Reviewed, UniProtKB/Swiss-Prot P56205 (CYC_ASPNG)

Names and origin

Protein names

Recommended name:
    Cytochrome c

Gene names

Name:

cycA

Organism

Aspergillus niger

Taxonomic identifier

5061 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location	Mitochondrion matrix.
Post-translational modification	Binds 1 heme group per subunit.
Sequence similarities	Belongs to the cytochrome c family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
PTM	Methylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 111	111	Cytochrome c		PRO_0000108317
Sites
	Metal binding	26	1	Iron (heme axial ligand)
	Metal binding	88	1	Iron (heme axial ligand) By similarity
	Binding site	22	1	Heme (covalent)
	Binding site	25	1	Heme (covalent)
Amino acid modifications
	Modified residue	80	1	N6,N6,N6-trimethyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56205-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 1F49BA817E205EB1	FASTA	111	11,954
	10 20 30 40 50 60 GKDASFAPGD SAKGAKLFQT RCAQCHTVEA GGPHKVGPNL HGLFGRKTGQ SEGYAYTDAN 70 80 90 100 110 KQAGVTWDEN TLFSYLENPK KFIPGTKMAF GGLKKGKERN DLITYLKEST A

References

[1]	"Amino acid sequence of cytochrome c from Aspergillus niger." Chin C.C.Q., Niehaus W.G., Wold F. J. Protein Chem. 8:165-171(1989) [PubMed: 2544196] [Abstract] Cited for: PROTEIN SEQUENCE.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
PIR	A61490.
3D structure databases
HSSP	HSSP built from PDB template 1CRH based on UniProtKB P00044.
SMR	P56205. Positions 6-109.
ModBase	Search...
Family and domain databases
InterPro	IPR009056. Cyt_c_monohaem. IPR003088. Cyt_CI. IPR002327. Cyt_CIAB. [Graphical view]
Gene3D	G3DSA:1.10.760.10. Cytochrome_c_R. 1 hit.
PANTHER	PTHR11961. Cyt_CIAB. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
ProDom	PD000375. Cyt_CIAB. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYC_ASPNG

Accession

Primary (citable) accession number: P56205

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 25, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)