P56166 (MPA53_PHAAQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Major pollen allergen Pha a 5.3 Alternative name(s): Allergen Pha a 5 Allergen=Pha a 5.3
Organism	Phalaris aquatica (Canary grass)
Taxonomic identifier	28479 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Pooideae › Poeae › Phalaridinae › Phalaris

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Allergenic properties	Causes an allergic reaction in human. Causes grass pollen allergy.
Sequence similarities	Belongs to the Poa p IX/Phl p VI allergen family.

Ontologies

Keywords
Disease	Allergen
Domain	Signal
Gene Ontology (GO)
Biological_process	type I hypersensitivity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 294	269	Major pollen allergen Pha a 5.3		PRO_0000021741

Sequences

	Sequence		Length	Mass (Da)
	P56166 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 9DFC541079C1CC00	FASTA	294	30,345
	10 20 30 40 50 60 MAVQKYTVAL FLAMALVAGP AASYAADAGT PPTPATPAVP GAAAGKATTH EQKLIEDINA 70 80 90 100 110 120 AFKWWPASAP PADKYKTFET AFSKANIAGA STKGLDAAYS VVYNTAAGAT PEAKYDSFVT 130 140 150 160 170 180 ALTEALRIMA GTLEVHAVKP ATEEEVPSAK ILRANSRSST RSSRFKIAAT VATPLSHSTA 190 200 210 220 230 240 ANSAPANDKF TVFEGAFNKA IKERHGGPTE TYKFIPSLEA AVKQAYGATV ARAPEVKYAV 250 260 270 280 290 FEAGLTKAIT AMSEAQKVAK PVRLSPQPPQ VLPLAAGGAA TVAAASDSRG GYKV

References

[1]	"Cloning, sequencing and expression in Escherichia coli of Pha a 1 and four isoforms of Pha a 5, the major allergens of canary grass pollen." Suphioglu C., Singh M.B. Clin. Exp. Allergy 25:853-865(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Pollen.

Cross-references

3D structure databases
ProteinModelPortal	P56166.
SMR	P56166. Positions 47-138, 187-260.
ModBase	Search...
Protein family/group databases
Allergome	548. Pha a 5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Gramene	P56166.
Family and domain databases
Gene3D	1.20.120.320. 2 hits.
InterPro	IPR001778. POA_allergen. IPR002914. POA_allergen_N. [Graphical view]
Pfam	PF01620. Pollen_allerg_2. 2 hits. [Graphical view]
PRINTS	PR00833. POAALLERGEN.
SUPFAM	SSF81736. POA_allergen_N. 2 hits.
ProtoNet	Search...

Entry information

Entry name

MPA53_PHAAQ

Accession

Primary (citable) accession number: P56166

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program