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Protein

Putative tyrosine-protein phosphatase TPTE

Gene

TPTE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Could be involved in signal transduction.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei338 – 3381Sequence Analysis

GO - Molecular functioni

GO - Biological processi

  • peptidyl-tyrosine dephosphorylation Source: GOC
  • protein dephosphorylation Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_120836. Synthesis of PIPs at the Golgi membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tyrosine-protein phosphatase TPTE (EC:3.1.3.48)
Alternative name(s):
Cancer/testis antigen 44
Short name:
CT44
Transmembrane phosphatase with tensin homology
Tumor antigen BJ-HCC-5
Gene namesi
Name:TPTE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:12023. TPTE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence AnalysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36702.

Polymorphism and mutation databases

BioMutaiTPTE.
DMDMi313104272.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Putative tyrosine-protein phosphatase TPTEPRO_0000215907Add
BLAST

Proteomic databases

PaxDbiP56180.
PRIDEiP56180.

PTM databases

DEPODiP56180.
PhosphoSiteiP56180.

Expressioni

Tissue specificityi

Exclusively expressed in testis.1 Publication

Gene expression databases

BgeeiP56180.
CleanExiHS_TPTE.
ExpressionAtlasiP56180. baseline.
GenevisibleiP56180. HS.

Organism-specific databases

HPAiHPA049690.

Interactioni

Protein-protein interaction databases

BioGridi113031. 2 interactions.
IntActiP56180. 1 interaction.
STRINGi9606.ENSP00000355208.

Structurei

3D structure databases

ProteinModelPortaliP56180.
SMRiP56180. Positions 85-206, 226-539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini228 – 404177Phosphatase tensin-typePROSITE-ProRule annotationAdd
BLAST
Domaini411 – 540130C2 tensin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 tensin-type domain.PROSITE-ProRule annotation
Contains 1 phosphatase tensin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000119113.
HOVERGENiHBG084209.
InParanoidiP56180.
KOiK18079.
OrthoDBiEOG7R2BJ5.
PhylomeDBiP56180.
TreeFamiTF354329.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR005821. Ion_trans_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
PF00520. Ion_trans. 1 hit.
PF10409. PTEN_C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P56180-1) [UniParc]FASTAAdd to basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES PHTSEFKGAA
60 70 80 90 100
RVSPISESVL ARLSKFEVED AENVASYDSK IKKIVHSIVS SFAFGLFGVF
110 120 130 140 150
LVLLDVTLIL ADLIFTDSKL YIPLEYRSIS LAIALFFLMD VLLRVFVERR
160 170 180 190 200
QQYFSDLFNI LDTAIIVILL LVDVVYIFFD IKLLRNIPRW THLLRLLRLI
210 220 230 240 250
ILLRIFHLFH QKRQLEKLIR RRVSENKRRY TRDGFDLDLT YVTERIIAMS
260 270 280 290 300
FPSSGRQSFY RNPIKEVVRF LDKKHRNHYR VYNLCSERAY DPKHFHNRVV
310 320 330 340 350
RIMIDDHNVP TLHQMVVFTK EVNEWMAQDL ENIVAIHCKG GTDRTGTMVC
360 370 380 390 400
AFLIASEICS TAKESLYYFG ERRTDKTHSE KFQGVKTPSQ KRYVAYFAQV
410 420 430 440 450
KHLYNWNLPP RRILFIKHFI IYSIPRYVRD LKIQIEMEKK VVFSTISLGK
460 470 480 490 500
CSVLDNITTD KILIDVFDGL PLYDDVKVQF FYSNLPTYYD NCSFYFWLHT
510 520 530 540 550
SFIENNRLYL PKNELDNLHK QKARRIYPSD FAVEILFGEK MTSSDVVAGS

D
Length:551
Mass (Da):64,322
Last modified:November 30, 2010 - v3
Checksum:i48C2F28BEAA0DDA6
GO
Isoform 2 (identifier: P56180-2) [UniParc]FASTAAdd to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     41-58: Missing.

Show »
Length:533
Mass (Da):62,440
Checksum:iAE2268E2EAABE825
GO
Isoform 3 (identifier: P56180-3) [UniParc]FASTAAdd to basket

Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     41-78: Missing.

Show »
Length:513
Mass (Da):60,203
Checksum:i7F1EE9541DA13348
GO
Isoform 4 (identifier: P56180-4) [UniParc]FASTAAdd to basket

Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:413
Mass (Da):49,344
Checksum:iA32CAAF888C73104
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti144 – 1441R → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_036516
Natural varianti195 – 1951R → Q.
Corresponds to variant rs1810856 [ dbSNP | Ensembl ].
VAR_057347
Natural varianti386 – 3861K → E.5 Publications
Corresponds to variant rs212146 [ dbSNP | Ensembl ].
VAR_065097
Natural varianti470 – 4701L → P.3 Publications
Corresponds to variant rs150482 [ dbSNP | Ensembl ].
VAR_025400
Natural varianti482 – 4821Y → S.
Corresponds to variant rs9996 [ dbSNP | Ensembl ].
VAR_061895
Natural varianti549 – 5491G → E.
Corresponds to variant rs169758 [ dbSNP | Ensembl ].
VAR_057348

