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P56183

- RRP1_MOUSE

UniProt

P56183 - RRP1_MOUSE

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Protein
Ribosomal RNA processing protein 1 homolog A
Gene
Rrp1, Nnp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a critical role in the generation of 28S rRNA By similarity.

GO - Biological processi

  1. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA processing protein 1 homolog A
Alternative name(s):
Novel nuclear protein 1
Short name:
NNP-1
Nucleolar protein Nop52
RRP1-like protein
Gene namesi
Name:Rrp1
Synonyms:Nnp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1203500. Rrp1.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
  2. preribosome, small subunit precursor Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Ribosomal RNA processing protein 1 homolog A
PRO_0000096888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei455 – 4551Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP56183.
PaxDbiP56183.
PRIDEiP56183.

PTM databases

PhosphoSiteiP56183.

Expressioni

Developmental stagei

Embryonic, expression starting between days 1 and 10.1 Publication

Gene expression databases

ArrayExpressiP56183.
BgeeiP56183.
GenevestigatoriP56183.

Interactioni

Subunit structurei

Interacts with C1QBP By similarity.

Structurei

3D structure databases

ProteinModelPortaliP56183.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi247 – 30559Asp-rich
Add
BLAST

Sequence similaritiesi

Belongs to the RRP1 family.

Phylogenomic databases

eggNOGiNOG299406.
GeneTreeiENSGT00390000011821.
HOGENOMiHOG000070179.
HOVERGENiHBG000394.
InParanoidiP56183.
KOiK14849.
OMAiVHAFQTT.
OrthoDBiEOG718KC8.
PhylomeDBiP56183.
TreeFamiTF315294.

Family and domain databases

InterProiIPR010301. Nop52.
[Graphical view]
PANTHERiPTHR13026. PTHR13026. 1 hit.
PfamiPF05997. Nop52. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P56183-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVPGVPLPPE IQLAQRLAGN EQVTRDRALR KLRKYIEARS QRATGGFTPD    50
ELLKVWKGLF YCMWMQDKPL QQEELGRTIA QLVHAFHTTE AQHQFLKAFW 100
QTMIREWVGI DRLRLDKFYM LMRMVLSESL KAVKARGWDE RQIEQLLELL 150
TTEILNPDSQ APSGVKSHFL EIFLEELAKV GAAELTADQN LQFIDPFCQI 200
AARTKDSQVL HKIIQSIFQT IVEQAPLAIE DIMNELDTQS GEGEASDGDD 250
GEASDGDDGE ASDDDDGEAS DGGDGDVADS DDSDGADDDD GDVSDGDGGD 300
NDEGDSNKSS EGEQDLQDTP PKKLPAGTAH RAGPEADKEQ AWDDEENAGP 350
VLQFDYEALA NRLFKLASRQ STPSQNRKRL YKVIQKLREL AGGTFPEDDV 400
PEKAYKKMLE GRRERKKKKK RLPKPQPQNK EAGSEAESSS ADPGPGRKRK 450
RNRKTDEKAG QGGPPGKRRK PGARAKGAGA QQPKKRIQSS QSAE 494
Length:494
Mass (Da):54,777
Last modified:June 6, 2002 - v2
Checksum:i9866F1BD7AE3E99D
GO
Isoform 2 (identifier: P56183-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-258: ASDGDDGEASDGDD → GSDEDDGDDDSDEA
     259-309: Missing.

Show »
Length:443
Mass (Da):50,013
Checksum:iA072C7291065336E
GO
Isoform 3 (identifier: P56183-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-484: Missing.

Show »
Length:459
Mass (Da):51,112
Checksum:i6849C76C180D18BA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei245 – 25814ASDGD…SDGDD → GSDEDDGDDDSDEA in isoform 2.
VSP_004335Add
BLAST
Alternative sequencei259 – 30951Missing in isoform 2.
VSP_004336Add
BLAST
Alternative sequencei450 – 48435Missing in isoform 3.
VSP_004337Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501D → C in AAG30293. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79773 mRNA. Translation: AAC53286.1.
U79774 mRNA. Translation: AAB63261.1.
AF294729 Genomic DNA. Translation: AAF76216.2.
AF312394 mRNA. Translation: AAG30293.1.
BC065993 mRNA. Translation: AAH65993.1.
BC065994 mRNA. Translation: AAH65994.1.
CCDSiCCDS35961.1. [P56183-1]
RefSeqiNP_035055.2. NM_010925.2. [P56183-1]
UniGeneiMm.38344.

Genome annotation databases

EnsembliENSMUST00000062678; ENSMUSP00000058785; ENSMUSG00000061032. [P56183-1]
GeneIDi18114.
KEGGimmu:18114.
UCSCiuc007fxs.1. mouse. [P56183-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79773 mRNA. Translation: AAC53286.1 .
U79774 mRNA. Translation: AAB63261.1 .
AF294729 Genomic DNA. Translation: AAF76216.2 .
AF312394 mRNA. Translation: AAG30293.1 .
BC065993 mRNA. Translation: AAH65993.1 .
BC065994 mRNA. Translation: AAH65994.1 .
CCDSi CCDS35961.1. [P56183-1 ]
RefSeqi NP_035055.2. NM_010925.2. [P56183-1 ]
UniGenei Mm.38344.

3D structure databases

ProteinModelPortali P56183.
ModBasei Search...

PTM databases

PhosphoSitei P56183.

Proteomic databases

MaxQBi P56183.
PaxDbi P56183.
PRIDEi P56183.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062678 ; ENSMUSP00000058785 ; ENSMUSG00000061032 . [P56183-1 ]
GeneIDi 18114.
KEGGi mmu:18114.
UCSCi uc007fxs.1. mouse. [P56183-1 ]

Organism-specific databases

CTDi 8568.
MGIi MGI:1203500. Rrp1.

Phylogenomic databases

eggNOGi NOG299406.
GeneTreei ENSGT00390000011821.
HOGENOMi HOG000070179.
HOVERGENi HBG000394.
InParanoidi P56183.
KOi K14849.
OMAi VHAFQTT.
OrthoDBi EOG718KC8.
PhylomeDBi P56183.
TreeFami TF315294.

Miscellaneous databases

ChiTaRSi RRP1. mouse.
NextBioi 293315.
PROi P56183.
SOURCEi Search...

Gene expression databases

ArrayExpressi P56183.
Bgeei P56183.
Genevestigatori P56183.

Family and domain databases

InterProi IPR010301. Nop52.
[Graphical view ]
PANTHERi PTHR13026. PTHR13026. 1 hit.
Pfami PF05997. Nop52. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3."
    Jansen E., Meulemans S.M.P., Orlans I.C.R., Van de Ven W.J.M.
    Genomics 42:336-341(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), DEVELOPMENTAL STAGE.
    Tissue: Pituitary.
  2. "Mouse homologues of human chromosome 21 genes."
    Tsyba L., Skripkina I., Anoprienko O., Kvasha S., Slavov D., Tassone F., Rynditch A., Gardiner K.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
    Strain: 129/Ola.
    Tissue: Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiRRP1_MOUSE
AccessioniPrimary (citable) accession number: P56183
Secondary accession number(s): O35712
, Q9ERE1, Q9JI07, Q9JK67, Q9JKU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi