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Protein

Ribonuclease J

Gene

rnj

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

An RNase that has 5'-3' exonuclease and possibly endoonuclease activity. Involved in maturation of mRNA but apparently not rRNA (By similarity).By similarity

Cofactori

Zn2+UniRule annotationNote: Binds up to 2 Zn2+ ions per subunit. It is not clear if Zn2+ or Mg2+ is physiologically important.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi206Zinc 1; catalyticUniRule annotation1
Metal bindingi208Zinc 1; catalyticUniRule annotation1
Metal bindingi210Zinc 2; catalyticUniRule annotation1
Metal bindingi211Zinc 2; catalyticUniRule annotation1
Metal bindingi275Zinc 1; catalyticUniRule annotation1
Metal bindingi297Zinc 1; catalyticUniRule annotation1
Metal bindingi297Zinc 2; catalyticUniRule annotation1
Metal bindingi524Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Exonuclease, Hydrolase, Nuclease, RNA-binding
Biological processrRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciHPY:HP1430-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease JUniRule annotation (EC:3.1.-.-UniRule annotation)
Short name:
RNase JUniRule annotation
Gene namesi
Name:rnjUniRule annotation
Ordered Locus Names:HP_1430
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002152691 – 689Ribonuclease JAdd BLAST689

Proteomic databases

PaxDbiP56185
PRIDEiP56185

Interactioni

Subunit structurei

Homodimer (Probable). Interacts with RNA helicase RhpA.Curated1 Publication

Protein-protein interaction databases

DIPiDIP-3218N
IntActiP56185, 14 interactors
MINTiP56185
STRINGi85962.HP1430

Structurei

3D structure databases

ProteinModelPortaliP56185
SMRiP56185
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni498 – 502Substrate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CN5 Bacteria
COG0595 LUCA
KOiK12574
OMAiKNTCVFE

Family and domain databases

Gene3Di3.60.15.10, 2 hits
HAMAPiMF_01491 RNase_J_bact, 1 hit
InterProiView protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR011108 RMMBL
IPR004613 RNase_J
IPR030854 RNase_J_bac
IPR001587 RNase_J_CS
PfamiView protein in Pfam
PF00753 Lactamase_B, 1 hit
PF07521 RMMBL, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
TIGRFAMsiTIGR00649 MG423, 1 hit
PROSITEiView protein in PROSITE
PS01292 UPF0036, 1 hit

Sequencei

Sequence statusi: Complete.

P56185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNNQNNEN HENSSENSKA DEMRAGAFER FTNRKKRFRE NAQKNAEYSN
60 70 80 90 100
HEASSHHKKE HRPNKKPNNH HKQKHAKTRN YAQEELDSNK VEGVTEILHV
110 120 130 140 150
NERGTLGFHK ELKKGVEANN KIQVEHLNPH YKMNLNSKAS VKITPLGGLG
160 170 180 190 200
EIGGNMMVIE TPKSAIVIDA GMSFPKEGLF GVDILIPDFS YLHQIKDKIA
210 220 230 240 250
GIIITHAHED HIGATPYLFK ELQFPLYGTP LSLGLIGSKF DEHGLKKYRS
260 270 280 290 300
YFKIVEKRCP ISVGEFIIEW IHITHSIIDS SALAIQTKAG TIIHTGDFKI
310 320 330 340 350
DHTPVDNLPT DLYRLAHYGE KGVMLLLSDS TNSHKSGTTP SESTIAPAFD
360 370 380 390 400
TLFKEAQGRV IMSTFSSNIH RVYQAIQYGI KYNRKIAVIG RSMEKNLDIA
410 420 430 440 450
RELGYIHLPY QSFIEANEVA KYPDNEILIV TTGSQGETMS ALYRMATDEH
460 470 480 490 500
RHISIKPNDL VIISAKAIPG NEASVSAVLN FLIKKEAKVA YQEFDNIHVS
510 520 530 540 550
GHAAQEEQKL MLRLIKPKFF LPVHGEYNHV ARHKQTAISC GVPEKNIYLM
560 570 580 590 600
EDGDQVEVGP AFIKKVGTIK SGKSYVDNQS NLSIDTSIVQ QREEVASAGV
610 620 630 640 650
FVATIFVNKN KQALLESSQF SSLGLVGFKD EKPLIKEIQG GLEVLLKSSN
660 670 680
AEILNNPKKL EDHTRNFIRK ALFKKFRKYP AIICHAHSF
Length:689
Mass (Da):77,386
Last modified:November 1, 1997 - v1
Checksum:i77791982943F5B80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08469.1
PIRiF64698
RefSeqiNP_208221.1, NC_000915.1
WP_000131629.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08469; AAD08469; HP_1430
GeneIDi899865
KEGGiheo:C694_07395
hpy:HP1430
PATRICifig|85962.47.peg.1534

Similar proteinsi

Entry informationi

Entry nameiRNJ_HELPY
AccessioniPrimary (citable) accession number: P56185
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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