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Protein

GDH/6PGL endoplasmic bifunctional protein

Gene

H6PD

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.By similarity

Catalytic activityi

D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.PROSITE-ProRule annotation
D-glucose 6-phosphate + NAD(P)+ = D-glucono-1,5-lactone 6-phosphate + NAD(P)H.
6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15NADPBy similarity1
Binding sitei47NADPBy similarity1
Binding sitei185SubstratePROSITE-ProRule annotation1
Binding sitei189SubstratePROSITE-ProRule annotation1
Active sitei248Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
GDH/6PGL endoplasmic bifunctional protein
Including the following 2 domains:
Glucose 1-dehydrogenase (EC:1.1.1.47)
Alternative name(s):
Hexose-6-phosphate dehydrogenase
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:H6PD
Synonyms:GDH
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681391 – 763GDH/6PGL endoplasmic bifunctional proteinAdd BLAST763

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1
Glycosylationi138N-linked (GlcNAc...)1
Modified residuei189N6-succinyllysineBy similarity1
Glycosylationi263N-linked (GlcNAc...)1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000694.

Structurei

3D structure databases

ProteinModelPortaliP56201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 507Glucose 1-dehydrogenaseAdd BLAST507
Regioni508 – 521LinkerAdd BLAST14
Regioni522 – 7636-phosphogluconolactonaseAdd BLAST242

Sequence similaritiesi

In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG0563. Eukaryota.
KOG3147. Eukaryota.
COG0363. LUCA.
COG0364. LUCA.
HOGENOMiHOG000231077.
HOVERGENiHBG005780.
InParanoidiP56201.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
Gene3Di3.40.50.720. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR006148. Glc/Gal-6P_isomerase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PF01182. Glucosamine_iso. 1 hit.
[Graphical view]
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01198. pgl. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QELQGHVSVI LLGATGDLAK KYLWQGLFQL FLDEAGKGHS FSFHGAALTA
60 70 80 90 100
PKQGQELMAK ALESLSCPRD MAPSLCAELQ AQFLRLSRYR QLKTAEDYQA
110 120 130 140 150
LGRDIEAQVQ QEGLREAGRM FYFSVPPFAY ADIARNINSS CRPGPGAWLR
160 170 180 190 200
VVLEKPFGHD HLSAQQLATE LGSFFQEEEM YRVDHYLGKQ AVAQILPFRD
210 220 230 240 250
QNRRALDSLW NRHHVERVEI IMKETVDAEG RTSFYEEYGV IRDTLQNHLT
260 270 280 290 300
EILTLVAMEL PANVSCSEAV LRHKLQAFRA LRRLQRGSAV VGQYQTYSEQ
310 320 330 340 350
VRGELRKPAG SPSLTPTFAG VLVHVDNLRM EGVPFILMSG KALDERVGYV
360 370 380 390 400
RVLFKNQAFC AQSEKHWAPA QSRCLPRCII FYIGHGELGH PAVVVSRNLF
410 420 430 440 450
RPFLPAQSWR EVEDRPGLQL FGRPLSDFYA FSPVKERDAY SILLSHIFHA
460 470 480 490 500
RKESFVPTEH LLASWVFWTP LLESLAREVP RLYPGGADSG RLLDFEFSGS
510 520 530 540 550
HLSFSLGQPE QLVPGPGSTP RPSDFQVLGA KYRESPLISA WPDELISKLA
560 570 580 590 600
SDIEAAAVQA VRRVGTFHLA LSGGSSPIAL FQQLASGHYG FPVPLSDPES
610 620 630 640 650
NFQGLQAHLL QHVRVPYYNI HPMPVNLHQR LCAEEDRGAQ AAYASEISAL
660 670 680 690 700
VTWCSFDEVL QGMGTDGHTA SLFPQSPTGL DGEQLVVLTE SPSRPHQQRR
710 720 730 740 750
MSLSLPLINR AKKVAVLVMG RTKRDITLLV SRVGREPKNW PISGVLPTSG
760
QLVWYMDYEA FLG
Length:763
Mass (Da):85,285
Last modified:May 30, 2000 - v2
Checksum:i2A4E1039062E8672
GO

Sequence cautioni

The sequence described in PubMed:8506377 differs from that shown. The sequence was incorrect due to the transposition of a section that was put in position 330 to 436 and which is now transposed to position 593 to 700.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti69R → K.1
Natural varianti75L → R.1

Cross-referencesi

3D structure databases

ProteinModelPortaliP56201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000694.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0563. Eukaryota.
KOG3147. Eukaryota.
COG0363. LUCA.
COG0364. LUCA.
HOGENOMiHOG000231077.
HOVERGENiHBG005780.
InParanoidiP56201.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
Gene3Di3.40.50.720. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR006148. Glc/Gal-6P_isomerase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PF01182. Glucosamine_iso. 1 hit.
[Graphical view]
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01198. pgl. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PE_RABIT
AccessioniPrimary (citable) accession number: P56201
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: October 5, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.