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P56183

- RRP1_MOUSE

UniProt

P56183 - RRP1_MOUSE

Protein

Ribosomal RNA processing protein 1 homolog A

Gene

Rrp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Plays a critical role in the generation of 28S rRNA.By similarity

    GO - Biological processi

    1. rRNA processing Source: UniProtKB-KW

    Keywords - Biological processi

    rRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA processing protein 1 homolog A
    Alternative name(s):
    Novel nuclear protein 1
    Short name:
    NNP-1
    Nucleolar protein Nop52
    RRP1-like protein
    Gene namesi
    Name:Rrp1
    Synonyms:Nnp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1203500. Rrp1.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell
    2. preribosome, small subunit precursor Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Ribosomal RNA processing protein 1 homolog APRO_0000096888Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei455 – 4551PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP56183.
    PaxDbiP56183.
    PRIDEiP56183.

    PTM databases

    PhosphoSiteiP56183.

    Expressioni

    Developmental stagei

    Embryonic, expression starting between days 1 and 10.1 Publication

    Gene expression databases

    ArrayExpressiP56183.
    BgeeiP56183.
    GenevestigatoriP56183.

    Interactioni

    Subunit structurei

    Interacts with C1QBP.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP56183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi247 – 30559Asp-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RRP1 family.Curated

    Phylogenomic databases

    eggNOGiNOG299406.
    GeneTreeiENSGT00390000011821.
    HOGENOMiHOG000070179.
    HOVERGENiHBG000394.
    InParanoidiP56183.
    KOiK14849.
    OMAiVHAFQTT.
    OrthoDBiEOG718KC8.
    PhylomeDBiP56183.
    TreeFamiTF315294.

    Family and domain databases

    InterProiIPR010301. Nop52.
    [Graphical view]
    PANTHERiPTHR13026. PTHR13026. 1 hit.
    PfamiPF05997. Nop52. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P56183-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPGVPLPPE IQLAQRLAGN EQVTRDRALR KLRKYIEARS QRATGGFTPD    50
    ELLKVWKGLF YCMWMQDKPL QQEELGRTIA QLVHAFHTTE AQHQFLKAFW 100
    QTMIREWVGI DRLRLDKFYM LMRMVLSESL KAVKARGWDE RQIEQLLELL 150
    TTEILNPDSQ APSGVKSHFL EIFLEELAKV GAAELTADQN LQFIDPFCQI 200
    AARTKDSQVL HKIIQSIFQT IVEQAPLAIE DIMNELDTQS GEGEASDGDD 250
    GEASDGDDGE ASDDDDGEAS DGGDGDVADS DDSDGADDDD GDVSDGDGGD 300
    NDEGDSNKSS EGEQDLQDTP PKKLPAGTAH RAGPEADKEQ AWDDEENAGP 350
    VLQFDYEALA NRLFKLASRQ STPSQNRKRL YKVIQKLREL AGGTFPEDDV 400
    PEKAYKKMLE GRRERKKKKK RLPKPQPQNK EAGSEAESSS ADPGPGRKRK 450
    RNRKTDEKAG QGGPPGKRRK PGARAKGAGA QQPKKRIQSS QSAE 494
    Length:494
    Mass (Da):54,777
    Last modified:June 6, 2002 - v2
    Checksum:i9866F1BD7AE3E99D
    GO
    Isoform 2 (identifier: P56183-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         245-258: ASDGDDGEASDGDD → GSDEDDGDDDSDEA
         259-309: Missing.

    Show »
    Length:443
    Mass (Da):50,013
    Checksum:iA072C7291065336E
    GO
    Isoform 3 (identifier: P56183-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         450-484: Missing.

    Show »
    Length:459
    Mass (Da):51,112
    Checksum:i6849C76C180D18BA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501D → C in AAG30293. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei245 – 25814ASDGD…SDGDD → GSDEDDGDDDSDEA in isoform 2. 1 PublicationVSP_004335Add
    BLAST
    Alternative sequencei259 – 30951Missing in isoform 2. 1 PublicationVSP_004336Add
    BLAST
    Alternative sequencei450 – 48435Missing in isoform 3. CuratedVSP_004337Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U79773 mRNA. Translation: AAC53286.1.
    U79774 mRNA. Translation: AAB63261.1.
    AF294729 Genomic DNA. Translation: AAF76216.2.
    AF312394 mRNA. Translation: AAG30293.1.
    BC065993 mRNA. Translation: AAH65993.1.
    BC065994 mRNA. Translation: AAH65994.1.
    CCDSiCCDS35961.1. [P56183-1]
    RefSeqiNP_035055.2. NM_010925.2. [P56183-1]
    UniGeneiMm.38344.

    Genome annotation databases

    EnsembliENSMUST00000062678; ENSMUSP00000058785; ENSMUSG00000061032. [P56183-1]
    GeneIDi18114.
    KEGGimmu:18114.
    UCSCiuc007fxs.1. mouse. [P56183-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U79773 mRNA. Translation: AAC53286.1 .
    U79774 mRNA. Translation: AAB63261.1 .
    AF294729 Genomic DNA. Translation: AAF76216.2 .
    AF312394 mRNA. Translation: AAG30293.1 .
    BC065993 mRNA. Translation: AAH65993.1 .
    BC065994 mRNA. Translation: AAH65994.1 .
    CCDSi CCDS35961.1. [P56183-1 ]
    RefSeqi NP_035055.2. NM_010925.2. [P56183-1 ]
    UniGenei Mm.38344.

    3D structure databases

    ProteinModelPortali P56183.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P56183.

    Proteomic databases

    MaxQBi P56183.
    PaxDbi P56183.
    PRIDEi P56183.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062678 ; ENSMUSP00000058785 ; ENSMUSG00000061032 . [P56183-1 ]
    GeneIDi 18114.
    KEGGi mmu:18114.
    UCSCi uc007fxs.1. mouse. [P56183-1 ]

    Organism-specific databases

    CTDi 8568.
    MGIi MGI:1203500. Rrp1.

    Phylogenomic databases

    eggNOGi NOG299406.
    GeneTreei ENSGT00390000011821.
    HOGENOMi HOG000070179.
    HOVERGENi HBG000394.
    InParanoidi P56183.
    KOi K14849.
    OMAi VHAFQTT.
    OrthoDBi EOG718KC8.
    PhylomeDBi P56183.
    TreeFami TF315294.

    Miscellaneous databases

    ChiTaRSi RRP1. mouse.
    NextBioi 293315.
    PROi P56183.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56183.
    Bgeei P56183.
    Genevestigatori P56183.

    Family and domain databases

    InterProi IPR010301. Nop52.
    [Graphical view ]
    PANTHERi PTHR13026. PTHR13026. 1 hit.
    Pfami PF05997. Nop52. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3."
      Jansen E., Meulemans S.M.P., Orlans I.C.R., Van de Ven W.J.M.
      Genomics 42:336-341(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), DEVELOPMENTAL STAGE.
      Tissue: Pituitary.
    2. "Mouse homologues of human chromosome 21 genes."
      Tsyba L., Skripkina I., Anoprienko O., Kvasha S., Slavov D., Tassone F., Rynditch A., Gardiner K.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
      Strain: 129/Ola.
      Tissue: Spleen.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiRRP1_MOUSE
    AccessioniPrimary (citable) accession number: P56183
    Secondary accession number(s): O35712
    , Q9ERE1, Q9JI07, Q9JK67, Q9JKU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3