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P56154 (PGK_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:HP_1345
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145950

Regions

Nucleotide binding357 – 3604ATP By similarity
Region29 – 313Substrate binding By similarity
Region69 – 724Substrate binding By similarity

Sites

Binding site451Substrate By similarity
Binding site1251Substrate By similarity
Binding site1581Substrate By similarity
Binding site2091ATP By similarity
Binding site3311ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P56154 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: D74B63DBAF4465D7

FASTA40244,772
        10         20         30         40         50         60 
MLAKMSFMQN VKNIQEVEVS HKRVLIRVDF NVPLDENLNI TDDTRIRESL PTIQYCIDNK 

        70         80         90        100        110        120 
AKDIILVSHL GRPKGVEEKL SLKPFLKRLE RLLNHEVVFS QNIVQLKQAL NENAPTRIFL 

       130        140        150        160        170        180 
LENIRFLRGE EENDENLAKD LASLCDVFVN DAFGTSHRKH ASTYGTAKFA PIKVSGFLLK 

       190        200        210        220        230        240 
KEIDSFYQAF NHPLRPLLLI VGGAKVSSKL TLLKNILDLI DKLIIAGAMS NTFLKALGYD 

       250        260        270        280        290        300 
VQDSSVEDAL INDALELLQS AKEKKVKVYL PIDAVTTDDI LNPKHIKISP VQDIEPKHKI 

       310        320        330        340        350        360 
ADIGPASLKL FSEVIESAPT ILWNGPLGVH EKQEFARGTT FLAHKIADTY AFSLIGGGDT 

       370        380        390        400 
IDAINRAGEK DNMSFISTGG GASLELLEGK ILPCFEVLDK RH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08386.1.
PIRA64688.
RefSeqNP_208137.1. NC_000915.1.
YP_006935266.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56154.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3617N.
IntActP56154. 1 interaction.
MINTMINT-174705.
STRING85962.HP1345.

Proteomic databases

PRIDEP56154.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08386; AAD08386; HP_1345.
GeneID13870553.
900358.
KEGGheo:C694_06940.
hpy:HP1345.
PATRIC20594075. VBIHelPyl33062_1408.

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OMAFGLADKM.
OrthoDBEOG64N9Z0.
ProtClustDBPRK00073.

Enzyme and pathway databases

BioCycHPY:HP1345-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_HELPY
AccessionPrimary (citable) accession number: P56154
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names