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Protein

Hemoglobin subunit beta

Gene

hbb

Organism
Leiostomus xanthurus (Spot)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Iron (heme distal ligand)By similarity1
Metal bindingi92Iron (heme proximal ligand)Combined sources1 Publication1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta
Alternative name(s):
Beta-globin
Hemoglobin beta chain
Gene namesi
Name:hbb
OrganismiLeiostomus xanthurus (Spot)
Taxonomic identifieri59837 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSciaenidaeLeiostomus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000529881 – 147Hemoglobin subunit betaAdd BLAST147

Proteomic databases

PRIDEiP56251.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

MINTiMINT-1515450.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 15Combined sources11
Helixi20 – 34Combined sources15
Helixi36 – 41Combined sources6
Helixi43 – 45Combined sources3
Helixi51 – 56Combined sources6
Helixi58 – 75Combined sources18
Turni78 – 80Combined sources3
Helixi81 – 84Combined sources4
Helixi86 – 94Combined sources9
Helixi101 – 118Combined sources18
Turni120 – 122Combined sources3
Helixi125 – 142Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SPGX-ray1.95B1-147[»]
ProteinModelPortaliP56251.
SMRiP56251.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56251.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002337. Haemoglobin_b.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P56251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VDWTDAERAA IKALWGKIDV GEIGPQALSR LLIVYPWTQR HFKGFGNIST
60 70 80 90 100
NAAILGNAKV AEHGKTVMGG LDRAVQNMDN IKNVYKQLSI KHSEKIHVDP
110 120 130 140
DNFRLLGEII TMCVGAKFGP SAFTPEIHEA WQKFLAVVVS ALGRQYH
Length:147
Mass (Da):16,294
Last modified:July 15, 1998 - v1
Checksum:i253C91230838BE0C
GO

Similar proteinsi

Entry informationi

Entry nameiHBB_LEIXA
AccessioniPrimary (citable) accession number: P56251
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 25, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families