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P56180 (TPTE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative tyrosine-protein phosphatase TPTE

EC=3.1.3.48
Alternative name(s):
Cancer/testis antigen 44
Short name=CT44
Transmembrane phosphatase with tensin homology
Tumor antigen BJ-HCC-5
Gene names
Name:TPTE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could be involved in signal transduction.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Exclusively expressed in testis. Ref.1

Sequence similarities

Contains 1 C2 tensin-type domain.

Contains 1 phosphatase tensin-type domain.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P56180-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P56180-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     41-58: Missing.
Isoform 3 (identifier: P56180-3)

Also known as: Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     41-78: Missing.
Isoform 4 (identifier: P56180-4)

Also known as: Delta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Putative tyrosine-protein phosphatase TPTE
PRO_0000215907

Regions

Transmembrane91 – 11121Helical; Potential
Transmembrane128 – 14821Helical; Potential
Transmembrane164 – 18421Helical; Potential
Domain228 – 404177Phosphatase tensin-type
Domain411 – 540130C2 tensin-type

Sites

Active site3381 Potential

Natural variations

Alternative sequence1 – 138138Missing in isoform 4.
VSP_017319
Alternative sequence41 – 7838Missing in isoform 3.
VSP_017320
Alternative sequence41 – 5818Missing in isoform 2.
VSP_017321
Natural variant1441R → Q in a breast cancer sample; somatic mutation. Ref.7
VAR_036516
Natural variant1951R → Q.
Corresponds to variant rs1810856 [ dbSNP | Ensembl ].
VAR_057347
Natural variant3861K → E. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6
Corresponds to variant rs212146 [ dbSNP | Ensembl ].
VAR_065097
Natural variant4701L → P. Ref.1 Ref.2 Ref.6
Corresponds to variant rs150482 [ dbSNP | Ensembl ].
VAR_025400
Natural variant4821Y → S.
Corresponds to variant rs9996 [ dbSNP | Ensembl ].
VAR_061895
Natural variant5491G → E.
Corresponds to variant rs169758 [ dbSNP | Ensembl ].
VAR_057348

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Alpha) [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: 48C2F28BEAA0DDA6

FASTA55164,322
        10         20         30         40         50         60 
MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES PHTSEFKGAA RVSPISESVL 

        70         80         90        100        110        120 
ARLSKFEVED AENVASYDSK IKKIVHSIVS SFAFGLFGVF LVLLDVTLIL ADLIFTDSKL 

       130        140        150        160        170        180 
YIPLEYRSIS LAIALFFLMD VLLRVFVERR QQYFSDLFNI LDTAIIVILL LVDVVYIFFD 

       190        200        210        220        230        240 
IKLLRNIPRW THLLRLLRLI ILLRIFHLFH QKRQLEKLIR RRVSENKRRY TRDGFDLDLT 

       250        260        270        280        290        300 
YVTERIIAMS FPSSGRQSFY RNPIKEVVRF LDKKHRNHYR VYNLCSERAY DPKHFHNRVV 

       310        320        330        340        350        360 
RIMIDDHNVP TLHQMVVFTK EVNEWMAQDL ENIVAIHCKG GTDRTGTMVC AFLIASEICS 

       370        380        390        400        410        420 
TAKESLYYFG ERRTDKTHSE KFQGVKTPSQ KRYVAYFAQV KHLYNWNLPP RRILFIKHFI 

       430        440        450        460        470        480 
IYSIPRYVRD LKIQIEMEKK VVFSTISLGK CSVLDNITTD KILIDVFDGL PLYDDVKVQF 

       490        500        510        520        530        540 
FYSNLPTYYD NCSFYFWLHT SFIENNRLYL PKNELDNLHK QKARRIYPSD FAVEILFGEK 

       550 
MTSSDVVAGS D 

« Hide

Isoform 2 (Beta) [UniParc].

Checksum: AE2268E2EAABE825
Show »

FASTA53362,440
Isoform 3 (Gamma) [UniParc].

