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Protein

Methionine--tRNA ligase, cytoplasmic

Gene

MARS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei596ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding, tRNA-binding

Enzyme and pathway databases

BioCyciZFISH:HS09496-MONOMER.
BRENDAi6.1.1.10. 2681.
ReactomeiR-HSA-2408517. SeMet incorporation into proteins.
R-HSA-379716. Cytosolic tRNA aminoacylation.
SignaLinkiP56192.
SIGNORiP56192.

Protein family/group databases

MoonProtiP56192.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligase, cytoplasmic (EC:6.1.1.10)
Alternative name(s):
Methionyl-tRNA synthetase
Short name:
MetRS
Gene namesi
Name:MARS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6898. MARS.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Interstitial lung and liver disease (ILLD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, life-threatening disorder characterized by respiratory insufficiency and progressive liver disease with onset in infancy or early childhood. Clinical features include failure to thrive, hypotonia, intermittent lactic acidosis, aminoaciduria, hypothyroidism, interstitial lung disease, pulmonary alveolar proteinosis, anemia, and liver canalicular cholestasis, steatosis, and iron deposition.
See also OMIM:615486
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075361344Y → C in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant rs766466297dbSNPEnsembl.1
Natural variantiVAR_070872370F → L in ILLD. 1 PublicationCorresponds to variant rs140467171dbSNPEnsembl.1
Natural variantiVAR_075362393A → T in ILLD; may act as a disease modifier aggravating the phenotype; found in patients that carried additional mutations C-344 and/or L-567; when assayed in yeast, does not exhibit any phenotype; when assayed in yeast in association with L-567, increases L-567-induced growth retardation and reduction in methionine incorporation. 1 PublicationCorresponds to variant rs141340466dbSNPEnsembl.1
Natural variantiVAR_070873523I → T in ILLD. 1 PublicationCorresponds to variant rs201555303dbSNPEnsembl.1
Natural variantiVAR_075363567S → L in ILLD; when assayed in yeast, reduces methionine incorporation; when assayed in yeast in association with T-393, induces growth retardation and strong reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant rs143592405dbSNPEnsembl.1
Natural variantiVAR_075364605D → V in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant rs756021768dbSNPEnsembl.1
Charcot-Marie-Tooth disease 2U (CMT2U)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2U is a slowly progressive, autosomal dominant form characterized by late-adult onset.
See also OMIM:616280
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073377618R → C in CMT2U; loss of function mutation. 1 PublicationCorresponds to variant rs587777718dbSNPEnsembl.1
Natural variantiVAR_073378800P → T in CMT2U. 1 PublicationCorresponds to variant rs781249411dbSNPEnsembl.1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNETi4141.
MalaCardsiMARS.
MIMi615486. phenotype.
616280. phenotype.
OpenTargetsiENSG00000166986.
Orphaneti370088. Acute infantile liver failure-multisystemic involvement syndrome.
397735. Autosomal dominant Charcot-Marie-Tooth disease type 2 due to MARS mutation.
401835. Autosomal recessive spastic paraplegia type 70.
PharmGKBiPA30642.

Chemistry databases

ChEMBLiCHEMBL2870.
DrugBankiDB00134. L-Methionine.

Polymorphism and mutation databases

BioMutaiMARS.
DMDMi20178332.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001392621 – 900Methionine--tRNA ligase, cytoplasmicAdd BLAST900

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei825PhosphoserineBy similarity1
Modified residuei835PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP56192.
MaxQBiP56192.
PaxDbiP56192.
PeptideAtlasiP56192.
PRIDEiP56192.

PTM databases

iPTMnetiP56192.
PhosphoSitePlusiP56192.
SwissPalmiP56192.

Expressioni

Gene expression databases

BgeeiENSG00000166986.
CleanExiHS_MARS.
ExpressionAtlasiP56192. baseline and differential.
GenevisibleiP56192. HS.

Organism-specific databases

HPAiCAB017097.
HPA004125.

Interactioni

Subunit structurei

Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43.

Protein-protein interaction databases

BioGridi110311. 68 interactors.
DIPiDIP-38164N.
IntActiP56192. 26 interactors.
MINTiMINT-5004366.
STRINGi9606.ENSP00000262027.

Chemistry databases

BindingDBiP56192.

