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Protein

Potassium channel toxin alpha-KTx 4.2

Gene
N/A
Organism
Tityus serrulatus (Brazilian scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocker for small-conductance calcium-activated potassium channels KCa2.2/KCNN2 (Kd=80 nM) and KCa2.3/KCNN3 (Kd=197 nM) (PubMed:11527975) and ERG1/Kv11.1/KCNH2 potassium channels (53% inhibition at 5 µM) (PubMed:18687312).2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionCalcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 4.2
Alternative name(s):
Neurotoxin Ts-kappa1 Publication
Short name:
TsK1 Publication
Short name:
TsKappa3 Publications
Ts91 Publication
OrganismiTityus serrulatus (Brazilian scorpion)
Taxonomic identifieri6887 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003532921 – 22Removed by a carboxypeptidase1 Publication2
ChainiPRO_000003533023 – 57Potassium channel toxin alpha-KTx 4.21 PublicationAdd BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 501 PublicationImported
Disulfide bondi35 ↔ 551 PublicationImported
Disulfide bondi39 ↔ 571 PublicationImported

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 32Combined sources3
Helixi36 – 42Combined sources7
Beta strandi44 – 46Combined sources3
Beta strandi49 – 51Combined sources3
Beta strandi54 – 56Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TSKNMR-A23-57[»]
ProteinModelPortaliP56219.
SMRiP56219.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56219.

Family & Domainsi

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR036574. Scorpion_toxin-like_sf.
IPR001947. Scorpion_toxinS_K_inh.
PfamiView protein in Pfam
PF00451. Toxin_2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586. Scorpion_toxinS. 1 hit.
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiView protein in PROSITE
PS01138. SCORP_SHORT_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56219-1 [UniParc]FASTAAdd to basket

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        10         20         30         40         50
MKVLYGILII FILCSMFYLS QEVVIGQRCY RSPDCYSACK KLVGKATGKC

TNGRCDC
Length:57
Mass (Da):6,392
Last modified:September 9, 2003 - v2
Checksum:i044A29EDE4512A18
GO

Sequence databases

PIRiS70473.

Similar proteinsi

Entry informationi

Entry nameiKAX42_TITSE
AccessioniPrimary (citable) accession number: P56219
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 9, 2003
Last modified: February 28, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing