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P56155

- PYRF_HELPY

UniProt

P56155 - PYRF_HELPY

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei8 – 81SubstrateUniRule annotation
    Binding sitei30 – 301SubstrateUniRule annotation
    Active sitei61 – 611Proton donorUniRule annotation
    Binding sitei118 – 1181SubstrateUniRule annotation
    Binding sitei178 – 1781SubstrateUniRule annotation
    Binding sitei187 – 1871SubstrateUniRule annotation
    Binding sitei207 – 2071Substrate; via amide nitrogenUniRule annotation
    Binding sitei208 – 2081SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciHPY:HP0005-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:HP_0005
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Orotidine 5'-phosphate decarboxylasePRO_0000134547Add
    BLAST

    Proteomic databases

    PRIDEiP56155.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    DIPiDIP-3056N.
    IntActiP56155. 16 interactions.
    MINTiMINT-163476.
    STRINGi85962.HP0005.

    Structurei

    3D structure databases

    ProteinModelPortaliP56155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni59 – 6810Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    KOiK01591.
    OMAiHAKEPRE.
    OrthoDBiEOG6N6815.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56155-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLCVALDLE KKEDNLSLLQ ELKGLDLWAK VGLRSFIRDG AVFLDEIRKI    50
    DENFKIFLDL KLYDIPYTMA NAALECAKLD IDMLTVHLSS AKSALTALMQ 100
    RLNALKKRPL IMGVSALTSF SEEEFLMVYN APLKTQAIKL SAMGKESGID 150
    GVVCSVFESL AIKEALGKDF LTLTPGIRLD QNDKEDQERV ANAKEAKQNL 200
    SDFIVVGRPI YQAKEPREVV LELLKDC 227
    Length:227
    Mass (Da):25,384
    Last modified:November 1, 1997 - v1
    Checksum:iB798A52AD593013F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07078.1.
    PIRiE64520.
    RefSeqiNP_206807.1. NC_000915.1.
    YP_006933929.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07078; AAD07078; HP_0005.
    GeneIDi13869178.
    898802.
    KEGGiheo:C694_00025.
    hpy:HP0005.
    PATRICi20591197. VBIHelPyl33062_0005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07078.1 .
    PIRi E64520.
    RefSeqi NP_206807.1. NC_000915.1.
    YP_006933929.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3056N.
    IntActi P56155. 16 interactions.
    MINTi MINT-163476.
    STRINGi 85962.HP0005.

    Proteomic databases

    PRIDEi P56155.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07078 ; AAD07078 ; HP_0005 .
    GeneIDi 13869178.
    898802.
    KEGGi heo:C694_00025.
    hpy:HP0005.
    PATRICi 20591197. VBIHelPyl33062_0005.

    Phylogenomic databases

    eggNOGi COG0284.
    KOi K01591.
    OMAi HAKEPRE.
    OrthoDBi EOG6N6815.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci HPY:HP0005-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiPYRF_HELPY
    AccessioniPrimary (citable) accession number: P56155
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3