Structurei

Secondary structure

1900
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 5Combined sources4
Helixi12 – 18Combined sources7
Helixi19 – 22Combined sources4
Turni23 – 25Combined sources3
Beta strandi29 – 32Combined sources4
Beta strandi48 – 52Combined sources5
Helixi62 – 72Combined sources11
Helixi79 – 90Combined sources12
Helixi92 – 104Combined sources13
Helixi111 – 114Combined sources4
Helixi115 – 117Combined sources3
Helixi118 – 130Combined sources13
Beta strandi131 – 140Combined sources10
Helixi143 – 156Combined sources14
Helixi159 – 161Combined sources3
Helixi167 – 177Combined sources11
Helixi180 – 190Combined sources11
Helixi194 – 198Combined sources5
Helixi199 – 202Combined sources4
Helixi838 – 861Combined sources24
Helixi866 – 887Combined sources22
Beta strandi893 – 895Combined sources3
Beta strandi897 – 899Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DJVNMR-A835-900[»]
4BL7X-ray1.89A1-224[»]
4BVXX-ray1.60A1-207[»]
4BVYX-ray1.99A1-225[»]
ProteinModelPortaliP56192.
SMRiP56192.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56192.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 198GST C-terminalAdd BLAST125
Domaini841 – 897WHEP-TRSAdd BLAST57

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi273 – 283"HIGH" regionAdd BLAST11
Motifi593 – 597"KMSKS" region5

Sequence similaritiesi

Contains 1 GST C-terminal domain.Curated
Contains 1 WHEP-TRS domain.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
KOG1247. Eukaryota.
COG0143. LUCA.
GeneTreeiENSGT00550000075017.
HOGENOMiHOG000200402.
HOVERGENiHBG036191.
InParanoidiP56192.
KOiK01874.
OMAiHPGCGYE.
OrthoDBiEOG091G020Y.
PhylomeDBiP56192.
TreeFamiTF300526.

Family and domain databases

CDDicd00814. MetRS_core. 1 hit.
Gene3Di1.10.287.10. 1 hit.
1.10.730.10. 1 hit.
1.20.1050.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00098. Met_tRNA_synth_type1. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR023458. Met-tRNA_ligase_1.
IPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR033911. MetRS_core.
IPR029038. MetRS_Zn.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009068. S15_NS1_RNA-bd.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR000738. WHEP-TRS_dom.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PF00458. WHEP-TRS. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SMARTiSM00991. WHEP-TRS. 1 hit.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 1 hit.
SSF47323. SSF47323. 1 hit.
SSF47616. SSF47616. 1 hit.
SSF57770. SSF57770. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50405. GST_CTER. 1 hit.
PS00762. WHEP_TRS_1. 1 hit.
PS51185. WHEP_TRS_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P56192-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLFVSDGVP GCLPVLAAAG RARGRAEVLI STVGPEDCVV PFLTRPKVPV
60 70 80 90 100
LQLDSGNYLF STSAICRYFF LLSGWEQDDL TNQWLEWEAT ELQPALSAAL
110 120 130 140 150
YYLVVQGKKG EDVLGSVRRA LTHIDHSLSR QNCPFLAGET ESLADIVLWG
160 170 180 190 200
ALYPLLQDPA YLPEELSALH SWFQTLSTQE PCQRAAETVL KQQGVLALRP
210 220 230 240 250
YLQKQPQPSP AEGRAVTNEP EEEELATLSE EEIAMAVTAW EKGLESLPPL
260 270 280 290 300
RPQQNPVLPV AGERNVLITS ALPYVNNVPH LGNIIGCVLS ADVFARYSRL
310 320 330 340 350
RQWNTLYLCG TDEYGTATET KALEEGLTPQ EICDKYHIIH ADIYRWFNIS
360 370 380 390 400
FDIFGRTTTP QQTKITQDIF QQLLKRGFVL QDTVEQLRCE HCARFLADRF
410 420 430 440 450
VEGVCPFCGY EEARGDQCDK CGKLINAVEL KKPQCKVCRS CPVVQSSQHL
460 470 480 490 500
FLDLPKLEKR LEEWLGRTLP GSDWTPNAQF ITRSWLRDGL KPRCITRDLK
510 520 530 540 550
WGTPVPLEGF EDKVFYVWFD ATIGYLSITA NYTDQWERWW KNPEQVDLYQ
560 570 580 590 600
FMAKDNVPFH SLVFPCSALG AEDNYTLVSH LIATEYLNYE DGKFSKSRGV
610 620 630 640 650
GVFGDMAQDT GIPADIWRFY LLYIRPEGQD SAFSWTDLLL KNNSELLNNL
660 670 680 690 700
GNFINRAGMF VSKFFGGYVP EMVLTPDDQR LLAHVTLELQ HYHQLLEKVR
710 720 730 740 750
IRDALRSILT ISRHGNQYIQ VNEPWKRIKG SEADRQRAGT VTGLAVNIAA
760 770 780 790 800
LLSVMLQPYM PTVSATIQAQ LQLPPPACSI LLTNFLCTLP AGHQIGTVSP
810 820 830 840 850
LFQKLENDQI ESLRQRFGGG QAKTSPKPAV VETVTTAKPQ QIQALMDEVT
860 870 880 890 900
KQGNIVRELK AQKADKNEVA AEVAKLLDLK KQLAVAEGKP PEAPKGKKKK
Length:900
Mass (Da):101,116
Last modified:April 16, 2002 - v2
Checksum:i3D687C77E17C5C96
GO
Isoform 2 (identifier: P56192-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-546: V → P
     547-900: Missing.

Note: No experimental confirmation available.
Show »
Length:546
Mass (Da):61,816
Checksum:iED19F00468D3C6AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53L → V in CAA64381 (PubMed:8921912).Curated1
Sequence conflicti99A → P in CAA64381 (PubMed:8921912).Curated1
Sequence conflicti152L → Q in CAA64381 (PubMed:8921912).Curated1
Sequence conflicti172W → S in AAH15011 (PubMed:15489334).Curated1
Sequence conflicti250L → P in BAD96487 (Ref. 5) Curated1
Sequence conflicti683A → G in CAA64381 (PubMed:8921912).Curated1
Sequence conflicti683A → G in CAA89153 (PubMed:8921912).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075360206P → L.1 PublicationCorresponds to variant rs138776588dbSNPEnsembl.1
Natural variantiVAR_075361344Y → C in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant rs766466297dbSNPEnsembl.1
Natural variantiVAR_070872370F → L in ILLD. 1 PublicationCorresponds to variant rs140467171dbSNPEnsembl.1
Natural variantiVAR_075362393A → T in ILLD; may act as a disease modifier aggravating the phenotype; found in patients that carried additional mutations C-344 and/or L-567; when assayed in yeast, does not exhibit any phenotype; when assayed in yeast in association with L-567, increases L-567-induced growth retardation and reduction in methionine incorporation. 1 PublicationCorresponds to variant rs141340466dbSNPEnsembl.1
Natural variantiVAR_070873523I → T in ILLD. 1 PublicationCorresponds to variant rs201555303dbSNPEnsembl.1
Natural variantiVAR_075363567S → L in ILLD; when assayed in yeast, reduces methionine incorporation; when assayed in yeast in association with T-393, induces growth retardation and strong reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant rs143592405dbSNPEnsembl.1
Natural variantiVAR_075364605D → V in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant rs756021768dbSNPEnsembl.1
Natural variantiVAR_073377618R → C in CMT2U; loss of function mutation. 1 PublicationCorresponds to variant rs587777718dbSNPEnsembl.1
Natural variantiVAR_020459683A → D.Corresponds to variant rs1054403dbSNPEnsembl.1
Natural variantiVAR_075365727R → Q.1 PublicationCorresponds to variant rs113808165dbSNPEnsembl.1
Natural variantiVAR_073378800P → T in CMT2U. 1 PublicationCorresponds to variant rs781249411dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056563546V → P in isoform 2. 1 Publication1
Alternative sequenceiVSP_056564547 – 900Missing in isoform 2. 1 PublicationAdd BLAST354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94754 mRNA. Translation: CAA64381.1.
Z49216 mRNA. Translation: CAA89153.1.
D84224 mRNA. Translation: BAA95668.1.
BT007338 mRNA. Translation: AAP36002.1.
AK122956 mRNA. Translation: BAG53819.1.
AK222767 mRNA. Translation: BAD96487.1.
AC022506 Genomic DNA. No translation available.
BC002384 mRNA. Translation: AAH02384.1.
BC006328 mRNA. Translation: AAH06328.1.
BC011639 mRNA. Translation: AAH11639.1.
BC011849 mRNA. Translation: AAH11849.1.
BC015011 mRNA. Translation: AAH15011.1.
CCDSiCCDS8942.1. [P56192-1]
PIRiJC5224.
RefSeqiNP_004981.2. NM_004990.3. [P56192-1]
UniGeneiHs.632707.

Genome annotation databases

EnsembliENST00000262027; ENSP00000262027; ENSG00000166986. [P56192-1]
ENST00000537638; ENSP00000446168; ENSG00000166986. [P56192-2]
GeneIDi4141.
KEGGihsa:4141.
UCSCiuc001sof.2. human. [P56192-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94754 mRNA. Translation: CAA64381.1.
Z49216 mRNA. Translation: CAA89153.1.
D84224 mRNA. Translation: BAA95668.1.
BT007338 mRNA. Translation: AAP36002.1.
AK122956 mRNA. Translation: BAG53819.1.
AK222767 mRNA. Translation: BAD96487.1.
AC022506 Genomic DNA. No translation available.
BC002384 mRNA. Translation: AAH02384.1.
BC006328 mRNA. Translation: AAH06328.1.
BC011639 mRNA. Translation: AAH11639.1.
BC011849 mRNA. Translation: AAH11849.1.
BC015011 mRNA. Translation: AAH15011.1.
CCDSiCCDS8942.1. [P56192-1]
PIRiJC5224.
RefSeqiNP_004981.2. NM_004990.3. [P56192-1]
UniGeneiHs.632707.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DJVNMR-A835-900[»]
4BL7X-ray1.89A1-224[»]
4BVXX-ray1.60A1-207[»]
4BVYX-ray1.99A1-225[»]
ProteinModelPortaliP56192.
SMRiP56192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110311. 68 interactors.
DIPiDIP-38164N.
IntActiP56192. 26 interactors.
MINTiMINT-5004366.
STRINGi9606.ENSP00000262027.

Chemistry databases

BindingDBiP56192.
ChEMBLiCHEMBL2870.
DrugBankiDB00134. L-Methionine.

Protein family/group databases

MoonProtiP56192.

PTM databases

iPTMnetiP56192.
PhosphoSitePlusiP56192.
SwissPalmiP56192.

Polymorphism and mutation databases

BioMutaiMARS.
DMDMi20178332.

Proteomic databases

EPDiP56192.
MaxQBiP56192.
PaxDbiP56192.
PeptideAtlasiP56192.
PRIDEiP56192.

Protocols and materials databases

DNASUi4141.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262027; ENSP00000262027; ENSG00000166986. [P56192-1]
ENST00000537638; ENSP00000446168; ENSG00000166986. [P56192-2]
GeneIDi4141.
KEGGihsa:4141.
UCSCiuc001sof.2. human. [P56192-1]

Organism-specific databases

CTDi4141.
DisGeNETi4141.
GeneCardsiMARS.
HGNCiHGNC:6898. MARS.
HPAiCAB017097.
HPA004125.
MalaCardsiMARS.
MIMi156560. gene.
615486. phenotype.
616280. phenotype.
neXtProtiNX_P56192.
OpenTargetsiENSG00000166986.
Orphaneti370088. Acute infantile liver failure-multisystemic involvement syndrome.
397735. Autosomal dominant Charcot-Marie-Tooth disease type 2 due to MARS mutation.
401835. Autosomal recessive spastic paraplegia type 70.
PharmGKBiPA30642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
KOG1247. Eukaryota.
COG0143. LUCA.
GeneTreeiENSGT00550000075017.
HOGENOMiHOG000200402.
HOVERGENiHBG036191.
InParanoidiP56192.
KOiK01874.
OMAiHPGCGYE.
OrthoDBiEOG091G020Y.
PhylomeDBiP56192.
TreeFamiTF300526.

Enzyme and pathway databases

BioCyciZFISH:HS09496-MONOMER.
BRENDAi6.1.1.10. 2681.
ReactomeiR-HSA-2408517. SeMet incorporation into proteins.
R-HSA-379716. Cytosolic tRNA aminoacylation.
SignaLinkiP56192.
SIGNORiP56192.

Miscellaneous databases

ChiTaRSiMARS. human.
EvolutionaryTraceiP56192.
GeneWikiiMARS_(gene).
GenomeRNAii4141.
PROiP56192.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166986.
CleanExiHS_MARS.
ExpressionAtlasiP56192. baseline and differential.
GenevisibleiP56192. HS.

Family and domain databases

CDDicd00814. MetRS_core. 1 hit.
Gene3Di1.10.287.10. 1 hit.
1.10.730.10. 1 hit.
1.20.1050.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00098. Met_tRNA_synth_type1. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR023458. Met-tRNA_ligase_1.
IPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR033911. MetRS_core.
IPR029038. MetRS_Zn.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009068. S15_NS1_RNA-bd.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR000738. WHEP-TRS_dom.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PF00458. WHEP-TRS. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SMARTiSM00991. WHEP-TRS. 1 hit.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 1 hit.
SSF47323. SSF47323. 1 hit.
SSF47616. SSF47616. 1 hit.
SSF57770. SSF57770. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50405. GST_CTER. 1 hit.
PS00762. WHEP_TRS_1. 1 hit.
PS51185. WHEP_TRS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYMC_HUMAN
AccessioniPrimary (citable) accession number: P56192
Secondary accession number(s): B3KVK7
, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: November 30, 2016
This is version 177 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.