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P56197 (AROA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase

EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:HP_0401
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP-Rule MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP-Rule MF_00210

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00210

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4294293-phosphoshikimate 1-carboxyvinyltransferase HAMAP-Rule MF_00210
PRO_0000088260

Sequences

Sequence LengthMass (Da)Tools
P56197 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 19545753E081FDAE

FASTA42947,241
        10         20         30         40         50         60 
MIELDINASD KSLSHRAVIF SLLAQKPCFV RNFLMGEDCL SSLEIAQNLG AKVENTAKNS 

        70         80         90        100        110        120 
FKITPPTTIK EPNKILNCNN SGTTMRLYSG LLSAQKGLFV LSGDNSLNAR PMKRIIEPLK 

       130        140        150        160        170        180 
AFGAKILGRE DNHFAPLVIL GSPLKACHYE SPIASAQVKS AFILSALQAQ GASTYKESEL 

       190        200        210        220        230        240 
SRNHTEIMLK SLGADIHNQD GVLKISPLEK PLEAFDFTIA NDPSSAFFFA LACAITPKSR 

       250        260        270        280        290        300 
LLLKNVLLNP TRIEAFEVLK KMGASIEYAI QSKDLEMIGD IYVEHAPLKA INIDQNIASL 

       310        320        330        340        350        360 
IDEIPALSIA MLFAKGKSMV KNAKDLRAKE SDRIKAVVSN FKALGIECEE FEDGFYVEGL 

       370        380        390        400        410        420 
EDISPLKQRF SRIKPPLIKS FNDHRIAMSF AVLTLALPLE IDNLECANIS FPQFKHLLNQ 


FKKGSLNGN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07470.1.
PIRA64570.
RefSeqNP_207199.1. NC_000915.1.
YP_006934325.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56197.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3563N.
IntActP56197. 2 interactions.
MINTMINT-183001.
STRING85962.HP0401.

PTM databases

PhosSiteP11041006.

Proteomic databases

PRIDEP56197.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07470; AAD07470; HP_0401.
GeneID13869587.
900233.
KEGGheo:C694_02035.
hpy:HP0401.
PATRIC20592041. VBIHelPyl33062_0414.

Phylogenomic databases

eggNOGCOG0128.
KOK00800.
OMAHTEIMLK.
OrthoDBEOG6Z6FZ4.
ProtClustDBPRK02427.

Enzyme and pathway databases

BioCycHPY:HP0401-MONOMER.
UniPathwayUPA00053; UER00089.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00210. EPSP_synth.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01356. aroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_HELPY
AccessionPrimary (citable) accession number: P56197
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names