Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribulose-phosphate 3-epimerase

Gene

rpe

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.By similarity

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Co2+By similarity, Fe2+By similarity, Mn2+By similarity, Zn2+By similarityNote: Binds 1 divalent metal cation per subunit. Active with Co2+, Fe2+, Mn2+ and Zn2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei6SubstrateBy similarity1
Metal bindingi29Divalent metal cationBy similarity1
Active sitei31Proton acceptorBy similarity1
Metal bindingi31Divalent metal cationBy similarity1
Metal bindingi62Divalent metal cationBy similarity1
Binding sitei62SubstrateBy similarity1
Active sitei171Proton donorBy similarity1
Metal bindingi171Divalent metal cationBy similarity1
Binding sitei173Substrate; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandCobalt, Iron, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciHPY:HP1386-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase (EC:5.1.3.1)
Alternative name(s):
Pentose-5-phosphate 3-epimerase
Short name:
PPE
R5P3E
Gene namesi
Name:rpe
Ordered Locus Names:HP_1386
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001715721 – 217Ribulose-phosphate 3-epimeraseAdd BLAST217

Proteomic databases

PaxDbiP56188.

Interactioni

Protein-protein interaction databases

IntActiP56188. 1 interactor.
STRINGi85962.HP1386.

Structurei

3D structure databases

ProteinModelPortaliP56188.
SMRiP56188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 141Substrate bindingBy similarity4
Regioni193 – 194Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DJV. Bacteria.
COG0036. LUCA.
KOiK01783.
OMAiNCETMLE.

Family and domain databases

CDDicd00429. RPE. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiView protein in Pfam
PF00834. Ribul_P_3_epim. 1 hit.
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01163. rpe. 1 hit.
PROSITEiView protein in PROSITE
PS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P56188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVAPSLLSA DFMHLAKEIE SVSNADFLHV DVMDGHYVPN LTMGPVVLEN
60 70 80 90 100
VTQMSQVPLD VHLMVENASF FAELFAPLKP QIISIHAENE KHPHRVLQLI
110 120 130 140 150
KNLGITPGIV LNPHTHEESI KYLLESVGLV LLMSVNPGFG GQKFLDLVLE
160 170 180 190 200
KCLKVKELIK RYNPSCLLEV DGGVNDKNIF ELQQAGVDVV VSGSYIFKSK
210
DRKLAIEGLQ NVRQSLA
Length:217
Mass (Da):24,045
Last modified:November 1, 1997 - v1
Checksum:i7CAA9E1E5DC9006F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08425.1.
PIRiB64693.
RefSeqiNP_208177.1. NC_000915.1.
WP_000861474.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08425; AAD08425; HP_1386.
GeneIDi900293.
KEGGiheo:C694_07155.
hpy:HP1386.
PATRICifig|85962.47.peg.1484.

Similar proteinsi

Entry informationi

Entry nameiRPE_HELPY
AccessioniPrimary (citable) accession number: P56188
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 7, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families