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Protein

Hemoglobin subunit beta

Gene

hbb

Organism
Leiostomus xanthurus (Spot)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Iron (heme distal ligand)By similarity1
Metal bindingi92Iron (heme proximal ligand)Combined sources1 Publication1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta
Alternative name(s):
Beta-globin
Hemoglobin beta chain
Gene namesi
Name:hbb
OrganismiLeiostomus xanthurus (Spot)
Taxonomic identifieri59837 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSciaenidaeLeiostomus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000529881 – 147Hemoglobin subunit betaAdd BLAST147

Proteomic databases

PRIDEiP56251

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

IntActiP56251 1 interactor.
MINTiP56251

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 15Combined sources11
Helixi20 – 34Combined sources15
Helixi36 – 41Combined sources6
Helixi43 – 45Combined sources3
Helixi51 – 56Combined sources6
Helixi58 – 75Combined sources18
Turni78 – 80Combined sources3
Helixi81 – 84Combined sources4
Helixi86 – 94Combined sources9
Helixi101 – 118Combined sources18
Turni120 – 122Combined sources3
Helixi125 – 142Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SPGX-ray1.95B1-147[»]
ProteinModelPortaliP56251
SMRiP56251
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56251

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.101 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

P56251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VDWTDAERAA IKALWGKIDV GEIGPQALSR LLIVYPWTQR HFKGFGNIST
60 70 80 90 100
NAAILGNAKV AEHGKTVMGG LDRAVQNMDN IKNVYKQLSI KHSEKIHVDP
110 120 130 140
DNFRLLGEII TMCVGAKFGP SAFTPEIHEA WQKFLAVVVS ALGRQYH
Length:147
Mass (Da):16,294
Last modified:July 15, 1998 - v1
Checksum:i253C91230838BE0C
GO

Similar proteinsi

Entry informationi

Entry nameiHBB_LEIXA
AccessioniPrimary (citable) accession number: P56251
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing