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P56191 (DDL_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase
EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Synonyms:ddlA
Ordered Locus Names:HP_0738
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell wall formation By similarity.

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177830

Regions

Domain134 – 332199ATP-grasp
Nucleotide binding161 – 21656ATP By similarity

Sites

Metal binding2881Magnesium or manganese 1 By similarity
Metal binding3001Magnesium or manganese 1 By similarity
Metal binding3001Magnesium or manganese 2 By similarity
Metal binding3021Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56191 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 5F19D9CEE4AE08CF

FASTA34739,736
        10         20         30         40         50         60 
MEFCVLFGGA SFEHEISIVS AIALKGVLKD RIKYFIFLDE NHHFYLIEES NMHSKYFAQI 

        70         80         90        100        110        120 
KEKKLPPLIL THNGLLKNSF LGAKIIELPL VINLVHGGDG EDGKLASLLE FYRIAFIGPR 

       130        140        150        160        170        180 
IEASVLSYNK YLTKLYAKDL GVKTLDHVLL NEKNRANALD LMNFNFPFII KPNNAGSSLG 

       190        200        210        220        230        240 
VNVVKEEKEL VYALDGAFEY SKEVLIEPFI QGVKEYNLAG CKIKKDFCFS YVEEPNKQEF 

       250        260        270        280        290        300 
LDFKQKYLDF SRNKAPKANL SNALEEQLKE NFKKLYNDLF DGAIIRCDFF VIKNEVYLNE 

       310        320        330        340 
INPIPGSLAN YLFDDFKTTL ENLAQSLPKT PKIQIKNSYL LQIQKNK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000511 Genomic DNA. Translation: AAD07784.1.
PIRB64612.
RefSeqNP_207532.1. NC_000915.1.
YP_006934654.1. NC_018939.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2PVPX-ray2.40A/B1-347[»]
ProteinModelPortalP56191.
SMRP56191. Positions 1-328.
ModBaseSearch...

Protein-protein interaction databases

STRING85962.HP0738.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07784; AAD07784; HP_0738.
GeneID13869922.
899019.
KEGGheo:C694_03790.
hpy:HP0738.
PATRIC20592763. VBIHelPyl33062_0770.

Phylogenomic databases

eggNOGCOG1181.
KOK01921.
OMALCMDKSL.
ProtClustDBPRK01966.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP56191.

Entry information

Entry nameDDL_HELPY
AccessionPrimary (citable) accession number: P56191
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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