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P56223

- PO6F1_RAT

UniProt

P56223 - PO6F1_RAT

Protein

POU domain, class 6, transcription factor 1

Gene

Pou6f1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    • Comment

    Functioni

    Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi234 – 29360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: RGD
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 6, transcription factor 1
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 5
    Short name:
    Brain-5
    Short name:
    Brn-5
    Gene namesi
    Name:Pou6f1
    Synonyms:Brn5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi620615. Pou6f1.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear membrane Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301POU domain, class 6, transcription factor 1PRO_0000100761Add
    BLAST

    Proteomic databases

    PaxDbiP56223.

    Expressioni

    Tissue specificityi

    In the embryo, widely expressed, with highest levels in the developing brain and spinal cord. In the adult, mostly found in the brain, where it is diffusely expressed with the exception of an enrichment in layer IV of the neocortex. Also found in kidney, lung, heart, adrenal, skin, and placenta. Low levels in spleen, muscle, liver, anterior pituitary, testis and ovary.

    Gene expression databases

    GenevestigatoriP56223.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000051525.

    Structurei

    3D structure databases

    ProteinModelPortaliP56223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 1771
    Repeati50 – 5672
    Domaini139 – 21375POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni11 – 56462 X 7 AA repeats of N-A-Q-G-Q-V-IAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 139139Gln/Pro-richAdd
    BLAST

    Domaini

    Contains two direct repeats of 7 amino acids in the N-terminus.

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, Repeat

    Phylogenomic databases

    eggNOGiNOG241882.
    GeneTreeiENSGT00750000117373.
    HOGENOMiHOG000063659.
    HOVERGENiHBG008230.
    InParanoidiP56223.
    KOiK09368.
    OMAiPESHLKE.
    OrthoDBiEOG7353Z3.
    PhylomeDBiP56223.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56223-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGISSPILT NAQGQVIGAL PWVVNSASVA TPAPAQSLQV QAVTPQLLLN    50
    AQGQVIATLA SSPLPQPVAV RKPSTPESPA KSEVQPIQPT QAVPPPAVIL 100
    TSPAPALKPS ASAPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF 150
    AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY SQSAICRFEK LDITPKSAQK 200
    LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS FTPQAIEALN 250
    AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI 300
    P 301
    Length:301
    Mass (Da):32,702
    Last modified:July 15, 1998 - v1
    Checksum:i44A50F627FEB9F28
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23204 mRNA. No translation available.
    PIRiA48880.
    RefSeqiNP_001099216.1. NM_001105746.1.
    XP_006242361.1. XM_006242299.1.
    XP_006242362.1. XM_006242300.1.
    UniGeneiRn.44845.

    Genome annotation databases

    EnsembliENSRNOT00000006095; ENSRNOP00000006095; ENSRNOG00000004595.
    GeneIDi116545.
    KEGGirno:116545.
    UCSCiRGD:620615. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23204 mRNA. No translation available.
    PIRi A48880.
    RefSeqi NP_001099216.1. NM_001105746.1.
    XP_006242361.1. XM_006242299.1.
    XP_006242362.1. XM_006242300.1.
    UniGenei Rn.44845.

    3D structure databases

    ProteinModelPortali P56223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000051525.

    Proteomic databases

    PaxDbi P56223.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006095 ; ENSRNOP00000006095 ; ENSRNOG00000004595 .
    GeneIDi 116545.
    KEGGi rno:116545.
    UCSCi RGD:620615. rat.

    Organism-specific databases

    CTDi 5463.
    RGDi 620615. Pou6f1.

    Phylogenomic databases

    eggNOGi NOG241882.
    GeneTreei ENSGT00750000117373.
    HOGENOMi HOG000063659.
    HOVERGENi HBG008230.
    InParanoidi P56223.
    KOi K09368.
    OMAi PESHLKE.
    OrthoDBi EOG7353Z3.
    PhylomeDBi P56223.

    Miscellaneous databases

    NextBioi 619155.
    PROi P56223.

    Gene expression databases

    Genevestigatori P56223.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Brn-5 is a divergent POU domain factor highly expressed in layer IV of the neocortex."
      Andersen B., Schonemann M.D., Pearse R.V. II, Jenne K., Sugarman J., Rosenfeld M.G.
      J. Biol. Chem. 268:23390-23398(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Fischer.
      Tissue: Pituitary anterior lobe.

    Entry informationi

    Entry nameiPO6F1_RAT
    AccessioniPrimary (citable) accession number: P56223
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3