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Protein

Laccase-1

Gene

LCC1

Organism
Thanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.Curated

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

pH dependencei

Optimum pH is 6.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82Copper 1; type 2By similarity1
Metal bindingi84Copper 2; type 3By similarity1
Metal bindingi127Copper 2; type 3By similarity1
Metal bindingi129Copper 3; type 3By similarity1
Metal bindingi471Copper 4; type 1By similarity1
Metal bindingi474Copper 1; type 2By similarity1
Metal bindingi476Copper 3; type 3By similarity1
Metal bindingi523Copper 3; type 3By similarity1
Metal bindingi524Copper 4; type 1By similarity1
Metal bindingi525Copper 2; type 3By similarity1
Metal bindingi529Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-1 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Diphenol oxidase 1
Urishiol oxidase 1
Gene namesi
Name:LCC1
OrganismiThanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani)
Taxonomic identifieri107832 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesCantharellalesCeratobasidiaceaeThanatephorus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000293520 – 576Laccase-1Add BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1
Glycosylationi294N-linked (GlcNAc...)Sequence analysis1
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

In mycelia, at a lower level than LCC4.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP56193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 145Plastocyanin-like 1Add BLAST125
Domaini157 – 304Plastocyanin-like 2Add BLAST148
Domaini376 – 576Plastocyanin-like 3Add BLAST201

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTTFLVSV SLFVSAVLAR TVEYGLKISD GEIAPDGVKR NATLVNGGYP
60 70 80 90 100
GPLIFANKGD TLKVKVQNKL TNPEMYRTTS IHWHGLLQHR NADDDGPSFV
110 120 130 140 150
TQCPIVPRES YTYTIPLDDQ TGTYWYHSHL SSQYVDGLRG PLVIYDPKDP
160 170 180 190 200
HRRLYDVDDE KTVLIIGDWY HESSKAILAS GNITRQRPVS ATINGKGRFD
210 220 230 240 250
PDNTPANPDT LYTLKVKRGK RYRLRVINSS EIASFRFSVE GHKVTVIAAD
260 270 280 290 300
GVSTKPYQVD AFDILAGQRI DCVVEANQEP DTYWINAPLT NVPNKTAQAL
310 320 330 340 350
LVYEEDRRPY HPPKGPYRKW SVSEAIIKYW NHKHKHGRGL LSGHGGLKAR
360 370 380 390 400
MIEGSHHLHS RSVVKRQNET TTVVMDESKL VPLEYPGAAC GSKPADLVLD
410 420 430 440 450
LTFGLNFATG HWMINGIPYE SPKIPTLLKI LTDEDGVTES DFTKEEHTVI
460 470 480 490 500
LPKNKCIEFN IKGNSGIPIT HPVHLHGHTW DVVQFGNNPP NYVNPPRRDV
510 520 530 540 550
VGSTDAGVRI QFKTDNPGPW FLHCHIDWHL EEGFAMVFAE APEAVKGGPK
560 570
SVAVDSQWEG LCGKYDNWLK SNPGQL
Length:576
Mass (Da):64,377
Last modified:November 1, 1997 - v1
Checksum:iCE5E32918038AE48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54275 Genomic DNA. No translation available.
PIRiS68117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54275 Genomic DNA. No translation available.
PIRiS68117.

3D structure databases

ProteinModelPortaliP56193.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC1_THACU
AccessioniPrimary (citable) accession number: P56193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 16, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.