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P56155 (PYRF_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:HP_0005
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134547

Regions

Region59 – 6810Substrate binding By similarity

Sites

Active site611Proton donor By similarity
Binding site81Substrate By similarity
Binding site301Substrate By similarity
Binding site1181Substrate By similarity
Binding site1781Substrate By similarity
Binding site1871Substrate By similarity
Binding site2071Substrate; via amide nitrogen By similarity
Binding site2081Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P56155 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: B798A52AD593013F

FASTA22725,384
        10         20         30         40         50         60 
MQLCVALDLE KKEDNLSLLQ ELKGLDLWAK VGLRSFIRDG AVFLDEIRKI DENFKIFLDL 

        70         80         90        100        110        120 
KLYDIPYTMA NAALECAKLD IDMLTVHLSS AKSALTALMQ RLNALKKRPL IMGVSALTSF 

       130        140        150        160        170        180 
SEEEFLMVYN APLKTQAIKL SAMGKESGID GVVCSVFESL AIKEALGKDF LTLTPGIRLD 

       190        200        210        220 
QNDKEDQERV ANAKEAKQNL SDFIVVGRPI YQAKEPREVV LELLKDC 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07078.1.
PIRE64520.
RefSeqNP_206807.1. NC_000915.1.
YP_006933929.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56155.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3056N.
IntActP56155. 16 interactions.
MINTMINT-163476.
STRING85962.HP0005.

Proteomic databases

PRIDEP56155.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07078; AAD07078; HP_0005.
GeneID898802.
KEGGheo:C694_00025.
hpy:HP0005.
PATRIC20591197. VBIHelPyl33062_0005.

Phylogenomic databases

eggNOGCOG0284.
KOK01591.
OMAHAKEPRE.
OrthoDBEOG6N6815.

Enzyme and pathway databases

BioCycHPY:HP0005-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_B. OMPdecase_type1_B.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_HELPY
AccessionPrimary (citable) accession number: P56155
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names