P56180 (TPTE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative tyrosine-protein phosphatase TPTE
EC=3.1.3.48

Alternative name(s):
Cancer/testis antigen 44
Short name=CT44
Transmembrane phosphatase with tensin homology
Tumor antigen BJ-HCC-5

Gene names

Name:

TPTE

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Could be involved in signal transduction.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Exclusively expressed in testis. Ref.1
Sequence similarities	Contains 1 C2 tensin-type domain. Contains 1 phosphatase tensin-type domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	ion channel activity Inferred from electronic annotation. Source: InterPro protein tyrosine phosphatase activity Traceable author statement Ref.1. Source: ProtInc protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P56180-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P56180-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     41-58: Missing.

Isoform 3 (identifier: P56180-3)

Also known as: Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     41-78: Missing.

Isoform 4 (identifier: P56180-4)

Also known as: Delta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 551	551	Putative tyrosine-protein phosphatase TPTE		PRO_0000215907
Regions
	Transmembrane	91 – 111	21	Helical; Potential
	Transmembrane	128 – 148	21	Helical; Potential
	Transmembrane	164 – 184	21	Helical; Potential
	Domain	228 – 404	177	Phosphatase tensin-type
	Domain	411 – 540	130	C2 tensin-type
Sites
	Active site	338	1	Potential
Natural variations
	Alternative sequence	1 – 138	138	Missing in isoform 4.		VSP_017319
	Alternative sequence	41 – 78	38	Missing in isoform 3.		VSP_017320
	Alternative sequence	41 – 58	18	Missing in isoform 2.		VSP_017321
	Natural variant	144	1	R → Q in a breast cancer sample; somatic mutation. Ref.7		VAR_036516
	Natural variant	195	1	R → Q. Corresponds to variant rs1810856 [ dbSNP | Ensembl ].		VAR_057347
	Natural variant	386	1	K → E. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6 Corresponds to variant rs212146 [ dbSNP | Ensembl ].		VAR_065097
	Natural variant	470	1	L → P. Ref.1 Ref.2 Ref.6 Corresponds to variant rs150482 [ dbSNP | Ensembl ].		VAR_025400
	Natural variant	482	1	Y → S. Corresponds to variant rs9996 [ dbSNP | Ensembl ].		VAR_061895
	Natural variant	549	1	G → E. Corresponds to variant rs169758 [ dbSNP | Ensembl ].		VAR_057348

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha) [UniParc]. Last modified November 30, 2010. Version 3. Checksum: 48C2F28BEAA0DDA6	FASTA	551	64,322
	10 20 30 40 50 60 MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES PHTSEFKGAA RVSPISESVL 70 80 90 100 110 120 ARLSKFEVED AENVASYDSK IKKIVHSIVS SFAFGLFGVF LVLLDVTLIL ADLIFTDSKL 130 140 150 160 170 180 YIPLEYRSIS LAIALFFLMD VLLRVFVERR QQYFSDLFNI LDTAIIVILL LVDVVYIFFD 190 200 210 220 230 240 IKLLRNIPRW THLLRLLRLI ILLRIFHLFH QKRQLEKLIR RRVSENKRRY TRDGFDLDLT 250 260 270 280 290 300 YVTERIIAMS FPSSGRQSFY RNPIKEVVRF LDKKHRNHYR VYNLCSERAY DPKHFHNRVV 310 320 330 340 350 360 RIMIDDHNVP TLHQMVVFTK EVNEWMAQDL ENIVAIHCKG GTDRTGTMVC AFLIASEICS 370 380 390 400 410 420 TAKESLYYFG ERRTDKTHSE KFQGVKTPSQ KRYVAYFAQV KHLYNWNLPP RRILFIKHFI 430 440 450 460 470 480 IYSIPRYVRD LKIQIEMEKK VVFSTISLGK CSVLDNITTD KILIDVFDGL PLYDDVKVQF 490 500 510 520 530 540 FYSNLPTYYD NCSFYFWLHT SFIENNRLYL PKNELDNLHK QKARRIYPSD FAVEILFGEK 550 MTSSDVVAGS D
	Isoform 2 (Beta) [UniParc]. Checksum: AE2268E2EAABE825	FASTA	533	62,440
	10 20 30 40 50 60 MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES VLARLSKFEV EDAENVASYD 70 80 90 100 110 120 SKIKKIVHSI VSSFAFGLFG VFLVLLDVTL ILADLIFTDS KLYIPLEYRS ISLAIALFFL 130 140 150 160 170 180 MDVLLRVFVE RRQQYFSDLF NILDTAIIVI LLLVDVVYIF FDIKLLRNIP RWTHLLRLLR 190 200 210 220 230 240 LIILLRIFHL FHQKRQLEKL IRRRVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS 250 260 270 280 290 300 FYRNPIKEVV RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VVRIMIDDHN VPTLHQMVVF 310 320 330 340 350 360 TKEVNEWMAQ DLENIVAIHC KGGTDRTGTM VCAFLIASEI CSTAKESLYY FGERRTDKTH 370 380 390 400 410 420 SEKFQGVKTP SQKRYVAYFA QVKHLYNWNL PPRRILFIKH FIIYSIPRYV RDLKIQIEME 430 440 450 460 470 480 KKVVFSTISL GKCSVLDNIT TDKILIDVFD GLPLYDDVKV QFFYSNLPTY YDNCSFYFWL 490 500 510 520 530 HTSFIENNRL YLPKNELDNL HKQKARRIYP SDFAVEILFG EKMTSSDVVA GSD
	Isoform 3 (Gamma) [UniParc]. Checksum: 7F1EE9541DA13348	FASTA	513	60,203
	10 20 30 40 50 60 MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES SKIKKIVHSI VSSFAFGLFG 70 80 90 100 110 120 VFLVLLDVTL ILADLIFTDS KLYIPLEYRS ISLAIALFFL MDVLLRVFVE RRQQYFSDLF 130 140 150 160 170 180 NILDTAIIVI LLLVDVVYIF FDIKLLRNIP RWTHLLRLLR LIILLRIFHL FHQKRQLEKL 190 200 210 220 230 240 IRRRVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS FYRNPIKEVV RFLDKKHRNH 250 260 270 280 290 300 YRVYNLCSER AYDPKHFHNR VVRIMIDDHN VPTLHQMVVF TKEVNEWMAQ DLENIVAIHC 310 320 330 340 350 360 KGGTDRTGTM VCAFLIASEI CSTAKESLYY FGERRTDKTH SEKFQGVKTP SQKRYVAYFA 370 380 390 400 410 420 QVKHLYNWNL PPRRILFIKH FIIYSIPRYV RDLKIQIEME KKVVFSTISL GKCSVLDNIT 430 440 450 460 470 480 TDKILIDVFD GLPLYDDVKV QFFYSNLPTY YDNCSFYFWL HTSFIENNRL YLPKNELDNL 490 500 510 HKQKARRIYP SDFAVEILFG EKMTSSDVVA GSD
	Isoform 4 (Delta) [UniParc]. Checksum: A32CAAF888C73104	FASTA	413	49,344
	10 20 30 40 50 60 MDVLLRVFVE RRQQYFSDLF NILDTAIIVI LLLVDVVYIF FDIKLLRNIP RWTHLLRLLR 70 80 90 100 110 120 LIILLRIFHL FHQKRQLEKL IRRRVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS 130 140 150 160 170 180 FYRNPIKEVV RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VVRIMIDDHN VPTLHQMVVF 190 200 210 220 230 240 TKEVNEWMAQ DLENIVAIHC KGGTDRTGTM VCAFLIASEI CSTAKESLYY FGERRTDKTH 250 260 270 280 290 300 SEKFQGVKTP SQKRYVAYFA QVKHLYNWNL PPRRILFIKH FIIYSIPRYV RDLKIQIEME 310 320 330 340 350 360 KKVVFSTISL GKCSVLDNIT TDKILIDVFD GLPLYDDVKV QFFYSNLPTY YDNCSFYFWL 370 380 390 400 410 HTSFIENNRL YLPKNELDNL HKQKARRIYP SDFAVEILFG EKMTSSDVVA GSD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y." Chen H., Rossier C., Morris M.A., Scott H.S., Gos A., Bairoch A., Antonarakis S.E. Hum. Genet. 105:399-409(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS GLU-386 AND PRO-470. Tissue: Testis.
[2]	"The TPTE gene family: cellular expression, subcellular localization and alternative splicing." Tapparel C., Reymond A., Girardet C., Guillou L., Lyle R., Lamon C., Hutter P., Antonarakis S.E. Gene 323:189-199(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), VARIANTS GLU-386 AND PRO-470.
[3]	"Cloning and identification of genes which are differentially expressed in hepatocellular carcinoma." Dong X.-Y., Chen W.-F. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLU-386. Tissue: Hepatoma.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-386. Tissue: Testis.
[5]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLU-386 AND PRO-470. Tissue: Testis.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-144.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF007118 mRNA. Translation: AAC34574.1. AY219886 mRNA. Translation: AAP45143.1. AY219887 mRNA. Translation: AAP45144.1. AY219888 mRNA. Translation: AAP45145.1. AF495908 mRNA. Translation: AAQ06674.1. AK314285 mRNA. Translation: BAG36944.1. AF254982 Genomic DNA. No translation available. AF254983 Genomic DNA. No translation available. AL078471 Genomic DNA. No translation available. AL163201 Genomic DNA. Translation: CAB90528.1. BC028719 mRNA. Translation: AAH28719.1.
IPI	IPI00215913. IPI00413147. IPI00414275. IPI00952568.
RefSeq	NP_954868.1. NM_199259.2. NP_954869.1. NM_199260.2. NP_954870.2. NM_199261.2.
UniGene	Hs.122986.
3D structure databases
ProteinModelPortal	P56180.
SMR	P56180. Positions 226-539.
ModBase	Search...
Protein-protein interaction databases
IntAct	P56180. 1 interaction.
STRING	9606.ENSP00000355208.
PTM databases
PhosphoSite	P56180.
Polymorphism databases
DMDM	160331915.
Proteomic databases
PaxDb	P56180.
PRIDE	P56180.
Protocols and materials databases
DNASU	7179.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298232; ENSP00000298232; ENSG00000166157. ENST00000342420; ENSP00000344441; ENSG00000166157. ENST00000361285; ENSP00000355208; ENSG00000166157.
GeneID	7179.
KEGG	hsa:7179.
UCSC	uc002yip.1. human. uc002yiq.1. human. uc002yir.1. human.
Organism-specific databases
CTD	7179.
GeneCards	GC21M010906.
HGNC	HGNC:12023. TPTE.
MIM	604336. gene.
neXtProt	NX_P56180.
PharmGKB	PA36702.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2453.
HOVERGEN	HBG084209.
KO	K01104.
OrthoDB	EOG45756J.
PhylomeDB	P56180.
Gene expression databases
ArrayExpress	P56180.
Bgee	P56180.
CleanEx	HS_TPTE.
Genevestigator	P56180.
GermOnline	ENSG00000166157. Homo sapiens.
Family and domain databases
InterPro	IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR000340. Dual-sp_phosphatase_cat-dom. IPR005821. Ion_trans_dom. IPR014019. Phosphatase_tensin-typ. IPR014020. Tensin_phosphatase_C2-dom. IPR016130. Tyr_Pase_AS. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. PF00520. Ion_trans. 1 hit. PF10409. PTEN_C2. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit.
PROSITE	PS51182. C2_TENSIN. 1 hit. PS51181. PPASE_TENSIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7179.
NextBio	28140.
SOURCE	Search...

Entry information

Entry name

TPTE_HUMAN

Accession

Primary (citable) accession number: P56180
Secondary accession number(s): B2RAP7 , C9J6D6, C9JKK8, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.