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Protein

Homeobox protein DLX-6

Gene

DLX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi49 – 108HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-8939902 Regulation of RUNX2 expression and activity

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-6
Gene namesi
Name:DLX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000006377.10
HGNCiHGNC:2919 DLX6
MIMi600030 gene
neXtProtiNX_P56179

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1750
MalaCardsiDLX6
OpenTargetsiENSG00000006377
PharmGKBiPA27374

Polymorphism and mutation databases

DMDMi12644330

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490341 – 175Homeobox protein DLX-6Add BLAST175

Proteomic databases

PaxDbiP56179
PeptideAtlasiP56179
PRIDEiP56179

PTM databases

iPTMnetiP56179
PhosphoSitePlusiP56179

Expressioni

Developmental stagei

First expressed in embryos at 8.5-9 days in facial and branchial arch mesenchyme, otic vesicles and frontonasal ectoderm around olfactory placodes, a day later expression is seen in the developing forebrain in primordia of the ganglionic eminence and ventral diencephalic regions. In day 12.5 embryos, expressed in the brain and bones, and also in all skeletal structures of midgestation embryos after the first cartilage formation, and expression progressively declines in both brain and skeleton in day 15 embryos.

Gene expression databases

BgeeiENSG00000006377
CleanExiHS_DLX6
ExpressionAtlasiP56179 baseline and differential
GenevisibleiP56179 HS

Organism-specific databases

HPAiHPA030608
HPA061460

Interactioni

Protein-protein interaction databases

BioGridi108094, 20 interactors
IntActiP56179, 1 interactor
STRINGi9606.ENSP00000428480

Structurei

3D structure databases

ProteinModelPortaliP56179
SMRiP56179
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0850 Eukaryota
ENOG410ZHZR LUCA
GeneTreeiENSGT00910000143987
HOGENOMiHOG000231941
HOVERGENiHBG005493
InParanoidiP56179
KOiK09314
OMAiHQDSMQR
OrthoDBiEOG091G0P17
PhylomeDBiP56179
TreeFamiTF315720

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P56179-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHSQHSPYL QSYHNSSAAA QTRGDDTDQQ KTTVIENGEI RFNGKGKKIR
60 70 80 90 100
KPRTIYSSLQ LQALNHRFQQ TQYLALPERA ELAASLGLTQ TQVKIWFQNK
110 120 130 140 150
RSKFKKLLKQ GSNPHESDPL QGSAALSPRS PALPPVWDVS ASAKGVSMPP
160 170
NSYMPGYSHW YSSPHQDTMQ RPQMM
Length:175
Mass (Da):19,708
Last modified:January 11, 2001 - v2
Checksum:iF5552738D7E0CB84
GO
Isoform 2 (identifier: P56179-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMTMTTMADG...HRSLAAYPYM

Show »
Length:265
Mass (Da):29,387
Checksum:iEBCA7528A559B068
GO
Isoform 3 (identifier: P56179-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMTMTTMADG...HRSLAAYPYM

Show »
Length:293
Mass (Da):32,582
Checksum:i89F34C88E4C4E44F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0407321M → MMTMTTMADGLEGQDSSKSA FMEFGQQQQQQHSPAMAGAH YPLHCLHSAAAAAAAGSHHH HHHQHHHHGSPYASGGGNSY NHRSLAAYPYM in isoform 2. Curated1
Alternative sequenceiVSP_0472481M → MMTMTTMADGLEGQDSSKSA FMEFGQQQQQQQQQQQQQQQ QQQQPPPPPPPPPQPHSQQS SPAMAGAHYPLHCLHSAAAA AAAGSHHHHHHQHHHHGSPY ASGGGNSYNHRSLAAYPYM in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004774 Genomic DNA Translation: AAC17832.1
CH236949 Genomic DNA Translation: EAL24122.1
CH471091 Genomic DNA Translation: EAW76744.1
BC069363 mRNA Translation: AAH69363.1
BC103688 mRNA Translation: AAI03689.1
BC103689 mRNA Translation: AAI03690.1
BC103690 mRNA Translation: AAI03691.1
BC109381 mRNA Translation: AAI09382.1
AK094086 mRNA Translation: BAG52812.1
CCDSiCCDS47647.2 [P56179-3]
PIRiD53495
RefSeqiNP_005213.3, NM_005222.3 [P56179-3]
UniGeneiHs.249196

Genome annotation databases

EnsembliENST00000518156; ENSP00000428480; ENSG00000006377 [P56179-3]
GeneIDi1750
KEGGihsa:1750
UCSCiuc022ahu.2 human [P56179-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDLX6_HUMAN
AccessioniPrimary (citable) accession number: P56179
Secondary accession number(s): A4D1I2
, B3KSQ0, J3KR92, Q3ZAR6, Q9UPL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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