Reviewed,
UniProtKB/Swiss-Prot P56201 (G6PE_RABIT)
Last modified
November 25, 2008.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: GDH/6PGL endoplasmic bifunctional protein Including the following 2 domains: 1- Recommended name: Glucose 1-dehydrogenase EC=1.1.1.47 Alternative name(s): Hexose-6-phosphate dehydrogenase 2- Recommended name: 6-phosphogluconolactonase Short name=6PGL EC=3.1.1.31 | ||||
| Gene names |
| ||||
| Organism | Oryctolagus cuniculus (Rabbit) | ||||
| Taxonomic identifier | 9986 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Protein attributes
| Sequence length | 763 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates By similarity. |
| Catalytic activity | Beta-D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H. D-glucose 6-phosphate + NAD(P)(+) = D-glucono-1,5-lactone 6-phosphate + NAD(P)H. 6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate. |
| Subcellular location | Endoplasmic reticulum lumen. Note= Microsomes, endoplasmic reticulum lumen. |
| Sequence similarities | In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family. In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. |
| Sequence caution | The sequence described in Ref.1 differs from that shown. Reason: Miscellaneous discrepancy. The sequence was incorrect due to the transposition of a section that was put in position 330 to 436 and which is now transposed to position 593 to 700. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 763 | 763 | GDH/6PGL endoplasmic bifunctional protein | PRO_0000068139 | |||||
Regions | |||||||||
| Region | 1 – 507 | 507 | Glucose 1-dehydrogenase | ||||||
| Region | 508 – 521 | 14 | Linker | ||||||
| Region | 522 – 763 | 242 | 6-phosphogluconolactonase | ||||||
Sites | |||||||||
| Active site | 248 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 15 | 1 | NADP By similarity | ||||||
| Binding site | 47 | 1 | NADP By similarity | ||||||
| Binding site | 185 | 1 | Substrate By similarity | ||||||
| Binding site | 189 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | Pyrrolidone carboxylic acid | ||||||
| Modified residue | 297 | 1 | Phosphotyrosine By similarity | ||||||
| Glycosylation | 138 | 1 | N-linked (GlcNAc...) | ||||||
| Glycosylation | 263 | 1 | N-linked (GlcNAc...) | ||||||
Natural variations | |||||||||
| Natural variant | 69 | 1 | R → K | ||||||
| Natural variant | 75 | 1 | L → R | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate dehydrogenase." Ozols J. Proc. Natl. Acad. Sci. U.S.A. 90:5302-5306(1993) [PubMed: 8506377] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: New Zealand white. Tissue: Liver. |
Cross-references
3D structure databases | |
|---|---|
| HSSP | HSSP built from PDB template 1QKI based on UniProtKB P11413. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSOCUG00000000798. Oryctolagus cuniculus. [Contig view] |
Phylogenomic databases | |
| HOVERGEN | P56201. |
Family and domain databases | |
| InterPro | IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. IPR005900. Phosphogluconlac. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR23429. G6PDH. 1 hit. |
| Pfam | PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view] |
| PRINTS | PR00079. G6PDHDRGNASE. |
| ProDom | PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01198. pgl. 1 hit. |
| PROSITE | PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | G6PE_RABIT | ||||||||
| Accession | Primary (citable) accession number: P56201 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


