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P56202

- CATW_HUMAN

UniProt

P56202 - CATW_HUMAN

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Protein

Cathepsin W

Gene
CTSW
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May have a specific function in the mechanism or regulation of T-cell cytolytic activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei153 – 1531 By similarity
Active sitei291 – 2911 By similarity
Active sitei331 – 3311 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: ProtInc

GO - Biological processi

  1. immune response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.037.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin W (EC:3.4.22.-)
Alternative name(s):
Lymphopain
Gene namesi
Name:CTSW
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:2546. CTSW.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27042.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Propeptidei22 – 127106 Reviewed predictionPRO_0000026327Add
BLAST
Chaini128 – 376249Cathepsin WPRO_0000026328Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi150 ↔ 191 By similarity
Disulfide bondi184 ↔ 226 By similarity
Glycosylationi205 – 2051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi284 ↔ 352 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP56202.
PaxDbiP56202.
PRIDEiP56202.

PTM databases

PhosphoSiteiP56202.

Expressioni

Tissue specificityi

Expressed in natural killer and cytotoxic T cells.

Gene expression databases

ArrayExpressiP56202.
BgeeiP56202.
CleanExiHS_CTSW.
GenevestigatoriP56202.

Organism-specific databases

HPAiCAB016345.

Interactioni

Protein-protein interaction databases

BioGridi107901. 1 interaction.
IntActiP56202. 1 interaction.
STRINGi9606.ENSP00000311300.

Structurei

3D structure databases

ProteinModelPortaliP56202.
SMRiP56202. Positions 49-363.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG288820.
HOGENOMiHOG000230774.
HOVERGENiHBG100117.
InParanoidiP56202.
KOiK08569.
OMAiNCNCCWA.
PhylomeDBiP56202.
TreeFamiTF337736.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56202-1 [UniParc]FASTAAdd to Basket

« Hide

MALTAHPSCL LALLVAGLAQ GIRGPLRAQD LGPQPLELKE AFKLFQIQFN    50
RSYLSPEEHA HRLDIFAHNL AQAQRLQEED LGTAEFGVTP FSDLTEEEFG 100
QLYGYRRAAG GVPSMGREIR SEEPEESVPF SCDWRKVASA ISPIKDQKNC 150
NCCWAMAAAG NIETLWRISF WDFVDVSVQE LLDCGRCGDG CHGGFVWDAF 200
ITVLNNSGLA SEKDYPFQGK VRAHRCHPKK YQKVAWIQDF IMLQNNEHRI 250
AQYLATYGPI TVTINMKPLQ LYRKGVIKAT PTTCDPQLVD HSVLLVGFGS 300
VKSEEGIWAE TVSSQSQPQP PHPTPYWILK NSWGAQWGEK GYFRLHRGSN 350
TCGITKFPLT ARVQKPDMKP RVSCPP 376
Length:376
Mass (Da):42,120
Last modified:September 22, 2009 - v2
Checksum:iD2956524D17B593A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti139 – 1391S → G.4 Publications
Corresponds to variant rs604630 [ dbSNP | Ensembl ].
VAR_058847
Natural varianti218 – 2181Q → R.
Corresponds to variant rs606830 [ dbSNP | Ensembl ].
VAR_057041

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791Q → H in AAB82449. 1 Publication
Sequence conflicti179 – 1791Q → H in AAB82457. 1 Publication
Sequence conflicti179 – 1791Q → H in AAC32181. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF013611 mRNA. Translation: AAB82449.1.
AF015954 Genomic DNA. Translation: AAB82457.1.
AF055903 Genomic DNA. Translation: AAC32181.1.
AP001201 Genomic DNA. No translation available.
BC048255 mRNA. Translation: AAH48255.1.
CCDSiCCDS8117.1.
RefSeqiNP_001326.2. NM_001335.3.
UniGeneiHs.416848.

Genome annotation databases

EnsembliENST00000307886; ENSP00000311300; ENSG00000172543.
GeneIDi1521.
KEGGihsa:1521.
UCSCiuc001ogc.1. human.

Polymorphism databases

DMDMi259016196.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF013611 mRNA. Translation: AAB82449.1 .
AF015954 Genomic DNA. Translation: AAB82457.1 .
AF055903 Genomic DNA. Translation: AAC32181.1 .
AP001201 Genomic DNA. No translation available.
BC048255 mRNA. Translation: AAH48255.1 .
CCDSi CCDS8117.1.
RefSeqi NP_001326.2. NM_001335.3.
UniGenei Hs.416848.

3D structure databases

ProteinModelPortali P56202.
SMRi P56202. Positions 49-363.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107901. 1 interaction.
IntActi P56202. 1 interaction.
STRINGi 9606.ENSP00000311300.

Protein family/group databases

MEROPSi C01.037.

PTM databases

PhosphoSitei P56202.

Polymorphism databases

DMDMi 259016196.

Proteomic databases

MaxQBi P56202.
PaxDbi P56202.
PRIDEi P56202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307886 ; ENSP00000311300 ; ENSG00000172543 .
GeneIDi 1521.
KEGGi hsa:1521.
UCSCi uc001ogc.1. human.

Organism-specific databases

CTDi 1521.
GeneCardsi GC11P065647.
HGNCi HGNC:2546. CTSW.
HPAi CAB016345.
MIMi 602364. gene.
neXtProti NX_P56202.
PharmGKBi PA27042.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288820.
HOGENOMi HOG000230774.
HOVERGENi HBG100117.
InParanoidi P56202.
KOi K08569.
OMAi NCNCCWA.
PhylomeDBi P56202.
TreeFami TF337736.

Miscellaneous databases

GeneWikii Cathepsin_W.
GenomeRNAii 1521.
NextBioi 6295.
PROi P56202.
SOURCEi Search...

Gene expression databases

ArrayExpressi P56202.
Bgeei P56202.
CleanExi HS_CTSW.
Genevestigatori P56202.

Family and domain databases

InterProi IPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view ]
PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase."
    Brown J., Matutes E., Singleton A., Price C., Molgaard H., Buttle D., Enver T.
    Leukemia 12:1771-1781(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT GLY-139.
  2. "Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes."
    Linnevers C., Smeekens S.P., Broemme D.
    FEBS Lett. 405:253-259(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-139.
  3. "Genomic structure, chromosomal localization, and expression of human cathepsin W."
    Wex T., Levy B., Smeekens S.P., Ansorge S., Desnick R.J., Bromme D.
    Biochem. Biophys. Res. Commun. 248:255-261(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-139.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-139.
    Tissue: Pancreas.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.

Entry informationi

Entry nameiCATW_HUMAN
AccessioniPrimary (citable) accession number: P56202
Secondary accession number(s): Q86VT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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