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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarityNote: Binds 4 Mg2+ ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg2+ ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg2+ ions form complexes with substrate and product.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Magnesium 1By similarity
Metal bindingi69 – 691Magnesium 1By similarity
Metal bindingi69 – 691Magnesium 2By similarity
Metal bindingi101 – 1011Magnesium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0620-MONOMER.
BRENDAi3.6.1.1. 2604.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppa
Ordered Locus Names:HP_0620
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Inorganic pyrophosphatasePRO_0000137501Add
BLAST

Proteomic databases

PaxDbiP56153.
PRIDEiP56153.

Interactioni

Protein-protein interaction databases

DIPiDIP-3464N.
IntActiP56153. 2 interactions.
MINTiMINT-163881.
STRINGi85962.HP0620.

Structurei

Secondary structure

1
173
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53Combined sources
Beta strandi14 – 218Combined sources
Beta strandi26 – 316Combined sources
Turni33 – 353Combined sources
Beta strandi38 – 436Combined sources
Beta strandi45 – 473Combined sources
Beta strandi51 – 566Combined sources
Beta strandi69 – 724Combined sources
Beta strandi83 – 9614Combined sources
Beta strandi99 – 10810Combined sources
Turni110 – 1123Combined sources
Turni115 – 1184Combined sources
Helixi122 – 1243Combined sources
Helixi127 – 13913Combined sources
Turni140 – 1434Combined sources
Beta strandi144 – 1463Combined sources
Beta strandi149 – 1568Combined sources
Helixi157 – 17115Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YGZX-ray2.60A/B/C/D/E/F1-173[»]
2BQXX-ray1.90A1-173[»]
2BQYX-ray2.30A1-173[»]
ProteinModelPortaliP56153.
SMRiP56153. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56153.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
KOiK01507.
OMAiPVALMKM.
OrthoDBiEOG6NKR4X.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLEKLEVSH DADSLCVVIE ISKHSNIKYE LDKESGALMV DRVLYGAQNY
60 70 80 90 100
PANYGFVPNT LGSDGDPVDA LVLSDVAFQA GSVVKARLVG VLNMEDESGM
110 120 130 140 150
DEKLIALPID KIDPTHSYVK DIDDLSKHTL DKIKHFFETY KDLEPNKWVK
160 170
VKGFENKESA IKVLEKAIKA YQG
Length:173
Mass (Da):19,272
Last modified:November 1, 1997 - v1
Checksum:i23A51C685A6EC7F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY153259 Genomic DNA. Translation: AAN74434.1.
AE000511 Genomic DNA. Translation: AAD07684.1.
PIRiD64597.
RefSeqiNP_207414.1. NC_000915.1.
WP_001047373.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07684; AAD07684; HP_0620.
GeneIDi898984.
KEGGiheo:C694_03210.
hpy:HP0620.
PATRICi20592521. VBIHelPyl33062_0649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY153259 Genomic DNA. Translation: AAN74434.1.
AE000511 Genomic DNA. Translation: AAD07684.1.
PIRiD64597.
RefSeqiNP_207414.1. NC_000915.1.
WP_001047373.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YGZX-ray2.60A/B/C/D/E/F1-173[»]
2BQXX-ray1.90A1-173[»]
2BQYX-ray2.30A1-173[»]
ProteinModelPortaliP56153.
SMRiP56153. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3464N.
IntActiP56153. 2 interactions.
MINTiMINT-163881.
STRINGi85962.HP0620.

Proteomic databases

PaxDbiP56153.
PRIDEiP56153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07684; AAD07684; HP_0620.
GeneIDi898984.
KEGGiheo:C694_03210.
hpy:HP0620.
PATRICi20592521. VBIHelPyl33062_0649.

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
KOiK01507.
OMAiPVALMKM.
OrthoDBiEOG6NKR4X.

Enzyme and pathway databases

BioCyciHPY:HP0620-MONOMER.
BRENDAi3.6.1.1. 2604.

Miscellaneous databases

EvolutionaryTraceiP56153.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Geographic partioning in Helicobacter pylori: gene pools of Spain and Peru are closely related, and distinct from those of Japan."
    Dailide G., Ogura M., Dailidiene D., Berg D.E.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PP34A2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiIPYR_HELPY
AccessioniPrimary (citable) accession number: P56153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 11, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.