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P56202

- CATW_HUMAN

UniProt

P56202 - CATW_HUMAN

Protein

Cathepsin W

Gene

CTSW

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    May have a specific function in the mechanism or regulation of T-cell cytolytic activity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei153 – 1531By similarity
    Active sitei291 – 2911By similarity
    Active sitei331 – 3311By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: ProtInc

    GO - Biological processi

    1. immune response Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Protein family/group databases

    MEROPSiC01.037.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin W (EC:3.4.22.-)
    Alternative name(s):
    Lymphopain
    Gene namesi
    Name:CTSW
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:2546. CTSW.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27042.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Propeptidei22 – 127106Sequence AnalysisPRO_0000026327Add
    BLAST
    Chaini128 – 376249Cathepsin WPRO_0000026328Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi150 ↔ 191By similarity
    Disulfide bondi184 ↔ 226By similarity
    Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi284 ↔ 352By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiP56202.
    PaxDbiP56202.
    PRIDEiP56202.

    PTM databases

    PhosphoSiteiP56202.

    Expressioni

    Tissue specificityi

    Expressed in natural killer and cytotoxic T cells.

    Gene expression databases

    ArrayExpressiP56202.
    BgeeiP56202.
    CleanExiHS_CTSW.
    GenevestigatoriP56202.

    Organism-specific databases

    HPAiCAB016345.

    Interactioni

    Protein-protein interaction databases

    BioGridi107901. 1 interaction.
    IntActiP56202. 1 interaction.
    STRINGi9606.ENSP00000311300.

    Structurei

    3D structure databases

    ProteinModelPortaliP56202.
    SMRiP56202. Positions 49-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG288820.
    HOGENOMiHOG000230774.
    HOVERGENiHBG100117.
    InParanoidiP56202.
    KOiK08569.
    OMAiNCNCCWA.
    PhylomeDBiP56202.
    TreeFamiTF337736.

    Family and domain databases

    InterProiIPR025661. Pept_asp_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56202-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALTAHPSCL LALLVAGLAQ GIRGPLRAQD LGPQPLELKE AFKLFQIQFN    50
    RSYLSPEEHA HRLDIFAHNL AQAQRLQEED LGTAEFGVTP FSDLTEEEFG 100
    QLYGYRRAAG GVPSMGREIR SEEPEESVPF SCDWRKVASA ISPIKDQKNC 150
    NCCWAMAAAG NIETLWRISF WDFVDVSVQE LLDCGRCGDG CHGGFVWDAF 200
    ITVLNNSGLA SEKDYPFQGK VRAHRCHPKK YQKVAWIQDF IMLQNNEHRI 250
    AQYLATYGPI TVTINMKPLQ LYRKGVIKAT PTTCDPQLVD HSVLLVGFGS 300
    VKSEEGIWAE TVSSQSQPQP PHPTPYWILK NSWGAQWGEK GYFRLHRGSN 350
    TCGITKFPLT ARVQKPDMKP RVSCPP 376
    Length:376
    Mass (Da):42,120
    Last modified:September 22, 2009 - v2
    Checksum:iD2956524D17B593A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791Q → H in AAB82449. (PubMed:9823953)Curated
    Sequence conflicti179 – 1791Q → H in AAB82457. (PubMed:9823953)Curated
    Sequence conflicti179 – 1791Q → H in AAC32181. (PubMed:9675123)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti139 – 1391S → G.4 Publications
    Corresponds to variant rs604630 [ dbSNP | Ensembl ].
    VAR_058847
    Natural varianti218 – 2181Q → R.
    Corresponds to variant rs606830 [ dbSNP | Ensembl ].
    VAR_057041

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013611 mRNA. Translation: AAB82449.1.
    AF015954 Genomic DNA. Translation: AAB82457.1.
    AF055903 Genomic DNA. Translation: AAC32181.1.
    AP001201 Genomic DNA. No translation available.
    BC048255 mRNA. Translation: AAH48255.1.
    CCDSiCCDS8117.1.
    RefSeqiNP_001326.2. NM_001335.3.
    UniGeneiHs.416848.

    Genome annotation databases

    EnsembliENST00000307886; ENSP00000311300; ENSG00000172543.
    GeneIDi1521.
    KEGGihsa:1521.
    UCSCiuc001ogc.1. human.

    Polymorphism databases

    DMDMi259016196.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013611 mRNA. Translation: AAB82449.1 .
    AF015954 Genomic DNA. Translation: AAB82457.1 .
    AF055903 Genomic DNA. Translation: AAC32181.1 .
    AP001201 Genomic DNA. No translation available.
    BC048255 mRNA. Translation: AAH48255.1 .
    CCDSi CCDS8117.1.
    RefSeqi NP_001326.2. NM_001335.3.
    UniGenei Hs.416848.

    3D structure databases

    ProteinModelPortali P56202.
    SMRi P56202. Positions 49-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107901. 1 interaction.
    IntActi P56202. 1 interaction.
    STRINGi 9606.ENSP00000311300.

    Protein family/group databases

    MEROPSi C01.037.

    PTM databases

    PhosphoSitei P56202.

    Polymorphism databases

    DMDMi 259016196.

    Proteomic databases

    MaxQBi P56202.
    PaxDbi P56202.
    PRIDEi P56202.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307886 ; ENSP00000311300 ; ENSG00000172543 .
    GeneIDi 1521.
    KEGGi hsa:1521.
    UCSCi uc001ogc.1. human.

    Organism-specific databases

    CTDi 1521.
    GeneCardsi GC11P065647.
    HGNCi HGNC:2546. CTSW.
    HPAi CAB016345.
    MIMi 602364. gene.
    neXtProti NX_P56202.
    PharmGKBi PA27042.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288820.
    HOGENOMi HOG000230774.
    HOVERGENi HBG100117.
    InParanoidi P56202.
    KOi K08569.
    OMAi NCNCCWA.
    PhylomeDBi P56202.
    TreeFami TF337736.

    Miscellaneous databases

    GeneWikii Cathepsin_W.
    GenomeRNAii 1521.
    NextBioi 6295.
    PROi P56202.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56202.
    Bgeei P56202.
    CleanExi HS_CTSW.
    Genevestigatori P56202.

    Family and domain databases

    InterProi IPR025661. Pept_asp_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase."
      Brown J., Matutes E., Singleton A., Price C., Molgaard H., Buttle D., Enver T.
      Leukemia 12:1771-1781(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT GLY-139.
    2. "Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes."
      Linnevers C., Smeekens S.P., Broemme D.
      FEBS Lett. 405:253-259(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-139.
    3. "Genomic structure, chromosomal localization, and expression of human cathepsin W."
      Wex T., Levy B., Smeekens S.P., Ansorge S., Desnick R.J., Bromme D.
      Biochem. Biophys. Res. Commun. 248:255-261(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-139.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-139.
      Tissue: Pancreas.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-36.

    Entry informationi

    Entry nameiCATW_HUMAN
    AccessioniPrimary (citable) accession number: P56202
    Secondary accession number(s): Q86VT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3