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Protein

Myc-associated zinc finger protein

Gene

MAZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 212C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 360C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri366 – 388C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 413C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST22

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
  • RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • termination of RNA polymerase II transcription Source: UniProtKB
  • transcription initiation from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103495-MONOMER.
SignaLinkiP56270.
SIGNORiP56270.

Names & Taxonomyi

Protein namesi
Recommended name:
Myc-associated zinc finger protein
Short name:
MAZI
Alternative name(s):
Pur-1
Purine-binding transcription factor
Serum amyloid A-activating factor-1
Short name:
SAF-1
Transcription factor Zif87
ZF87
Zinc finger protein 801
Gene namesi
Name:MAZ
Synonyms:ZNF801
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:6914. MAZ.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: In brains of Alzheimer disease patients, present in a plaque-like structures.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4150.
OpenTargetsiENSG00000103495.
PharmGKBiPA30657.

Polymorphism and mutation databases

DMDMi3024110.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472151 – 477Myc-associated zinc finger proteinAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei361PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP56270.
PaxDbiP56270.
PeptideAtlasiP56270.
PRIDEiP56270.

PTM databases

iPTMnetiP56270.
PhosphoSitePlusiP56270.

Expressioni

Tissue specificityi

Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000103495.
CleanExiHS_MAZ.
ExpressionAtlasiP56270. baseline and differential.
GenevisibleiP56270. HS.

Organism-specific databases

HPAiHPA048315.
HPA065930.
HPA066008.

Interactioni

Subunit structurei

Interacts with BPTF.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DCCP431464EBI-1809742,EBI-1222919
DccP702112EBI-1809742,EBI-1798863From a different organism.
dccQ915622EBI-1809742,EBI-1809954From a different organism.

Protein-protein interaction databases

BioGridi110320. 13 interactors.
IntActiP56270. 12 interactors.
MINTiMINT-7004867.
STRINGi9606.ENSP00000219782.

Structurei

3D structure databases

ProteinModelPortaliP56270.
SMRiP56270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 108Poly-AlaAdd BLAST13
Compositional biasi133 – 139Poly-Pro7
Compositional biasi157 – 161Poly-Ala5
Compositional biasi245 – 249Poly-Gly5
Compositional biasi435 – 449Poly-AlaAdd BLAST15

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 212C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 360C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri366 – 388C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 413C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063522.
HOGENOMiHOG000294183.
HOVERGENiHBG018163.
InParanoidiP56270.
OrthoDBiEOG091G07SU.
PhylomeDBiP56270.
TreeFamiTF331686.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P56270-1) [UniParc]FASTAAdd to basket
Also known as: SAF-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPVFPCTLL APPFPVLGLD SRGVGGLMNS FPPPQGHAQN PLQVGAELQS
60 70 80 90 100
RFFASQGCAQ SPFQAAPAPP PTPQAPAAEP LQVDLLPVLA AAQESAAAAA
110 120 130 140 150
AAAAAAAAVA AAPPAPAAAS TVDTAALKQP PAPPPPPPPV SAPAAEAAPP
160 170 180 190 200
ASAATIAAAA ATAVVAPTST VAVAPVASAL EKKTKSKGPY ICALCAKEFK
210 220 230 240 250
NGYNLRRHEA IHTGAKAGRV PSGAMKMPTM VPLSLLSVPQ LSGAGGGGGE
260 270 280 290 300
AGAGGGAAAV AAGGVVTTTA SGKRIRKNHA CEMCGKAFRD VYHLNRHKLS
310 320 330 340 350
HSDEKPYQCP VCQQRFKRKD RMSYHVRSHD GAVHKPYNCS HCGKSFSRPD
360 370 380 390 400
HLNSHVRQVH STERPFKCEK CEAAFATKDR LRAHTVRHEE KVPCHVCGKM
410 420 430 440 450
LSSAYISDHM KVHSQGPHHV CELCNKGTGE VCPMAAAAAA AAAAAAAAVA
460 470
APPTAVGSLS GAEGVPVSSQ PLPSQPW
Length:477
Mass (Da):48,608
Last modified:July 15, 1998 - v1
Checksum:iC04C80F32C3C6825
GO
Isoform 2 (identifier: P56270-2) [UniParc]FASTAAdd to basket
Also known as: SAF-2

The sequence of this isoform differs from the canonical sequence as follows:
     428-477: TGEVCPMAAA...SSQPLPSQPW → FTTAAYLRIH...GDAPQPQPTC

Note: May act as a dominant negative of isoform 1. Reduced expression during inflammatory conditions.
Show »
Length:493
Mass (Da):51,073
Checksum:iAEC386D7CC718E50
GO
Isoform 3 (identifier: P56270-3) [UniParc]FASTAAdd to basket
Also known as: SAF-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MFPVFPCTLLAPPFPVLGLDSRGVGGLMNSFPPP → MDPSNWSSFIF

Note: Very low expression in normal tissues, but high expression during inflammation. The transactivation potential of SAF-3 is much greater than that of the predominantly expressed form 1.
Show »
Length:454
Mass (Da):46,366
Checksum:i4DD5531A4AD4846D
GO
Isoform 4 (identifier: P56270-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-369: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:172
Mass (Da):17,763
Checksum:iC972B7CF156DA9EB
GO

Sequence cautioni

The sequence AAB04121 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA12728 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti259Missing in BAA12728 (PubMed:8831693).Curated1
Sequence conflicti389E → K in AAN03800 (PubMed:12270922).Curated1
Sequence conflicti395 – 396HV → PW in AAN03800 (PubMed:12270922).Curated2
Sequence conflicti401L → M (PubMed:1567856).Curated1
Sequence conflicti401L → M (PubMed:8626793).Curated1
Sequence conflicti443 – 447Missing (PubMed:8831693).Curated5

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0475601 – 34MFPVF…SFPPP → MDPSNWSSFIF in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_05510865 – 369Missing in isoform 4. CuratedAdd BLAST305
Alternative sequenceiVSP_044561428 – 477TGEVC…PSQPW → FTTAAYLRIHAVKDHGLQAP RADRILCKLCSVHCKTPAQL AGHMQTHLGGAAPPVPGDAP QPQPTC in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94046 mRNA. No translation available.
M93339 mRNA. No translation available.
D85131 mRNA. Translation: BAA12728.1. Different initiation.
U33819 mRNA. Translation: AAB04121.1. Different initiation.
AB017335 Genomic DNA. Translation: BAA33064.1.
AF489858 mRNA. Translation: AAN03800.1.
EF059746 mRNA. Translation: ABN80996.1.
FJ532357 mRNA. Translation: ACS26236.1.
AC009133 Genomic DNA. No translation available.
CH471238 Genomic DNA. Translation: EAW79996.1.
CH471238 Genomic DNA. Translation: EAW79997.1.
CCDSiCCDS42143.1. [P56270-1]
CCDS42144.1. [P56270-2]
CCDS61902.1. [P56270-3]
CCDS61903.1. [P56270-4]
PIRiA42170.
JC5076.
RefSeqiNP_001036004.1. NM_001042539.2. [P56270-2]
NP_001263204.1. NM_001276275.1. [P56270-3]
NP_001263205.1. NM_001276276.1. [P56270-4]
NP_002374.2. NM_002383.3. [P56270-1]
UniGeneiHs.23650.

Genome annotation databases

EnsembliENST00000219782; ENSP00000219782; ENSG00000103495. [P56270-2]
ENST00000322945; ENSP00000313362; ENSG00000103495. [P56270-1]
ENST00000545521; ENSP00000443956; ENSG00000103495. [P56270-3]
ENST00000562337; ENSP00000455726; ENSG00000103495. [P56270-4]
GeneIDi4150.
KEGGihsa:4150.
UCSCiuc002dtx.5. human. [P56270-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94046 mRNA. No translation available.
M93339 mRNA. No translation available.
D85131 mRNA. Translation: BAA12728.1. Different initiation.
U33819 mRNA. Translation: AAB04121.1. Different initiation.
AB017335 Genomic DNA. Translation: BAA33064.1.
AF489858 mRNA. Translation: AAN03800.1.
EF059746 mRNA. Translation: ABN80996.1.
FJ532357 mRNA. Translation: ACS26236.1.
AC009133 Genomic DNA. No translation available.
CH471238 Genomic DNA. Translation: EAW79996.1.
CH471238 Genomic DNA. Translation: EAW79997.1.
CCDSiCCDS42143.1. [P56270-1]
CCDS42144.1. [P56270-2]
CCDS61902.1. [P56270-3]
CCDS61903.1. [P56270-4]
PIRiA42170.
JC5076.
RefSeqiNP_001036004.1. NM_001042539.2. [P56270-2]
NP_001263204.1. NM_001276275.1. [P56270-3]
NP_001263205.1. NM_001276276.1. [P56270-4]
NP_002374.2. NM_002383.3. [P56270-1]
UniGeneiHs.23650.

3D structure databases

ProteinModelPortaliP56270.
SMRiP56270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110320. 13 interactors.
IntActiP56270. 12 interactors.
MINTiMINT-7004867.
STRINGi9606.ENSP00000219782.

PTM databases

iPTMnetiP56270.
PhosphoSitePlusiP56270.

Polymorphism and mutation databases

DMDMi3024110.

Proteomic databases

MaxQBiP56270.
PaxDbiP56270.
PeptideAtlasiP56270.
PRIDEiP56270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219782; ENSP00000219782; ENSG00000103495. [P56270-2]
ENST00000322945; ENSP00000313362; ENSG00000103495. [P56270-1]
ENST00000545521; ENSP00000443956; ENSG00000103495. [P56270-3]
ENST00000562337; ENSP00000455726; ENSG00000103495. [P56270-4]
GeneIDi4150.
KEGGihsa:4150.
UCSCiuc002dtx.5. human. [P56270-1]

Organism-specific databases

CTDi4150.
DisGeNETi4150.
GeneCardsiMAZ.
HGNCiHGNC:6914. MAZ.
HPAiHPA048315.
HPA065930.
HPA066008.
MIMi600999. gene.
neXtProtiNX_P56270.
OpenTargetsiENSG00000103495.
PharmGKBiPA30657.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063522.
HOGENOMiHOG000294183.
HOVERGENiHBG018163.
InParanoidiP56270.
OrthoDBiEOG091G07SU.
PhylomeDBiP56270.
TreeFamiTF331686.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103495-MONOMER.
SignaLinkiP56270.
SIGNORiP56270.

Miscellaneous databases

GeneWikiiMAZ_(gene).
GenomeRNAii4150.
PROiP56270.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103495.
CleanExiHS_MAZ.
ExpressionAtlasiP56270. baseline and differential.
GenevisibleiP56270. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAZ_HUMAN
AccessioniPrimary (citable) accession number: P56270
Secondary accession number(s): A8QJL9
, C6G496, G5E927, H3BQD6, Q15703, Q8NFN7, Q99443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.