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P56193

- LAC1_THACU

UniProt

P56193 - LAC1_THACU

Protein

Laccase-1

Gene

LCC1

Organism
Thanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.Curated

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    pH dependencei

    Optimum pH is 6.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi82 – 821Copper 1; type 2By similarity
    Metal bindingi84 – 841Copper 2; type 3By similarity
    Metal bindingi127 – 1271Copper 2; type 3By similarity
    Metal bindingi129 – 1291Copper 3; type 3By similarity
    Metal bindingi471 – 4711Copper 4; type 1By similarity
    Metal bindingi474 – 4741Copper 1; type 2By similarity
    Metal bindingi476 – 4761Copper 3; type 3By similarity
    Metal bindingi523 – 5231Copper 3; type 3By similarity
    Metal bindingi524 – 5241Copper 4; type 1By similarity
    Metal bindingi525 – 5251Copper 2; type 3By similarity
    Metal bindingi529 – 5291Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-1 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 1
    Diphenol oxidase 1
    Urishiol oxidase 1
    Gene namesi
    Name:LCC1
    OrganismiThanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
    Taxonomic identifieri107832 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesCantharellalesCeratobasidiaceaeThanatephorus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 576557Laccase-1PRO_0000002935Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    In mycelia, at a lower level than LCC4.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP56193.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 145125Plastocyanin-like 1Add
    BLAST
    Domaini157 – 304148Plastocyanin-like 2Add
    BLAST
    Domaini376 – 576201Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56193-1 [UniParc]FASTAAdd to Basket

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    MARTTFLVSV SLFVSAVLAR TVEYGLKISD GEIAPDGVKR NATLVNGGYP    50
    GPLIFANKGD TLKVKVQNKL TNPEMYRTTS IHWHGLLQHR NADDDGPSFV 100
    TQCPIVPRES YTYTIPLDDQ TGTYWYHSHL SSQYVDGLRG PLVIYDPKDP 150
    HRRLYDVDDE KTVLIIGDWY HESSKAILAS GNITRQRPVS ATINGKGRFD 200
    PDNTPANPDT LYTLKVKRGK RYRLRVINSS EIASFRFSVE GHKVTVIAAD 250
    GVSTKPYQVD AFDILAGQRI DCVVEANQEP DTYWINAPLT NVPNKTAQAL 300
    LVYEEDRRPY HPPKGPYRKW SVSEAIIKYW NHKHKHGRGL LSGHGGLKAR 350
    MIEGSHHLHS RSVVKRQNET TTVVMDESKL VPLEYPGAAC GSKPADLVLD 400
    LTFGLNFATG HWMINGIPYE SPKIPTLLKI LTDEDGVTES DFTKEEHTVI 450
    LPKNKCIEFN IKGNSGIPIT HPVHLHGHTW DVVQFGNNPP NYVNPPRRDV 500
    VGSTDAGVRI QFKTDNPGPW FLHCHIDWHL EEGFAMVFAE APEAVKGGPK 550
    SVAVDSQWEG LCGKYDNWLK SNPGQL 576
    Length:576
    Mass (Da):64,377
    Last modified:November 1, 1997 - v1
    Checksum:iCE5E32918038AE48
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z54275 Genomic DNA. No translation available.
    PIRiS68117.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z54275 Genomic DNA. No translation available.
    PIRi S68117.

    3D structure databases

    ProteinModelPortali P56193.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The identification and characterization of four laccases from the plant pathogenic fungus Rhizoctonia solani."
      Wahleithner J.A., Xu F., Brown K.M., Brown S.H., Golightly E.J., Halkier T., Kauppinen S., Pederson A., Schneider P.
      Curr. Genet. 29:395-403(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: R22 / IMI 358730 / AG-6.

    Entry informationi

    Entry nameiLAC1_THACU
    AccessioniPrimary (citable) accession number: P56193
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3