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P56161 (ACES_ANOST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetylcholinesterase

Short name=AChE
EC=3.1.1.7
OrganismAnopheles stephensi (Indo-Pakistan malaria mosquito)
Taxonomic identifier30069 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Protein attributes

Sequence length664 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine.

Catalytic activity

Acetylcholine + H2O = choline + acetate.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Cell junctionsynapse. Cell membrane; Lipid-anchorGPI-anchor. Note: Attached to the membrane of the neuronal cholinergic synapses by a GPI-anchor.

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 647618Acetylcholinesterase
PRO_0000008600
Propeptide648 – 66417Removed in mature form Potential
PRO_0000008601

Sites

Active site2611Acyl-ester intermediate By similarity
Active site3901Charge relay system By similarity
Active site5041Charge relay system By similarity

Amino acid modifications

Lipidation6471GPI-anchor amidated asparagine Potential
Glycosylation1171N-linked (GlcNAc...) By similarity
Glycosylation3161N-linked (GlcNAc...) By similarity
Glycosylation5171N-linked (GlcNAc...) By similarity
Disulfide bond95 ↔ 122 By similarity
Disulfide bond315 ↔ 330 By similarity
Disulfide bond466 ↔ 588 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56161 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 0BFBF9414F8020C7

FASTA66474,629
        10         20         30         40         50         60 
MFVNQRTRRP YMSVFVLVLG AAVICPAYGI IDRLVVQTSS GPIRGRSTMV QGREVHVFNG 

        70         80         90        100        110        120 
VPFAKPPVDS LRFKKPVPAE PWHGVLDATR LPPSCIQERY EYFPGFAGEE MWNPNTNVSE 

       130        140        150        160        170        180 
DCLYLNIWVP TKTRLRHGRG LNFGSNDYFQ DDDDFQRQHQ SKGGLAMLVW IYGGGFMSGT 

       190        200        210        220        230        240 
STLDIYNAEI LAAVGNVIVA SMQYRVGAFG FLYLAPYING YEEDAPGNMG MWDQALAIRW 

       250        260        270        280        290        300 
LKENAKAFGG DPDLITLFGE SAGGSSVSLH LLSPVTRGLS KRGILQSGTL NAPWSHMTAE 

       310        320        330        340        350        360 
KALQIAEGLI DDCNCNLTML KESPSTVMQC MRNVDAKTIS VQQWNSYSGI LGFPSAPTID 

       370        380        390        400        410        420 
GVFMTADPMT MLREANLEGI DILVGSNRDE GTYFLLYDFI DYFEKDAATS LPRDKFLEIM 

       430        440        450        460        470        480 
NTIFNKASEP EREAIIFQYT GWESGNDGYQ NQHQVGRAVG DHFFICPTNE FALGLTERGA 

       490        500        510        520        530        540 
SVHYYYFTHR TSTSLWGEWM GVLHGDEVEY IFGQPMNASL QYRQRERDLS RRMVLSVSEF 

       550        560        570        580        590        600 
ARTGNPALEG EHWPLYTREN PIFFIFNAEG EDDLRGEKYG RGPMATSCAF WNDFLPRLRA 

       610        620        630        640        650        660 
WSVPSKSPCN LLEQMSIASV SSTMPIVVMV VLVLIPLCAW WWAIKKNKTP PHPQVILETR 


AFMH 

« Hide

References

[1]"The acetylcholinesterase gene of Anopheles stephensi."
Hall L.M.C., Malcolm C.A.
Cell. Mol. Neurobiol. 11:131-141(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

3D structure databases

ProteinModelPortalP56161.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.979.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001445. Acylcholinesterase_insect.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSPR00880. ACHEINSECT.
PR00878. CHOLNESTRASE.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACES_ANOST
AccessionPrimary (citable) accession number: P56161
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families