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Protein

CCAAT/enhancer-binding protein epsilon

Gene

Cebpe

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein epsilon
Short name:
C/EBP epsilon
Alternative name(s):
C/EBP-related protein 11 Publication
Gene namesi
Name:Cebpe
Synonyms:Crp11 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi2329. Cebpe.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281CCAAT/enhancer-binding protein epsilonPRO_0000076626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei181 – 1811PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP56261.

Expressioni

Gene expression databases

GenevisibleiP56261. RN.

Interactioni

Subunit structurei

Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPD (PubMed:1884998).1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019154.

Structurei

3D structure databases

ProteinModelPortaliP56261.
SMRiP56261. Positions 198-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 26764bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni208 – 24538Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni246 – 26722Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3119. Eukaryota.
ENOG410YJ8G. LUCA.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000013112.
HOVERGENiHBG050879.
InParanoidiP56261.
KOiK10051.
OMAiCDHEASI.
OrthoDBiEOG7R56TQ.
PhylomeDBiP56261.
TreeFamiTF105008.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
IPR016468. C/EBP_chordates.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE
60 70 80 90 100
EQLLSDLFAM KPTPEARSLK GPGTPSFPHY LPADPRPFAY PSHTFGPDRK
110 120 130 140 150
ALGPGIYSNP GSYDPRAVAV KEEPRGPEGN RGTGRGSYNP LQYQVAHCGQ
160 170 180 190 200
TAVHLPPTLA APGQPLRVLK APVAAAAPPC SPLLKAPSPA GPSHKGKKAV
210 220 230 240 250
NKDSLEYRLR RERNNIAVRK SRDKAKRRIM ETQQKVLEYM AENERLRSRV
260 270 280
DQLTQELDTL RNLFRQIPEA ASLIKGVGGC S
Length:281
Mass (Da):30,590
Last modified:May 30, 2000 - v2
Checksum:i68B16455C034E250
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034716 Genomic DNA. Translation: AAC24455.1.
PIRiA37280.
RefSeqiNP_058791.1. NM_017095.1.
UniGeneiRn.44462.

Genome annotation databases

EnsembliENSRNOT00000019155; ENSRNOP00000019154; ENSRNOG00000014282.
GeneIDi25410.
KEGGirno:25410.
UCSCiRGD:2329. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034716 Genomic DNA. Translation: AAC24455.1.
PIRiA37280.
RefSeqiNP_058791.1. NM_017095.1.
UniGeneiRn.44462.

3D structure databases

ProteinModelPortaliP56261.
SMRiP56261. Positions 198-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019154.

Proteomic databases

PaxDbiP56261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019155; ENSRNOP00000019154; ENSRNOG00000014282.
GeneIDi25410.
KEGGirno:25410.
UCSCiRGD:2329. rat.

Organism-specific databases

CTDi1053.
RGDi2329. Cebpe.

Phylogenomic databases

eggNOGiKOG3119. Eukaryota.
ENOG410YJ8G. LUCA.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000013112.
HOVERGENiHBG050879.
InParanoidiP56261.
KOiK10051.
OMAiCDHEASI.
OrthoDBiEOG7R56TQ.
PhylomeDBiP56261.
TreeFamiTF105008.

Miscellaneous databases

NextBioi606535.
PROiP56261.

Gene expression databases

GenevisibleiP56261. RN.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
IPR016468. C/EBP_chordates.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "C/EBPepsilon is a myeloid-specific activator of cytokine, chemokine, and macrophage-colony-stimulating factor receptor genes."
    Williams S.C., Du Y., Schwartz R.C., Weiler S.R., Ortiz M., Keller J.R., Johnson P.F.
    J. Biol. Chem. 273:13493-13501(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro."
    Williams S.C., Cantwell C.A., Johnson P.F.
    Genes Dev. 5:1553-1567(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-281, SUBUNIT.

Entry informationi

Entry nameiCEBPE_RAT
AccessioniPrimary (citable) accession number: P56261
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: February 17, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.