Reviewed, UniProtKB/Swiss-Prot P56175 (RCL1_DROME)

Names and origin

Protein names

Recommended name:
    Probable RNA 3'-terminal phosphate cyclase-like protein

Gene names

Name:	Rtc1
Synonyms:	RCL1, RTC2
ORF Names:	CG11130

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Probable RNA 3'-terminal phosphate cyclase-like protein		PRO_0000156440
Experimental info
	Sequence conflict	165 – 168	4	PLGG → SAGR in M15898. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P56175-1 [UniParc]. Last modified February 2, 2004. Version 3. Checksum: 2B1E35D144C1CFAE	FASTA	384	42,091
	10 20 30 40 50 60 MPPIAQEGNC LIYRGSNFLK QRLILACLSG KPVKISQIRS EDETAPGLRE YEISLIRLLD 70 80 90 100 110 120 KITNGTKIEL NPAGTSVMFS PGLLHGGQLN HDCCVQRGIG YYLDALIALG PFCKSPLQCT 130 140 150 160 170 180 LRGVTNSKDS PSVDHIKGAA LSLLKRFLLV DEGLELKVVR RGVAPLGGGE IIFRCPVRKS 190 200 210 220 230 240 LRAIQFQSQG MVKRIRGTVY ACKVSPAMAN RTVEAAKGCM LKFLPDVYIY TDQNKGKMSG 250 260 270 280 290 300 NSPGFGICLI AETTDGVCFA ADCCSNTREE SEDTPSIPEN LGKEVALRLL DEIYRGGCVD 310 320 330 340 350 360 SSYQWLAALY IALGQKHVSK FLTGALSNYT VHFLQHLRDF FSITFKLENP EAEDEDEAEN 370 380 VRGAQKVLMA CVGIGYTNIN KRVI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[4]	"Sequence homologies among the three yolk polypeptide (Yp) genes in Drosophila melanogaster." Yan Y.L., Kunert C.J., Postlethwait J.H. Nucleic Acids Res. 15:67-85(1987) [PubMed: 3029679] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-384.
[5]	"The nucleotide sequence of the gene coding for Drosophila melanogaster yolk protein 3." Garabedian M.J., Shirras A.D., Bownes M., Wensink P.C. Gene 55:1-8(1987) [PubMed: 3114046] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-384.
[6]	"The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea." Genschik P., Billy E., Swianiewicz M., Filipowicz W. EMBO J. 16:2955-2967(1997) [PubMed: 9184239] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014298 Genomic DNA. Translation: AAF48313.2. AY058762 mRNA. Translation: AAL13991.1. X04754 Genomic DNA. Translation: CAB55765.1. M15898 Genomic DNA. No translation available.
RefSeq	NP_572919.1.
3D structure databases
SMR	P56175. Positions 14-349.
ModBase	Search...
Protein-protein interaction databases
STRING	P56175.
Genome annotation databases
Ensembl	FBtr0073820; FBpp0073651; FBgn0020909; Drosophila melanogaster. [Genome view]
GeneID	32338.
KEGG	dme:Dmel_CG11130.
NMPDR	fig|7227.3.peg.17749.
UCSC	CG11130-RA. d. melanogaster.
Organism-specific databases
CTD	32338.
FlyBase	FBgn0020909. Rtc1.
Phylogenomic databases
eggNOG	inNOG05510.
InParanoid	P56175.
OMA	CPVRKVL.
OrthoDB	EOG9DBTNK.
PhylomeDB	P56175.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-001801-MONOMER.
Gene expression databases
Bgee	P56175.
GermOnline	CG11130. Drosophila melanogaster.
Family and domain databases
InterPro	IPR000228. RNA3'_term_phos_cycl-like. IPR020719. RNA3'_term_phos_cycl-like_CS. IPR016443. RNA3'_term_phos_cycl-like_euk. IPR013796. RNA3'_term_phos_cycl_insert. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.20. RNA3'_term_phos_cycl. 1 hit.
PANTHER	PTHR11096. RNA3'_term_phos_cycl. 1 hit.
Pfam	PF01137. RTC. 1 hit. PF05189. RTC_insert. 1 hit. [Graphical view]
PIRSF	PIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
TIGRFAMs	TIGR03400. 18S_RNA_Rcl1p. 1 hit.
PROSITE	PS01287. RTC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	777999.

Entry information

Entry name

RCL1_DROME

Accession

Primary (citable) accession number: P56175
Secondary accession number(s): Q95TH8, Q9VY90

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 2, 2004
Last modified:	February 9, 2010
This is version 77 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project