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P56199

- ITA1_HUMAN

UniProt

P56199 - ITA1_HUMAN

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Protein

Integrin alpha-1

Gene

ITGA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi498 – 5069Sequence Analysis
Calcium bindingi580 – 5889Sequence Analysis
Calcium bindingi642 – 6509Sequence Analysis

GO - Molecular functioni

  1. collagen binding Source: UniProtKB
  2. collagen binding involved in cell-matrix adhesion Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. protein phosphatase binding Source: UniProtKB

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. axon guidance Source: Reactome
  3. blood coagulation Source: Reactome
  4. cell-matrix adhesion Source: UniProtKB
  5. cellular extravasation Source: Ensembl
  6. extracellular matrix organization Source: Reactome
  7. integrin-mediated signaling pathway Source: UniProtKB-KW
  8. muscle contraction Source: Reactome
  9. negative regulation of cell proliferation Source: UniProtKB
  10. negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
  11. neutrophil chemotaxis Source: Ensembl
  12. positive regulation of neuron apoptotic process Source: Ensembl
  13. positive regulation of phosphoprotein phosphatase activity Source: UniProtKB
  14. vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_1230. Platelet Adhesion to exposed collagen.
REACT_13552. Integrin cell surface interactions.
REACT_169262. Laminin interactions.
REACT_19200. Other semaphorin interactions.
REACT_20558. Smooth Muscle Contraction.
REACT_22292. CHL1 interactions.
SignaLinkiP56199.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-1
Alternative name(s):
CD49 antigen-like family member A
Laminin and collagen receptor
VLA-1
CD_antigen: CD49a
Gene namesi
Name:ITGA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6134. ITGA1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 11411113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1142 – 116423HelicalSequence AnalysisAdd
BLAST
Topological domaini1165 – 117915CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. basal part of cell Source: Ensembl
  3. cell surface Source: UniProtKB
  4. external side of plasma membrane Source: Ensembl
  5. extracellular vesicular exosome Source: UniProt
  6. focal adhesion Source: UniProtKB
  7. integrin alpha1-beta1 complex Source: UniProtKB
  8. integrin complex Source: UniProtKB
  9. membrane Source: UniProtKB
  10. membrane raft Source: Ensembl
  11. neuron projection Source: Ensembl
  12. perikaryon Source: Ensembl
  13. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29935.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 11791151Integrin alpha-1PRO_0000174215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi82 ↔ 92By similarity
Glycosylationi100 – 1001N-linked (GlcNAc...)1 Publication
Glycosylationi105 – 1051N-linked (GlcNAc...)1 Publication
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi217 – 2171N-linked (GlcNAc...)1 Publication
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi341 – 3411N-linked (GlcNAc...)1 Publication
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)1 Publication
Glycosylationi460 – 4601N-linked (GlcNAc...)1 Publication
Glycosylationi532 – 5321N-linked (GlcNAc...)2 Publications
Disulfide bondi688 ↔ 697By similarity
Glycosylationi699 – 6991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi703 ↔ 756By similarity
Glycosylationi748 – 7481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi780 – 7801N-linked (GlcNAc...)1 Publication
Disulfide bondi808 ↔ 814By similarity
Glycosylationi840 – 8401N-linked (GlcNAc...)1 Publication
Disulfide bondi878 ↔ 886By similarity
Glycosylationi883 – 8831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi908 – 9081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi915 – 9151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi939 – 9391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi966 – 9661N-linked (GlcNAc...)1 Publication
Glycosylationi974 – 9741N-linked (GlcNAc...)1 Publication
Glycosylationi1008 – 10081N-linked (GlcNAc...)1 Publication
Disulfide bondi1030 ↔ 1062By similarity
Disulfide bondi1065 ↔ 1072By similarity
Glycosylationi1073 – 10731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1083 – 10831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1102 – 11021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1113 – 11131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP56199.
PaxDbiP56199.
PRIDEiP56199.

PTM databases

PhosphoSiteiP56199.

Expressioni

Gene expression databases

BgeeiP56199.
GenevestigatoriP56199.

Organism-specific databases

HPAiHPA042555.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21. Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling.2 Publications

Protein-protein interaction databases

BioGridi109879. 10 interactions.
DIPiDIP-206N.
IntActiP56199. 6 interactions.
MINTiMINT-7004837.
STRINGi9606.ENSP00000282588.

Structurei

Secondary structure

1
1179
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi171 – 1788Combined sources
Helixi186 – 19712Combined sources
Beta strandi206 – 22217Combined sources
Turni224 – 2263Combined sources
Helixi230 – 2389Combined sources
Helixi250 – 25910Combined sources
Turni260 – 2623Combined sources
Helixi264 – 2663Combined sources
Beta strandi273 – 28210Combined sources
Helixi288 – 29912Combined sources
Beta strandi302 – 3098Combined sources
Helixi311 – 3155Combined sources
Helixi321 – 33010Combined sources
Helixi335 – 3384Combined sources
Beta strandi339 – 3446Combined sources
Helixi345 – 3517Combined sources
Helixi352 – 3598Combined sources
Helixi1143 – 116826Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PT6X-ray1.87A/B166-366[»]
1QC5X-ray2.00A/B168-359[»]
1QCYX-ray2.30A169-361[»]
2L8SNMR-A1135-1179[»]
2M32NMR-A168-359[»]
4A0QX-ray1.90A/B166-366[»]
ProteinModelPortaliP56199.
SMRiP56199. Positions 29-359, 371-1081, 1135-1179.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56199.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati30 – 9162FG-GAP 1Add
BLAST
Repeati101 – 16060FG-GAP 2Add
BLAST
Domaini161 – 360200VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati365 – 41753FG-GAP 3Add
BLAST
Repeati422 – 47554FG-GAP 4Add
BLAST
Repeati476 – 53863FG-GAP 5Add
BLAST
Repeati557 – 61559FG-GAP 6Add
BLAST
Repeati619 – 67961FG-GAP 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1167 – 11715GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG322251.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiP56199.
KOiK06480.
OMAiQRFSIAI.
OrthoDBiEOG7GBFW6.
PhylomeDBiP56199.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56199-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPRPRARPG VAVACCWLLT VVLRCCVSFN VDVKNSMTFS GPVEDMFGYT
60 70 80 90 100
VQQYENEEGK WVLIGSPLVG QPKNRTGDVY KCPVGRGESL PCVKLDLPVN
110 120 130 140 150
TSIPNVTEVK ENMTFGSTLV TNPNGGFLAC GPLYAYRCGH LHYTTGICSD
160 170 180 190 200
VSPTFQVVNS IAPVQECSTQ LDIVIVLDGS NSIYPWDSVT AFLNDLLERM
210 220 230 240 250
DIGPKQTQVG IVQYGENVTH EFNLNKYSST EEVLVAAKKI VQRGGRQTMT
260 270 280 290 300
ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNHRL KKVIQDCEDE
310 320 330 340 350
NIQRFSIAIL GSYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT
360 370 380 390 400
IVKTLGERIF ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD
410 420 430 440 450
WNGTVVMQKA SQIIIPRNTT FNVESTKKNE PLASYLGYTV NSATASSGDV
460 470 480 490 500
LYIAGQPRYN HTGQVIIYRM EDGNIKILQT LSGEQIGSYF GSILTTTDID
510 520 530 540 550
KDSNTDILLV GAPMYMGTEK EEQGKVYVYA LNQTRFEYQM SLEPIKQTCC
560 570 580 590 600
SSRQHNSCTT ENKNEPCGAR FGTAIAAVKD LNLDGFNDIV IGAPLEDDHG
610 620 630 640 650
GAVYIYHGSG KTIRKEYAQR IPSGGDGKTL KFFGQSIHGE MDLNGDGLTD
660 670 680 690 700
VTIGGLGGAA LFWSRDVAVV KVTMNFEPNK VNIQKKNCHM EGKETVCINA
710 720 730 740 750
TVCFDVKLKS KEDTIYEADL QYRVTLDSLR QISRSFFSGT QERKVQRNIT
760 770 780 790 800
VRKSECTKHS FYMLDKHDFQ DSVRITLDFN LTDPENGPVL DDSLPNSVHE
810 820 830 840 850
YIPFAKDCGN KEKCISDLSL HVATTEKDLL IVRSQNDKFN VSLTVKNTKD
860 870 880 890 900
SAYNTRTIVH YSPNLVFSGI EAIQKDSCES NHNITCKVGY PFLRRGEMVT
910 920 930 940 950
FKILFQFNTS YLMENVTIYL SATSDSEEPP ETLSDNVVNI SIPVKYEVGL
960 970 980 990 1000
QFYSSASEYH ISIAANETVP EVINSTEDIG NEINIFYLIR KSGSFPMPEL
1010 1020 1030 1040 1050
KLSISFPNMT SNGYPVLYPT GLSSSENANC RPHIFEDPFS INSGKKMTTS
1060 1070 1080 1090 1100
TDHLKRGTIL DCNTCKFATI TCNLTSSDIS QVNVSLILWK PTFIKSYFSS
1110 1120 1130 1140 1150
LNLTIRGELR SENASLVLSS SNQKRELAIQ ISKDGLPGRV PLWVILLSAF
1160 1170
AGLLLLMLLI LALWKIGFFK RPLKKKMEK
Length:1,179
Mass (Da):130,848
Last modified:January 23, 2007 - v2
Checksum:i1A86F30FD916C845
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981E → K(PubMed:8428973)Curated
Sequence conflicti254 – 2541I → T(PubMed:8428973)Curated
Sequence conflicti705 – 7051D → E(PubMed:8428973)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti480 – 4801T → M.
Corresponds to variant rs4145748 [ dbSNP | Ensembl ].
VAR_034022
Natural varianti670 – 6701V → I.
Corresponds to variant rs2279587 [ dbSNP | Ensembl ].
VAR_049630
Natural varianti961 – 9611I → M.
Corresponds to variant rs12520591 [ dbSNP | Ensembl ].
VAR_034023
Natural varianti1108 – 11081E → G.
Corresponds to variant rs988574 [ dbSNP | Ensembl ].
VAR_034024

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027326 Genomic DNA. No translation available.
AC022133 Genomic DNA. No translation available.
AC025180 Genomic DNA. No translation available.
BC137121 mRNA. Translation: AAI37122.1.
BC137122 mRNA. Translation: AAI37123.1.
X68742 mRNA. No translation available.
CCDSiCCDS3955.1.
PIRiA45226.
RefSeqiNP_852478.1. NM_181501.1.
UniGeneiHs.644352.

