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P56192

- SYMC_HUMAN

UniProt

P56192 - SYMC_HUMAN

Protein

Methionine--tRNA ligase, cytoplasmic

Gene

MARS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 2 (16 Apr 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei596 – 5961ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. methionine-tRNA ligase activity Source: Reactome
    3. tRNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. gene expression Source: Reactome
    2. methionyl-tRNA aminoacylation Source: InterPro
    3. tRNA aminoacylation for protein translation Source: Reactome

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding, tRNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_15306. Cytosolic tRNA aminoacylation.
    SignaLinkiP56192.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine--tRNA ligase, cytoplasmic (EC:6.1.1.10)
    Alternative name(s):
    Methionyl-tRNA synthetase
    Short name:
    MetRS
    Gene namesi
    Name:MARS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:6898. MARS.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. extracellular vesicular exosome Source: UniProt
    4. membrane Source: UniProtKB
    5. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    Infantile liver failure syndrome 2 (ILFS2) [MIM:615486]: A life-threatening disorder of hepatic function that manifests with liver failure in the first months of life. Clinical features include failure to thrive, hypotonia, intermittent lactic acidosis, aminoaciduria, hypothyroidism, interstitial lung disease, anemia, liver canalicular cholestasis, steatosis, and iron deposition.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti370 – 3701F → L in ILFS2. 1 Publication
    VAR_070872
    Natural varianti523 – 5231I → T in ILFS2. 1 Publication
    VAR_070873

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi615486. phenotype.
    Orphaneti370088. Acute infantile liver failure-multisystemic involvement syndrome.
    PharmGKBiPA30642.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 900900Methionine--tRNA ligase, cytoplasmicPRO_0000139262Add
    BLAST

    Proteomic databases

    MaxQBiP56192.
    PaxDbiP56192.
    PeptideAtlasiP56192.
    PRIDEiP56192.

    PTM databases

    PhosphoSiteiP56192.

    Expressioni

    Gene expression databases

    ArrayExpressiP56192.
    BgeeiP56192.
    CleanExiHS_MARS.
    GenevestigatoriP56192.

    Organism-specific databases

    HPAiCAB017097.
    HPA004125.

    Interactioni

    Subunit structurei

    Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43.

    Protein-protein interaction databases

    BioGridi110311. 39 interactions.
    DIPiDIP-38164N.
    IntActiP56192. 16 interactions.
    MINTiMINT-5004366.
    STRINGi9606.ENSP00000262027.

    Structurei

    Secondary structure

    1
    900
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 54
    Helixi12 – 187
    Helixi19 – 224
    Turni23 – 253
    Beta strandi29 – 324
    Beta strandi48 – 525
    Helixi62 – 7211
    Helixi79 – 9012
    Helixi92 – 10413
    Helixi111 – 1144
    Turni115 – 1173
    Helixi118 – 13013
    Beta strandi131 – 14010
    Helixi143 – 15614
    Helixi159 – 1613
    Helixi167 – 17711
    Helixi180 – 19011
    Helixi196 – 1983
    Helixi199 – 2035
    Helixi838 – 86124
    Helixi866 – 88722
    Beta strandi893 – 8953
    Beta strandi897 – 8993

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DJVNMR-A835-900[»]
    4BL7X-ray1.89A1-224[»]
    ProteinModelPortaliP56192.
    SMRiP56192. Positions 267-893.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP56192.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini74 – 198125GST C-terminalAdd
    BLAST
    Domaini841 – 89757WHEP-TRSAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi273 – 28311"HIGH" regionAdd
    BLAST
    Motifi593 – 5975"KMSKS" region

    Sequence similaritiesi

    Contains 1 GST C-terminal domain.Curated
    Contains 1 WHEP-TRS domain.Curated

    Phylogenomic databases

    eggNOGiCOG0143.
    HOGENOMiHOG000200402.
    HOVERGENiHBG036191.
    InParanoidiP56192.
    KOiK01874.
    OMAiFIKADTY.
    PhylomeDBiP56192.
    TreeFamiTF300526.

    Family and domain databases

    Gene3Di1.10.287.10. 1 hit.
    1.10.730.10. 1 hit.
    1.20.1050.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00098. Met_tRNA_synth_type1.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR010987. Glutathione-S-Trfase_C-like.
    IPR023458. Met-tRNA_ligase_1.
    IPR014758. Met-tRNA_synth.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR029038. MetRS_Zn.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009068. S15_NS1_RNA-bd.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR000738. WHEP-TRS.
    [Graphical view]
    PfamiPF09334. tRNA-synt_1g. 1 hit.
    PF00458. WHEP-TRS. 1 hit.
    [Graphical view]
    PRINTSiPR01041. TRNASYNTHMET.
    SMARTiSM00991. WHEP-TRS. 1 hit.
    [Graphical view]
    SUPFAMiSSF47060. SSF47060. 1 hit.
    SSF47323. SSF47323. 1 hit.
    SSF47616. SSF47616. 1 hit.
    SSF57770. SSF57770. 1 hit.
    TIGRFAMsiTIGR00398. metG. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    PS50405. GST_CTER. 1 hit.
    PS00762. WHEP_TRS_1. 1 hit.
    PS51185. WHEP_TRS_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P56192-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLFVSDGVP GCLPVLAAAG RARGRAEVLI STVGPEDCVV PFLTRPKVPV    50
    LQLDSGNYLF STSAICRYFF LLSGWEQDDL TNQWLEWEAT ELQPALSAAL 100
    YYLVVQGKKG EDVLGSVRRA LTHIDHSLSR QNCPFLAGET ESLADIVLWG 150
    ALYPLLQDPA YLPEELSALH SWFQTLSTQE PCQRAAETVL KQQGVLALRP 200
    YLQKQPQPSP AEGRAVTNEP EEEELATLSE EEIAMAVTAW EKGLESLPPL 250
    RPQQNPVLPV AGERNVLITS ALPYVNNVPH LGNIIGCVLS ADVFARYSRL 300
    RQWNTLYLCG TDEYGTATET KALEEGLTPQ EICDKYHIIH ADIYRWFNIS 350
    FDIFGRTTTP QQTKITQDIF QQLLKRGFVL QDTVEQLRCE HCARFLADRF 400
    VEGVCPFCGY EEARGDQCDK CGKLINAVEL KKPQCKVCRS CPVVQSSQHL 450
    FLDLPKLEKR LEEWLGRTLP GSDWTPNAQF ITRSWLRDGL KPRCITRDLK 500
    WGTPVPLEGF EDKVFYVWFD ATIGYLSITA NYTDQWERWW KNPEQVDLYQ 550
    FMAKDNVPFH SLVFPCSALG AEDNYTLVSH LIATEYLNYE DGKFSKSRGV 600
    GVFGDMAQDT GIPADIWRFY LLYIRPEGQD SAFSWTDLLL KNNSELLNNL 650
    GNFINRAGMF VSKFFGGYVP EMVLTPDDQR LLAHVTLELQ HYHQLLEKVR 700
    IRDALRSILT ISRHGNQYIQ VNEPWKRIKG SEADRQRAGT VTGLAVNIAA 750
    LLSVMLQPYM PTVSATIQAQ LQLPPPACSI LLTNFLCTLP AGHQIGTVSP 800
    LFQKLENDQI ESLRQRFGGG QAKTSPKPAV VETVTTAKPQ QIQALMDEVT 850
    KQGNIVRELK AQKADKNEVA AEVAKLLDLK KQLAVAEGKP PEAPKGKKKK 900
    Length:900
    Mass (Da):101,116
    Last modified:April 16, 2002 - v2
    Checksum:i3D687C77E17C5C96
    GO
    Isoform 2 (identifier: P56192-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         546-546: V → P
         547-900: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:546
    Mass (Da):61,816
    Checksum:iED19F00468D3C6AB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531L → V in CAA64381. (PubMed:8921912)Curated
    Sequence conflicti99 – 991A → P in CAA64381. (PubMed:8921912)Curated
    Sequence conflicti152 – 1521L → Q in CAA64381. (PubMed:8921912)Curated
    Sequence conflicti172 – 1721W → S in AAH15011. (PubMed:15489334)Curated
    Sequence conflicti250 – 2501L → P in BAD96487. 1 PublicationCurated
    Sequence conflicti683 – 6831A → G in CAA64381. (PubMed:8921912)Curated
    Sequence conflicti683 – 6831A → G in CAA89153. (PubMed:8921912)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti370 – 3701F → L in ILFS2. 1 Publication
    VAR_070872
    Natural varianti523 – 5231I → T in ILFS2. 1 Publication
    VAR_070873
    Natural varianti683 – 6831A → D.
    Corresponds to variant rs1054403 [ dbSNP | Ensembl ].
    VAR_020459

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei546 – 5461V → P in isoform 2. 1 PublicationVSP_056563
    Alternative sequencei547 – 900354Missing in isoform 2. 1 PublicationVSP_056564Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94754 mRNA. Translation: CAA64381.1.
    Z49216 mRNA. Translation: CAA89153.1.
    D84224 mRNA. Translation: BAA95668.1.
    BT007338 mRNA. Translation: AAP36002.1.
    AK122956 mRNA. Translation: BAG53819.1.
    AK222767 mRNA. Translation: BAD96487.1.
    AC022506 Genomic DNA. No translation available.
    BC002384 mRNA. Translation: AAH02384.1.
    BC006328 mRNA. Translation: AAH06328.1.
    BC011639 mRNA. Translation: AAH11639.1.
    BC011849 mRNA. Translation: AAH11849.1.
    BC015011 mRNA. Translation: AAH15011.1.
    CCDSiCCDS8942.1.
    PIRiJC5224.
    RefSeqiNP_004981.2. NM_004990.3.
    UniGeneiHs.632707.

    Genome annotation databases

    EnsembliENST00000262027; ENSP00000262027; ENSG00000166986.
    ENST00000537638; ENSP00000446168; ENSG00000166986.
    GeneIDi4141.
    KEGGihsa:4141.
    UCSCiuc001sog.3. human.

    Polymorphism databases

    DMDMi20178332.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94754 mRNA. Translation: CAA64381.1 .
    Z49216 mRNA. Translation: CAA89153.1 .
    D84224 mRNA. Translation: BAA95668.1 .
    BT007338 mRNA. Translation: AAP36002.1 .
    AK122956 mRNA. Translation: BAG53819.1 .
    AK222767 mRNA. Translation: BAD96487.1 .
    AC022506 Genomic DNA. No translation available.
    BC002384 mRNA. Translation: AAH02384.1 .
    BC006328 mRNA. Translation: AAH06328.1 .
    BC011639 mRNA. Translation: AAH11639.1 .
    BC011849 mRNA. Translation: AAH11849.1 .
    BC015011 mRNA. Translation: AAH15011.1 .
    CCDSi CCDS8942.1.
    PIRi JC5224.
    RefSeqi NP_004981.2. NM_004990.3.
    UniGenei Hs.632707.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DJV NMR - A 835-900 [» ]
    4BL7 X-ray 1.89 A 1-224 [» ]
    ProteinModelPortali P56192.
    SMRi P56192. Positions 267-893.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110311. 39 interactions.
    DIPi DIP-38164N.
    IntActi P56192. 16 interactions.
    MINTi MINT-5004366.
    STRINGi 9606.ENSP00000262027.

    Chemistry

    BindingDBi P56192.
    ChEMBLi CHEMBL2870.
    DrugBanki DB00134. L-Methionine.

    PTM databases

    PhosphoSitei P56192.

    Polymorphism databases

    DMDMi 20178332.

    Proteomic databases

    MaxQBi P56192.
    PaxDbi P56192.
    PeptideAtlasi P56192.
    PRIDEi P56192.

    Protocols and materials databases

    DNASUi 4141.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262027 ; ENSP00000262027 ; ENSG00000166986 .
    ENST00000537638 ; ENSP00000446168 ; ENSG00000166986 .
    GeneIDi 4141.
    KEGGi hsa:4141.
    UCSCi uc001sog.3. human.

    Organism-specific databases

    CTDi 4141.
    GeneCardsi GC12P057881.
    HGNCi HGNC:6898. MARS.
    HPAi CAB017097.
    HPA004125.
    MIMi 156560. gene.
    615486. phenotype.
    neXtProti NX_P56192.
    Orphaneti 370088. Acute infantile liver failure-multisystemic involvement syndrome.
    PharmGKBi PA30642.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0143.
    HOGENOMi HOG000200402.
    HOVERGENi HBG036191.
    InParanoidi P56192.
    KOi K01874.
    OMAi FIKADTY.
    PhylomeDBi P56192.
    TreeFami TF300526.

    Enzyme and pathway databases

    Reactomei REACT_15306. Cytosolic tRNA aminoacylation.
    SignaLinki P56192.

    Miscellaneous databases

    ChiTaRSi MARS. human.
    EvolutionaryTracei P56192.
    GeneWikii MARS_(gene).
    GenomeRNAii 4141.
    NextBioi 16264.
    PROi P56192.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56192.
    Bgeei P56192.
    CleanExi HS_MARS.
    Genevestigatori P56192.

    Family and domain databases

    Gene3Di 1.10.287.10. 1 hit.
    1.10.730.10. 1 hit.
    1.20.1050.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00098. Met_tRNA_synth_type1.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR010987. Glutathione-S-Trfase_C-like.
    IPR023458. Met-tRNA_ligase_1.
    IPR014758. Met-tRNA_synth.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR029038. MetRS_Zn.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009068. S15_NS1_RNA-bd.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR000738. WHEP-TRS.
    [Graphical view ]
    Pfami PF09334. tRNA-synt_1g. 1 hit.
    PF00458. WHEP-TRS. 1 hit.
    [Graphical view ]
    PRINTSi PR01041. TRNASYNTHMET.
    SMARTi SM00991. WHEP-TRS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47060. SSF47060. 1 hit.
    SSF47323. SSF47323. 1 hit.
    SSF47616. SSF47616. 1 hit.
    SSF57770. SSF57770. 1 hit.
    TIGRFAMsi TIGR00398. metG. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    PS50405. GST_CTER. 1 hit.
    PS00762. WHEP_TRS_1. 1 hit.
    PS51185. WHEP_TRS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase."
      Lage H., Dietel M.
      Gene 178:187-189(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Gastric carcinoma.
    2. "Cloning and sequence determination of a human cytoplasmic methionyl-tRNA synthetase gene."
      Motegi H., Noda T., Shiba K.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Thymus.
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver.
    6. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain, Colon and Muscle.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Solution structures of the WHEP-TRS domain of human methionyl-tRNA synthetase."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 835-900.
    15. "Rare recessive loss-of-function methionyl-tRNA synthetase mutations presenting as a multi-organ phenotype."
      van Meel E., Wegner D.J., Cliften P., Willing M.C., White F.V., Kornfeld S., Cole F.S.
      BMC Med. Genet. 14:106-106(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ILFS2 LEU-370 AND THR-523.

    Entry informationi

    Entry nameiSYMC_HUMAN
    AccessioniPrimary (citable) accession number: P56192
    Secondary accession number(s): B3KVK7
    , Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: April 16, 2002
    Last modified: October 1, 2014
    This is version 152 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3