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P56193

- LAC1_THACU

UniProt

P56193 - LAC1_THACU

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Protein
Laccase-1
Gene
LCC1
Organism
Thanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products Inferred.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

pH dependencei

Optimum pH is 6.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821Copper 1; type 2 By similarity
Metal bindingi84 – 841Copper 2; type 3 By similarity
Metal bindingi127 – 1271Copper 2; type 3 By similarity
Metal bindingi129 – 1291Copper 3; type 3 By similarity
Metal bindingi471 – 4711Copper 4; type 1 By similarity
Metal bindingi474 – 4741Copper 1; type 2 By similarity
Metal bindingi476 – 4761Copper 3; type 3 By similarity
Metal bindingi523 – 5231Copper 3; type 3 By similarity
Metal bindingi524 – 5241Copper 4; type 1 By similarity
Metal bindingi525 – 5251Copper 2; type 3 By similarity
Metal bindingi529 – 5291Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-1 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Diphenol oxidase 1
Urishiol oxidase 1
Gene namesi
Name:LCC1
OrganismiThanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
Taxonomic identifieri107832 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesCantharellalesCeratobasidiaceaeThanatephorus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 576557Laccase-1
PRO_0000002935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi182 – 1821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi294 – 2941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi368 – 3681N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

In mycelia, at a lower level than LCC4.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP56193.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 145125Plastocyanin-like 1
Add
BLAST
Domaini157 – 304148Plastocyanin-like 2
Add
BLAST
Domaini376 – 576201Plastocyanin-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56193-1 [UniParc]FASTAAdd to Basket

« Hide

MARTTFLVSV SLFVSAVLAR TVEYGLKISD GEIAPDGVKR NATLVNGGYP    50
GPLIFANKGD TLKVKVQNKL TNPEMYRTTS IHWHGLLQHR NADDDGPSFV 100
TQCPIVPRES YTYTIPLDDQ TGTYWYHSHL SSQYVDGLRG PLVIYDPKDP 150
HRRLYDVDDE KTVLIIGDWY HESSKAILAS GNITRQRPVS ATINGKGRFD 200
PDNTPANPDT LYTLKVKRGK RYRLRVINSS EIASFRFSVE GHKVTVIAAD 250
GVSTKPYQVD AFDILAGQRI DCVVEANQEP DTYWINAPLT NVPNKTAQAL 300
LVYEEDRRPY HPPKGPYRKW SVSEAIIKYW NHKHKHGRGL LSGHGGLKAR 350
MIEGSHHLHS RSVVKRQNET TTVVMDESKL VPLEYPGAAC GSKPADLVLD 400
LTFGLNFATG HWMINGIPYE SPKIPTLLKI LTDEDGVTES DFTKEEHTVI 450
LPKNKCIEFN IKGNSGIPIT HPVHLHGHTW DVVQFGNNPP NYVNPPRRDV 500
VGSTDAGVRI QFKTDNPGPW FLHCHIDWHL EEGFAMVFAE APEAVKGGPK 550
SVAVDSQWEG LCGKYDNWLK SNPGQL 576
Length:576
Mass (Da):64,377
Last modified:November 1, 1997 - v1
Checksum:iCE5E32918038AE48
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54275 Genomic DNA. No translation available.
PIRiS68117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54275 Genomic DNA. No translation available.
PIRi S68117.

3D structure databases

ProteinModelPortali P56193.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The identification and characterization of four laccases from the plant pathogenic fungus Rhizoctonia solani."
    Wahleithner J.A., Xu F., Brown K.M., Brown S.H., Golightly E.J., Halkier T., Kauppinen S., Pederson A., Schneider P.
    Curr. Genet. 29:395-403(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: R22 / IMI 358730 / AG-6.

Entry informationi

Entry nameiLAC1_THACU
AccessioniPrimary (citable) accession number: P56193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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