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Protein

Methionine--tRNA ligase, cytoplasmic

Gene

MARS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei596 – 5961ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding, tRNA-binding

Enzyme and pathway databases

BRENDAi6.1.1.10. 2681.
ReactomeiR-HSA-2408517. SeMet incorporation into proteins.
R-HSA-379716. Cytosolic tRNA aminoacylation.
SignaLinkiP56192.
SIGNORiP56192.

Protein family/group databases

MoonProtiP56192.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligase, cytoplasmic (EC:6.1.1.10)
Alternative name(s):
Methionyl-tRNA synthetase
Short name:
MetRS
Gene namesi
Name:MARS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6898. MARS.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Interstitial lung and liver disease (ILLD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, life-threatening disorder characterized by respiratory insufficiency and progressive liver disease with onset in infancy or early childhood. Clinical features include failure to thrive, hypotonia, intermittent lactic acidosis, aminoaciduria, hypothyroidism, interstitial lung disease, pulmonary alveolar proteinosis, anemia, and liver canalicular cholestasis, steatosis, and iron deposition.
See also OMIM:615486
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti344 – 3441Y → C in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 Publication
Corresponds to variant rs766466297 [ dbSNP | Ensembl ].
VAR_075361
Natural varianti370 – 3701F → L in ILLD. 1 Publication
Corresponds to variant rs140467171 [ dbSNP | Ensembl ].
VAR_070872
Natural varianti393 – 3931A → T in ILLD; may act as a disease modifier aggravating the phenotype; found in patients that carried additional mutations C-344 and/or L-567; when assayed in yeast, does not exhibit any phenotype; when assayed in yeast in association with L-567, increases L-567-induced growth retardation and reduction in methionine incorporation. 1 Publication
Corresponds to variant rs141340466 [ dbSNP | Ensembl ].
VAR_075362
Natural varianti523 – 5231I → T in ILLD. 1 Publication
Corresponds to variant rs201555303 [ dbSNP | Ensembl ].
VAR_070873
Natural varianti567 – 5671S → L in ILLD; when assayed in yeast, reduces methionine incorporation; when assayed in yeast in association with T-393, induces growth retardation and strong reduction in methionine incorporation; may interfere with efficient substrate binding. 1 Publication
Corresponds to variant rs143592405 [ dbSNP | Ensembl ].
VAR_075363
Natural varianti605 – 6051D → V in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 Publication
Corresponds to variant rs756021768 [ dbSNP | Ensembl ].
VAR_075364
Charcot-Marie-Tooth disease 2U (CMT2U)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2U is a slowly progressive, autosomal dominant form characterized by late-adult onset.
See also OMIM:616280
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti618 – 6181R → C in CMT2U; loss of function mutation. 1 Publication
Corresponds to variant rs587777718 [ dbSNP | Ensembl ].
VAR_073377
Natural varianti800 – 8001P → T in CMT2U. 1 Publication
Corresponds to variant rs781249411 [ dbSNP | Ensembl ].
VAR_073378

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

MalaCardsiMARS.
MIMi615486. phenotype.
616280. phenotype.
Orphaneti370088. Acute infantile liver failure-multisystemic involvement syndrome.
397735. Autosomal dominant Charcot-Marie-Tooth disease type 2 due to MARS mutation.
401835. Autosomal recessive spastic paraplegia type 70.
PharmGKBiPA30642.

Chemistry

ChEMBLiCHEMBL2870.
DrugBankiDB00134. L-Methionine.

Polymorphism and mutation databases

BioMutaiMARS.
DMDMi20178332.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 900900Methionine--tRNA ligase, cytoplasmicPRO_0000139262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei825 – 8251PhosphoserineBy similarity
Modified residuei835 – 8351PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP56192.
MaxQBiP56192.
PaxDbiP56192.
PeptideAtlasiP56192.
PRIDEiP56192.

PTM databases

iPTMnetiP56192.
PhosphoSiteiP56192.
SwissPalmiP56192.

Expressioni

Gene expression databases

BgeeiENSG00000166986.
CleanExiHS_MARS.
ExpressionAtlasiP56192. baseline and differential.
GenevisibleiP56192. HS.

Organism-specific databases

HPAiCAB017097.
HPA004125.

Interactioni

Subunit structurei

Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43.

Protein-protein interaction databases

BioGridi110311. 68 interactions.
DIPiDIP-38164N.
IntActiP56192. 26 interactions.
MINTiMINT-5004366.
STRINGi9606.ENSP00000262027.

Chemistry

BindingDBiP56192.

Structurei

Secondary structure

1
900
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 54Combined sources
Helixi12 – 187Combined sources
Helixi19 – 224Combined sources
Turni23 – 253Combined sources
Beta strandi29 – 324Combined sources
Beta strandi48 – 525Combined sources
Helixi62 – 7211Combined sources
Helixi79 – 9012Combined sources
Helixi92 – 10413Combined sources
Helixi111 – 1144Combined sources
Helixi115 – 1173Combined sources
Helixi118 – 13013Combined sources
Beta strandi131 – 14010Combined sources
Helixi143 – 15614Combined sources
Helixi159 – 1613Combined sources
Helixi167 – 17711Combined sources
Helixi180 – 19011Combined sources
Helixi194 – 1985Combined sources
Helixi199 – 2024Combined sources
Helixi838 – 86124Combined sources
Helixi866 – 88722Combined sources
Beta strandi893 – 8953Combined sources
Beta strandi897 – 8993Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DJVNMR-A835-900[»]
4BL7X-ray1.89A1-224[»]
4BVXX-ray1.60A1-207[»]
4BVYX-ray1.99A1-225[»]
ProteinModelPortaliP56192.
SMRiP56192. Positions 1-208, 267-893.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56192.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 198125GST C-terminalAdd
BLAST
Domaini841 – 89757WHEP-TRSAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi273 – 28311"HIGH" regionAdd
BLAST
Motifi593 – 5975"KMSKS" region

Sequence similaritiesi

Contains 1 GST C-terminal domain.Curated
Contains 1 WHEP-TRS domain.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
KOG1247. Eukaryota.
COG0143. LUCA.
GeneTreeiENSGT00550000075017.
HOGENOMiHOG000200402.
HOVERGENiHBG036191.
InParanoidiP56192.
KOiK01874.
OMAiHPGCGYE.
OrthoDBiEOG091G020Y.
PhylomeDBiP56192.
TreeFamiTF300526.

Family and domain databases

Gene3Di1.10.287.10. 1 hit.
1.10.730.10. 1 hit.
1.20.1050.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00098. Met_tRNA_synth_type1. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR023458. Met-tRNA_ligase_1.
IPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR029038. MetRS_Zn.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009068. S15_NS1_RNA-bd.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR000738. WHEP-TRS_dom.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PF00458. WHEP-TRS. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SMARTiSM00991. WHEP-TRS. 1 hit.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 1 hit.
SSF47323. SSF47323. 1 hit.
SSF47616. SSF47616. 1 hit.
SSF57770. SSF57770. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50405. GST_CTER. 1 hit.
PS00762. WHEP_TRS_1. 1 hit.
PS51185. WHEP_TRS_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P56192-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLFVSDGVP GCLPVLAAAG RARGRAEVLI STVGPEDCVV PFLTRPKVPV
60 70 80 90 100
LQLDSGNYLF STSAICRYFF LLSGWEQDDL TNQWLEWEAT ELQPALSAAL
110 120 130 140 150
YYLVVQGKKG EDVLGSVRRA LTHIDHSLSR QNCPFLAGET ESLADIVLWG
160 170 180 190 200
ALYPLLQDPA YLPEELSALH SWFQTLSTQE PCQRAAETVL KQQGVLALRP
210 220 230 240 250
YLQKQPQPSP AEGRAVTNEP EEEELATLSE EEIAMAVTAW EKGLESLPPL
260 270 280 290 300
RPQQNPVLPV AGERNVLITS ALPYVNNVPH LGNIIGCVLS ADVFARYSRL
310 320 330 340 350
RQWNTLYLCG TDEYGTATET KALEEGLTPQ EICDKYHIIH ADIYRWFNIS
360 370 380 390 400
FDIFGRTTTP QQTKITQDIF QQLLKRGFVL QDTVEQLRCE HCARFLADRF
410 420 430 440 450
VEGVCPFCGY EEARGDQCDK CGKLINAVEL KKPQCKVCRS CPVVQSSQHL
460 470 480 490 500
FLDLPKLEKR LEEWLGRTLP GSDWTPNAQF ITRSWLRDGL KPRCITRDLK
510 520 530 540 550
WGTPVPLEGF EDKVFYVWFD ATIGYLSITA NYTDQWERWW KNPEQVDLYQ
560 570 580 590 600
FMAKDNVPFH SLVFPCSALG AEDNYTLVSH LIATEYLNYE DGKFSKSRGV
610 620 630 640 650
GVFGDMAQDT GIPADIWRFY LLYIRPEGQD SAFSWTDLLL KNNSELLNNL
660 670 680 690 700
GNFINRAGMF VSKFFGGYVP EMVLTPDDQR LLAHVTLELQ HYHQLLEKVR
710 720 730 740 750
IRDALRSILT ISRHGNQYIQ VNEPWKRIKG SEADRQRAGT VTGLAVNIAA
760 770 780 790 800
LLSVMLQPYM PTVSATIQAQ LQLPPPACSI LLTNFLCTLP AGHQIGTVSP
810 820 830 840 850
LFQKLENDQI ESLRQRFGGG QAKTSPKPAV VETVTTAKPQ QIQALMDEVT
860 870 880 890 900
KQGNIVRELK AQKADKNEVA AEVAKLLDLK KQLAVAEGKP PEAPKGKKKK
Length:900
Mass (Da):101,116
Last modified:April 16, 2002 - v2
Checksum:i3D687C77E17C5C96
GO
Isoform 2 (identifier: P56192-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-546: V → P
     547-900: Missing.

Note: No experimental confirmation available.
Show »
Length:546
Mass (Da):61,816
Checksum:iED19F00468D3C6AB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531L → V in CAA64381 (PubMed:8921912).Curated
Sequence conflicti99 – 991A → P in CAA64381 (PubMed:8921912).Curated
Sequence conflicti152 – 1521L → Q in CAA64381 (PubMed:8921912).Curated
Sequence conflicti172 – 1721W → S in AAH15011 (PubMed:15489334).Curated
Sequence conflicti250 – 2501L → P in BAD96487 (Ref. 5) Curated
Sequence conflicti683 – 6831A → G in CAA64381 (PubMed:8921912).Curated
Sequence conflicti683 – 6831A → G in CAA89153 (PubMed:8921912).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti206 – 2061P → L.1 Publication
Corresponds to variant rs138776588 [ dbSNP | Ensembl ].
VAR_075360
Natural varianti344 – 3441Y → C in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 Publication
Corresponds to variant rs766466297 [ dbSNP | Ensembl ].
VAR_075361
Natural varianti370 – 3701F → L in ILLD. 1 Publication
Corresponds to variant rs140467171 [ dbSNP | Ensembl ].
VAR_070872
Natural varianti393 – 3931A → T in ILLD; may act as a disease modifier aggravating the phenotype; found in patients that carried additional mutations C-344 and/or L-567; when assayed in yeast, does not exhibit any phenotype; when assayed in yeast in association with L-567, increases L-567-induced growth retardation and reduction in methionine incorporation. 1 Publication
Corresponds to variant rs141340466 [ dbSNP | Ensembl ].
VAR_075362
Natural varianti523 – 5231I → T in ILLD. 1 Publication
Corresponds to variant rs201555303 [ dbSNP | Ensembl ].
VAR_070873
Natural varianti567 – 5671S → L in ILLD; when assayed in yeast, reduces methionine incorporation; when assayed in yeast in association with T-393, induces growth retardation and strong reduction in methionine incorporation; may interfere with efficient substrate binding. 1 Publication
Corresponds to variant rs143592405 [ dbSNP | Ensembl ].
VAR_075363
Natural varianti605 – 6051D → V in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 Publication
Corresponds to variant rs756021768 [ dbSNP | Ensembl ].
VAR_075364
Natural varianti618 – 6181R → C in CMT2U; loss of function mutation. 1 Publication
Corresponds to variant rs587777718 [ dbSNP | Ensembl ].
VAR_073377
Natural varianti683 – 6831A → D.
Corresponds to variant rs1054403 [ dbSNP | Ensembl ].
VAR_020459
Natural varianti727 – 7271R → Q.1 Publication
Corresponds to variant rs113808165 [ dbSNP | Ensembl ].
VAR_075365
Natural varianti800 – 8001P → T in CMT2U. 1 Publication
Corresponds to variant rs781249411 [ dbSNP | Ensembl ].
VAR_073378

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei546 – 5461V → P in isoform 2. 1 PublicationVSP_056563
Alternative sequencei547 – 900354Missing in isoform 2. 1 PublicationVSP_056564Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94754 mRNA. Translation: CAA64381.1.
Z49216 mRNA. Translation: CAA89153.1.
D84224 mRNA. Translation: BAA95668.1.
BT007338 mRNA. Translation: AAP36002.1.
AK122956 mRNA. Translation: BAG53819.1.
AK222767 mRNA. Translation: BAD96487.1.
AC022506 Genomic DNA. No translation available.
BC002384 mRNA. Translation: AAH02384.1.
BC006328 mRNA. Translation: AAH06328.1.
BC011639 mRNA. Translation: AAH11639.1.
BC011849 mRNA. Translation: AAH11849.1.
BC015011 mRNA. Translation: AAH15011.1.
CCDSiCCDS8942.1. [P56192-1]
PIRiJC5224.
RefSeqiNP_004981.2. NM_004990.3. [P56192-1]
UniGeneiHs.632707.

Genome annotation databases

EnsembliENST00000262027; ENSP00000262027; ENSG00000166986. [P56192-1]
ENST00000537638; ENSP00000446168; ENSG00000166986. [P56192-2]
GeneIDi4141.
KEGGihsa:4141.
UCSCiuc001sof.2. human. [P56192-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94754 mRNA. Translation: CAA64381.1.
Z49216 mRNA. Translation: CAA89153.1.
D84224 mRNA. Translation: BAA95668.1.
BT007338 mRNA. Translation: AAP36002.1.
AK122956 mRNA. Translation: BAG53819.1.
AK222767 mRNA. Translation: BAD96487.1.
AC022506 Genomic DNA. No translation available.
BC002384 mRNA. Translation: AAH02384.1.
BC006328 mRNA. Translation: AAH06328.1.
BC011639 mRNA. Translation: AAH11639.1.
BC011849 mRNA. Translation: AAH11849.1.
BC015011 mRNA. Translation: AAH15011.1.
CCDSiCCDS8942.1. [P56192-1]
PIRiJC5224.
RefSeqiNP_004981.2. NM_004990.3. [P56192-1]
UniGeneiHs.632707.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DJVNMR-A835-900[»]
4BL7X-ray1.89A1-224[»]
4BVXX-ray1.60A1-207[»]
4BVYX-ray1.99A1-225[»]
ProteinModelPortaliP56192.
SMRiP56192. Positions 1-208, 267-893.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110311. 68 interactions.
DIPiDIP-38164N.
IntActiP56192. 26 interactions.
MINTiMINT-5004366.
STRINGi9606.ENSP00000262027.

Chemistry

BindingDBiP56192.
ChEMBLiCHEMBL2870.
DrugBankiDB00134. L-Methionine.

Protein family/group databases

MoonProtiP56192.

PTM databases

iPTMnetiP56192.
PhosphoSiteiP56192.
SwissPalmiP56192.

Polymorphism and mutation databases

BioMutaiMARS.
DMDMi20178332.

Proteomic databases

EPDiP56192.
MaxQBiP56192.
PaxDbiP56192.
PeptideAtlasiP56192.
PRIDEiP56192.

Protocols and materials databases

DNASUi4141.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262027; ENSP00000262027; ENSG00000166986. [P56192-1]
ENST00000537638; ENSP00000446168; ENSG00000166986. [P56192-2]
GeneIDi4141.
KEGGihsa:4141.
UCSCiuc001sof.2. human. [P56192-1]

Organism-specific databases

CTDi4141.
GeneCardsiMARS.
HGNCiHGNC:6898. MARS.
HPAiCAB017097.
HPA004125.
MalaCardsiMARS.
MIMi156560. gene.
615486. phenotype.
616280. phenotype.
neXtProtiNX_P56192.
Orphaneti370088. Acute infantile liver failure-multisystemic involvement syndrome.
397735. Autosomal dominant Charcot-Marie-Tooth disease type 2 due to MARS mutation.
401835. Autosomal recessive spastic paraplegia type 70.
PharmGKBiPA30642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
KOG1247. Eukaryota.
COG0143. LUCA.
GeneTreeiENSGT00550000075017.
HOGENOMiHOG000200402.
HOVERGENiHBG036191.
InParanoidiP56192.
KOiK01874.
OMAiHPGCGYE.
OrthoDBiEOG091G020Y.
PhylomeDBiP56192.
TreeFamiTF300526.

Enzyme and pathway databases

BRENDAi6.1.1.10. 2681.
ReactomeiR-HSA-2408517. SeMet incorporation into proteins.
R-HSA-379716. Cytosolic tRNA aminoacylation.
SignaLinkiP56192.
SIGNORiP56192.

Miscellaneous databases

ChiTaRSiMARS. human.
EvolutionaryTraceiP56192.
GeneWikiiMARS_(gene).
GenomeRNAii4141.
PROiP56192.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166986.
CleanExiHS_MARS.
ExpressionAtlasiP56192. baseline and differential.
GenevisibleiP56192. HS.

Family and domain databases

Gene3Di1.10.287.10. 1 hit.
1.10.730.10. 1 hit.
1.20.1050.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00098. Met_tRNA_synth_type1. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR023458. Met-tRNA_ligase_1.
IPR014758. Met-tRNA_synth.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR029038. MetRS_Zn.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009068. S15_NS1_RNA-bd.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR000738. WHEP-TRS_dom.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PF00458. WHEP-TRS. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SMARTiSM00991. WHEP-TRS. 1 hit.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 1 hit.
SSF47323. SSF47323. 1 hit.
SSF47616. SSF47616. 1 hit.
SSF57770. SSF57770. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50405. GST_CTER. 1 hit.
PS00762. WHEP_TRS_1. 1 hit.
PS51185. WHEP_TRS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYMC_HUMAN
AccessioniPrimary (citable) accession number: P56192
Secondary accession number(s): B3KVK7
, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: September 7, 2016
This is version 174 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.