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P56154

- PGK_HELPY

UniProt

P56154 - PGK_HELPY

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451SubstrateBy similarity
    Binding sitei125 – 1251SubstrateBy similarity
    Binding sitei158 – 1581SubstrateBy similarity
    Binding sitei209 – 2091ATPBy similarity
    Binding sitei331 – 3311ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi357 – 3604ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1345-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:pgk
    Ordered Locus Names:HP_1345
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 402402Phosphoglycerate kinasePRO_0000145950Add
    BLAST

    Proteomic databases

    PRIDEiP56154.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3617N.
    IntActiP56154. 3 interactions.
    MINTiMINT-174705.
    STRINGi85962.HP1345.

    Structurei

    3D structure databases

    ProteinModelPortaliP56154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni29 – 313Substrate bindingBy similarity
    Regioni69 – 724Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    KOiK00927.
    OMAiDSICEND.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56154-1 [UniParc]FASTAAdd to Basket

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    MLAKMSFMQN VKNIQEVEVS HKRVLIRVDF NVPLDENLNI TDDTRIRESL    50
    PTIQYCIDNK AKDIILVSHL GRPKGVEEKL SLKPFLKRLE RLLNHEVVFS 100
    QNIVQLKQAL NENAPTRIFL LENIRFLRGE EENDENLAKD LASLCDVFVN 150
    DAFGTSHRKH ASTYGTAKFA PIKVSGFLLK KEIDSFYQAF NHPLRPLLLI 200
    VGGAKVSSKL TLLKNILDLI DKLIIAGAMS NTFLKALGYD VQDSSVEDAL 250
    INDALELLQS AKEKKVKVYL PIDAVTTDDI LNPKHIKISP VQDIEPKHKI 300
    ADIGPASLKL FSEVIESAPT ILWNGPLGVH EKQEFARGTT FLAHKIADTY 350
    AFSLIGGGDT IDAINRAGEK DNMSFISTGG GASLELLEGK ILPCFEVLDK 400
    RH 402
    Length:402
    Mass (Da):44,772
    Last modified:November 1, 1997 - v1
    Checksum:iD74B63DBAF4465D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08386.1.
    PIRiA64688.
    RefSeqiNP_208137.1. NC_000915.1.
    YP_006935266.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08386; AAD08386; HP_1345.
    GeneIDi13870553.
    900358.
    KEGGiheo:C694_06940.
    hpy:HP1345.
    PATRICi20594075. VBIHelPyl33062_1408.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08386.1 .
    PIRi A64688.
    RefSeqi NP_208137.1. NC_000915.1.
    YP_006935266.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3617N.
    IntActi P56154. 3 interactions.
    MINTi MINT-174705.
    STRINGi 85962.HP1345.

    Proteomic databases

    PRIDEi P56154.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08386 ; AAD08386 ; HP_1345 .
    GeneIDi 13870553.
    900358.
    KEGGi heo:C694_06940.
    hpy:HP1345.
    PATRICi 20594075. VBIHelPyl33062_1408.

    Phylogenomic databases

    eggNOGi COG0126.
    KOi K00927.
    OMAi DSICEND.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci HPY:HP1345-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiPGK_HELPY
    AccessioniPrimary (citable) accession number: P56154
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3