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P56193

- LAC1_THACU

UniProt

P56193 - LAC1_THACU

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Protein

Laccase-1

Gene

LCC1

Organism
Thanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.Curated

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer.By similarity

pH dependencei

Optimum pH is 6.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821Copper 1; type 2By similarity
Metal bindingi84 – 841Copper 2; type 3By similarity
Metal bindingi127 – 1271Copper 2; type 3By similarity
Metal bindingi129 – 1291Copper 3; type 3By similarity
Metal bindingi471 – 4711Copper 4; type 1By similarity
Metal bindingi474 – 4741Copper 1; type 2By similarity
Metal bindingi476 – 4761Copper 3; type 3By similarity
Metal bindingi523 – 5231Copper 3; type 3By similarity
Metal bindingi524 – 5241Copper 4; type 1By similarity
Metal bindingi525 – 5251Copper 2; type 3By similarity
Metal bindingi529 – 5291Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-1 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Diphenol oxidase 1
Urishiol oxidase 1
Gene namesi
Name:LCC1
OrganismiThanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
Taxonomic identifieri107832 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesCantharellalesCeratobasidiaceaeThanatephorus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 576557Laccase-1PRO_0000002935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

In mycelia, at a lower level than LCC4.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP56193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 145125Plastocyanin-like 1Add
BLAST
Domaini157 – 304148Plastocyanin-like 2Add
BLAST
Domaini376 – 576201Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56193-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARTTFLVSV SLFVSAVLAR TVEYGLKISD GEIAPDGVKR NATLVNGGYP
60 70 80 90 100
GPLIFANKGD TLKVKVQNKL TNPEMYRTTS IHWHGLLQHR NADDDGPSFV
110 120 130 140 150
TQCPIVPRES YTYTIPLDDQ TGTYWYHSHL SSQYVDGLRG PLVIYDPKDP
160 170 180 190 200
HRRLYDVDDE KTVLIIGDWY HESSKAILAS GNITRQRPVS ATINGKGRFD
210 220 230 240 250
PDNTPANPDT LYTLKVKRGK RYRLRVINSS EIASFRFSVE GHKVTVIAAD
260 270 280 290 300
GVSTKPYQVD AFDILAGQRI DCVVEANQEP DTYWINAPLT NVPNKTAQAL
310 320 330 340 350
LVYEEDRRPY HPPKGPYRKW SVSEAIIKYW NHKHKHGRGL LSGHGGLKAR
360 370 380 390 400
MIEGSHHLHS RSVVKRQNET TTVVMDESKL VPLEYPGAAC GSKPADLVLD
410 420 430 440 450
LTFGLNFATG HWMINGIPYE SPKIPTLLKI LTDEDGVTES DFTKEEHTVI
460 470 480 490 500
LPKNKCIEFN IKGNSGIPIT HPVHLHGHTW DVVQFGNNPP NYVNPPRRDV
510 520 530 540 550
VGSTDAGVRI QFKTDNPGPW FLHCHIDWHL EEGFAMVFAE APEAVKGGPK
560 570
SVAVDSQWEG LCGKYDNWLK SNPGQL
Length:576
Mass (Da):64,377
Last modified:November 1, 1997 - v1
Checksum:iCE5E32918038AE48
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54275 Genomic DNA. No translation available.
PIRiS68117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54275 Genomic DNA. No translation available.
PIRi S68117.

3D structure databases

ProteinModelPortali P56193.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The identification and characterization of four laccases from the plant pathogenic fungus Rhizoctonia solani."
    Wahleithner J.A., Xu F., Brown K.M., Brown S.H., Golightly E.J., Halkier T., Kauppinen S., Pederson A., Schneider P.
    Curr. Genet. 29:395-403(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: R22 / IMI 358730 / AG-6.

Entry informationi

Entry nameiLAC1_THACU
AccessioniPrimary (citable) accession number: P56193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3