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Protein

POU domain, class 6, transcription factor 1

Gene

Pou6f1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi234 – 293HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: RGD
  • DNA binding transcription factor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 5
Short name:
Brain-5
Short name:
Brn-5
Gene namesi
Name:Pou6f1
Synonyms:Brn5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi620615 Pou6f1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007611 – 301POU domain, class 6, transcription factor 1Add BLAST301

Proteomic databases

PaxDbiP56223

Expressioni

Tissue specificityi

In the embryo, widely expressed, with highest levels in the developing brain and spinal cord. In the adult, mostly found in the brain, where it is diffusely expressed with the exception of an enrichment in layer IV of the neocortex. Also found in kidney, lung, heart, adrenal, skin, and placenta. Low levels in spleen, muscle, liver, anterior pituitary, testis and ovary.

Gene expression databases

BgeeiENSRNOG00000004595
GenevisibleiP56223 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006095

Structurei

3D structure databases

ProteinModelPortaliP56223
SMRiP56223
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 1717
Repeati50 – 5627
Domaini139 – 213POU-specificPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 562 X 7 AA repeats of N-A-Q-G-Q-V-IAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 139Gln/Pro-richAdd BLAST139

Domaini

Contains two direct repeats of 7 amino acids in the N-terminus.

Sequence similaritiesi

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
GeneTreeiENSGT00760000118935
HOGENOMiHOG000063659
HOVERGENiHBG008230
InParanoidiP56223
KOiK09368
OMAiKINVFQV
OrthoDBiEOG091G04YJ
PhylomeDBiP56223

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequencei

Sequence statusi: Complete.

P56223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGISSPILT NAQGQVIGAL PWVVNSASVA TPAPAQSLQV QAVTPQLLLN
60 70 80 90 100
AQGQVIATLA SSPLPQPVAV RKPSTPESPA KSEVQPIQPT QAVPPPAVIL
110 120 130 140 150
TSPAPALKPS ASAPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF
160 170 180 190 200
AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY SQSAICRFEK LDITPKSAQK
210 220 230 240 250
LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS FTPQAIEALN
260 270 280 290 300
AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI

P
Length:301
Mass (Da):32,702
Last modified:July 15, 1998 - v1
Checksum:i44A50F627FEB9F28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23204 mRNA No translation available.
PIRiA48880
RefSeqiNP_001099216.1, NM_001105746.1
XP_017450058.1, XM_017594569.1
XP_017450059.1, XM_017594570.1
XP_017450060.1, XM_017594571.1
UniGeneiRn.44845

Genome annotation databases

EnsembliENSRNOT00000006095; ENSRNOP00000006095; ENSRNOG00000004595
GeneIDi116545
KEGGirno:116545
UCSCiRGD:620615 rat

Entry informationi

Entry nameiPO6F1_RAT
AccessioniPrimary (citable) accession number: P56223
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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