SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P56161

- ACES_ANOST

UniProt

P56161 - ACES_ANOST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Acetylcholinesterase

Gene
N/A
Organism
Anopheles stephensi (Indo-Pakistan malaria mosquito)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine.

Catalytic activityi

Acetylcholine + H2O = choline + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei261 – 2611Acyl-ester intermediate By similarity
Active sitei390 – 3901Charge relay system By similarity
Active sitei504 – 5041Charge relay system By similarity

GO - Molecular functioni

  1. acetylcholinesterase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetylcholine catabolic process in synaptic cleft Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Keywords - Biological processi

Neurotransmitter degradation

Protein family/group databases

MEROPSiS09.979.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholinesterase (EC:3.1.1.7)
Short name:
AChE
OrganismiAnopheles stephensi (Indo-Pakistan malaria mosquito)
Taxonomic identifieri30069 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Subcellular locationi

Cell junctionsynapse. Cell membrane; Lipid-anchorGPI-anchor
Note: Attached to the membrane of the neuronal cholinergic synapses by a GPI-anchor.

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell junction Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
  4. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Chaini30 – 647618AcetylcholinesterasePRO_0000008600Add
BLAST
Propeptidei648 – 66417Removed in mature form Reviewed predictionPRO_0000008601Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi95 ↔ 122 By similarity
Glycosylationi117 – 1171N-linked (GlcNAc...) By similarity
Disulfide bondi315 ↔ 330 By similarity
Glycosylationi316 – 3161N-linked (GlcNAc...) By similarity
Disulfide bondi466 ↔ 588 By similarity
Glycosylationi517 – 5171N-linked (GlcNAc...) By similarity
Lipidationi647 – 6471GPI-anchor amidated asparagine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Structurei

3D structure databases

ProteinModelPortaliP56161.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001445. Acylcholinesterase_insect.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00880. ACHEINSECT.
PR00878. CHOLNESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56161-1 [UniParc]FASTAAdd to Basket

« Hide

MFVNQRTRRP YMSVFVLVLG AAVICPAYGI IDRLVVQTSS GPIRGRSTMV    50
QGREVHVFNG VPFAKPPVDS LRFKKPVPAE PWHGVLDATR LPPSCIQERY 100
EYFPGFAGEE MWNPNTNVSE DCLYLNIWVP TKTRLRHGRG LNFGSNDYFQ 150
DDDDFQRQHQ SKGGLAMLVW IYGGGFMSGT STLDIYNAEI LAAVGNVIVA 200
SMQYRVGAFG FLYLAPYING YEEDAPGNMG MWDQALAIRW LKENAKAFGG 250
DPDLITLFGE SAGGSSVSLH LLSPVTRGLS KRGILQSGTL NAPWSHMTAE 300
KALQIAEGLI DDCNCNLTML KESPSTVMQC MRNVDAKTIS VQQWNSYSGI 350
LGFPSAPTID GVFMTADPMT MLREANLEGI DILVGSNRDE GTYFLLYDFI 400
DYFEKDAATS LPRDKFLEIM NTIFNKASEP EREAIIFQYT GWESGNDGYQ 450
NQHQVGRAVG DHFFICPTNE FALGLTERGA SVHYYYFTHR TSTSLWGEWM 500
GVLHGDEVEY IFGQPMNASL QYRQRERDLS RRMVLSVSEF ARTGNPALEG 550
EHWPLYTREN PIFFIFNAEG EDDLRGEKYG RGPMATSCAF WNDFLPRLRA 600
WSVPSKSPCN LLEQMSIASV SSTMPIVVMV VLVLIPLCAW WWAIKKNKTP 650
PHPQVILETR AFMH 664
Length:664
Mass (Da):74,629
Last modified:November 1, 1997 - v1
Checksum:i0BFBF9414F8020C7
GO

Cross-referencesi

3D structure databases

ProteinModelPortali P56161.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.979.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001445. Acylcholinesterase_insect.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view ]
Pfami PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR00880. ACHEINSECT.
PR00878. CHOLNESTRASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The acetylcholinesterase gene of Anopheles stephensi."
    Hall L.M.C., Malcolm C.A.
    Cell. Mol. Neurobiol. 11:131-141(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiACES_ANOST
AccessioniPrimary (citable) accession number: P56161
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi