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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gapA)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi11Manganese 2UniRule annotation1
Active sitei61Phosphoserine intermediateUniRule annotation1
Metal bindingi61Manganese 2UniRule annotation1
Binding sitei118SubstrateUniRule annotation1
Binding sitei177SubstrateUniRule annotation1
Binding sitei183SubstrateUniRule annotation1
Binding sitei320SubstrateUniRule annotation1
Metal bindingi386Manganese 1UniRule annotation1
Metal bindingi390Manganese 1UniRule annotation1
Metal bindingi427Manganese 2UniRule annotation1
Metal bindingi428Manganese 2UniRule annotation1
Metal bindingi445Manganese 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0974-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
iPGMUniRule annotation
Gene namesi
Name:gpmIUniRule annotation
Synonyms:pgm
Ordered Locus Names:HP_0974
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002121541 – 4912,3-bisphosphoglycerate-independent phosphoglycerate mutaseAdd BLAST491

Proteomic databases

PaxDbiP56196.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3166N.
IntActiP56196. 1 interactor.
MINTiMINT-172669.
STRINGi85962.HP0974.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LNOmodel-A3-491[»]
ProteinModelPortaliP56196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 148Substrate bindingUniRule annotation2
Regioni247 – 250Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJI. Bacteria.
COG0696. LUCA.
KOiK15633.
OMAiLHIATMT.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

P56196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKTLLIIT DGIGYRKDSD HNAFFHAKKP TYDLMFKTLP YSLIDTHGLS
60 70 80 90 100
VGLPKGQMGN SEVGHMCIGA GRVLYQDLVK ISLSLQNDEL KNNPAFLNTI
110 120 130 140 150
QKSPVVHLMG LMSDGGVHSH IEHFIALALE CEKSHKKVCL HLITDGRDVA
160 170 180 190 200
PKSALTYLKQ MQNICNESIQ IATISGRFYA MDRDKRFERI ELAYHSLMGL
210 220 230 240 250
NHTPLSPSEY IQSQYDKNIT DEFIMPACFK NYCGMQDDES FIFINFRNDR
260 270 280 290 300
AREIVSALGQ KQFSGFKRQV FKKLHIATMT PYDNTFPYPV LFPKESVQNT
310 320 330 340 350
LAEVVSQHNL TQSHIAETEK YAHVTFFING GVETPFKNEN RVLIQSPKVT
360 370 380 390 400
TYDLKPEMSA KEVTLAVLEQ MKLGTDLIIV NFANGDMVGH TGNFEASVKA
410 420 430 440 450
VEAVDACLGE ILSLAKKLDY AMLLTSDHGN CERMKDENQN PLTNHTAGSV
460 470 480 490
YCFVLGDGVK SIKNGALNNI ASSVLKLMGL KAPATMDEPL F
Length:491
Mass (Da):54,788
Last modified:November 1, 1997 - v1
Checksum:iF72F8CDA04EA9D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08020.1.
PIRiF64641.
RefSeqiNP_207765.1. NC_000915.1.
WP_000057737.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08020; AAD08020; HP_0974.
GeneIDi899506.
KEGGiheo:C694_05010.
hpy:HP0974.
PATRICi20593263. VBIHelPyl33062_1013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08020.1.
PIRiF64641.
RefSeqiNP_207765.1. NC_000915.1.
WP_000057737.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LNOmodel-A3-491[»]
ProteinModelPortaliP56196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3166N.
IntActiP56196. 1 interactor.
MINTiMINT-172669.
STRINGi85962.HP0974.

Proteomic databases

PaxDbiP56196.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08020; AAD08020; HP_0974.
GeneIDi899506.
KEGGiheo:C694_05010.
hpy:HP0974.
PATRICi20593263. VBIHelPyl33062_1013.

Phylogenomic databases

eggNOGiENOG4105CJI. Bacteria.
COG0696. LUCA.
KOiK15633.
OMAiLHIATMT.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.
BioCyciHPY:HP0974-MONOMER.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPMI_HELPY
AccessioniPrimary (citable) accession number: P56196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.