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P56222

- PO3F2_RAT

UniProt

P56222 - PO3F2_RAT

Protein

POU domain, class 3, transcription factor 2

Gene

Pou3f2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi356 – 41560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: RGD
    2. HMG box domain binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. RNA polymerase II transcription coactivator activity Source: UniProtKB
    5. sequence-specific DNA binding Source: RGD
    6. sequence-specific DNA binding transcription factor activity Source: RGD

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: GOC
    2. regulation of transcription, DNA-templated Source: RGD

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 3, transcription factor 2
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 2
    Short name:
    Brain-2
    Short name:
    Brn-2
    Nervous system-specific octamer-binding transcription factor N-Oct-3
    Octamer-binding protein 7
    Short name:
    Oct-7
    Octamer-binding transcription factor 7
    Short name:
    OTF-7
    Gene namesi
    Name:Pou3f2
    Synonyms:Brn2, Otf7
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi61946. Pou3f2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: RGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445POU domain, class 3, transcription factor 2PRO_0000100724Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei343 – 3431PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP56222.

    PTM databases

    PhosphoSiteiP56222.

    Expressioni

    Tissue specificityi

    Expressed specifically at high levels in the brain.

    Gene expression databases

    GenevestigatoriP56222.

    Interactioni

    Subunit structurei

    Interacts with PQBP1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009043.

    Structurei

    3D structure databases

    ProteinModelPortaliP56222.
    SMRiP56222. Positions 270-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini264 – 33875POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi68 – 9023Poly-GlyAdd
    BLAST
    Compositional biasi125 – 15127Poly-GlnAdd
    BLAST
    Compositional biasi173 – 1775Poly-Ala
    Compositional biasi241 – 2477Poly-Pro

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG261729.
    HOGENOMiHOG000116303.
    HOVERGENiHBG053120.
    InParanoidiP56222.
    KOiK09365.
    PhylomeDBiP56222.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56222-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATAASNHYS LLTSSASIVH AEPPGGMQQG AGGYREAQSL QVQGDYGALQ    50
    SNGHPLSHAH WITALSHGGS GGGGGGGGGG GGGGGGGGDG SPWSTSPLGQ 100
    PDIKPSVVVQ QGGRGDELHG PGALQQQHQQ QQQQQQQQQQ QQQQQQQQQQ 150
    QRPPHLVHHA ANNHPGPGAW RSAAAAAHLP PSMGASNGGL LYSQPSFTVN 200
    GMLGAGGQPA GLHHHGLRDA HDEPHHADHH PHPHSHPHQQ PPPPPPPQGP 250
    PGHPGAHHDP HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL 300
    YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS SGSPTSIDKI 350
    ASQGRKRKKR TSIEVSVKGA LESHFLKCPK PSAQEITSLA DSLQLEKEVV 400
    RVWFCNRRQK EKRMTPPGGT LPGAEDVYGG SRDTPPHHGV QTPVQ 445
    Length:445
    Mass (Da):47,172
    Last modified:July 15, 1998 - v1
    Checksum:i9D2729E34E359FD3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27663 mRNA. No translation available.
    PIRiA49447.
    RefSeqiNP_742082.1. NM_172085.1.
    UniGeneiRn.82733.

    Genome annotation databases

    GeneIDi29588.
    KEGGirno:29588.
    UCSCiRGD:61946. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27663 mRNA. No translation available.
    PIRi A49447.
    RefSeqi NP_742082.1. NM_172085.1.
    UniGenei Rn.82733.

    3D structure databases

    ProteinModelPortali P56222.
    SMRi P56222. Positions 270-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009043.

    PTM databases

    PhosphoSitei P56222.

    Proteomic databases

    PaxDbi P56222.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29588.
    KEGGi rno:29588.
    UCSCi RGD:61946. rat.

    Organism-specific databases

    CTDi 5454.
    RGDi 61946. Pou3f2.

    Phylogenomic databases

    eggNOGi NOG261729.
    HOGENOMi HOG000116303.
    HOVERGENi HBG053120.
    InParanoidi P56222.
    KOi K09365.
    PhylomeDBi P56222.

    Miscellaneous databases

    NextBioi 609715.
    PROi P56222.

    Gene expression databases

    Genevestigatori P56222.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors."
      Li P., He X., Gerrero M.R., Mok M., Aggarwal A., Rosenfeld M.G.
      Genes Dev. 7:2483-2496(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPO3F2_RAT
    AccessioniPrimary (citable) accession number: P56222
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3