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Protein

Ribosomal RNA processing protein 1 homolog A

Gene

RRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in the generation of 28S rRNA.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA processing protein 1 homolog A
Alternative name(s):
Novel nuclear protein 1
Short name:
NNP-1
Nucleolar protein Nop52
RRP1-like protein
Gene namesi
Name:RRP1
Synonyms:D21S2056E, NNP1, NOP52, RRP1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18785. RRP1.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: UniProtKB
  • nucleus Source: ProtInc
  • preribosome, large subunit precursor Source: GO_Central
  • preribosome, small subunit precursor Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402091.

Polymorphism and mutation databases

BioMutaiRRP1.
DMDMi2829451.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Ribosomal RNA processing protein 1 homolog APRO_0000096887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei245 – 2451PhosphoserineCombined sources
Modified residuei247 – 2471PhosphoserineCombined sources
Modified residuei250 – 2501PhosphoserineCombined sources
Modified residuei251 – 2511PhosphoserineCombined sources
Modified residuei383 – 3831PhosphoserineCombined sources
Modified residuei412 – 4121PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP56182.
MaxQBiP56182.
PaxDbiP56182.
PeptideAtlasiP56182.
PRIDEiP56182.

2D gel databases

SWISS-2DPAGEP56182.

PTM databases

iPTMnetiP56182.
PhosphoSiteiP56182.

Expressioni

Tissue specificityi

Ubiquitously expressed in fetal and adult tissues.1 Publication

Gene expression databases

BgeeiENSG00000160214.
CleanExiHS_RRP1.
ExpressionAtlasiP56182. baseline and differential.
GenevisibleiP56182. HS.

Organism-specific databases

HPAiHPA016818.
HPA018166.

Interactioni

Subunit structurei

Interacts with C1QBP.1 Publication

Protein-protein interaction databases

BioGridi114137. 27 interactions.
IntActiP56182. 8 interactions.
MINTiMINT-3021272.
STRINGi9606.ENSP00000417464.

Structurei

3D structure databases

ProteinModelPortaliP56182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RRP1 family.Curated

Phylogenomic databases

eggNOGiKOG3911. Eukaryota.
ENOG4111GJ6. LUCA.
GeneTreeiENSGT00390000011821.
HOVERGENiHBG000394.
InParanoidiP56182.
KOiK14849.
OMAiVHAFQTT.
OrthoDBiEOG091G0AX5.
PhylomeDBiP56182.
TreeFamiTF315294.

Family and domain databases

InterProiIPR010301. Nop52.
[Graphical view]
PANTHERiPTHR13026. PTHR13026. 1 hit.
PfamiPF05997. Nop52. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSRVQLPPE IQLAQRLAGN EQVTRDRAVR KLRKYIVART QRAAGGFTHD
60 70 80 90 100
ELLKVWKGLF YCMWMQDKPL LQEELGRTIS QLVHAFQTTE AQHLFLQAFW
110 120 130 140 150
QTMNREWTGI DRLRLDKFYM LMRMVLNESL KVLKMQGWEE RQIEELLELL
160 170 180 190 200
MTEILHPSSQ APNGVKSHFI EIFLEELTKV GAEELTADQN LKFIDPFCRI
210 220 230 240 250
AARTKDSLVL NNITRGIFET IVEQAPLAIE DLLNELDTQD EEVASDSDES
260 270 280 290 300
SEGGERGDAL SQKRSEKPPA GSICRAEPEA GEEQAGDDRD SGGPVLQFDY
310 320 330 340 350
EAVANRLFEM ASRQSTPSQN RKRLYKVIRK LQDLAGGIFP EDEIPEKACR
360 370 380 390 400
RLLEGRRQKK TKKQKRLLRL QQERGKGEKE PPSPGMERKR SRRRGVGADP
410 420 430 440 450
EARAEAGEQP GTAERALLRD QPRGRGQRGA RQRRRTPRPL TSARAKAANV
460
QEPEKKKKRR E
Length:461
Mass (Da):52,839
Last modified:November 1, 1997 - v1
Checksum:iC6F204EF4161AEAE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti194 – 1941I → V.
Corresponds to variant rs34224504 [ dbSNP | Ensembl ].
VAR_053894
Natural varianti326 – 3261K → R.1 Publication
Corresponds to variant rs915770 [ dbSNP | Ensembl ].
VAR_053895

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79775 mRNA. Translation: AAC51625.1.
AP001752 Genomic DNA. Translation: BAA95542.1.
BC000380 mRNA. Translation: AAH00380.1.
AL137757 mRNA. Translation: CAB70909.1.
CCDSiCCDS42951.1.
PIRiT46485.
RefSeqiNP_003674.1. NM_003683.5.
UniGeneiHs.110757.

Genome annotation databases

EnsembliENST00000497547; ENSP00000417464; ENSG00000160214.
GeneIDi8568.
KEGGihsa:8568.
UCSCiuc002zds.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79775 mRNA. Translation: AAC51625.1.
AP001752 Genomic DNA. Translation: BAA95542.1.
BC000380 mRNA. Translation: AAH00380.1.
AL137757 mRNA. Translation: CAB70909.1.
CCDSiCCDS42951.1.
PIRiT46485.
RefSeqiNP_003674.1. NM_003683.5.
UniGeneiHs.110757.

3D structure databases

ProteinModelPortaliP56182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114137. 27 interactions.
IntActiP56182. 8 interactions.
MINTiMINT-3021272.
STRINGi9606.ENSP00000417464.

PTM databases

iPTMnetiP56182.
PhosphoSiteiP56182.

Polymorphism and mutation databases

BioMutaiRRP1.
DMDMi2829451.

2D gel databases

SWISS-2DPAGEP56182.

Proteomic databases

EPDiP56182.
MaxQBiP56182.
PaxDbiP56182.
PeptideAtlasiP56182.
PRIDEiP56182.

Protocols and materials databases

DNASUi8568.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000497547; ENSP00000417464; ENSG00000160214.
GeneIDi8568.
KEGGihsa:8568.
UCSCiuc002zds.3. human.

Organism-specific databases

CTDi8568.
GeneCardsiRRP1.
HGNCiHGNC:18785. RRP1.
HPAiHPA016818.
HPA018166.
MIMi610653. gene.
neXtProtiNX_P56182.
PharmGKBiPA162402091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3911. Eukaryota.
ENOG4111GJ6. LUCA.
GeneTreeiENSGT00390000011821.
HOVERGENiHBG000394.
InParanoidiP56182.
KOiK14849.
OMAiVHAFQTT.
OrthoDBiEOG091G0AX5.
PhylomeDBiP56182.
TreeFamiTF315294.

Miscellaneous databases

ChiTaRSiRRP1. human.
GeneWikiiRRP1.
GenomeRNAii8568.
PROiP56182.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160214.
CleanExiHS_RRP1.
ExpressionAtlasiP56182. baseline and differential.
GenevisibleiP56182. HS.

Family and domain databases

InterProiIPR010301. Nop52.
[Graphical view]
PANTHERiPTHR13026. PTHR13026. 1 hit.
PfamiPF05997. Nop52. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRRP1_HUMAN
AccessioniPrimary (citable) accession number: P56182
Secondary accession number(s): Q9NST5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.