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P56197

- AROA_HELPY

UniProt

P56197 - AROA_HELPY

Protein

3-phosphoshikimate 1-carboxyvinyltransferase

Gene

aroA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.

    Pathwayi

    GO - Molecular functioni

    1. 3-phosphoshikimate 1-carboxyvinyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-KW
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Enzyme and pathway databases

    BioCyciHPY:HP0401-MONOMER.
    UniPathwayiUPA00053; UER00089.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase (EC:2.5.1.19)
    Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
    Short name:
    EPSP synthase
    Short name:
    EPSPS
    Gene namesi
    Name:aroA
    Ordered Locus Names:HP_0401
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4294293-phosphoshikimate 1-carboxyvinyltransferasePRO_0000088260Add
    BLAST

    Proteomic databases

    PRIDEiP56197.

    PTM databases

    PhosSiteiP11041006.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    DIPiDIP-3563N.
    IntActiP56197. 2 interactions.
    MINTiMINT-183001.
    STRINGi85962.HP0401.

    Structurei

    3D structure databases

    ProteinModelPortaliP56197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EPSP synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0128.
    KOiK00800.
    OMAiRNAKDLR.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.65.10.10. 2 hits.
    HAMAPiMF_00210. EPSP_synth.
    InterProiIPR001986. Enolpyruvate_Tfrase_dom.
    IPR006264. EPSP_synthase.
    IPR023193. EPSP_synthase_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view]
    PfamiPF00275. EPSP_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000505. EPSPS. 1 hit.
    SUPFAMiSSF55205. SSF55205. 1 hit.
    TIGRFAMsiTIGR01356. aroA. 1 hit.
    PROSITEiPS00104. EPSP_SYNTHASE_1. 1 hit.
    PS00885. EPSP_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56197-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIELDINASD KSLSHRAVIF SLLAQKPCFV RNFLMGEDCL SSLEIAQNLG    50
    AKVENTAKNS FKITPPTTIK EPNKILNCNN SGTTMRLYSG LLSAQKGLFV 100
    LSGDNSLNAR PMKRIIEPLK AFGAKILGRE DNHFAPLVIL GSPLKACHYE 150
    SPIASAQVKS AFILSALQAQ GASTYKESEL SRNHTEIMLK SLGADIHNQD 200
    GVLKISPLEK PLEAFDFTIA NDPSSAFFFA LACAITPKSR LLLKNVLLNP 250
    TRIEAFEVLK KMGASIEYAI QSKDLEMIGD IYVEHAPLKA INIDQNIASL 300
    IDEIPALSIA MLFAKGKSMV KNAKDLRAKE SDRIKAVVSN FKALGIECEE 350
    FEDGFYVEGL EDISPLKQRF SRIKPPLIKS FNDHRIAMSF AVLTLALPLE 400
    IDNLECANIS FPQFKHLLNQ FKKGSLNGN 429
    Length:429
    Mass (Da):47,241
    Last modified:November 1, 1997 - v1
    Checksum:i19545753E081FDAE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07470.1.
    PIRiA64570.
    RefSeqiNP_207199.1. NC_000915.1.
    YP_006934325.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07470; AAD07470; HP_0401.
    GeneIDi13869587.
    900233.
    KEGGiheo:C694_02035.
    hpy:HP0401.
    PATRICi20592041. VBIHelPyl33062_0414.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07470.1 .
    PIRi A64570.
    RefSeqi NP_207199.1. NC_000915.1.
    YP_006934325.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3563N.
    IntActi P56197. 2 interactions.
    MINTi MINT-183001.
    STRINGi 85962.HP0401.

    PTM databases

    PhosSitei P11041006.

    Proteomic databases

    PRIDEi P56197.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07470 ; AAD07470 ; HP_0401 .
    GeneIDi 13869587.
    900233.
    KEGGi heo:C694_02035.
    hpy:HP0401.
    PATRICi 20592041. VBIHelPyl33062_0414.

    Phylogenomic databases

    eggNOGi COG0128.
    KOi K00800.
    OMAi RNAKDLR.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00089 .
    BioCyci HPY:HP0401-MONOMER.

    Family and domain databases

    Gene3Di 3.65.10.10. 2 hits.
    HAMAPi MF_00210. EPSP_synth.
    InterProi IPR001986. Enolpyruvate_Tfrase_dom.
    IPR006264. EPSP_synthase.
    IPR023193. EPSP_synthase_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view ]
    Pfami PF00275. EPSP_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000505. EPSPS. 1 hit.
    SUPFAMi SSF55205. SSF55205. 1 hit.
    TIGRFAMsi TIGR01356. aroA. 1 hit.
    PROSITEi PS00104. EPSP_SYNTHASE_1. 1 hit.
    PS00885. EPSP_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiAROA_HELPY
    AccessioniPrimary (citable) accession number: P56197
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3