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P56197

- AROA_HELPY

UniProt

P56197 - AROA_HELPY

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Protein

3-phosphoshikimate 1-carboxyvinyltransferase

Gene

aroA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.

Pathwayi

GO - Molecular functioni

  1. 3-phosphoshikimate 1-carboxyvinyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-KW
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

BioCyciHPY:HP0401-MONOMER.
UniPathwayiUPA00053; UER00089.

Names & Taxonomyi

Protein namesi
Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase (EC:2.5.1.19)
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name:
EPSP synthase
Short name:
EPSPS
Gene namesi
Name:aroA
Ordered Locus Names:HP_0401
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4294293-phosphoshikimate 1-carboxyvinyltransferasePRO_0000088260Add
BLAST

Proteomic databases

PRIDEiP56197.

PTM databases

PhosSiteiP11041006.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

DIPiDIP-3563N.
IntActiP56197. 2 interactions.
MINTiMINT-183001.
STRINGi85962.HP0401.

Structurei

3D structure databases

ProteinModelPortaliP56197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPSP synthase family.Curated

Phylogenomic databases

eggNOGiCOG0128.
KOiK00800.
OMAiRNAKDLR.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00210. EPSP_synth.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF000505. EPSPS. 1 hit.
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01356. aroA. 1 hit.
PROSITEiPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56197-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIELDINASD KSLSHRAVIF SLLAQKPCFV RNFLMGEDCL SSLEIAQNLG
60 70 80 90 100
AKVENTAKNS FKITPPTTIK EPNKILNCNN SGTTMRLYSG LLSAQKGLFV
110 120 130 140 150
LSGDNSLNAR PMKRIIEPLK AFGAKILGRE DNHFAPLVIL GSPLKACHYE
160 170 180 190 200
SPIASAQVKS AFILSALQAQ GASTYKESEL SRNHTEIMLK SLGADIHNQD
210 220 230 240 250
GVLKISPLEK PLEAFDFTIA NDPSSAFFFA LACAITPKSR LLLKNVLLNP
260 270 280 290 300
TRIEAFEVLK KMGASIEYAI QSKDLEMIGD IYVEHAPLKA INIDQNIASL
310 320 330 340 350
IDEIPALSIA MLFAKGKSMV KNAKDLRAKE SDRIKAVVSN FKALGIECEE
360 370 380 390 400
FEDGFYVEGL EDISPLKQRF SRIKPPLIKS FNDHRIAMSF AVLTLALPLE
410 420
IDNLECANIS FPQFKHLLNQ FKKGSLNGN
Length:429
Mass (Da):47,241
Last modified:November 1, 1997 - v1
Checksum:i19545753E081FDAE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07470.1.
PIRiA64570.
RefSeqiNP_207199.1. NC_000915.1.
YP_006934325.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07470; AAD07470; HP_0401.
GeneIDi13869587.
900233.
KEGGiheo:C694_02035.
hpy:HP0401.
PATRICi20592041. VBIHelPyl33062_0414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07470.1 .
PIRi A64570.
RefSeqi NP_207199.1. NC_000915.1.
YP_006934325.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56197.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3563N.
IntActi P56197. 2 interactions.
MINTi MINT-183001.
STRINGi 85962.HP0401.

PTM databases

PhosSitei P11041006.

Proteomic databases

PRIDEi P56197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07470 ; AAD07470 ; HP_0401 .
GeneIDi 13869587.
900233.
KEGGi heo:C694_02035.
hpy:HP0401.
PATRICi 20592041. VBIHelPyl33062_0414.

Phylogenomic databases

eggNOGi COG0128.
KOi K00800.
OMAi RNAKDLR.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00089 .
BioCyci HPY:HP0401-MONOMER.

Family and domain databases

Gene3Di 3.65.10.10. 2 hits.
HAMAPi MF_00210. EPSP_synth.
InterProi IPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view ]
Pfami PF00275. EPSP_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000505. EPSPS. 1 hit.
SUPFAMi SSF55205. SSF55205. 1 hit.
TIGRFAMsi TIGR01356. aroA. 1 hit.
PROSITEi PS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiAROA_HELPY
AccessioniPrimary (citable) accession number: P56197
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3