Reviewed,
UniProtKB/Swiss-Prot P56202 (CATW_HUMAN)
Last modified
January 19, 2010.
Version 81.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cathepsin W EC=3.4.22.- Alternative name(s): Lymphopain | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 376 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May have a specific function in the mechanism or regulation of T-cell cytolytic activity. |
| Tissue specificity | Expressed in natural killer and cytotoxic T cells. |
| Sequence similarities | Belongs to the peptidase C1 family. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| Molecular function | Hydrolase Protease Thiol protease |
| PTM | Disulfide bond Glycoprotein Zymogen |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | immune response Ref.1 Traceable author statement. Source: ProtInc proteolysisInferred from electronic annotation. Source: InterPro |
| Molecular function | cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Ref.6 | ||||||||
| Propeptide | 22 – 127 | 106 | Potential | PRO_0000026327 | |||||||
| Chain | 128 – 376 | 249 | Cathepsin W | PRO_0000026328 | |||||||
Sites | |||||||||||
| Active site | 153 | 1 | By similarity | ||||||||
| Active site | 291 | 1 | By similarity | ||||||||
| Active site | 331 | 1 | By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 50 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 205 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 150 ↔ 191 | By similarity | |||||||||
| Disulfide bond | 184 ↔ 226 | By similarity | |||||||||
| Disulfide bond | 284 ↔ 352 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 139 | 1 | S → G: dbSNP rs604630. Ref.1 Ref.2 Ref.3 Ref.5 | VAR_058847 | |||||||
| Natural variant | 218 | 1 | Q → R: dbSNP rs606830. | VAR_057041 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 179 | 1 | Q → H in AAB82449. Ref.1 | ||||||||
| Sequence conflict | 179 | 1 | Q → H in AAB82457. Ref.1 | ||||||||
| Sequence conflict | 179 | 1 | Q → H in AAC32181. Ref.3 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase." Brown J., Matutes E., Singleton A., Price C., Molgaard H., Buttle D., Enver T. Leukemia 12:1771-1781(1998) [PubMed: 9823953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT GLY-139. |
| [2] | "Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes." Linnevers C., Smeekens S.P., Broemme D. FEBS Lett. 405:253-259(1997) [PubMed: 9108299] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-139. |
| [3] | "Genomic structure, chromosomal localization, and expression of human cathepsin W." Wex T., Levy B., Smeekens S.P., Ansorge S., Desnick R.J., Bromme D. Biochem. Biophys. Res. Commun. 248:255-261(1998) [PubMed: 9675123] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-139. |
| [4] | "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y.Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-139. Tissue: Pancreas. |
| [6] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-36. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF013611 mRNA. Translation: AAB82449.1. AF015954 Genomic DNA. Translation: AAB82457.1. AF055903 Genomic DNA. Translation: AAC32181.1. AP001201 Genomic DNA. No translation available. BC048255 mRNA. Translation: AAH48255.1. |
| IPI | IPI00328978. |
| RefSeq | NP_001326.2. |
| UniGene | Hs.416848 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P56202. |
Protein family/group databases | |
| MEROPS | C01.037. |
Proteomic databases | |
| PRIDE | P56202. |
Genome annotation databases | |
| Ensembl | ENST00000307886; ENSP00000311300; ENSG00000172543; Homo sapiens. [Genome view] |
| GeneID | 1521. |
| KEGG | hsa:1521. |
| UCSC | uc001ogc.1. human. |
Organism-specific databases | |
| CTD | 1521. |
| GeneCards | GC11P065405. |
| HGNC | HGNC:2546. CTSW. |
| HPA | CAB016345. |
| MIM | 602364. gene. |
| PharmGKB | PA27042. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG06142. |
| HOGENOM | HBG746690. |
| HOVERGEN | P56202. |
| InParanoid | P56202. |
| OMA | TEEEFGQ. |
Gene expression databases | |
| ArrayExpress | P56202. |
| Bgee | P56202. |
| CleanEx | HS_CTSW. |
| Genevestigator | P56202. |
| GermOnline | ENSG00000172543. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. [Graphical view] |
| PANTHER | PTHR12411. Peptidase_C1A. 1 hit. |
| Pfam | PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view] |
| PRINTS | PR00705. PAPAIN. |
| SMART | SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. [Graphical view] |
| PROSITE | PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. False negative. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 6295. |
| SOURCE | Search... |
Entry information
| Entry name | CATW_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P56202 Secondary accession number(s): Q86VT4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

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