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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.By similarity

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi11 – 111Manganese 2By similarity
Active sitei61 – 611Phosphoserine intermediateBy similarity
Metal bindingi61 – 611Manganese 2By similarity
Metal bindingi386 – 3861Manganese 1By similarity
Metal bindingi390 – 3901Manganese 1By similarity
Metal bindingi427 – 4271Manganese 2By similarity
Metal bindingi428 – 4281Manganese 2By similarity
Metal bindingi445 – 4451Manganese 1By similarity

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucose catabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0974-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC:5.4.2.12)
Short name:
BPG-independent PGAM
Short name:
Phosphoglyceromutase
Short name:
iPGM
Gene namesi
Name:gpmI
Synonyms:pgm
Ordered Locus Names:HP_0974
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4914912,3-bisphosphoglycerate-independent phosphoglycerate mutasePRO_0000212154Add
BLAST

Proteomic databases

PRIDEiP56196.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

DIPiDIP-3166N.
IntActiP56196. 1 interaction.
MINTiMINT-172669.
STRINGi85962.HP0974.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LNOmodel-A3-491[»]
ProteinModelPortaliP56196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0696.
KOiK15633.
OMAiDEFIMPA.
OrthoDBiEOG6HJ22X.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

P56196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKTLLIIT DGIGYRKDSD HNAFFHAKKP TYDLMFKTLP YSLIDTHGLS
60 70 80 90 100
VGLPKGQMGN SEVGHMCIGA GRVLYQDLVK ISLSLQNDEL KNNPAFLNTI
110 120 130 140 150
QKSPVVHLMG LMSDGGVHSH IEHFIALALE CEKSHKKVCL HLITDGRDVA
160 170 180 190 200
PKSALTYLKQ MQNICNESIQ IATISGRFYA MDRDKRFERI ELAYHSLMGL
210 220 230 240 250
NHTPLSPSEY IQSQYDKNIT DEFIMPACFK NYCGMQDDES FIFINFRNDR
260 270 280 290 300
AREIVSALGQ KQFSGFKRQV FKKLHIATMT PYDNTFPYPV LFPKESVQNT
310 320 330 340 350
LAEVVSQHNL TQSHIAETEK YAHVTFFING GVETPFKNEN RVLIQSPKVT
360 370 380 390 400
TYDLKPEMSA KEVTLAVLEQ MKLGTDLIIV NFANGDMVGH TGNFEASVKA
410 420 430 440 450
VEAVDACLGE ILSLAKKLDY AMLLTSDHGN CERMKDENQN PLTNHTAGSV
460 470 480 490
YCFVLGDGVK SIKNGALNNI ASSVLKLMGL KAPATMDEPL F
Length:491
Mass (Da):54,788
Last modified:October 31, 1997 - v1
Checksum:iF72F8CDA04EA9D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08020.1.
PIRiF64641.
RefSeqiNP_207765.1. NC_000915.1.
YP_006934888.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08020; AAD08020; HP_0974.
GeneIDi13870164.
899506.
KEGGiheo:C694_05010.
hpy:HP0974.
PATRICi20593263. VBIHelPyl33062_1013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08020.1.
PIRiF64641.
RefSeqiNP_207765.1. NC_000915.1.
YP_006934888.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LNOmodel-A3-491[»]
ProteinModelPortaliP56196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3166N.
IntActiP56196. 1 interaction.
MINTiMINT-172669.
STRINGi85962.HP0974.

Proteomic databases

PRIDEiP56196.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08020; AAD08020; HP_0974.
GeneIDi13870164.
899506.
KEGGiheo:C694_05010.
hpy:HP0974.
PATRICi20593263. VBIHelPyl33062_1013.

Phylogenomic databases

eggNOGiCOG0696.
KOiK15633.
OMAiDEFIMPA.
OrthoDBiEOG6HJ22X.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.
BioCyciHPY:HP0974-MONOMER.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiGPMI_HELPY
AccessioniPrimary (citable) accession number: P56196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: October 31, 1997
Last modified: January 6, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.