Checksum: 7F1EE9541DA13348
Show »

FASTA51360,203
Isoform 4 (Delta) [UniParc].

Checksum: A32CAAF888C73104
Show »

FASTA41349,344

References

« Hide 'large scale' references
[1]"A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y."
Chen H., Rossier C., Morris M.A., Scott H.S., Gos A., Bairoch A., Antonarakis S.E.
Hum. Genet. 105:399-409(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS GLU-386 AND PRO-470.
Tissue: Testis.
[2]"The TPTE gene family: cellular expression, subcellular localization and alternative splicing."
Tapparel C., Reymond A., Girardet C., Guillou L., Lyle R., Lamon C., Hutter P., Antonarakis S.E.
Gene 323:189-199(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), VARIANTS GLU-386 AND PRO-470.
[3]"Cloning and identification of genes which are differentially expressed in hepatocellular carcinoma."
Dong X.-Y., Chen W.-F.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLU-386.
Tissue: Hepatoma.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-386.
Tissue: Testis.
[5]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLU-386 AND PRO-470.
Tissue: Testis.
[7]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-144.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007118 mRNA. Translation: AAC34574.1.
AY219886 mRNA. Translation: AAP45143.1.
AY219887 mRNA. Translation: AAP45144.1.
AY219888 mRNA. Translation: AAP45145.1.
AF495908 mRNA. Translation: AAQ06674.1.
AK314285 mRNA. Translation: BAG36944.1.
AF254982 Genomic DNA. No translation available.
AF254983 Genomic DNA. No translation available.
AL078471 Genomic DNA. No translation available.
AL163201 Genomic DNA. Translation: CAB90528.1.
BC028719 mRNA. Translation: AAH28719.1.
CCDSCCDS13560.2. [P56180-1]
CCDS33511.1. [P56180-3]
CCDS33512.1. [P56180-2]
RefSeqNP_001277153.1. NM_001290224.1.
NP_954868.1. NM_199259.3.
NP_954869.1. NM_199260.3.
NP_954870.2. NM_199261.3.
UniGeneHs.122986.

3D structure databases

ProteinModelPortalP56180.
SMRP56180. Positions 85-206, 226-539.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113031. 2 interactions.
IntActP56180. 1 interaction.
STRING9606.ENSP00000355208.

PTM databases

PhosphoSiteP56180.

Polymorphism databases

DMDM313104272.

Proteomic databases

PaxDbP56180.
PRIDEP56180.

Protocols and materials databases

DNASU7179.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298232; ENSP00000298232; ENSG00000166157. [P56180-2]
ENST00000342420; ENSP00000344441; ENSG00000166157. [P56180-3]
ENST00000361285; ENSP00000355208; ENSG00000166157. [P56180-1]
GeneID7179.
KEGGhsa:7179.
UCSCuc002yip.1. human. [P56180-1]
uc002yiq.1. human. [P56180-2]
uc002yir.1. human. [P56180-3]

Organism-specific databases

CTD7179.
GeneCardsGC21M010906.
HGNCHGNC:12023. TPTE.
HPAHPA049690.
MIM604336. gene.
neXtProtNX_P56180.
PharmGKBPA36702.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2453.
HOVERGENHBG084209.
KOK18079.
OMASEICSTA.
OrthoDBEOG7R2BJ5.
PhylomeDBP56180.
TreeFamTF354329.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressP56180.
BgeeP56180.
CleanExHS_TPTE.
GenevestigatorP56180.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR000008. C2_dom.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR005821. Ion_trans_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF00782. DSPc. 1 hit.
PF00520. Ion_trans. 1 hit.
PF10409. PTEN_C2. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTPTE.
GenomeRNAi7179.
NextBio28140.
PROP56180.
SOURCESearch...

Entry information

Entry nameTPTE_HUMAN
AccessionPrimary (citable) accession number: P56180
Secondary accession number(s): B2RAP7 expand/collapse secondary AC list , C9J6D6, C9JKK8, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM