P56202 (CATW_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cathepsin W
EC=3.4.22.-

Alternative name(s):
Lymphopain

Gene names

Name:

CTSW

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a specific function in the mechanism or regulation of T-cell cytolytic activity.
Tissue specificity	Expressed in natural killer and cytotoxic T cells.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	immune response Traceable author statement Ref.1. Source: ProtInc proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cysteine-type peptidase activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.6
	Propeptide	22 – 127	106	Potential		PRO_0000026327
	Chain	128 – 376	249	Cathepsin W		PRO_0000026328
Sites
	Active site	153	1	By similarity
	Active site	291	1	By similarity
	Active site	331	1	By similarity
Amino acid modifications
	Glycosylation	50	1	N-linked (GlcNAc...) Potential
	Glycosylation	205	1	N-linked (GlcNAc...) Potential
	Disulfide bond	150 ↔ 191		By similarity
	Disulfide bond	184 ↔ 226		By similarity
	Disulfide bond	284 ↔ 352		By similarity
Natural variations
	Natural variant	139	1	S → G. Ref.1 Ref.2 Ref.3 Ref.5 Corresponds to variant rs604630 [ dbSNP | Ensembl ].		VAR_058847
	Natural variant	218	1	Q → R. Corresponds to variant rs606830 [ dbSNP | Ensembl ].		VAR_057041
Experimental info
	Sequence conflict	179	1	Q → H in AAB82449. Ref.1
	Sequence conflict	179	1	Q → H in AAB82457. Ref.1
	Sequence conflict	179	1	Q → H in AAC32181. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P56202 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: D2956524D17B593A	FASTA	376	42,120
	10 20 30 40 50 60 MALTAHPSCL LALLVAGLAQ GIRGPLRAQD LGPQPLELKE AFKLFQIQFN RSYLSPEEHA 70 80 90 100 110 120 HRLDIFAHNL AQAQRLQEED LGTAEFGVTP FSDLTEEEFG QLYGYRRAAG GVPSMGREIR 130 140 150 160 170 180 SEEPEESVPF SCDWRKVASA ISPIKDQKNC NCCWAMAAAG NIETLWRISF WDFVDVSVQE 190 200 210 220 230 240 LLDCGRCGDG CHGGFVWDAF ITVLNNSGLA SEKDYPFQGK VRAHRCHPKK YQKVAWIQDF 250 260 270 280 290 300 IMLQNNEHRI AQYLATYGPI TVTINMKPLQ LYRKGVIKAT PTTCDPQLVD HSVLLVGFGS 310 320 330 340 350 360 VKSEEGIWAE TVSSQSQPQP PHPTPYWILK NSWGAQWGEK GYFRLHRGSN TCGITKFPLT 370 ARVQKPDMKP RVSCPP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase." Brown J., Matutes E., Singleton A., Price C., Molgaard H., Buttle D., Enver T. Leukemia 12:1771-1781(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT GLY-139.
[2]	"Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes." Linnevers C., Smeekens S.P., Broemme D. FEBS Lett. 405:253-259(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-139.
[3]	"Genomic structure, chromosomal localization, and expression of human cathepsin W." Wex T., Levy B., Smeekens S.P., Ansorge S., Desnick R.J., Bromme D. Biochem. Biophys. Res. Commun. 248:255-261(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-139.
[4]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-139. Tissue: Pancreas.
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-36.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF013611 mRNA. Translation: AAB82449.1. AF015954 Genomic DNA. Translation: AAB82457.1. AF055903 Genomic DNA. Translation: AAC32181.1. AP001201 Genomic DNA. No translation available. BC048255 mRNA. Translation: AAH48255.1.
IPI	IPI00328978.
RefSeq	NP_001326.2. NM_001335.3.
UniGene	Hs.416848.
3D structure databases
ProteinModelPortal	P56202.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000311300.
Protein family/group databases
MEROPS	C01.037.
PTM databases
PhosphoSite	P56202.
Polymorphism databases
DMDM	259016196.
Proteomic databases
PaxDb	P56202.
PRIDE	P56202.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307886; ENSP00000311300; ENSG00000172543.
GeneID	1521.
KEGG	hsa:1521.
UCSC	uc001ogc.1. human.
Organism-specific databases
CTD	1521.
GeneCards	GC11P065647.
HGNC	HGNC:2546. CTSW.
HPA	CAB016345.
MIM	602364. gene.
neXtProt	NX_P56202.
PharmGKB	PA27042.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG288820.
HOGENOM	HOG000230774.
HOVERGEN	HBG100117.
InParanoid	P56202.
KO	K08569.
OMA	GRCGDGC.
OrthoDB	EOG4Q2DG3.
PhylomeDB	P56202.
Gene expression databases
ArrayExpress	P56202.
Bgee	P56202.
CleanEx	HS_CTSW.
Genevestigator	P56202.
GermOnline	ENSG00000172543. Homo sapiens.
Family and domain databases
InterPro	IPR025661. Pept_asp_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHER	PTHR12411. PTHR12411. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
SMART	SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. False negative. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1521.
NextBio	6295.
SOURCE	Search...

Entry information

Entry name

CATW_HUMAN

Accession

Primary (citable) accession number: P56202
Secondary accession number(s): Q86VT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	September 22, 2009
Last modified:	May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.