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P56183 (RRP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosomal RNA processing protein 1 homolog A
Alternative name(s):
Novel nuclear protein 1
Short name=NNP-1
Nucleolar protein Nop52
RRP1-like protein
Gene names
Name:Rrp1
Synonyms:Nnp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a critical role in the generation of 28S rRNA By similarity.

Subunit structure

Interacts with C1QBP By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Developmental stage

Embryonic, expression starting between days 1 and 10. Ref.1

Sequence similarities

Belongs to the RRP1 family.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processrRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

preribosome, small subunit precursor

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P56183-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P56183-2)

The sequence of this isoform differs from the canonical sequence as follows:
     245-258: ASDGDDGEASDGDD → GSDEDDGDDDSDEA
     259-309: Missing.
Isoform 3 (identifier: P56183-3)

The sequence of this isoform differs from the canonical sequence as follows:
     450-484: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Ribosomal RNA processing protein 1 homolog A
PRO_0000096888

Regions

Compositional bias247 – 30559Asp-rich

Amino acid modifications

Modified residue4551Phosphothreonine By similarity

Natural variations

Alternative sequence245 – 25814ASDGD…SDGDD → GSDEDDGDDDSDEA in isoform 2.
VSP_004335
Alternative sequence259 – 30951Missing in isoform 2.
VSP_004336
Alternative sequence450 – 48435Missing in isoform 3.
VSP_004337

Experimental info

Sequence conflict501D → C in AAG30293. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: 9866F1BD7AE3E99D

FASTA49454,777
        10         20         30         40         50         60 
MVPGVPLPPE IQLAQRLAGN EQVTRDRALR KLRKYIEARS QRATGGFTPD ELLKVWKGLF 

        70         80         90        100        110        120 
YCMWMQDKPL QQEELGRTIA QLVHAFHTTE AQHQFLKAFW QTMIREWVGI DRLRLDKFYM 

       130        140        150        160        170        180 
LMRMVLSESL KAVKARGWDE RQIEQLLELL TTEILNPDSQ APSGVKSHFL EIFLEELAKV 

       190        200        210        220        230        240 
GAAELTADQN LQFIDPFCQI AARTKDSQVL HKIIQSIFQT IVEQAPLAIE DIMNELDTQS 

       250        260        270        280        290        300 
GEGEASDGDD GEASDGDDGE ASDDDDGEAS DGGDGDVADS DDSDGADDDD GDVSDGDGGD 

       310        320        330        340        350        360 
NDEGDSNKSS EGEQDLQDTP PKKLPAGTAH RAGPEADKEQ AWDDEENAGP VLQFDYEALA 

       370        380        390        400        410        420 
NRLFKLASRQ STPSQNRKRL YKVIQKLREL AGGTFPEDDV PEKAYKKMLE GRRERKKKKK 

       430        440        450        460        470        480 
RLPKPQPQNK EAGSEAESSS ADPGPGRKRK RNRKTDEKAG QGGPPGKRRK PGARAKGAGA 

       490 
QQPKKRIQSS QSAE 

« Hide

Isoform 2 [UniParc].

Checksum: A072C7291065336E
Show »

FASTA44350,013
Isoform 3 [UniParc].

Checksum: 6849C76C180D18BA
Show »

FASTA45951,112

References

« Hide 'large scale' references
[1]"The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3."
Jansen E., Meulemans S.M.P., Orlans I.C.R., Van de Ven W.J.M.
Genomics 42:336-341(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), DEVELOPMENTAL STAGE.
Tissue: Pituitary.
[2]"Mouse homologues of human chromosome 21 genes."
Tsyba L., Skripkina I., Anoprienko O., Kvasha S., Slavov D., Tassone F., Rynditch A., Gardiner K.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
Strain: 129/Ola.
Tissue: Spleen.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U79773 mRNA. Translation: AAC53286.1.
U79774 mRNA. Translation: AAB63261.1.
AF294729 Genomic DNA. Translation: AAF76216.2.
AF312394 mRNA. Translation: AAG30293.1.
BC065993 mRNA. Translation: AAH65993.1.
BC065994 mRNA. Translation: AAH65994.1.
RefSeqNP_035055.2. NM_010925.2.
UniGeneMm.38344.

3D structure databases

ProteinModelPortalP56183.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP56183.

Proteomic databases

PaxDbP56183.
PRIDEP56183.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000062678; ENSMUSP00000058785; ENSMUSG00000061032. [P56183-1]
GeneID18114.
KEGGmmu:18114.
UCSCuc007fxs.1. mouse. [P56183-1]

Organism-specific databases

CTD8568.
MGIMGI:1203500. Rrp1.

Phylogenomic databases

eggNOGNOG299406.
GeneTreeENSGT00390000011821.
HOGENOMHOG000070179.
HOVERGENHBG000394.
InParanoidP56183.
KOK14849.
OMAGWEERQI.
OrthoDBEOG718KC8.
PhylomeDBP56183.
TreeFamTF315294.

Gene expression databases

ArrayExpressP56183.
BgeeP56183.
GenevestigatorP56183.

Family and domain databases

InterProIPR010301. Nop52.
[Graphical view]
PANTHERPTHR13026. PTHR13026. 1 hit.
PfamPF05997. Nop52. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRRP1. mouse.
NextBio293315.
PROP56183.
SOURCESearch...

Entry information

Entry nameRRP1_MOUSE
AccessionPrimary (citable) accession number: P56183
Secondary accession number(s): O35712 expand/collapse secondary AC list , Q9ERE1, Q9JI07, Q9JK67, Q9JKU2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: April 16, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot