Reviewed, UniProtKB/Swiss-Prot P56215 (KAX81_ANDMA)

Names and origin

Protein names	Recommended name:     Potassium channel toxin alpha-KTx 8.1 Alternative name(s):     AmP01     Neurotoxin P01
Organism	Androctonus mauretanicus mauretanicus (Scorpion)
Taxonomic identifier	6860 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Androctonus

Protein attributes

Sequence length	29 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Blocker for the small conductance calcium-activated potassium channels (SK-Ca); also known as apamine-sensitive potassium channel.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 8 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Peptide

1 – 29

29

Potassium channel toxin alpha-KTx 8.1

PRO_0000044945

Amino acid modifications

Disulfide bond

3 ↔ 19

Ref.2

Disulfide bond

6 ↔ 24

Ref.2

Disulfide bond

10 ↔ 26

Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

29

Helix Strand Turn

Details...

Helix

5 – 11

7

Turn

12 – 14

3

Beta strand

16 – 20

5

Beta strand

23 – 27

5

Sequences

	Sequence		Length	Mass (Da)
	P56215-1 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: BC5F650C196E01C8	FASTA	29	3,185
	10 20 VSCEDCPEHC STQKAQAKCD NDKCVCEPI

References

[1]	"Characterization of PO1, a new peptide ligand of the apamin-sensitive Ca2+ activated K+ channel." Zerrouk H., Laraba-Djebari F., Fremont V., Meki A., Darbon H., Mansuelle P., Oughideni R., van Rietschoten J., Rochat H., Martin-Eauclaire M.-F. Int. J. Pept. Protein Res. 48:514-521(1996) [PubMed: 8985784] [Abstract] Cited for: PROTEIN SEQUENCE, CHARACTERIZATION. Tissue: Venom.
[2]	"Solution structure of P01, a natural scorpion peptide structurally analogous to scorpion toxins specific for apamin-sensitive potassium channel." Blanc E., Fremont V., Sizun P., Meunier S., van Rietschoten J., Thevand A., Bernassau J.-M., Darbon H. Proteins 24:359-369(1996) [PubMed: 8778783] [Abstract] Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

Cross-references

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ACW	NMR	-	A	1-29	[»]

ModBase

Search...

Family and domain databases

InterPro

IPR008911. Toxin_6.
[Graphical view]

Pfam

PF05453. Toxin_6. 1 hit.
[Graphical view]

PROSITE

PS01138. SCORP_SHORT_TOXIN. False negative.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

KAX81_ANDMA

Accession

Primary (citable) accession number: P56215

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	November 24, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)