P56197 (AROA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	HP_0401

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP-Rule MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP-Rule MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP-Rule MF_00210		PRO_0000088260

Sequences

	Sequence		Length	Mass (Da)
	P56197 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 19545753E081FDAE	FASTA	429	47,241
	10 20 30 40 50 60 MIELDINASD KSLSHRAVIF SLLAQKPCFV RNFLMGEDCL SSLEIAQNLG AKVENTAKNS 70 80 90 100 110 120 FKITPPTTIK EPNKILNCNN SGTTMRLYSG LLSAQKGLFV LSGDNSLNAR PMKRIIEPLK 130 140 150 160 170 180 AFGAKILGRE DNHFAPLVIL GSPLKACHYE SPIASAQVKS AFILSALQAQ GASTYKESEL 190 200 210 220 230 240 SRNHTEIMLK SLGADIHNQD GVLKISPLEK PLEAFDFTIA NDPSSAFFFA LACAITPKSR 250 260 270 280 290 300 LLLKNVLLNP TRIEAFEVLK KMGASIEYAI QSKDLEMIGD IYVEHAPLKA INIDQNIASL 310 320 330 340 350 360 IDEIPALSIA MLFAKGKSMV KNAKDLRAKE SDRIKAVVSN FKALGIECEE FEDGFYVEGL 370 380 390 400 410 420 EDISPLKQRF SRIKPPLIKS FNDHRIAMSF AVLTLALPLE IDNLECANIS FPQFKHLLNQ FKKGSLNGN

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07470.1.
PIR	A64570.
RefSeq	NP_207199.1. NC_000915.1. YP_006934325.1. NC_018939.1.
3D structure databases
ProteinModelPortal	P56197.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3563N.
MINT	MINT-183001.
STRING	85962.HP0401.
PTM databases
PhosSite	P11041006.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD07470; AAD07470; HP_0401.
GeneID	13869587. 900233.
KEGG	heo:C694_02035. hpy:HP0401.
PATRIC	20592041. VBIHelPyl33062_0414.
Phylogenomic databases
eggNOG	COG0128.
KO	K00800.
OMA	ANDPSSA.
ProtClustDB	PRK02427.
Enzyme and pathway databases
UniPathway	UPA00053; UER00089.
Family and domain databases
Gene3D	3.65.10.10. 2 hits.
HAMAP	MF_00210. EPSP_synth.
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_HELPY

Accession

Primary (citable) accession number: P56197

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program