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P56201

- G6PE_RABIT

UniProt

P56201 - G6PE_RABIT

Protein

GDH/6PGL endoplasmic bifunctional protein

Gene

H6PD

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.By similarity

    Catalytic activityi

    Beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.PROSITE-ProRule annotation
    D-glucose 6-phosphate + NAD(P)+ = D-glucono-1,5-lactone 6-phosphate + NAD(P)H.
    6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151NADPBy similarity
    Binding sitei47 – 471NADPBy similarity
    Binding sitei185 – 1851SubstratePROSITE-ProRule annotation
    Binding sitei189 – 1891SubstratePROSITE-ProRule annotation
    Active sitei248 – 2481Proton acceptorBy similarity

    GO - Molecular functioni

    1. 6-phosphogluconolactonase activity Source: UniProtKB-EC
    2. glucose 1-dehydrogenase [NAD(P)] activity Source: UniProtKB-EC
    3. glucose-6-phosphate dehydrogenase activity Source: InterPro
    4. NADP binding Source: InterPro

    GO - Biological processi

    1. pentose-phosphate shunt Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NAD, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDH/6PGL endoplasmic bifunctional protein
    Including the following 2 domains:
    Glucose 1-dehydrogenase (EC:1.1.1.47)
    Alternative name(s):
    Hexose-6-phosphate dehydrogenase
    6-phosphogluconolactonase (EC:3.1.1.31)
    Short name:
    6PGL
    Gene namesi
    Name:H6PD
    Synonyms:GDH
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    Endoplasmic reticulum lumen
    Note: Microsomes, endoplasmic reticulum lumen.

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 763763GDH/6PGL endoplasmic bifunctional proteinPRO_0000068139Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11Pyrrolidone carboxylic acid
    Glycosylationi138 – 1381N-linked (GlcNAc...)
    Modified residuei189 – 1891N6-succinyllysineBy similarity
    Glycosylationi263 – 2631N-linked (GlcNAc...)

    Keywords - PTMi

    Glycoprotein, Pyrrolidone carboxylic acid

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000000694.

    Structurei

    3D structure databases

    ProteinModelPortaliP56201.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 507507Glucose 1-dehydrogenaseAdd
    BLAST
    Regioni508 – 52114LinkerAdd
    BLAST
    Regioni522 – 7632426-phosphogluconolactonaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0363.
    HOGENOMiHOG000231077.
    HOVERGENiHBG005780.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR005900. 6-phosphogluconolactonase_DevB.
    IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR006148. Glc/Gal-6P_isomerase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    PF01182. Glucosamine_iso. 1 hit.
    [Graphical view]
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR01198. pgl. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56201-1 [UniParc]FASTAAdd to Basket

    « Hide

    QELQGHVSVI LLGATGDLAK KYLWQGLFQL FLDEAGKGHS FSFHGAALTA    50
    PKQGQELMAK ALESLSCPRD MAPSLCAELQ AQFLRLSRYR QLKTAEDYQA 100
    LGRDIEAQVQ QEGLREAGRM FYFSVPPFAY ADIARNINSS CRPGPGAWLR 150
    VVLEKPFGHD HLSAQQLATE LGSFFQEEEM YRVDHYLGKQ AVAQILPFRD 200
    QNRRALDSLW NRHHVERVEI IMKETVDAEG RTSFYEEYGV IRDTLQNHLT 250
    EILTLVAMEL PANVSCSEAV LRHKLQAFRA LRRLQRGSAV VGQYQTYSEQ 300
    VRGELRKPAG SPSLTPTFAG VLVHVDNLRM EGVPFILMSG KALDERVGYV 350
    RVLFKNQAFC AQSEKHWAPA QSRCLPRCII FYIGHGELGH PAVVVSRNLF 400
    RPFLPAQSWR EVEDRPGLQL FGRPLSDFYA FSPVKERDAY SILLSHIFHA 450
    RKESFVPTEH LLASWVFWTP LLESLAREVP RLYPGGADSG RLLDFEFSGS 500
    HLSFSLGQPE QLVPGPGSTP RPSDFQVLGA KYRESPLISA WPDELISKLA 550
    SDIEAAAVQA VRRVGTFHLA LSGGSSPIAL FQQLASGHYG FPVPLSDPES 600
    NFQGLQAHLL QHVRVPYYNI HPMPVNLHQR LCAEEDRGAQ AAYASEISAL 650
    VTWCSFDEVL QGMGTDGHTA SLFPQSPTGL DGEQLVVLTE SPSRPHQQRR 700
    MSLSLPLINR AKKVAVLVMG RTKRDITLLV SRVGREPKNW PISGVLPTSG 750
    QLVWYMDYEA FLG 763
    Length:763
    Mass (Da):85,285
    Last modified:May 30, 2000 - v2
    Checksum:i2A4E1039062E8672
    GO

    Sequence cautioni

    The sequence described in 1 Publication differs from that shown. Reason: The sequence was incorrect due to the transposition of a section that was put in position 330 to 436 and which is now transposed to position 593 to 700.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti69 – 691R → K.
    Natural varianti75 – 751L → R.

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P56201.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000000694.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0363.
    HOGENOMi HOG000231077.
    HOVERGENi HBG005780.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR005900. 6-phosphogluconolactonase_DevB.
    IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR006148. Glc/Gal-6P_isomerase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    PF01182. Glucosamine_iso. 1 hit.
    [Graphical view ]
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR01198. pgl. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate dehydrogenase."
      Ozols J.
      Proc. Natl. Acad. Sci. U.S.A. 90:5302-5306(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Strain: New Zealand white.
      Tissue: Liver.

    Entry informationi

    Entry nameiG6PE_RABIT
    AccessioniPrimary (citable) accession number: P56201
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3