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P56193 (LAC1_THACU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Laccase-1
EC=1.10.3.2
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Diphenol oxidase 1
Urishiol oxidase 1
Gene names
Name:LCC1
OrganismThanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
Taxonomic identifier107832 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Agaricomycetes › Cantharellales › Ceratobasidiaceae › Thanatephorus

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Lignin degradation and detoxification of lignin-derived products Probable.

Catalytic activity

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactor

Binds 4 copper ions per monomer By similarity.

Subunit structure

Homodimer.

Subcellular location

Secreted.

Tissue specificity

In mycelia, at a lower level than LCC4.

Sequence similarities

Belongs to the multicopper oxidase family.

Contains 3 plastocyanin-like domains.

Biophysicochemical properties

pH dependence:

Optimum pH is 6.

Ontologies

Keywords
   Biological processLignin degradation
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processlignin catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncopper ion binding

Inferred from electronic annotation. Source: InterPro

hydroquinone:oxygen oxidoreductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 576557Laccase-1
PRO_0000002935

Regions

Domain21 – 145125Plastocyanin-like 1
Domain157 – 304148Plastocyanin-like 2
Domain376 – 576201Plastocyanin-like 3

Sites

Metal binding821Copper 1; type 2 By similarity
Metal binding841Copper 2; type 3 By similarity
Metal binding1271Copper 2; type 3 By similarity
Metal binding1291Copper 3; type 3 By similarity
Metal binding4711Copper 4; type 1 By similarity
Metal binding4741Copper 1; type 2 By similarity
Metal binding4761Copper 3; type 3 By similarity
Metal binding5231Copper 3; type 3 By similarity
Metal binding5241Copper 4; type 1 By similarity
Metal binding5251Copper 2; type 3 By similarity
Metal binding5291Copper 4; type 1 By similarity

Amino acid modifications

Glycosylation411N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Glycosylation2281N-linked (GlcNAc...) Potential
Glycosylation2941N-linked (GlcNAc...) Potential
Glycosylation3681N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P56193 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: CE5E32918038AE48

FASTA57664,377
        10         20         30         40         50         60 
MARTTFLVSV SLFVSAVLAR TVEYGLKISD GEIAPDGVKR NATLVNGGYP GPLIFANKGD 

        70         80         90        100        110        120 
TLKVKVQNKL TNPEMYRTTS IHWHGLLQHR NADDDGPSFV TQCPIVPRES YTYTIPLDDQ 

       130        140        150        160        170        180 
TGTYWYHSHL SSQYVDGLRG PLVIYDPKDP HRRLYDVDDE KTVLIIGDWY HESSKAILAS 

       190        200        210        220        230        240 
GNITRQRPVS ATINGKGRFD PDNTPANPDT LYTLKVKRGK RYRLRVINSS EIASFRFSVE 

       250        260        270        280        290        300 
GHKVTVIAAD GVSTKPYQVD AFDILAGQRI DCVVEANQEP DTYWINAPLT NVPNKTAQAL 

       310        320        330        340        350        360 
LVYEEDRRPY HPPKGPYRKW SVSEAIIKYW NHKHKHGRGL LSGHGGLKAR MIEGSHHLHS 

       370        380        390        400        410        420 
RSVVKRQNET TTVVMDESKL VPLEYPGAAC GSKPADLVLD LTFGLNFATG HWMINGIPYE 

       430        440        450        460        470        480 
SPKIPTLLKI LTDEDGVTES DFTKEEHTVI LPKNKCIEFN IKGNSGIPIT HPVHLHGHTW 

       490        500        510        520        530        540 
DVVQFGNNPP NYVNPPRRDV VGSTDAGVRI QFKTDNPGPW FLHCHIDWHL EEGFAMVFAE 

       550        560        570 
APEAVKGGPK SVAVDSQWEG LCGKYDNWLK SNPGQL

« Hide

References

[1]"The identification and characterization of four laccases from the plant pathogenic fungus Rhizoctonia solani."
Wahleithner J.A., Xu F., Brown K.M., Brown S.H., Golightly E.J., Halkier T., Kauppinen S., Pederson A., Schneider P.
Curr. Genet. 29:395-403(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: R22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z54275 Genomic DNA. No translation available.
PIRS68117.

3D structure databases

ProteinModelPortalP56193.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.420. 3 hits.
InterProIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMSSF49503. Cupredoxin. 3 hits.
PROSITEPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLAC1_THACU
AccessionPrimary (citable) accession number: P56193
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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