – 59

12

Turn

60 – 63

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform Short (Type A) (p8 MTCP1) [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 0646725C35A915D9	FASTA	68	7,747
	10 20 30 40 50 60 MPQKDPCQKQ ACEIQKCLQA NSYMESKCQA VIQELRKCCA QYPKGRSVVC SGFEKEEEEN LTRKSASK
	Isoform Long (Type B1) (p13 MTCP1). See P56278.	FASTA	–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations." Stern M.-H., Soulier J., Rosenzwajg M., Nakahara K., Canki-Klain N., Aurias A., Sigaux F., Kirsch I.R. Oncogene 8:2475-2483(1993) [PubMed: 8361760] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: T-cell.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein." Madani A., Soulier J., Schmid M., Plichtova R., Lerme F., Gateau-Roesch O., Garnier J.-P., Pla M., Sigaux F., Stern M.-H. Oncogene 10:2259-2262(1995) [PubMed: 7784073] [Abstract] Cited for: SUBCELLULAR LOCATION.
[5]	"Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif." Barthe P., Yang Y.-S., Chiche L., Hoh F., Strub M.-P., Guignard L., Soulier J., Stern M.-H., van Tilbeurgh H., Lhoste J.-M., Roumestand C. J. Mol. Biol. 274:801-815(1997) [PubMed: 9405159] [Abstract] Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBLGenBankDDBJ

Z24459 Genomic DNA. Translation: CAA80829.1.
BT006749 mRNA. Translation: AAP35395.1.
BC002600 mRNA. Translation: AAH02600.1.

IPI

IPI00446798.

PIR

S70751.

RefSeq

NP_001018024.1.

UniGene

Hs.6917

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EI0	NMR	-	A	5-42	[»]
1HP8	NMR	-	A	1-68	[»]
2HP8	NMR	-	A	1-68	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

P56277. 1 interaction.

Proteomic databases

PeptideAtlas

P56277.

PRIDE

P56277.

Genome annotation databases

Ensembl

ENSG00000182712. Homo sapiens. [Contig view]

GeneID

100272147.

KEGG

hsa:4515.

Organism-specific databases

GeneCards

GC0XM153853.

HGNC

HGNC:7423. MTCP1.

MIM

300116. gene.

PharmGKB

PA31230.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

P56277.

OMA

P56277. CEIQKCL.

Gene expression databases

CleanEx

HS_MTCP1.

GermOnline

ENSG00000182712. Homo sapiens.

Family and domain databases

InterPro

IPR009069. MTCP1.
[Graphical view]

Gene3D

G3DSA:1.10.810.10. pMTCP1. 1 hit.

Pfam

PF08991. DUF1903. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

17437.

SOURCE

Search...

Entry information

Entry name

MTCPA_HUMAN

Accession

Primary (citable) accession number: P56277

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	June 16, 2009
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)