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P56180

- TPTE_HUMAN

UniProt

P56180 - TPTE_HUMAN

Protein

Putative tyrosine-protein phosphatase TPTE

Gene

TPTE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Could be involved in signal transduction.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei338 – 3381Sequence Analysis

    GO - Molecular functioni

    1. ion channel activity Source: InterPro
    2. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
    3. protein tyrosine phosphatase activity Source: ProtInc

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: GOC
    2. protein dephosphorylation Source: ProtInc
    3. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    ReactomeiREACT_120836. Synthesis of PIPs at the Golgi membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative tyrosine-protein phosphatase TPTE (EC:3.1.3.48)
    Alternative name(s):
    Cancer/testis antigen 44
    Short name:
    CT44
    Transmembrane phosphatase with tensin homology
    Tumor antigen BJ-HCC-5
    Gene namesi
    Name:TPTE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:12023. TPTE.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36702.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Putative tyrosine-protein phosphatase TPTEPRO_0000215907Add
    BLAST

    Proteomic databases

    PaxDbiP56180.
    PRIDEiP56180.

    PTM databases

    PhosphoSiteiP56180.

    Expressioni

    Tissue specificityi

    Exclusively expressed in testis.1 Publication

    Gene expression databases

    ArrayExpressiP56180.
    BgeeiP56180.
    CleanExiHS_TPTE.
    GenevestigatoriP56180.

    Organism-specific databases

    HPAiHPA049690.

    Interactioni

    Protein-protein interaction databases

    BioGridi113031. 3 interactions.
    IntActiP56180. 1 interaction.
    STRINGi9606.ENSP00000355208.

    Structurei

    3D structure databases

    ProteinModelPortaliP56180.
    SMRiP56180. Positions 85-206, 226-539.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini228 – 404177Phosphatase tensin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini411 – 540130C2 tensin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C2 tensin-type domain.PROSITE-ProRule annotation
    Contains 1 phosphatase tensin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2453.
    HOVERGENiHBG084209.
    KOiK18079.
    OMAiSEICSTA.
    OrthoDBiEOG7R2BJ5.
    PhylomeDBiP56180.
    TreeFamiTF354329.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR005821. Ion_trans_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR014020. Tensin_C2-dom.
    IPR029023. Tensin_lipid_phosphatase_dom.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PfamiPF00782. DSPc. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF10409. PTEN_C2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF52799. SSF52799. 1 hit.
    PROSITEiPS51182. C2_TENSIN. 1 hit.
    PS51181. PPASE_TENSIN. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P56180-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES PHTSEFKGAA    50
    RVSPISESVL ARLSKFEVED AENVASYDSK IKKIVHSIVS SFAFGLFGVF 100
    LVLLDVTLIL ADLIFTDSKL YIPLEYRSIS LAIALFFLMD VLLRVFVERR 150
    QQYFSDLFNI LDTAIIVILL LVDVVYIFFD IKLLRNIPRW THLLRLLRLI 200
    ILLRIFHLFH QKRQLEKLIR RRVSENKRRY TRDGFDLDLT YVTERIIAMS 250
    FPSSGRQSFY RNPIKEVVRF LDKKHRNHYR VYNLCSERAY DPKHFHNRVV 300
    RIMIDDHNVP TLHQMVVFTK EVNEWMAQDL ENIVAIHCKG GTDRTGTMVC 350
    AFLIASEICS TAKESLYYFG ERRTDKTHSE KFQGVKTPSQ KRYVAYFAQV 400
    KHLYNWNLPP RRILFIKHFI IYSIPRYVRD LKIQIEMEKK VVFSTISLGK 450
    CSVLDNITTD KILIDVFDGL PLYDDVKVQF FYSNLPTYYD NCSFYFWLHT 500
    SFIENNRLYL PKNELDNLHK QKARRIYPSD FAVEILFGEK MTSSDVVAGS 550
    D 551
    Length:551
    Mass (Da):64,322
    Last modified:November 30, 2010 - v3
    Checksum:i48C2F28BEAA0DDA6
    GO
    Isoform 2 (identifier: P56180-2) [UniParc]FASTAAdd to Basket

    Also known as: Beta

    The sequence of this isoform differs from the canonical sequence as follows:
         41-58: Missing.

    Show »
    Length:533
    Mass (Da):62,440
    Checksum:iAE2268E2EAABE825
    GO
    Isoform 3 (identifier: P56180-3) [UniParc]FASTAAdd to Basket

    Also known as: Gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         41-78: Missing.

    Show »
    Length:513
    Mass (Da):60,203
    Checksum:i7F1EE9541DA13348
    GO
    Isoform 4 (identifier: P56180-4) [UniParc]FASTAAdd to Basket

    Also known as: Delta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-138: Missing.

    Show »
    Length:413
    Mass (Da):49,344
    Checksum:iA32CAAF888C73104
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti144 – 1441R → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036516
    Natural varianti195 – 1951R → Q.
    Corresponds to variant rs1810856 [ dbSNP | Ensembl ].
    VAR_057347
    Natural varianti386 – 3861K → E.5 Publications
    Corresponds to variant rs212146 [ dbSNP | Ensembl ].
    VAR_065097
    Natural varianti470 – 4701L → P.3 Publications
    Corresponds to variant rs150482 [ dbSNP | Ensembl ].
    VAR_025400
    Natural varianti482 – 4821Y → S.
    Corresponds to variant rs9996 [ dbSNP | Ensembl ].
    VAR_061895
    Natural varianti549 – 5491G → E.
    Corresponds to variant rs169758 [ dbSNP | Ensembl ].
    VAR_057348

