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Protein

ATP-dependent Clp protease proteolytic subunit

Gene

clpP

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99NucleophileUniRule annotation1
Active sitei124UniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciHPY:HP0794-MONOMER.

Protein family/group databases

MEROPSiS14.001.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase ClpUniRule annotation
Gene namesi
Name:clpPUniRule annotation
Ordered Locus Names:HP_0794
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001795681 – 196ATP-dependent Clp protease proteolytic subunitAdd BLAST196

Proteomic databases

PaxDbiP56156.

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3357N.
IntActiP56156. 1 interactor.
MINTiMINT-179817.
STRINGi85962.HP0794.

Structurei

Secondary structure

1196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 26Combined sources6
Turni27 – 29Combined sources3
Beta strandi30 – 35Combined sources6
Helixi39 – 55Combined sources17
Beta strandi57 – 59Combined sources3
Beta strandi61 – 67Combined sources7
Helixi72 – 84Combined sources13
Beta strandi85 – 87Combined sources3
Beta strandi89 – 98Combined sources10
Helixi100 – 105Combined sources6
Beta strandi113 – 115Combined sources3
Beta strandi120 – 123Combined sources4
Beta strandi127 – 133Combined sources7
Helixi134 – 159Combined sources26
Helixi163 – 169Combined sources7
Beta strandi174 – 177Combined sources4
Helixi178 – 183Combined sources6
Beta strandi188 – 190Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZL0X-ray2.60A/B/C/D/E/F/G/H/I/J/K/L/M/N1-196[»]
2ZL2X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N1-196[»]
2ZL3X-ray2.81A/B/C/D/E/F/G/H/I/J/K/L/M/N1-196[»]
2ZL4X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N1-196[»]
ProteinModelPortaliP56156.
SMRiP56156.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56156.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCQ. Bacteria.
COG0740. LUCA.
KOiK01358.
OMAiARMNELM.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP. 1 hit.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR033135. ClpP_His_AS.
IPR018215. ClpP_Ser_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00493. clpP. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGYIPYVIE NTDRGERSYD IYSRLLKDRI VLLSGEINDS VASSIVAQLL
60 70 80 90 100
FLEAEDPEKD IGLYINSPGG VITSGLSIYD TMNFIRPDVS TICIGQAASM
110 120 130 140 150
GAFLLSCGAK GKRFSLPHSR IMIHQPLGGA QGQASDIEII SNEILRLKGL
160 170 180 190
MNSILAQNSG QSLEQIAKDT DRDFYMSAKE AKEYGLIDKV LQKNVK
Length:196
Mass (Da):21,526
Last modified:November 1, 1997 - v1
Checksum:i4E19BE5FE44656B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07842.1.
PIRiB64619.
RefSeqiNP_207587.1. NC_000915.1.
WP_001853304.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD07842; AAD07842; HP_0794.
GeneIDi898920.
KEGGihpy:HP0794.
PATRICi20592875. VBIHelPyl33062_0826.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07842.1.
PIRiB64619.
RefSeqiNP_207587.1. NC_000915.1.
WP_001853304.1. NC_000915.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZL0X-ray2.60A/B/C/D/E/F/G/H/I/J/K/L/M/N1-196[»]
2ZL2X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N1-196[»]
2ZL3X-ray2.81A/B/C/D/E/F/G/H/I/J/K/L/M/N1-196[»]
2ZL4X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N1-196[»]
ProteinModelPortaliP56156.
SMRiP56156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3357N.
IntActiP56156. 1 interactor.
MINTiMINT-179817.
STRINGi85962.HP0794.

Protein family/group databases

MEROPSiS14.001.

Proteomic databases

PaxDbiP56156.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07842; AAD07842; HP_0794.
GeneIDi898920.
KEGGihpy:HP0794.
PATRICi20592875. VBIHelPyl33062_0826.

Phylogenomic databases

eggNOGiENOG4105CCQ. Bacteria.
COG0740. LUCA.
KOiK01358.
OMAiARMNELM.

Enzyme and pathway databases

BioCyciHPY:HP0794-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP56156.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP. 1 hit.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR033135. ClpP_His_AS.
IPR018215. ClpP_Ser_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00493. clpP. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLPP_HELPY
AccessioniPrimary (citable) accession number: P56156
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.