Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pepsin-2B

Gene
N/A
Organism
Gadus morhua (Atlantic cod)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei32PROSITE-ProRule annotation1
Active sitei214PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Keywords - Biological processi

Digestion

Protein family/group databases

MEROPSiA01.055.

Names & Taxonomyi

Protein namesi
Recommended name:
Pepsin-2B (EC:3.4.23.-)
Alternative name(s):
Pepsin IIB
OrganismiGadus morhua (Atlantic cod)
Taxonomic identifieri8049 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995161 – 324Pepsin-2BAdd BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 50By similarity
Disulfide bondi206 ↔ 209By similarity
Disulfide bondi247 ↔ 280By similarity

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1324
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 9Combined sources8
Turni10 – 12Combined sources3
Beta strandi13 – 20Combined sources8
Turni21 – 24Combined sources4
Beta strandi25 – 32Combined sources8
Beta strandi38 – 40Combined sources3
Helixi48 – 51Combined sources4
Helixi58 – 60Combined sources3
Beta strandi65 – 74Combined sources10
Beta strandi79 – 94Combined sources16
Beta strandi96 – 106Combined sources11
Turni110 – 114Combined sources5
Beta strandi116 – 122Combined sources7
Helixi126 – 128Combined sources3
Helixi130 – 132Combined sources3
Helixi136 – 142Combined sources7
Beta strandi146 – 154Combined sources9
Beta strandi163 – 169Combined sources7
Helixi172 – 174Combined sources3
Beta strandi180 – 183Combined sources4
Turni187 – 190Combined sources4
Beta strandi191 – 194Combined sources4
Beta strandi196 – 199Combined sources4
Beta strandi209 – 213Combined sources5
Beta strandi218 – 222Combined sources5
Turni224 – 226Combined sources3
Helixi227 – 234Combined sources8
Beta strandi249 – 253Combined sources5
Beta strandi256 – 260Combined sources5
Beta strandi263 – 267Combined sources5
Helixi269 – 272Combined sources4
Beta strandi273 – 278Combined sources6
Beta strandi280 – 282Combined sources3
Beta strandi284 – 286Combined sources3
Beta strandi292 – 294Combined sources3
Beta strandi296 – 299Combined sources4
Helixi301 – 306Combined sources6
Beta strandi307 – 312Combined sources6
Turni313 – 316Combined sources4
Beta strandi317 – 323Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AM5X-ray2.16A1-324[»]
ProteinModelPortaliP56272.
SMRiP56272.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56272.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 321Peptidase A1PROSITE-ProRule annotationAdd BLAST308

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG000482.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56272-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RVTEQMKNEA DTEYYGVISI GTPPESFKVI FDTGSSNLWV SSSHCSAQAC
60 70 80 90 100
SNHNKFKPRQ SSTYVETGKT VDLTYGTGGM RGILGQDTVS VGGGSDPNQE
110 120 130 140 150
LGESQTEPGP FQAAAPFDGI LGLAYPSIAA AGAVPVFDNM GSQSLVEKDL
160 170 180 190 200
FSFYLSGGGA NGSEVMLGGV DNSHYTGSIH WIPVTAEKYW QVALDGITVN
210 220 230 240 250
GQTAACEGCQ AIVDTGTSKI VAPVSALANI MKDIGASENQ GEMMGNCASV
260 270 280 290 300
QSLPDITFTI NGVKQPLPPS AYIEGDQAFC TSGLGSSGVP SNTSELWIFG
310 320
DVFLRNYYTI YDRTNNKVGF APAA
Length:324
Mass (Da):34,014
Last modified:July 15, 1998 - v1
Checksum:iEE3A6097B6941DD7
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AM5X-ray2.16A1-324[»]
ProteinModelPortaliP56272.
SMRiP56272.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA01.055.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000482.

Miscellaneous databases

EvolutionaryTraceiP56272.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEP2B_GADMO
AccessioniPrimary (citable) accession number: P56272
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.