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Protein

Cathepsin W

Gene

Ctsw

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a specific function in the mechanism or regulation of T-cell cytolytic activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei151By similarity1
Active sitei289By similarity1
Active sitei326By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Protein family/group databases

MEROPSiC01.037

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin W (EC:3.4.22.-)
Alternative name(s):
Lymphopain
Gene namesi
Name:Ctsw
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1338045 Ctsw

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002632922 – 125Sequence analysisAdd BLAST104
ChainiPRO_0000026330126 – 371Cathepsin WAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi148 ↔ 189By similarity
Disulfide bondi182 ↔ 224By similarity
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi282 ↔ 347By similarity
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiP56203
PaxDbiP56203
PRIDEiP56203

PTM databases

PhosphoSitePlusiP56203

Expressioni

Gene expression databases

BgeeiENSMUSG00000024910
CleanExiMM_CTSW
ExpressionAtlasiP56203 baseline and differential
GenevisibleiP56203 MM

Interactioni

Protein-protein interaction databases

BioGridi198977, 1 interactor
STRINGi10090.ENSMUSP00000025844

Structurei

3D structure databases

ProteinModelPortaliP56203
SMRiP56203
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1542 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140823
HOGENOMiHOG000230774
HOVERGENiHBG100117
InParanoidiP56203
KOiK08569
OMAiIFAHNLA
OrthoDBiEOG091G0AKT
TreeFamiTF337736

Family and domain databases

InterProiView protein in InterPro
IPR033158 Cathepsin_W
IPR025661 Pept_asp_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PTHR12411:SF101 PTHR12411:SF101, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLTAHLSYF LVLLLAGQGL SDSLLTKDAG PRPLELKEVF KLFQIRFNRS
60 70 80 90 100
YWNPAEYTRR LSIFAHNLAQ AQRLQQEDLG TAEFGETPFS DLTEEEFGQL
110 120 130 140 150
YGQERSPERT PNMTKKVESN TWGESVPRTC DWRKAKNIIS SVKNQGSCKC
160 170 180 190 200
CWAMAAADNI QALWRIKHQQ FVDVSVQELL DCERCGNGCN GGFVWDAYLT
210 220 230 240 250
VLNNSGLASE KDYPFQGDRK PHRCLAKKYK KVAWIQDFTM LSNNEQAIAH
260 270 280 290 300
YLAVHGPITV TINMKLLQHY QKGVIKATPS SCDPRQVDHS VLLVGFGKEK
310 320 330 340 350
EGMQTGTVLS HSRKRRHSSP YWILKNSWGA HWGEKGYFRL YRGNNTCGVT
360 370
KYPFTAQVDS PVKKARTSCP P
Length:371
Mass (Da):42,120
Last modified:July 27, 2011 - v2
Checksum:i1192C3D0C607DDB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014941 mRNA Translation: AAB82455.1
AC122861 Genomic DNA No translation available.
CCDSiCCDS29465.1
RefSeqiNP_034115.2, NM_009985.5
UniGeneiMm.113590

Genome annotation databases

EnsembliENSMUST00000025844; ENSMUSP00000025844; ENSMUSG00000024910
GeneIDi13041
KEGGimmu:13041
UCSCiuc008gdk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCATW_MOUSE
AccessioniPrimary (citable) accession number: P56203
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health