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P56196

- GPMI_HELPY

UniProt

P56196 - GPMI_HELPY

Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.By similarity

    Catalytic activityi

    2-phospho-D-glycerate = 3-phospho-D-glycerate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi11 – 111Manganese 2By similarity
    Active sitei61 – 611Phosphoserine intermediateBy similarity
    Metal bindingi61 – 611Manganese 2By similarity
    Metal bindingi386 – 3861Manganese 1By similarity
    Metal bindingi390 – 3901Manganese 1By similarity
    Metal bindingi427 – 4271Manganese 2By similarity
    Metal bindingi428 – 4281Manganese 2By similarity
    Metal bindingi445 – 4451Manganese 1By similarity

    GO - Molecular functioni

    1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glucose catabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0974-MONOMER.
    UniPathwayiUPA00109; UER00186.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC:5.4.2.12)
    Short name:
    BPG-independent PGAM
    Short name:
    Phosphoglyceromutase
    Short name:
    iPGM
    Gene namesi
    Name:gpmI
    Synonyms:pgm
    Ordered Locus Names:HP_0974
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4914912,3-bisphosphoglycerate-independent phosphoglycerate mutasePRO_0000212154Add
    BLAST

    Proteomic databases

    PRIDEiP56196.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    DIPiDIP-3166N.
    IntActiP56196. 1 interaction.
    MINTiMINT-172669.
    STRINGi85962.HP0974.

    Structurei

    Secondary structure

    1
    491
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 105
    Helixi23 – 264
    Helixi30 – 389
    Beta strandi41 – 455
    Helixi48 – 514
    Helixi61 – 7010
    Helixi77 – 8610
    Helixi90 – 923
    Helixi94 – 996
    Beta strandi106 – 1149
    Helixi121 – 1277
    Helixi130 – 1334
    Beta strandi138 – 1447
    Beta strandi146 – 1494
    Turni151 – 1533
    Helixi154 – 16714
    Beta strandi170 – 1767
    Helixi177 – 1804
    Helixi187 – 19812
    Helixi207 – 21610
    Helixi221 – 2233
    Beta strandi240 – 2434
    Turni249 – 2513
    Helixi252 – 2598
    Beta strandi275 – 2806
    Beta strandi284 – 2863
    Beta strandi290 – 2923
    Helixi301 – 3077
    Beta strandi312 – 3176
    Helixi318 – 3258
    Turni326 – 3305
    Beta strandi339 – 3446
    Helixi352 – 3543
    Turni356 – 3594
    Helixi360 – 37314
    Beta strandi376 – 3827
    Helixi384 – 3896
    Turni390 – 3923
    Helixi394 – 41724
    Beta strandi422 – 4254
    Beta strandi427 – 4304
    Beta strandi449 – 4546
    Beta strandi463 – 4664
    Helixi469 – 47810

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LNOmodel-A3-491[»]
    ProteinModelPortaliP56196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0696.
    KOiK15633.
    OMAiGMVEYSS.
    OrthoDBiEOG6HJ22X.

    Family and domain databases

    Gene3Di3.40.1450.10. 1 hit.
    3.40.720.10. 2 hits.
    HAMAPiMF_01038. GpmI.
    InterProiIPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR011258. BPG-indep_PGM_N.
    IPR006124. Metalloenzyme.
    IPR005995. Pgm_bpd_ind.
    [Graphical view]
    PfamiPF06415. iPGM_N. 1 hit.
    PF01676. Metalloenzyme. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001492. IPGAM. 1 hit.
    SUPFAMiSSF53649. SSF53649. 2 hits.
    SSF64158. SSF64158. 1 hit.
    TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P56196-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQKTLLIIT DGIGYRKDSD HNAFFHAKKP TYDLMFKTLP YSLIDTHGLS    50
    VGLPKGQMGN SEVGHMCIGA GRVLYQDLVK ISLSLQNDEL KNNPAFLNTI 100
    QKSPVVHLMG LMSDGGVHSH IEHFIALALE CEKSHKKVCL HLITDGRDVA 150
    PKSALTYLKQ MQNICNESIQ IATISGRFYA MDRDKRFERI ELAYHSLMGL 200
    NHTPLSPSEY IQSQYDKNIT DEFIMPACFK NYCGMQDDES FIFINFRNDR 250
    AREIVSALGQ KQFSGFKRQV FKKLHIATMT PYDNTFPYPV LFPKESVQNT 300
    LAEVVSQHNL TQSHIAETEK YAHVTFFING GVETPFKNEN RVLIQSPKVT 350
    TYDLKPEMSA KEVTLAVLEQ MKLGTDLIIV NFANGDMVGH TGNFEASVKA 400
    VEAVDACLGE ILSLAKKLDY AMLLTSDHGN CERMKDENQN PLTNHTAGSV 450
    YCFVLGDGVK SIKNGALNNI ASSVLKLMGL KAPATMDEPL F 491
    Length:491
    Mass (Da):54,788
    Last modified:November 1, 1997 - v1
    Checksum:iF72F8CDA04EA9D6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08020.1.
    PIRiF64641.
    RefSeqiNP_207765.1. NC_000915.1.
    YP_006934888.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08020; AAD08020; HP_0974.
    GeneIDi13870164.
    899506.
    KEGGiheo:C694_05010.
    hpy:HP0974.
    PATRICi20593263. VBIHelPyl33062_1013.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08020.1 .
    PIRi F64641.
    RefSeqi NP_207765.1. NC_000915.1.
    YP_006934888.1. NC_018939.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LNO model - A 3-491 [» ]
    ProteinModelPortali P56196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3166N.
    IntActi P56196. 1 interaction.
    MINTi MINT-172669.
    STRINGi 85962.HP0974.

    Proteomic databases

    PRIDEi P56196.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08020 ; AAD08020 ; HP_0974 .
    GeneIDi 13870164.
    899506.
    KEGGi heo:C694_05010.
    hpy:HP0974.
    PATRICi 20593263. VBIHelPyl33062_1013.

    Phylogenomic databases

    eggNOGi COG0696.
    KOi K15633.
    OMAi GMVEYSS.
    OrthoDBi EOG6HJ22X.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00186 .
    BioCyci HPY:HP0974-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1450.10. 1 hit.
    3.40.720.10. 2 hits.
    HAMAPi MF_01038. GpmI.
    InterProi IPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR011258. BPG-indep_PGM_N.
    IPR006124. Metalloenzyme.
    IPR005995. Pgm_bpd_ind.
    [Graphical view ]
    Pfami PF06415. iPGM_N. 1 hit.
    PF01676. Metalloenzyme. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001492. IPGAM. 1 hit.
    SUPFAMi SSF53649. SSF53649. 2 hits.
    SSF64158. SSF64158. 1 hit.
    TIGRFAMsi TIGR01307. pgm_bpd_ind. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiGPMI_HELPY
    AccessioniPrimary (citable) accession number: P56196
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3