Reviewed, UniProtKB/Swiss-Prot P56243 (CR42_LITCE)

Names and origin

Protein names	Recommended name:     Caerin-4.2
Organism	Litoria caerulea (Green tree frog)
Taxonomic identifier	30344 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Hyloidea › Hylidae › Pelodryadinae › Litoria

Protein attributes

Sequence length	23 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the skin parotoid and/or rostral glands.
Sequence similarities	Belongs to the frog skin active peptide (FSAP) family. Caerin subfamily.
Mass spectrometry	Molecular weight is 2340 Da from positions 1 - 23. Determined by FAB. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Amphibian defense peptide Antibiotic Antimicrobial
PTM	Amidation
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Peptide	1 – 23	23	Caerin-4.2
Amino acid modifications
	Modified residue	23	1	Serine amide

Sequences

	Sequence		Length	Mass (Da)
	P56243-1 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 83BFDD8516ADDC87	FASTA	23	2,343
	10 20 GLWQKIKSAA GDLASGIVEA IKS

References

[1]	"Peptides from Australian frogs. The structures of the caerins from Litoria caerula." Stone D.J.M., Waugh R.J., Bowie J.H., Wallace J.C., Tyler M.J. J. Chem. Res. 138:910-936(1993) Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY. Tissue: Parotoid gland.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P56243.
Family and domain databases
ProDom	P56243. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CR42_LITCE

Accession

Primary (citable) accession number: P56243

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	July 22, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)