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P56199

- ITA1_HUMAN

UniProt

P56199 - ITA1_HUMAN

Protein

Integrin alpha-1

Gene

ITGA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi498 – 5069Sequence Analysis
    Calcium bindingi580 – 5889Sequence Analysis
    Calcium bindingi642 – 6509Sequence Analysis

    GO - Molecular functioni

    1. collagen binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB
    4. protein phosphatase binding Source: UniProtKB

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. axon guidance Source: Reactome
    3. blood coagulation Source: Reactome
    4. cell adhesion Source: UniProtKB-KW
    5. cellular extravasation Source: Ensembl
    6. extracellular matrix organization Source: Reactome
    7. integrin-mediated signaling pathway Source: UniProtKB-KW
    8. muscle contraction Source: Reactome
    9. negative regulation of cell proliferation Source: UniProtKB
    10. negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
    11. neutrophil chemotaxis Source: Ensembl
    12. positive regulation of neuron apoptotic process Source: Ensembl
    13. positive regulation of phosphoprotein phosphatase activity Source: UniProtKB
    14. vasodilation Source: Ensembl

    Keywords - Molecular functioni

    Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_1230. Platelet Adhesion to exposed collagen.
    REACT_13552. Integrin cell surface interactions.
    REACT_169262. Laminin interactions.
    REACT_19200. Other semaphorin interactions.
    REACT_20558. Smooth Muscle Contraction.
    REACT_22292. CHL1 interactions.
    SignaLinkiP56199.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-1
    Alternative name(s):
    CD49 antigen-like family member A
    Laminin and collagen receptor
    VLA-1
    CD_antigen: CD49a
    Gene namesi
    Name:ITGA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:6134. ITGA1.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. basal part of cell Source: Ensembl
    3. cell surface Source: UniProtKB
    4. external side of plasma membrane Source: Ensembl
    5. extracellular vesicular exosome Source: UniProt
    6. focal adhesion Source: UniProtKB
    7. integrin complex Source: UniProtKB
    8. membrane Source: UniProtKB
    9. membrane raft Source: Ensembl
    10. neuron projection Source: Ensembl
    11. perikaryon Source: Ensembl
    12. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29935.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 11791151Integrin alpha-1PRO_0000174215Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi82 ↔ 92By similarity
    Glycosylationi100 – 1001N-linked (GlcNAc...)1 Publication
    Glycosylationi105 – 1051N-linked (GlcNAc...)1 Publication
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi217 – 2171N-linked (GlcNAc...)1 Publication
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi341 – 3411N-linked (GlcNAc...)1 Publication
    Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi418 – 4181N-linked (GlcNAc...)1 Publication
    Glycosylationi460 – 4601N-linked (GlcNAc...)1 Publication
    Glycosylationi532 – 5321N-linked (GlcNAc...)2 Publications
    Disulfide bondi688 ↔ 697By similarity
    Glycosylationi699 – 6991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi703 ↔ 756By similarity
    Glycosylationi748 – 7481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi780 – 7801N-linked (GlcNAc...)1 Publication
    Disulfide bondi808 ↔ 814By similarity
    Glycosylationi840 – 8401N-linked (GlcNAc...)1 Publication
    Disulfide bondi878 ↔ 886By similarity
    Glycosylationi883 – 8831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi908 – 9081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi915 – 9151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi939 – 9391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi966 – 9661N-linked (GlcNAc...)1 Publication
    Glycosylationi974 – 9741N-linked (GlcNAc...)1 Publication
    Glycosylationi1008 – 10081N-linked (GlcNAc...)1 Publication
    Disulfide bondi1030 ↔ 1062By similarity
    Disulfide bondi1065 ↔ 1072By similarity
    Glycosylationi1073 – 10731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1083 – 10831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1102 – 11021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1113 – 11131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP56199.
    PaxDbiP56199.
    PRIDEiP56199.

    PTM databases

    PhosphoSiteiP56199.

    Expressioni

    Gene expression databases

    BgeeiP56199.
    GenevestigatoriP56199.

    Organism-specific databases

    HPAiHPA042555.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21. Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling.2 Publications

    Protein-protein interaction databases

    BioGridi109879. 8 interactions.
    DIPiDIP-206N.
    IntActiP56199. 6 interactions.
    MINTiMINT-7004837.
    STRINGi9606.ENSP00000282588.

    Structurei

    Secondary structure

    1
    1179
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi171 – 1788
    Helixi186 – 19712
    Beta strandi206 – 22217
    Turni224 – 2263
    Helixi230 – 2389
    Helixi250 – 25910
    Turni260 – 2623
    Helixi264 – 2663
    Beta strandi273 – 28210
    Helixi288 – 29912
    Beta strandi302 – 3098
    Helixi311 – 3155
    Helixi321 – 33010
    Helixi335 – 3384
    Beta strandi339 – 3446
    Helixi345 – 3517
    Helixi352 – 3598
    Helixi1143 – 116826

