Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pepsin-2B

Gene
N/A
Organism
Gadus morhua (Atlantic cod)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei32 – 321PROSITE-ProRule annotation
Active sitei214 – 2141PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Keywords - Biological processi

Digestion

Protein family/group databases

MEROPSiA01.055.

Names & Taxonomyi

Protein namesi
Recommended name:
Pepsin-2B (EC:3.4.23.-)
Alternative name(s):
Pepsin IIB
OrganismiGadus morhua (Atlantic cod)
Taxonomic identifieri8049 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Pepsin-2BPRO_0000199516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 50By similarity
Disulfide bondi206 ↔ 209By similarity
Disulfide bondi247 ↔ 280By similarity

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
324
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 98Combined sources
Turni10 – 123Combined sources
Beta strandi13 – 208Combined sources
Turni21 – 244Combined sources
Beta strandi25 – 328Combined sources
Beta strandi38 – 403Combined sources
Helixi48 – 514Combined sources
Helixi58 – 603Combined sources
Beta strandi65 – 7410Combined sources
Beta strandi79 – 9416Combined sources
Beta strandi96 – 10611Combined sources
Turni110 – 1145Combined sources
Beta strandi116 – 1227Combined sources
Helixi126 – 1283Combined sources
Helixi130 – 1323Combined sources
Helixi136 – 1427Combined sources
Beta strandi146 – 1549Combined sources
Beta strandi163 – 1697Combined sources
Helixi172 – 1743Combined sources
Beta strandi180 – 1834Combined sources
Turni187 – 1904Combined sources
Beta strandi191 – 1944Combined sources
Beta strandi196 – 1994Combined sources
Beta strandi209 – 2135Combined sources
Beta strandi218 – 2225Combined sources
Turni224 – 2263Combined sources
Helixi227 – 2348Combined sources
Beta strandi249 – 2535Combined sources
Beta strandi256 – 2605Combined sources
Beta strandi263 – 2675Combined sources
Helixi269 – 2724Combined sources
Beta strandi273 – 2786Combined sources
Beta strandi280 – 2823Combined sources
Beta strandi284 – 2863Combined sources
Beta strandi292 – 2943Combined sources
Beta strandi296 – 2994Combined sources
Helixi301 – 3066Combined sources
Beta strandi307 – 3126Combined sources
Turni313 – 3164Combined sources
Beta strandi317 – 3237Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AM5X-ray2.16A1-324[»]
ProteinModelPortaliP56272.
SMRiP56272. Positions 1-324.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56272.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 321308Peptidase A1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG000482.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56272-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RVTEQMKNEA DTEYYGVISI GTPPESFKVI FDTGSSNLWV SSSHCSAQAC
60 70 80 90 100
SNHNKFKPRQ SSTYVETGKT VDLTYGTGGM RGILGQDTVS VGGGSDPNQE
110 120 130 140 150
LGESQTEPGP FQAAAPFDGI LGLAYPSIAA AGAVPVFDNM GSQSLVEKDL
160 170 180 190 200
FSFYLSGGGA NGSEVMLGGV DNSHYTGSIH WIPVTAEKYW QVALDGITVN
210 220 230 240 250
GQTAACEGCQ AIVDTGTSKI VAPVSALANI MKDIGASENQ GEMMGNCASV
260 270 280 290 300
QSLPDITFTI NGVKQPLPPS AYIEGDQAFC TSGLGSSGVP SNTSELWIFG
310 320
DVFLRNYYTI YDRTNNKVGF APAA
Length:324
Mass (Da):34,014
Last modified:July 15, 1998 - v1
Checksum:iEE3A6097B6941DD7
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AM5X-ray2.16A1-324[»]
ProteinModelPortaliP56272.
SMRiP56272. Positions 1-324.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA01.055.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000482.

Miscellaneous databases

EvolutionaryTraceiP56272.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEP2B_GADMO
AccessioniPrimary (citable) accession number: P56272
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 13, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.