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P56202 (CATW_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cathepsin W

EC=3.4.22.-
Alternative name(s):
Lymphopain
Gene names
Name:CTSW
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have a specific function in the mechanism or regulation of T-cell cytolytic activity.

Tissue specificity

Expressed in natural killer and cytotoxic T cells.

Sequence similarities

Belongs to the peptidase C1 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionHydrolase
Protease
Thiol protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processimmune response

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functioncysteine-type peptidase activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.6
Propeptide22 – 127106 Potential
PRO_0000026327
Chain128 – 376249Cathepsin W
PRO_0000026328

Sites

Active site1531 By similarity
Active site2911 By similarity
Active site3311 By similarity

Amino acid modifications

Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation2051N-linked (GlcNAc...) Potential
Disulfide bond150 ↔ 191 By similarity
Disulfide bond184 ↔ 226 By similarity
Disulfide bond284 ↔ 352 By similarity

Natural variations

Natural variant1391S → G. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs604630 [ dbSNP | Ensembl ].
VAR_058847
Natural variant2181Q → R.
Corresponds to variant rs606830 [ dbSNP | Ensembl ].
VAR_057041

Experimental info

Sequence conflict1791Q → H in AAB82449. Ref.1
Sequence conflict1791Q → H in AAB82457. Ref.1
Sequence conflict1791Q → H in AAC32181. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P56202 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: D2956524D17B593A

FASTA37642,120
        10         20         30         40         50         60 
MALTAHPSCL LALLVAGLAQ GIRGPLRAQD LGPQPLELKE AFKLFQIQFN RSYLSPEEHA 

        70         80         90        100        110        120 
HRLDIFAHNL AQAQRLQEED LGTAEFGVTP FSDLTEEEFG QLYGYRRAAG GVPSMGREIR 

       130        140        150        160        170        180 
SEEPEESVPF SCDWRKVASA ISPIKDQKNC NCCWAMAAAG NIETLWRISF WDFVDVSVQE 

       190        200        210        220        230        240 
LLDCGRCGDG CHGGFVWDAF ITVLNNSGLA SEKDYPFQGK VRAHRCHPKK YQKVAWIQDF 

       250        260        270        280        290        300 
IMLQNNEHRI AQYLATYGPI TVTINMKPLQ LYRKGVIKAT PTTCDPQLVD HSVLLVGFGS 

       310        320        330        340        350        360 
VKSEEGIWAE TVSSQSQPQP PHPTPYWILK NSWGAQWGEK GYFRLHRGSN TCGITKFPLT 

       370 
ARVQKPDMKP RVSCPP 

« Hide

References

« Hide 'large scale' references
[1]"Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase."
Brown J., Matutes E., Singleton A., Price C., Molgaard H., Buttle D., Enver T.
Leukemia 12:1771-1781(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT GLY-139.
[2]"Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes."
Linnevers C., Smeekens S.P., Broemme D.
FEBS Lett. 405:253-259(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-139.
[3]"Genomic structure, chromosomal localization, and expression of human cathepsin W."
Wex T., Levy B., Smeekens S.P., Ansorge S., Desnick R.J., Bromme D.
Biochem. Biophys. Res. Commun. 248:255-261(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-139.
[4]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-139.
Tissue: Pancreas.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-36.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF013611 mRNA. Translation: AAB82449.1.
AF015954 Genomic DNA. Translation: AAB82457.1.
AF055903 Genomic DNA. Translation: AAC32181.1.
AP001201 Genomic DNA. No translation available.
BC048255 mRNA. Translation: AAH48255.1.
CCDSCCDS8117.1.
RefSeqNP_001326.2. NM_001335.3.
UniGeneHs.416848.

3D structure databases

ProteinModelPortalP56202.
SMRP56202. Positions 49-363.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107901. 1 interaction.
IntActP56202. 1 interaction.
STRING9606.ENSP00000311300.

Protein family/group databases

MEROPSC01.037.

PTM databases

PhosphoSiteP56202.

Polymorphism databases

DMDM259016196.

Proteomic databases

MaxQBP56202.
PaxDbP56202.
PRIDEP56202.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307886; ENSP00000311300; ENSG00000172543.
GeneID1521.
KEGGhsa:1521.
UCSCuc001ogc.1. human.

Organism-specific databases

CTD1521.
GeneCardsGC11P065647.
HGNCHGNC:2546. CTSW.
HPACAB016345.
MIM602364. gene.
neXtProtNX_P56202.
PharmGKBPA27042.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288820.
HOGENOMHOG000230774.
HOVERGENHBG100117.
InParanoidP56202.
KOK08569.
OMANCNCCWA.
PhylomeDBP56202.
TreeFamTF337736.

Gene expression databases

ArrayExpressP56202.
BgeeP56202.
CleanExHS_CTSW.
GenevestigatorP56202.

Family and domain databases

InterProIPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCathepsin_W.
GenomeRNAi1521.
NextBio6295.
PROP56202.
SOURCESearch...

Entry information

Entry nameCATW_HUMAN
AccessionPrimary (citable) accession number: P56202
Secondary accession number(s): Q86VT4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM