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P56196

- GPMI_HELPY

UniProt

P56196 - GPMI_HELPY

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Protein
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Gene
gpmI, pgm, HP_0974
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi11 – 111Manganese 2 By similarity
Active sitei61 – 611Phosphoserine intermediate By similarity
Metal bindingi61 – 611Manganese 2 By similarity
Metal bindingi386 – 3861Manganese 1 By similarity
Metal bindingi390 – 3901Manganese 1 By similarity
Metal bindingi427 – 4271Manganese 2 By similarity
Metal bindingi428 – 4281Manganese 2 By similarity
Metal bindingi445 – 4451Manganese 1 By similarity

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. glucose catabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0974-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC:5.4.2.12)
Short name:
BPG-independent PGAM
Short name:
Phosphoglyceromutase
Short name:
iPGM
Gene namesi
Name:gpmI
Synonyms:pgm
Ordered Locus Names:HP_0974
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4914912,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation
PRO_0000212154Add
BLAST

Proteomic databases

PRIDEiP56196.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3166N.
IntActiP56196. 1 interaction.
MINTiMINT-172669.
STRINGi85962.HP0974.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 105
Helixi23 – 264
Helixi30 – 389
Beta strandi41 – 455
Helixi48 – 514
Helixi61 – 7010
Helixi77 – 8610
Helixi90 – 923
Helixi94 – 996
Beta strandi106 – 1149
Helixi121 – 1277
Helixi130 – 1334
Beta strandi138 – 1447
Beta strandi146 – 1494
Turni151 – 1533
Helixi154 – 16714
Beta strandi170 – 1767
Helixi177 – 1804
Helixi187 – 19812
Helixi207 – 21610
Helixi221 – 2233
Beta strandi240 – 2434
Turni249 – 2513
Helixi252 – 2598
Beta strandi275 – 2806
Beta strandi284 – 2863
Beta strandi290 – 2923
Helixi301 – 3077
Beta strandi312 – 3176
Helixi318 – 3258
Turni326 – 3305
Beta strandi339 – 3446
Helixi352 – 3543
Turni356 – 3594
Helixi360 – 37314
Beta strandi376 – 3827
Helixi384 – 3896
Turni390 – 3923
Helixi394 – 41724
Beta strandi422 – 4254
Beta strandi427 – 4304
Beta strandi449 – 4546
Beta strandi463 – 4664
Helixi469 – 47810

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LNOmodel-A3-491[»]
ProteinModelPortaliP56196.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0696.
KOiK15633.
OMAiGMVEYSS.
OrthoDBiEOG6HJ22X.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

P56196-1 [UniParc]FASTAAdd to Basket

« Hide

MAQKTLLIIT DGIGYRKDSD HNAFFHAKKP TYDLMFKTLP YSLIDTHGLS    50
VGLPKGQMGN SEVGHMCIGA GRVLYQDLVK ISLSLQNDEL KNNPAFLNTI 100
QKSPVVHLMG LMSDGGVHSH IEHFIALALE CEKSHKKVCL HLITDGRDVA 150
PKSALTYLKQ MQNICNESIQ IATISGRFYA MDRDKRFERI ELAYHSLMGL 200
NHTPLSPSEY IQSQYDKNIT DEFIMPACFK NYCGMQDDES FIFINFRNDR 250
AREIVSALGQ KQFSGFKRQV FKKLHIATMT PYDNTFPYPV LFPKESVQNT 300
LAEVVSQHNL TQSHIAETEK YAHVTFFING GVETPFKNEN RVLIQSPKVT 350
TYDLKPEMSA KEVTLAVLEQ MKLGTDLIIV NFANGDMVGH TGNFEASVKA 400
VEAVDACLGE ILSLAKKLDY AMLLTSDHGN CERMKDENQN PLTNHTAGSV 450
YCFVLGDGVK SIKNGALNNI ASSVLKLMGL KAPATMDEPL F 491
Length:491
Mass (Da):54,788
Last modified:November 1, 1997 - v1
Checksum:iF72F8CDA04EA9D6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08020.1.
PIRiF64641.
RefSeqiNP_207765.1. NC_000915.1.
YP_006934888.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08020; AAD08020; HP_0974.
GeneIDi13870164.
899506.
KEGGiheo:C694_05010.
hpy:HP0974.
PATRICi20593263. VBIHelPyl33062_1013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08020.1 .
PIRi F64641.
RefSeqi NP_207765.1. NC_000915.1.
YP_006934888.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LNO model - A 3-491 [» ]
ProteinModelPortali P56196.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-3166N.
IntActi P56196. 1 interaction.
MINTi MINT-172669.
STRINGi 85962.HP0974.

Proteomic databases

PRIDEi P56196.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08020 ; AAD08020 ; HP_0974 .
GeneIDi 13870164.
899506.
KEGGi heo:C694_05010.
hpy:HP0974.
PATRICi 20593263. VBIHelPyl33062_1013.

Phylogenomic databases

eggNOGi COG0696.
KOi K15633.
OMAi GMVEYSS.
OrthoDBi EOG6HJ22X.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00186 .
BioCyci HPY:HP0974-MONOMER.

Family and domain databases

Gene3Di 3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPi MF_01038. GpmI.
InterProi IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view ]
Pfami PF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view ]
PIRSFi PIRSF001492. IPGAM. 1 hit.
SUPFAMi SSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsi TIGR01307. pgm_bpd_ind. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiGPMI_HELPY
AccessioniPrimary (citable) accession number: P56196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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