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 138138Missing in isoform 4. 1 PublicationVSP_017319Add
    BLAST
    Alternative sequencei41 – 7838Missing in isoform 3. 1 PublicationVSP_017320Add
    BLAST
    Alternative sequencei41 – 5818Missing in isoform 2. 3 PublicationsVSP_017321Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007118 mRNA. Translation: AAC34574.1.
    AY219886 mRNA. Translation: AAP45143.1.
    AY219887 mRNA. Translation: AAP45144.1.
    AY219888 mRNA. Translation: AAP45145.1.
    AF495908 mRNA. Translation: AAQ06674.1.
    AK314285 mRNA. Translation: BAG36944.1.
    AF254982 Genomic DNA. No translation available.
    AF254983 Genomic DNA. No translation available.
    AL078471 Genomic DNA. No translation available.
    AL163201 Genomic DNA. Translation: CAB90528.1.
    BC028719 mRNA. Translation: AAH28719.1.
    CCDSiCCDS13560.2. [P56180-1]
    CCDS33511.1. [P56180-3]
    CCDS33512.1. [P56180-2]
    RefSeqiNP_001277153.1. NM_001290224.1.
    NP_954868.1. NM_199259.3.
    NP_954869.1. NM_199260.3.
    NP_954870.2. NM_199261.3.
    UniGeneiHs.122986.

    Genome annotation databases

    GeneIDi7179.
    KEGGihsa:7179.
    UCSCiuc002yip.1. human. [P56180-1]
    uc002yiq.1. human. [P56180-2]
    uc002yir.1. human. [P56180-3]

    Polymorphism databases

    DMDMi313104272.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007118 mRNA. Translation: AAC34574.1 .
    AY219886 mRNA. Translation: AAP45143.1 .
    AY219887 mRNA. Translation: AAP45144.1 .
    AY219888 mRNA. Translation: AAP45145.1 .
    AF495908 mRNA. Translation: AAQ06674.1 .
    AK314285 mRNA. Translation: BAG36944.1 .
    AF254982 Genomic DNA. No translation available.
    AF254983 Genomic DNA. No translation available.
    AL078471 Genomic DNA. No translation available.
    AL163201 Genomic DNA. Translation: CAB90528.1 .
    BC028719 mRNA. Translation: AAH28719.1 .
    CCDSi CCDS13560.2. [P56180-1 ]
    CCDS33511.1. [P56180-3 ]
    CCDS33512.1. [P56180-2 ]
    RefSeqi NP_001277153.1. NM_001290224.1.
    NP_954868.1. NM_199259.3.
    NP_954869.1. NM_199260.3.
    NP_954870.2. NM_199261.3.
    UniGenei Hs.122986.

    3D structure databases

    ProteinModelPortali P56180.
    SMRi P56180. Positions 85-206, 226-539.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113031. 3 interactions.
    IntActi P56180. 1 interaction.
    STRINGi 9606.ENSP00000355208.

    PTM databases

    PhosphoSitei P56180.

    Polymorphism databases

    DMDMi 313104272.

    Proteomic databases

    PaxDbi P56180.
    PRIDEi P56180.

    Protocols and materials databases

    DNASUi 7179.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7179.
    KEGGi hsa:7179.
    UCSCi uc002yip.1. human. [P56180-1 ]
    uc002yiq.1. human. [P56180-2 ]
    uc002yir.1. human. [P56180-3 ]

    Organism-specific databases

    CTDi 7179.
    GeneCardsi GC21M010906.
    HGNCi HGNC:12023. TPTE.
    HPAi HPA049690.
    MIMi 604336. gene.
    neXtProti NX_P56180.
    PharmGKBi PA36702.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2453.
    HOVERGENi HBG084209.
    KOi K18079.
    OMAi SEICSTA.
    OrthoDBi EOG7R2BJ5.
    PhylomeDBi P56180.
    TreeFami TF354329.

    Enzyme and pathway databases

    Reactomei REACT_120836. Synthesis of PIPs at the Golgi membrane.

    Miscellaneous databases

    GeneWikii TPTE.
    GenomeRNAii 7179.
    NextBioi 28140.
    PROi P56180.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56180.
    Bgeei P56180.
    CleanExi HS_TPTE.
    Genevestigatori P56180.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR005821. Ion_trans_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR014020. Tensin_C2-dom.
    IPR029023. Tensin_lipid_phosphatase_dom.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    Pfami PF00782. DSPc. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF10409. PTEN_C2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF52799. SSF52799. 1 hit.
    PROSITEi PS51182. C2_TENSIN. 1 hit.
    PS51181. PPASE_TENSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y."
      Chen H., Rossier C., Morris M.A., Scott H.S., Gos A., Bairoch A., Antonarakis S.E.
      Hum. Genet. 105:399-409(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS GLU-386 AND PRO-470.
      Tissue: Testis.
    2. "The TPTE gene family: cellular expression, subcellular localization and alternative splicing."
      Tapparel C., Reymond A., Girardet C., Guillou L., Lyle R., Lamon C., Hutter P., Antonarakis S.E.
      Gene 323:189-199(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), VARIANTS GLU-386 AND PRO-470.
    3. "Cloning and identification of genes which are differentially expressed in hepatocellular carcinoma."
      Dong X.-Y., Chen W.-F.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLU-386.
      Tissue: Hepatoma.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-386.
      Tissue: Testis.
    5. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLU-386 AND PRO-470.
      Tissue: Testis.
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-144.

    Entry informationi

    Entry nameiTPTE_HUMAN
    AccessioniPrimary (citable) accession number: P56180
    Secondary accession number(s): B2RAP7
    , C9J6D6, C9JKK8, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3