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 138138Missing in isoform 4. 1 PublicationVSP_017319Add
BLAST
Alternative sequencei41 – 7838Missing in isoform 3. 1 PublicationVSP_017320Add
BLAST
Alternative sequencei41 – 5818Missing in isoform 2. 3 PublicationsVSP_017321Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007118 mRNA. Translation: AAC34574.1.
AY219886 mRNA. Translation: AAP45143.1.
AY219887 mRNA. Translation: AAP45144.1.
AY219888 mRNA. Translation: AAP45145.1.
AF495908 mRNA. Translation: AAQ06674.1.
AK314285 mRNA. Translation: BAG36944.1.
AF254982 Genomic DNA. No translation available.
AF254983 Genomic DNA. No translation available.
AL078471 Genomic DNA. No translation available.
AL163201 Genomic DNA. Translation: CAB90528.1.
BC028719 mRNA. Translation: AAH28719.1.
CCDSiCCDS74771.1. [P56180-1]
CCDS74772.1. [P56180-2]
CCDS74773.1. [P56180-3]
CCDS77617.1. [P56180-4]
RefSeqiNP_001277153.1. NM_001290224.1.
NP_954868.1. NM_199259.3.
NP_954869.1. NM_199260.3.
NP_954870.2. NM_199261.3.
UniGeneiHs.122986.

Genome annotation databases

EnsembliENST00000427445; ENSP00000482488; ENSG00000274391. [P56180-3]
ENST00000612746; ENSP00000483087; ENSG00000274391. [P56180-4]
ENST00000618007; ENSP00000484403; ENSG00000274391.
ENST00000622113; ENSP00000482040; ENSG00000274391. [P56180-2]
GeneIDi7179.
KEGGihsa:7179.
UCSCiuc002yip.1. human. [P56180-1]
uc002yiq.1. human. [P56180-2]
uc002yir.1. human. [P56180-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007118 mRNA. Translation: AAC34574.1.
AY219886 mRNA. Translation: AAP45143.1.
AY219887 mRNA. Translation: AAP45144.1.
AY219888 mRNA. Translation: AAP45145.1.
AF495908 mRNA. Translation: AAQ06674.1.
AK314285 mRNA. Translation: BAG36944.1.
AF254982 Genomic DNA. No translation available.
AF254983 Genomic DNA. No translation available.
AL078471 Genomic DNA. No translation available.
AL163201 Genomic DNA. Translation: CAB90528.1.
BC028719 mRNA. Translation: AAH28719.1.
CCDSiCCDS74771.1. [P56180-1]
CCDS74772.1. [P56180-2]
CCDS74773.1. [P56180-3]
CCDS77617.1. [P56180-4]
RefSeqiNP_001277153.1. NM_001290224.1.
NP_954868.1. NM_199259.3.
NP_954869.1. NM_199260.3.
NP_954870.2. NM_199261.3.
UniGeneiHs.122986.

3D structure databases

ProteinModelPortaliP56180.
SMRiP56180. Positions 85-206, 226-539.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113031. 2 interactions.
IntActiP56180. 1 interaction.
STRINGi9606.ENSP00000355208.

PTM databases

DEPODiP56180.
PhosphoSiteiP56180.

Polymorphism and mutation databases

BioMutaiTPTE.
DMDMi313104272.

Proteomic databases

PaxDbiP56180.
PRIDEiP56180.

Protocols and materials databases

DNASUi7179.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427445; ENSP00000482488; ENSG00000274391. [P56180-3]
ENST00000612746; ENSP00000483087; ENSG00000274391. [P56180-4]
ENST00000618007; ENSP00000484403; ENSG00000274391.
ENST00000622113; ENSP00000482040; ENSG00000274391. [P56180-2]
GeneIDi7179.
KEGGihsa:7179.
UCSCiuc002yip.1. human. [P56180-1]
uc002yiq.1. human. [P56180-2]
uc002yir.1. human. [P56180-3]

Organism-specific databases

CTDi7179.
GeneCardsiGC21M010906.
HGNCiHGNC:12023. TPTE.
HPAiHPA049690.
MIMi604336. gene.
neXtProtiNX_P56180.
PharmGKBiPA36702.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000119113.
HOVERGENiHBG084209.
InParanoidiP56180.
KOiK18079.
OrthoDBiEOG7R2BJ5.
PhylomeDBiP56180.
TreeFamiTF354329.

Enzyme and pathway databases

ReactomeiREACT_120836. Synthesis of PIPs at the Golgi membrane.

Miscellaneous databases

GeneWikiiTPTE.
GenomeRNAii7179.
NextBioi28140.
PROiP56180.
SOURCEiSearch...

Gene expression databases

BgeeiP56180.
CleanExiHS_TPTE.
ExpressionAtlasiP56180. baseline.
GenevisibleiP56180. HS.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR005821. Ion_trans_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
PF00520. Ion_trans. 1 hit.
PF10409. PTEN_C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y."
    Chen H., Rossier C., Morris M.A., Scott H.S., Gos A., Bairoch A., Antonarakis S.E.
    Hum. Genet. 105:399-409(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS GLU-386 AND PRO-470.
    Tissue: Testis.
  2. "The TPTE gene family: cellular expression, subcellular localization and alternative splicing."
    Tapparel C., Reymond A., Girardet C., Guillou L., Lyle R., Lamon C., Hutter P., Antonarakis S.E.
    Gene 323:189-199(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), VARIANTS GLU-386 AND PRO-470.
  3. "Cloning and identification of genes which are differentially expressed in hepatocellular carcinoma."
    Dong X.-Y., Chen W.-F.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLU-386.
    Tissue: Hepatoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-386.
    Tissue: Testis.
  5. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLU-386 AND PRO-470.
    Tissue: Testis.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-144.

Entry informationi

Entry nameiTPTE_HUMAN
AccessioniPrimary (citable) accession number: P56180
Secondary accession number(s): B2RAP7
, C9J6D6, C9JKK8, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 30, 2010
Last modified: July 22, 2015
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.