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P56223

- PO6F1_RAT

UniProt

P56223 - PO6F1_RAT

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Protein

POU domain, class 6, transcription factor 1

Gene

Pou6f1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi234 – 29360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: RGD
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 5
Short name:
Brain-5
Short name:
Brn-5
Gene namesi
Name:Pou6f1
Synonyms:Brn5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi620615. Pou6f1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301POU domain, class 6, transcription factor 1PRO_0000100761Add
BLAST

Proteomic databases

PaxDbiP56223.

Expressioni

Tissue specificityi

In the embryo, widely expressed, with highest levels in the developing brain and spinal cord. In the adult, mostly found in the brain, where it is diffusely expressed with the exception of an enrichment in layer IV of the neocortex. Also found in kidney, lung, heart, adrenal, skin, and placenta. Low levels in spleen, muscle, liver, anterior pituitary, testis and ovary.

Gene expression databases

GenevestigatoriP56223.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051525.

Structurei

3D structure databases

ProteinModelPortaliP56223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 1771
Repeati50 – 5672
Domaini139 – 21375POU-specificPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni11 – 56462 X 7 AA repeats of N-A-Q-G-Q-V-IAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 139139Gln/Pro-richAdd
BLAST

Domaini

Contains two direct repeats of 7 amino acids in the N-terminus.

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiNOG241882.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000063659.
HOVERGENiHBG008230.
InParanoidiP56223.
KOiK09368.
OMAiPESHLKE.
OrthoDBiEOG7353Z3.
PhylomeDBiP56223.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56223-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGISSPILT NAQGQVIGAL PWVVNSASVA TPAPAQSLQV QAVTPQLLLN
60 70 80 90 100
AQGQVIATLA SSPLPQPVAV RKPSTPESPA KSEVQPIQPT QAVPPPAVIL
110 120 130 140 150
TSPAPALKPS ASAPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF
160 170 180 190 200
AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY SQSAICRFEK LDITPKSAQK
210 220 230 240 250
LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS FTPQAIEALN
260 270 280 290 300
AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI

P
Length:301
Mass (Da):32,702
Last modified:July 15, 1998 - v1
Checksum:i44A50F627FEB9F28
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23204 mRNA. No translation available.
PIRiA48880.
RefSeqiNP_001099216.1. NM_001105746.1.
UniGeneiRn.44845.

Genome annotation databases

EnsembliENSRNOT00000006095; ENSRNOP00000006095; ENSRNOG00000004595.
GeneIDi116545.
KEGGirno:116545.
UCSCiRGD:620615. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23204 mRNA. No translation available.
PIRi A48880.
RefSeqi NP_001099216.1. NM_001105746.1.
UniGenei Rn.44845.

3D structure databases

ProteinModelPortali P56223.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000051525.

Proteomic databases

PaxDbi P56223.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006095 ; ENSRNOP00000006095 ; ENSRNOG00000004595 .
GeneIDi 116545.
KEGGi rno:116545.
UCSCi RGD:620615. rat.

Organism-specific databases

CTDi 5463.
RGDi 620615. Pou6f1.

Phylogenomic databases

eggNOGi NOG241882.
GeneTreei ENSGT00760000118935.
HOGENOMi HOG000063659.
HOVERGENi HBG008230.
InParanoidi P56223.
KOi K09368.
OMAi PESHLKE.
OrthoDBi EOG7353Z3.
PhylomeDBi P56223.

Miscellaneous databases

NextBioi 619155.
PROi P56223.

Gene expression databases

Genevestigatori P56223.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Brn-5 is a divergent POU domain factor highly expressed in layer IV of the neocortex."
    Andersen B., Schonemann M.D., Pearse R.V. II, Jenne K., Sugarman J., Rosenfeld M.G.
    J. Biol. Chem. 268:23390-23398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer.
    Tissue: Pituitary anterior lobe.

Entry informationi

Entry nameiPO6F1_RAT
AccessioniPrimary (citable) accession number: P56223
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3