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Protein

Cathepsin W

Gene

Ctsw

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have a specific function in the mechanism or regulation of T-cell cytolytic activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei151 – 1511By similarity
Active sitei289 – 2891By similarity
Active sitei326 – 3261By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.037.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin W (EC:3.4.22.-)
Alternative name(s):
Lymphopain
Gene namesi
Name:Ctsw
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1338045. Ctsw.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 125104Sequence analysisPRO_0000026329Add
BLAST
Chaini126 – 371246Cathepsin WPRO_0000026330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis
Disulfide bondi148 ↔ 189By similarity
Disulfide bondi182 ↔ 224By similarity
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi282 ↔ 347By similarity
Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiP56203.
PaxDbiP56203.
PRIDEiP56203.

PTM databases

PhosphoSiteiP56203.

Expressioni

Gene expression databases

BgeeiP56203.
CleanExiMM_CTSW.
ExpressionAtlasiP56203. baseline and differential.
GenevisibleiP56203. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025844.

Structurei

3D structure databases

ProteinModelPortaliP56203.
SMRiP56203. Positions 40-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1542. Eukaryota.
COG4870. LUCA.
HOGENOMiHOG000230774.
HOVERGENiHBG100117.
InParanoidiP56203.
KOiK08569.
OMAiIMLQNNE.
OrthoDBiEOG79PJPJ.
TreeFamiTF337736.

Family and domain databases

InterProiIPR033158. Cathepsin_W.
IPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 2 hits.
PTHR12411:SF101. PTHR12411:SF101. 2 hits.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLTAHLSYF LVLLLAGQGL SDSLLTKDAG PRPLELKEVF KLFQIRFNRS
60 70 80 90 100
YWNPAEYTRR LSIFAHNLAQ AQRLQQEDLG TAEFGETPFS DLTEEEFGQL
110 120 130 140 150
YGQERSPERT PNMTKKVESN TWGESVPRTC DWRKAKNIIS SVKNQGSCKC
160 170 180 190 200
CWAMAAADNI QALWRIKHQQ FVDVSVQELL DCERCGNGCN GGFVWDAYLT
210 220 230 240 250
VLNNSGLASE KDYPFQGDRK PHRCLAKKYK KVAWIQDFTM LSNNEQAIAH
260 270 280 290 300
YLAVHGPITV TINMKLLQHY QKGVIKATPS SCDPRQVDHS VLLVGFGKEK
310 320 330 340 350
EGMQTGTVLS HSRKRRHSSP YWILKNSWGA HWGEKGYFRL YRGNNTCGVT
360 370
KYPFTAQVDS PVKKARTSCP P
Length:371
Mass (Da):42,120
Last modified:July 27, 2011 - v2
Checksum:i1192C3D0C607DDB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014941 mRNA. Translation: AAB82455.1.
AC122861 Genomic DNA. No translation available.
CCDSiCCDS29465.1.
RefSeqiNP_034115.2. NM_009985.5.
UniGeneiMm.113590.

Genome annotation databases

EnsembliENSMUST00000025844; ENSMUSP00000025844; ENSMUSG00000024910.
GeneIDi13041.
KEGGimmu:13041.
UCSCiuc008gdk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014941 mRNA. Translation: AAB82455.1.
AC122861 Genomic DNA. No translation available.
CCDSiCCDS29465.1.
RefSeqiNP_034115.2. NM_009985.5.
UniGeneiMm.113590.

3D structure databases

ProteinModelPortaliP56203.
SMRiP56203. Positions 40-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025844.

Protein family/group databases

MEROPSiC01.037.

PTM databases

PhosphoSiteiP56203.

Proteomic databases

EPDiP56203.
PaxDbiP56203.
PRIDEiP56203.

Protocols and materials databases

DNASUi13041.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025844; ENSMUSP00000025844; ENSMUSG00000024910.
GeneIDi13041.
KEGGimmu:13041.
UCSCiuc008gdk.2. mouse.

Organism-specific databases

CTDi1521.
MGIiMGI:1338045. Ctsw.

Phylogenomic databases

eggNOGiKOG1542. Eukaryota.
COG4870. LUCA.
HOGENOMiHOG000230774.
HOVERGENiHBG100117.
InParanoidiP56203.
KOiK08569.
OMAiIMLQNNE.
OrthoDBiEOG79PJPJ.
TreeFamiTF337736.

Miscellaneous databases

NextBioi282936.
PROiP56203.
SOURCEiSearch...

Gene expression databases

BgeeiP56203.
CleanExiMM_CTSW.
ExpressionAtlasiP56203. baseline and differential.
GenevisibleiP56203. MM.

Family and domain databases

InterProiIPR033158. Cathepsin_W.
IPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 2 hits.
PTHR12411:SF101. PTHR12411:SF101. 2 hits.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase."
    Brown J., Matutes E., Singleton A., Price C., Molgaard H., Buttle D., Enver T.
    Leukemia 12:1771-1781(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCATW_MOUSE
AccessioniPrimary (citable) accession number: P56203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.