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P56156 (CLPP_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease proteolytic subunit
EC=3.4.21.92
Alternative name(s):
Endopeptidase Clp
Gene names
Name:clpP
Ordered Locus Names:HP_0794
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444

Catalytic activity

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444

Subcellular location

Cytoplasm By similarity HAMAP MF_00444.

Sequence similarities

Belongs to the peptidase S14 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
Protease
Serine protease
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196ATP-dependent Clp protease proteolytic subunit HAMAP MF_00444
PRO_0000179568

Sites

Active site991 By similarity
Active site1241 By similarity

Secondary structure

1 ............................. 196
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P56156 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 4E19BE5FE44656B0

FASTA19621,526
        10         20         30         40         50         60 
MMGYIPYVIE NTDRGERSYD IYSRLLKDRI VLLSGEINDS VASSIVAQLL FLEAEDPEKD 

        70         80         90        100        110        120 
IGLYINSPGG VITSGLSIYD TMNFIRPDVS TICIGQAASM GAFLLSCGAK GKRFSLPHSR 

       130        140        150        160        170        180 
IMIHQPLGGA QGQASDIEII SNEILRLKGL MNSILAQNSG QSLEQIAKDT DRDFYMSAKE 

       190 
AKEYGLIDKV LQKNVK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000511 Genomic DNA. Translation: AAD07842.1.
PIRB64619.
RefSeqNP_207587.1. NC_000915.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZL0X-ray2.60A/B/C/D/E/F/G/H/I/J/K/L/M/N1-196[»]
2ZL2X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N1-196[»]
2ZL3X-ray2.81A/B/C/D/E/F/G/H/I/J/K/L/M/N1-196[»]
2ZL4X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N1-196[»]
ProteinModelPortalP56156.
SMRP56156. Positions 20-193.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-3357N.
MINTMINT-179817.

Protein family/group databases

MEROPSS14.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID898920.
GenomeReviewsGene locus HP_0794 in contig AE000511_GR.
KEGGhpy:HP0794.
PATRIC20592875. VBIHelPyl33062_0826.
TIGRHP_0794.

Phylogenomic databases

HOGENOMHBG558421.
OMACTICIGL.
ProtClustDBPRK00277.

Family and domain databases

HAMAPMF_00444. ClpP.
[Tree]
InterProIPR023562. Pept_S14/S49.
IPR001907. Pept_S14_ClpP.
IPR018215. Pept_S14_ClpP_AS.
[Graphical view]
KOK01358.
PANTHERPTHR10381. Pept_S14_ClpP. 1 hit.
PfamPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSPR00127. CLPPROTEASEP.
TIGRFAMsTIGR00493. ClpP. 1 hit.
PROSITEPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCLPP_HELPY
AccessionPrimary (citable) accession number: P56156
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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