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PT6X-ray1.87A/B166-366[»]
    1QC5X-ray2.00A/B168-359[»]
    1QCYX-ray2.30A169-361[»]
    2L8SNMR-A1135-1179[»]
    2M32NMR-A168-359[»]
    4A0QX-ray1.90A/B166-366[»]
    ProteinModelPortaliP56199.
    SMRiP56199. Positions 29-359, 371-1081, 1135-1179.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP56199.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 11411113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1165 – 117915CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1142 – 116423HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati30 – 9162FG-GAP 1Add
    BLAST
    Repeati101 – 16060FG-GAP 2Add
    BLAST
    Domaini161 – 360200VWFAPROSITE-ProRule annotationAdd
    BLAST
    Repeati365 – 41753FG-GAP 3Add
    BLAST
    Repeati422 – 47554FG-GAP 4Add
    BLAST
    Repeati476 – 53863FG-GAP 5Add
    BLAST
    Repeati557 – 61559FG-GAP 6Add
    BLAST
    Repeati619 – 67961FG-GAP 7Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1167 – 11715GFFKR motif

    Domaini

    The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG322251.
    HOGENOMiHOG000059610.
    HOVERGENiHBG006185.
    InParanoidiP56199.
    KOiK06480.
    OMAiQRFSIAI.
    OrthoDBiEOG7GBFW6.
    PhylomeDBiP56199.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF01839. FG-GAP. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 5 hits.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    PS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56199-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPRPRARPG VAVACCWLLT VVLRCCVSFN VDVKNSMTFS GPVEDMFGYT     50
    VQQYENEEGK WVLIGSPLVG QPKNRTGDVY KCPVGRGESL PCVKLDLPVN 100
    TSIPNVTEVK ENMTFGSTLV TNPNGGFLAC GPLYAYRCGH LHYTTGICSD 150
    VSPTFQVVNS IAPVQECSTQ LDIVIVLDGS NSIYPWDSVT AFLNDLLERM 200
    DIGPKQTQVG IVQYGENVTH EFNLNKYSST EEVLVAAKKI VQRGGRQTMT 250
    ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNHRL KKVIQDCEDE 300
    NIQRFSIAIL GSYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT 350
    IVKTLGERIF ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD 400
    WNGTVVMQKA SQIIIPRNTT FNVESTKKNE PLASYLGYTV NSATASSGDV 450
    LYIAGQPRYN HTGQVIIYRM EDGNIKILQT LSGEQIGSYF GSILTTTDID 500
    KDSNTDILLV GAPMYMGTEK EEQGKVYVYA LNQTRFEYQM SLEPIKQTCC 550
    SSRQHNSCTT ENKNEPCGAR FGTAIAAVKD LNLDGFNDIV IGAPLEDDHG 600
    GAVYIYHGSG KTIRKEYAQR IPSGGDGKTL KFFGQSIHGE MDLNGDGLTD 650
    VTIGGLGGAA LFWSRDVAVV KVTMNFEPNK VNIQKKNCHM EGKETVCINA 700
    TVCFDVKLKS KEDTIYEADL QYRVTLDSLR QISRSFFSGT QERKVQRNIT 750
    VRKSECTKHS FYMLDKHDFQ DSVRITLDFN LTDPENGPVL DDSLPNSVHE 800
    YIPFAKDCGN KEKCISDLSL HVATTEKDLL IVRSQNDKFN VSLTVKNTKD 850
    SAYNTRTIVH YSPNLVFSGI EAIQKDSCES NHNITCKVGY PFLRRGEMVT 900
    FKILFQFNTS YLMENVTIYL SATSDSEEPP ETLSDNVVNI SIPVKYEVGL 950
    QFYSSASEYH ISIAANETVP EVINSTEDIG NEINIFYLIR KSGSFPMPEL 1000
    KLSISFPNMT SNGYPVLYPT GLSSSENANC RPHIFEDPFS INSGKKMTTS 1050
    TDHLKRGTIL DCNTCKFATI TCNLTSSDIS QVNVSLILWK PTFIKSYFSS 1100
    LNLTIRGELR SENASLVLSS SNQKRELAIQ ISKDGLPGRV PLWVILLSAF 1150
    AGLLLLMLLI LALWKIGFFK RPLKKKMEK 1179
    Length:1,179
    Mass (Da):130,848
    Last modified:January 23, 2007 - v2
    Checksum:i1A86F30FD916C845
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti198 – 1981E → K(PubMed:8428973)Curated
    Sequence conflicti254 – 2541I → T(PubMed:8428973)Curated
    Sequence conflicti705 – 7051D → E(PubMed:8428973)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti480 – 4801T → M.
    Corresponds to variant rs4145748 [ dbSNP | Ensembl ].
    VAR_034022
    Natural varianti670 – 6701V → I.
    Corresponds to variant rs2279587 [ dbSNP | Ensembl ].
    VAR_049630
    Natural varianti961 – 9611I → M.
    Corresponds to variant rs12520591 [ dbSNP | Ensembl ].
    VAR_034023
    Natural varianti1108 – 11081E → G.
    Corresponds to variant rs988574 [ dbSNP | Ensembl ].
    VAR_034024

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC027326 Genomic DNA. No translation available.
    AC022133 Genomic DNA. No translation available.
    AC025180 Genomic DNA. No translation available.
    BC137121 mRNA. Translation: AAI37122.1.
    BC137122 mRNA. Translation: AAI37123.1.
    X68742 mRNA. No translation available.
    CCDSiCCDS3955.1.
    PIRiA45226.
    RefSeqiNP_852478.1. NM_181501.1.
    UniGeneiHs.644352.

    Genome annotation databases

    EnsembliENST00000282588; ENSP00000282588; ENSG00000213949.
    GeneIDi3672.
    KEGGihsa:3672.
    UCSCiuc003jou.3. human.

    Polymorphism databases

    DMDMi124056463.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC027326 Genomic DNA. No translation available.
    AC022133 Genomic DNA. No translation available.
    AC025180 Genomic DNA. No translation available.
    BC137121 mRNA. Translation: AAI37122.1 .
    BC137122 mRNA. Translation: AAI37123.1 .
    X68742 mRNA. No translation available.
    CCDSi CCDS3955.1.
    PIRi A45226.
    RefSeqi NP_852478.1. NM_181501.1.
    UniGenei Hs.644352.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PT6 X-ray 1.87 A/B 166-366 [» ]
    1QC5 X-ray 2.00 A/B 168-359 [» ]
    1QCY X-ray 2.30 A 169-361 [» ]
    2L8S NMR - A 1135-1179 [» ]
    2M32 NMR - A 168-359 [» ]
    4A0Q X-ray 1.90 A/B 166-366 [» ]
    ProteinModelPortali P56199.
    SMRi P56199. Positions 29-359, 371-1081, 1135-1179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109879. 8 interactions.
    DIPi DIP-206N.
    IntActi P56199. 6 interactions.
    MINTi MINT-7004837.
    STRINGi 9606.ENSP00000282588.

    Chemistry

    BindingDBi P56199.
    ChEMBLi CHEMBL3682.

    PTM databases

    PhosphoSitei P56199.

    Polymorphism databases

    DMDMi 124056463.

    Proteomic databases

    MaxQBi P56199.
    PaxDbi P56199.
    PRIDEi P56199.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282588 ; ENSP00000282588 ; ENSG00000213949 .
    GeneIDi 3672.
    KEGGi hsa:3672.
    UCSCi uc003jou.3. human.

    Organism-specific databases

    CTDi 3672.
    GeneCardsi GC05P052083.
    HGNCi HGNC:6134. ITGA1.
    HPAi HPA042555.
    MIMi 192968. gene.
    neXtProti NX_P56199.
    PharmGKBi PA29935.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322251.
    HOGENOMi HOG000059610.
    HOVERGENi HBG006185.
    InParanoidi P56199.
    KOi K06480.
    OMAi QRFSIAI.
    OrthoDBi EOG7GBFW6.
    PhylomeDBi P56199.
    TreeFami TF105391.

    Enzyme and pathway databases

    Reactomei REACT_1230. Platelet Adhesion to exposed collagen.
    REACT_13552. Integrin cell surface interactions.
    REACT_169262. Laminin interactions.
    REACT_19200. Other semaphorin interactions.
    REACT_20558. Smooth Muscle Contraction.
    REACT_22292. CHL1 interactions.
    SignaLinki P56199.

    Miscellaneous databases

    EvolutionaryTracei P56199.
    GeneWikii CD49a.
    GenomeRNAii 3672.
    NextBioi 14373.
    PROi P56199.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56199.
    Genevestigatori P56199.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 5 hits.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Expression of native and truncated forms of the human integrin alpha 1 subunit."
      Briesewitz R., Epstein M.R., Marcantonio E.E.
      J. Biol. Chem. 268:2989-2996(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-1179.
    4. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-532.
      Tissue: Plasma.
    5. "Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP."
      Mattila E., Pellinen T., Nevo J., Vuoriluoto K., Arjonen A., Ivaska J.
      Nat. Cell Biol. 7:78-85(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN EGFR SIGNALING, INTERACTION WITH PTPN2.
    6. "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
      Pellinen T., Arjonen A., Vuoriluoto K., Kallio K., Fransen J.A.M., Ivaska J.
      J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RAB21.
    7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-100; ASN-105; ASN-217; ASN-341; ASN-418; ASN-460; ASN-532; ASN-780; ASN-840; ASN-966; ASN-974 AND ASN-1008.
      Tissue: Liver.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM."
      Rich R.L., Deivanayagam C.C., Owens R.T., Carson M., Hook A., Moore D., Symersky J., Yang V.W., Narayana S.V., Hook M.
      J. Biol. Chem. 274:24906-24913(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 168-359.
    10. "Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1."
      Nymalm Y., Puranen J.S., Nyholm T.K., Kapyla J., Kidron H., Pentikainen O.T., Airenne T.T., Heino J., Slotte J.P., Johnson M.S., Salminen T.A.
      J. Biol. Chem. 279:7962-7970(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.87 ANGSTROMS) OF 166-356.

    Entry informationi

    Entry nameiITA1_HUMAN
    AccessioniPrimary (citable) accession number: P56199
    Secondary accession number(s): B2RNU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 151 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3