Genome annotation databases

EnsembliENST00000282588; ENSP00000282588; ENSG00000213949.
GeneIDi3672.
KEGGihsa:3672.
UCSCiuc003jou.3. human.

Polymorphism databases

DMDMi124056463.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027326 Genomic DNA. No translation available.
AC022133 Genomic DNA. No translation available.
AC025180 Genomic DNA. No translation available.
BC137121 mRNA. Translation: AAI37122.1 .
BC137122 mRNA. Translation: AAI37123.1 .
X68742 mRNA. No translation available.
CCDSi CCDS3955.1.
PIRi A45226.
RefSeqi NP_852478.1. NM_181501.1.
UniGenei Hs.644352.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PT6 X-ray 1.87 A/B 166-366 [» ]
1QC5 X-ray 2.00 A/B 168-359 [» ]
1QCY X-ray 2.30 A 169-361 [» ]
2L8S NMR - A 1135-1179 [» ]
2M32 NMR - A 168-359 [» ]
4A0Q X-ray 1.90 A/B 166-366 [» ]
ProteinModelPortali P56199.
SMRi P56199. Positions 29-359, 371-1081, 1135-1179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109879. 10 interactions.
DIPi DIP-206N.
IntActi P56199. 6 interactions.
MINTi MINT-7004837.
STRINGi 9606.ENSP00000282588.

Chemistry

BindingDBi P56199.
ChEMBLi CHEMBL3682.

PTM databases

PhosphoSitei P56199.

Polymorphism databases

DMDMi 124056463.

Proteomic databases

MaxQBi P56199.
PaxDbi P56199.
PRIDEi P56199.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282588 ; ENSP00000282588 ; ENSG00000213949 .
GeneIDi 3672.
KEGGi hsa:3672.
UCSCi uc003jou.3. human.

Organism-specific databases

CTDi 3672.
GeneCardsi GC05P052083.
HGNCi HGNC:6134. ITGA1.
HPAi HPA042555.
MIMi 192968. gene.
neXtProti NX_P56199.
PharmGKBi PA29935.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322251.
GeneTreei ENSGT00760000118782.
HOGENOMi HOG000059610.
HOVERGENi HBG006185.
InParanoidi P56199.
KOi K06480.
OMAi QRFSIAI.
OrthoDBi EOG7GBFW6.
PhylomeDBi P56199.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_1230. Platelet Adhesion to exposed collagen.
REACT_13552. Integrin cell surface interactions.
REACT_169262. Laminin interactions.
REACT_19200. Other semaphorin interactions.
REACT_20558. Smooth Muscle Contraction.
REACT_22292. CHL1 interactions.
SignaLinki P56199.

Miscellaneous databases

ChiTaRSi ITGA1. human.
EvolutionaryTracei P56199.
GeneWikii CD49a.
GenomeRNAii 3672.
NextBioi 14373.
PROi P56199.
SOURCEi Search...

Gene expression databases

Bgeei P56199.
Genevestigatori P56199.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01839. FG-GAP. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Expression of native and truncated forms of the human integrin alpha 1 subunit."
    Briesewitz R., Epstein M.R., Marcantonio E.E.
    J. Biol. Chem. 268:2989-2996(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-1179.
  4. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-532.
    Tissue: Plasma.
  5. "Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP."
    Mattila E., Pellinen T., Nevo J., Vuoriluoto K., Arjonen A., Ivaska J.
    Nat. Cell Biol. 7:78-85(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN EGFR SIGNALING, INTERACTION WITH PTPN2.
  6. "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
    Pellinen T., Arjonen A., Vuoriluoto K., Kallio K., Fransen J.A.M., Ivaska J.
    J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB21.
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-100; ASN-105; ASN-217; ASN-341; ASN-418; ASN-460; ASN-532; ASN-780; ASN-840; ASN-966; ASN-974 AND ASN-1008.
    Tissue: Liver.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM."
    Rich R.L., Deivanayagam C.C., Owens R.T., Carson M., Hook A., Moore D., Symersky J., Yang V.W., Narayana S.V., Hook M.
    J. Biol. Chem. 274:24906-24913(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 168-359.
  10. "Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1."
    Nymalm Y., Puranen J.S., Nyholm T.K., Kapyla J., Kidron H., Pentikainen O.T., Airenne T.T., Heino J., Slotte J.P., Johnson M.S., Salminen T.A.
    J. Biol. Chem. 279:7962-7970(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.87 ANGSTROMS) OF 166-356.

Entry informationi

Entry nameiITA1_HUMAN
AccessioniPrimary (citable) accession number: P56199
Secondary accession number(s): B2RNU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3