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P56223 (PO6F1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
Brain-specific homeobox/POU domain protein 5
Short name=Brain-5
Short name=Brn-5
Gene names
Name:Pou6f1
Synonyms:Brn5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').

Subcellular location

Nucleus.

Tissue specificity

In the embryo, widely expressed, with highest levels in the developing brain and spinal cord. In the adult, mostly found in the brain, where it is diffusely expressed with the exception of an enrichment in layer IV of the neocortex. Also found in kidney, lung, heart, adrenal, skin, and placenta. Low levels in spleen, muscle, liver, anterior pituitary, testis and ovary.

Domain

Contains two direct repeats of 7 amino acids in the N-terminus.

Sequence similarities

Belongs to the POU transcription factor family. Class-6 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301POU domain, class 6, transcription factor 1
PRO_0000100761

Regions

Repeat11 – 1771
Repeat50 – 5672
Domain139 – 21375POU-specific
DNA binding234 – 29360Homeobox
Region11 – 56462 X 7 AA repeats of N-A-Q-G-Q-V-I
Compositional bias1 – 139139Gln/Pro-rich

Sequences

Sequence LengthMass (Da)Tools
P56223 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 44A50F627FEB9F28

FASTA30132,702
        10         20         30         40         50         60 
MPGISSPILT NAQGQVIGAL PWVVNSASVA TPAPAQSLQV QAVTPQLLLN AQGQVIATLA 

        70         80         90        100        110        120 
SSPLPQPVAV RKPSTPESPA KSEVQPIQPT QAVPPPAVIL TSPAPALKPS ASAPIPITCS 

       130        140        150        160        170        180 
ETPTVSQLVS KPHTPSLDED GINLEEIREF AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY 

       190        200        210        220        230        240 
SQSAICRFEK LDITPKSAQK LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS 

       250        260        270        280        290        300 
FTPQAIEALN AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI 


P 

« Hide

References

[1]"Brn-5 is a divergent POU domain factor highly expressed in layer IV of the neocortex."
Andersen B., Schonemann M.D., Pearse R.V. II, Jenne K., Sugarman J., Rosenfeld M.G.
J. Biol. Chem. 268:23390-23398(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Fischer.
Tissue: Pituitary anterior lobe.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L23204 mRNA. No translation available.
PIRA48880.
RefSeqNP_001099216.1. NM_001105746.1.
XP_006242361.1. XM_006242299.1.
XP_006242362.1. XM_006242300.1.
UniGeneRn.44845.

3D structure databases

ProteinModelPortalP56223.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000051525.

Proteomic databases

PaxDbP56223.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006095; ENSRNOP00000006095; ENSRNOG00000004595.
GeneID116545.
KEGGrno:116545.
UCSCRGD:620615. rat.

Organism-specific databases

CTD5463.
RGD620615. Pou6f1.

Phylogenomic databases

eggNOGNOG241882.
GeneTreeENSGT00750000117373.
HOGENOMHOG000063659.
HOVERGENHBG008230.
InParanoidP56223.
KOK09368.
OMAPESHLKE.
OrthoDBEOG7353Z3.
PhylomeDBP56223.

Gene expression databases

GenevestigatorP56223.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio619155.
PROP56223.

Entry information

Entry namePO6F1_RAT
AccessionPrimary (citable) accession number: P56223
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 14, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families