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P56201 (G6PE_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GDH/6PGL endoplasmic bifunctional protein

Including the following 2 domains:

  1. Glucose 1-dehydrogenase
    EC=1.1.1.47
    Alternative name(s):
    Hexose-6-phosphate dehydrogenase
  2. 6-phosphogluconolactonase
    Short name=6PGL
    EC=3.1.1.31
Gene names
Name:H6PD
Synonyms:GDH
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length763 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates By similarity.

Catalytic activity

Beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.

D-glucose 6-phosphate + NAD(P)+ = D-glucono-1,5-lactone 6-phosphate + NAD(P)H.

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Subcellular location

Endoplasmic reticulum lumen. Note: Microsomes, endoplasmic reticulum lumen.

Sequence similarities

In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.

In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Sequence caution

The sequence described in Ref.1 differs from that shown. Reason: The sequence was incorrect due to the transposition of a section that was put in position 330 to 436 and which is now transposed to position 593 to 700.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 763763GDH/6PGL endoplasmic bifunctional protein
PRO_0000068139

Regions

Region1 – 507507Glucose 1-dehydrogenase
Region508 – 52114Linker
Region522 – 7632426-phosphogluconolactonase

Sites

Active site2481Proton acceptor By similarity
Binding site151NADP By similarity
Binding site471NADP By similarity
Binding site1851Substrate By similarity
Binding site1891Substrate By similarity

Amino acid modifications

Modified residue11Pyrrolidone carboxylic acid
Glycosylation1381N-linked (GlcNAc...)
Glycosylation2631N-linked (GlcNAc...)

Natural variations

Natural variant691R → K.
Natural variant751L → R.

Sequences

Sequence LengthMass (Da)Tools
P56201 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 2A4E1039062E8672

FASTA76385,285
        10         20         30         40         50         60 
QELQGHVSVI LLGATGDLAK KYLWQGLFQL FLDEAGKGHS FSFHGAALTA PKQGQELMAK 

        70         80         90        100        110        120 
ALESLSCPRD MAPSLCAELQ AQFLRLSRYR QLKTAEDYQA LGRDIEAQVQ QEGLREAGRM 

       130        140        150        160        170        180 
FYFSVPPFAY ADIARNINSS CRPGPGAWLR VVLEKPFGHD HLSAQQLATE LGSFFQEEEM 

       190        200        210        220        230        240 
YRVDHYLGKQ AVAQILPFRD QNRRALDSLW NRHHVERVEI IMKETVDAEG RTSFYEEYGV 

       250        260        270        280        290        300 
IRDTLQNHLT EILTLVAMEL PANVSCSEAV LRHKLQAFRA LRRLQRGSAV VGQYQTYSEQ 

       310        320        330        340        350        360 
VRGELRKPAG SPSLTPTFAG VLVHVDNLRM EGVPFILMSG KALDERVGYV RVLFKNQAFC 

       370        380        390        400        410        420 
AQSEKHWAPA QSRCLPRCII FYIGHGELGH PAVVVSRNLF RPFLPAQSWR EVEDRPGLQL 

       430        440        450        460        470        480 
FGRPLSDFYA FSPVKERDAY SILLSHIFHA RKESFVPTEH LLASWVFWTP LLESLAREVP 

       490        500        510        520        530        540 
RLYPGGADSG RLLDFEFSGS HLSFSLGQPE QLVPGPGSTP RPSDFQVLGA KYRESPLISA 

       550        560        570        580        590        600 
WPDELISKLA SDIEAAAVQA VRRVGTFHLA LSGGSSPIAL FQQLASGHYG FPVPLSDPES 

       610        620        630        640        650        660 
NFQGLQAHLL QHVRVPYYNI HPMPVNLHQR LCAEEDRGAQ AAYASEISAL VTWCSFDEVL 

       670        680        690        700        710        720 
QGMGTDGHTA SLFPQSPTGL DGEQLVVLTE SPSRPHQQRR MSLSLPLINR AKKVAVLVMG 

       730        740        750        760 
RTKRDITLLV SRVGREPKNW PISGVLPTSG QLVWYMDYEA FLG

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References

[1]"Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate dehydrogenase."
Ozols J.
Proc. Natl. Acad. Sci. U.S.A. 90:5302-5306(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Strain: New Zealand white.
Tissue: Liver.

Cross-references

3D structure databases

ProteinModelPortalP56201.
ModBaseSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000000694.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0363.
HOGENOMHOG000231077.
HOVERGENHBG005780.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR005900. 6-phosphogluconolactonase_DevB.
IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR006148. Glc/Gal-6P_isomerase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PF01182. Glucosamine_iso. 1 hit.
[Graphical view]
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR01198. pgl. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PE_RABIT
AccessionPrimary (citable) accession number: P56201
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: April 3, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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