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Protein

3-phosphoshikimate 1-carboxyvinyltransferase

Gene

aroA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei16 – 161Shikimate-3-phosphateUniRule annotation
Binding sitei110 – 1101PhosphoenolpyruvateUniRule annotation
Active sitei302 – 3021Proton acceptorUniRule annotation
Binding sitei329 – 3291Shikimate-3-phosphateUniRule annotation
Active sitei330 – 3301Proton donorUniRule annotation
Binding sitei333 – 3331PhosphoenolpyruvateUniRule annotation
Binding sitei385 – 3851PhosphoenolpyruvateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

BioCyciHPY:HP0401-MONOMER.
UniPathwayiUPA00053; UER00089.

Names & Taxonomyi

Protein namesi
Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.19UniRule annotation)
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthaseUniRule annotation
Short name:
EPSP synthaseUniRule annotation
Short name:
EPSPSUniRule annotation
Gene namesi
Name:aroAUniRule annotation
Ordered Locus Names:HP_0401
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4294293-phosphoshikimate 1-carboxyvinyltransferasePRO_0000088260Add
BLAST

Proteomic databases

PRIDEiP56197.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3563N.
IntActiP56197. 2 interactions.
MINTiMINT-183001.
STRINGi85962.HP0401.

Structurei

3D structure databases

ProteinModelPortaliP56197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni11 – 122Shikimate-3-phosphate bindingUniRule annotation
Regioni80 – 834PhosphoenolpyruvateUniRule annotation

Sequence similaritiesi

Belongs to the EPSP synthase family.UniRule annotationCurated

Phylogenomic databases

eggNOGiCOG0128.
KOiK00800.
OMAiHTEIMLK.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00210. EPSP_synth.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF000505. EPSPS. 1 hit.
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01356. aroA. 1 hit.
PROSITEiPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIELDINASD KSLSHRAVIF SLLAQKPCFV RNFLMGEDCL SSLEIAQNLG
60 70 80 90 100
AKVENTAKNS FKITPPTTIK EPNKILNCNN SGTTMRLYSG LLSAQKGLFV
110 120 130 140 150
LSGDNSLNAR PMKRIIEPLK AFGAKILGRE DNHFAPLVIL GSPLKACHYE
160 170 180 190 200
SPIASAQVKS AFILSALQAQ GASTYKESEL SRNHTEIMLK SLGADIHNQD
210 220 230 240 250
GVLKISPLEK PLEAFDFTIA NDPSSAFFFA LACAITPKSR LLLKNVLLNP
260 270 280 290 300
TRIEAFEVLK KMGASIEYAI QSKDLEMIGD IYVEHAPLKA INIDQNIASL
310 320 330 340 350
IDEIPALSIA MLFAKGKSMV KNAKDLRAKE SDRIKAVVSN FKALGIECEE
360 370 380 390 400
FEDGFYVEGL EDISPLKQRF SRIKPPLIKS FNDHRIAMSF AVLTLALPLE
410 420
IDNLECANIS FPQFKHLLNQ FKKGSLNGN
Length:429
Mass (Da):47,241
Last modified:November 1, 1997 - v1
Checksum:i19545753E081FDAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07470.1.
PIRiA64570.
RefSeqiNP_207199.1. NC_000915.1.
WP_000570922.1. NC_018939.1.
YP_006934325.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07470; AAD07470; HP_0401.
GeneIDi900233.
KEGGiheo:C694_02035.
hpy:HP0401.
PATRICi20592041. VBIHelPyl33062_0414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07470.1.
PIRiA64570.
RefSeqiNP_207199.1. NC_000915.1.
WP_000570922.1. NC_018939.1.
YP_006934325.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3563N.
IntActiP56197. 2 interactions.
MINTiMINT-183001.
STRINGi85962.HP0401.

Proteomic databases

PRIDEiP56197.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07470; AAD07470; HP_0401.
GeneIDi900233.
KEGGiheo:C694_02035.
hpy:HP0401.
PATRICi20592041. VBIHelPyl33062_0414.

Phylogenomic databases

eggNOGiCOG0128.
KOiK00800.
OMAiHTEIMLK.
OrthoDBiEOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00089.
BioCyciHPY:HP0401-MONOMER.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00210. EPSP_synth.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF000505. EPSPS. 1 hit.
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01356. aroA. 1 hit.
PROSITEiPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiAROA_HELPY
AccessioniPrimary (citable) accession number: P56197
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 27, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.