SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P56201

- G6PE_RABIT

UniProt

P56201 - G6PE_RABIT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

GDH/6PGL endoplasmic bifunctional protein

Gene
H6PD, GDH
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates By similarity.

Catalytic activityi

Beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.
D-glucose 6-phosphate + NAD(P)+ = D-glucono-1,5-lactone 6-phosphate + NAD(P)H.
6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151NADP By similarity
Binding sitei47 – 471NADP By similarity
Binding sitei185 – 1851Substrate By similarity
Binding sitei189 – 1891Substrate By similarity
Active sitei248 – 2481Proton acceptor By similarity

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB-EC
  2. glucose 1-dehydrogenase [NAD(P)] activity Source: UniProtKB-EC
  3. glucose-6-phosphate dehydrogenase activity Source: InterPro
  4. NADP binding Source: InterPro

GO - Biological processi

  1. pentose-phosphate shunt Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
GDH/6PGL endoplasmic bifunctional protein
Including the following 2 domains:
Glucose 1-dehydrogenase (EC:1.1.1.47)
Alternative name(s):
Hexose-6-phosphate dehydrogenase
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:H6PD
Synonyms:GDH
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Endoplasmic reticulum lumen
Note: Microsomes, endoplasmic reticulum lumen.

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763GDH/6PGL endoplasmic bifunctional proteinPRO_0000068139Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11Pyrrolidone carboxylic acid
Glycosylationi138 – 1381N-linked (GlcNAc...)
Modified residuei189 – 1891N6-succinyllysine By similarity
Glycosylationi263 – 2631N-linked (GlcNAc...)

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000694.

Structurei

3D structure databases

ProteinModelPortaliP56201.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 507507Glucose 1-dehydrogenaseAdd
BLAST
Regioni508 – 52114LinkerAdd
BLAST
Regioni522 – 7632426-phosphogluconolactonaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.

Phylogenomic databases

eggNOGiCOG0363.
HOGENOMiHOG000231077.
HOVERGENiHBG005780.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR006148. Glc/Gal-6P_isomerase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PF01182. Glucosamine_iso. 1 hit.
[Graphical view]
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR01198. pgl. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56201-1 [UniParc]FASTAAdd to Basket

« Hide

QELQGHVSVI LLGATGDLAK KYLWQGLFQL FLDEAGKGHS FSFHGAALTA    50
PKQGQELMAK ALESLSCPRD MAPSLCAELQ AQFLRLSRYR QLKTAEDYQA 100
LGRDIEAQVQ QEGLREAGRM FYFSVPPFAY ADIARNINSS CRPGPGAWLR 150
VVLEKPFGHD HLSAQQLATE LGSFFQEEEM YRVDHYLGKQ AVAQILPFRD 200
QNRRALDSLW NRHHVERVEI IMKETVDAEG RTSFYEEYGV IRDTLQNHLT 250
EILTLVAMEL PANVSCSEAV LRHKLQAFRA LRRLQRGSAV VGQYQTYSEQ 300
VRGELRKPAG SPSLTPTFAG VLVHVDNLRM EGVPFILMSG KALDERVGYV 350
RVLFKNQAFC AQSEKHWAPA QSRCLPRCII FYIGHGELGH PAVVVSRNLF 400
RPFLPAQSWR EVEDRPGLQL FGRPLSDFYA FSPVKERDAY SILLSHIFHA 450
RKESFVPTEH LLASWVFWTP LLESLAREVP RLYPGGADSG RLLDFEFSGS 500
HLSFSLGQPE QLVPGPGSTP RPSDFQVLGA KYRESPLISA WPDELISKLA 550
SDIEAAAVQA VRRVGTFHLA LSGGSSPIAL FQQLASGHYG FPVPLSDPES 600
NFQGLQAHLL QHVRVPYYNI HPMPVNLHQR LCAEEDRGAQ AAYASEISAL 650
VTWCSFDEVL QGMGTDGHTA SLFPQSPTGL DGEQLVVLTE SPSRPHQQRR 700
MSLSLPLINR AKKVAVLVMG RTKRDITLLV SRVGREPKNW PISGVLPTSG 750
QLVWYMDYEA FLG 763
Length:763
Mass (Da):85,285
Last modified:May 30, 2000 - v2
Checksum:i2A4E1039062E8672
GO

Sequence cautioni

The sequence described in 1 Publication differs from that shown. Reason: The sequence was incorrect due to the transposition of a section that was put in position 330 to 436 and which is now transposed to position 593 to 700.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti69 – 691R → K.
Natural varianti75 – 751L → R.

Cross-referencesi

3D structure databases

ProteinModelPortali P56201.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000000694.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0363.
HOGENOMi HOG000231077.
HOVERGENi HBG005780.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR005900. 6-phosphogluconolactonase_DevB.
IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR006148. Glc/Gal-6P_isomerase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PF01182. Glucosamine_iso. 1 hit.
[Graphical view ]
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR01198. pgl. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate dehydrogenase."
    Ozols J.
    Proc. Natl. Acad. Sci. U.S.A. 90:5302-5306(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Strain: New Zealand white.
    Tissue: Liver.

Entry informationi

Entry nameiG6PE_RABIT
AccessioniPrimary (citable) accession number: P56201
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: March 19, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi