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P56222

- PO3F2_RAT

UniProt

P56222 - PO3F2_RAT

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Protein

POU domain, class 3, transcription factor 2

Gene

Pou3f2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi356 – 41560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: RGD
  2. HMG box domain binding Source: UniProtKB
  3. RNA polymerase II transcription coactivator activity Source: UniProtKB
  4. sequence-specific DNA binding Source: RGD
  5. sequence-specific DNA binding transcription factor activity Source: RGD

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase II promoter Source: GOC
  2. regulation of transcription, DNA-templated Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 2
Alternative name(s):
Brain-specific homeobox/POU domain protein 2
Short name:
Brain-2
Short name:
Brn-2
Nervous system-specific octamer-binding transcription factor N-Oct-3
Octamer-binding protein 7
Short name:
Oct-7
Octamer-binding transcription factor 7
Short name:
OTF-7
Gene namesi
Name:Pou3f2
Synonyms:Brn2, Otf7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi61946. Pou3f2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445POU domain, class 3, transcription factor 2PRO_0000100724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei343 – 3431PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP56222.

PTM databases

PhosphoSiteiP56222.

Expressioni

Tissue specificityi

Expressed specifically at high levels in the brain.

Gene expression databases

GenevestigatoriP56222.

Interactioni

Subunit structurei

Interacts with PQBP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009043.

Structurei

3D structure databases

ProteinModelPortaliP56222.
SMRiP56222. Positions 270-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini264 – 33875POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi68 – 9023Poly-GlyAdd
BLAST
Compositional biasi125 – 15127Poly-GlnAdd
BLAST
Compositional biasi173 – 1775Poly-Ala
Compositional biasi241 – 2477Poly-Pro

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG261729.
HOGENOMiHOG000116303.
HOVERGENiHBG053120.
InParanoidiP56222.
KOiK09365.
PhylomeDBiP56222.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56222 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATAASNHYS LLTSSASIVH AEPPGGMQQG AGGYREAQSL QVQGDYGALQ
60 70 80 90 100
SNGHPLSHAH WITALSHGGS GGGGGGGGGG GGGGGGGGDG SPWSTSPLGQ
110 120 130 140 150
PDIKPSVVVQ QGGRGDELHG PGALQQQHQQ QQQQQQQQQQ QQQQQQQQQQ
160 170 180 190 200
QRPPHLVHHA ANNHPGPGAW RSAAAAAHLP PSMGASNGGL LYSQPSFTVN
210 220 230 240 250
GMLGAGGQPA GLHHHGLRDA HDEPHHADHH PHPHSHPHQQ PPPPPPPQGP
260 270 280 290 300
PGHPGAHHDP HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL
310 320 330 340 350
YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS SGSPTSIDKI
360 370 380 390 400
ASQGRKRKKR TSIEVSVKGA LESHFLKCPK PSAQEITSLA DSLQLEKEVV
410 420 430 440
RVWFCNRRQK EKRMTPPGGT LPGAEDVYGG SRDTPPHHGV QTPVQ
Length:445
Mass (Da):47,172
Last modified:July 15, 1998 - v1
Checksum:i9D2729E34E359FD3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27663 mRNA. No translation available.
PIRiA49447.
RefSeqiNP_742082.1. NM_172085.1.
UniGeneiRn.82733.

Genome annotation databases

GeneIDi29588.
KEGGirno:29588.
UCSCiRGD:61946. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27663 mRNA. No translation available.
PIRi A49447.
RefSeqi NP_742082.1. NM_172085.1.
UniGenei Rn.82733.

3D structure databases

ProteinModelPortali P56222.
SMRi P56222. Positions 270-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000009043.

PTM databases

PhosphoSitei P56222.

Proteomic databases

PaxDbi P56222.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29588.
KEGGi rno:29588.
UCSCi RGD:61946. rat.

Organism-specific databases

CTDi 5454.
RGDi 61946. Pou3f2.

Phylogenomic databases

eggNOGi NOG261729.
HOGENOMi HOG000116303.
HOVERGENi HBG053120.
InParanoidi P56222.
KOi K09365.
PhylomeDBi P56222.

Miscellaneous databases

NextBioi 609715.
PROi P56222.

Gene expression databases

Genevestigatori P56222.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors."
    Li P., He X., Gerrero M.R., Mok M., Aggarwal A., Rosenfeld M.G.
    Genes Dev. 7:2483-2496(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPO3F2_RAT
AccessioniPrimary (citable) accession number: P56222
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3