P56201 (G6PE_RABIT) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 94.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: GDH/6PGL endoplasmic bifunctional protein | ||||
| Gene names |
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| Organism | Oryctolagus cuniculus (Rabbit) [Reference proteome] | ||||
| Taxonomic identifier | 9986 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus![]() |
Protein attributes
| Sequence length | 763 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates By similarity. |
| Catalytic activity | Beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H. D-glucose 6-phosphate + NAD(P)+ = D-glucono-1,5-lactone 6-phosphate + NAD(P)H. 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. |
| Subcellular location | Endoplasmic reticulum lumen. Note: Microsomes, endoplasmic reticulum lumen. |
| Sequence similarities | In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family. In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. |
| Sequence caution | The sequence described in Ref.1 differs from that shown. Reason: The sequence was incorrect due to the transposition of a section that was put in position 330 to 436 and which is now transposed to position 593 to 700. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism Glucose metabolism |
| Cellular component | Endoplasmic reticulum |
| Ligand | NAD NADP |
| Molecular function | Hydrolase Oxidoreductase |
| PTM | Glycoprotein Pyrrolidone carboxylic acid |
| Technical term | Complete proteome Direct protein sequencing Multifunctional enzyme Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro |
| Cellular_component | endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | 6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC NADP bindingInferred from electronic annotation. Source: InterPro glucose 1-dehydrogenase [NAD(P)] activityInferred from electronic annotation. Source: EC glucose-6-phosphate dehydrogenase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 763 | 763 | GDH/6PGL endoplasmic bifunctional protein | PRO_0000068139 | |||||
Regions | |||||||||
| Region | 1 – 507 | 507 | Glucose 1-dehydrogenase | ||||||
| Region | 508 – 521 | 14 | Linker | ||||||
| Region | 522 – 763 | 242 | 6-phosphogluconolactonase | ||||||
Sites | |||||||||
| Active site | 248 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 15 | 1 | NADP By similarity | ||||||
| Binding site | 47 | 1 | NADP By similarity | ||||||
| Binding site | 185 | 1 | Substrate By similarity | ||||||
| Binding site | 189 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | Pyrrolidone carboxylic acid | ||||||
| Glycosylation | 138 | 1 | N-linked (GlcNAc...) | ||||||
| Glycosylation | 263 | 1 | N-linked (GlcNAc...) | ||||||
Natural variations | |||||||||
| Natural variant | 69 | 1 | R → K. | ||||||
| Natural variant | 75 | 1 | L → R. | ||||||
Sequences
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References
| [1] | "Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate dehydrogenase." Ozols J. Proc. Natl. Acad. Sci. U.S.A. 90:5302-5306(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: New Zealand white. Tissue: Liver. |
Cross-references
3D structure databases | |
|---|---|
| ProteinModelPortal | P56201. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9986.ENSOCUP00000000694. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| eggNOG | COG0363. |
| HOGENOM | HOG000231077. |
| HOVERGEN | HBG005780. |
Family and domain databases | |
| Gene3D | 3.40.50.720. 1 hit. |
| InterPro | IPR005900. 6-phosphogluconolactonase_DevB. IPR001282. G6P_DH. IPR019796. G6P_DH_AS. IPR022675. G6P_DH_C. IPR022674. G6P_DH_NAD-bd. IPR006148. Glc/Gal-6P_isomerase. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| PANTHER | PTHR23429. PTHR23429. 1 hit. |
| Pfam | PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. PF01182. Glucosamine_iso. 1 hit. [Graphical view] |
| PRINTS | PR00079. G6PDHDRGNASE. |
| TIGRFAMs | TIGR01198. pgl. 1 hit. |
| PROSITE | PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | G6PE_RABIT | ||||||||
| Accession | Primary (citable) accession number: P56201 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
