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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28SubstrateUniRule annotation1
Binding sitei42SubstrateUniRule annotation1
Binding sitei54SubstrateUniRule annotation1
Metal bindingi64Magnesium 1UniRule annotation1
Metal bindingi69Magnesium 1UniRule annotation1
Metal bindingi69Magnesium 2UniRule annotation1
Metal bindingi101Magnesium 1UniRule annotation1
Binding sitei140SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0620-MONOMER.
BRENDAi3.6.1.1. 2604.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaUniRule annotation
Ordered Locus Names:HP_0620
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375011 – 173Inorganic pyrophosphataseAdd BLAST173

Proteomic databases

PaxDbiP56153.

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3464N.
IntActiP56153. 2 interactors.
MINTiMINT-163881.
STRINGi85962.HP0620.

Structurei

Secondary structure

1173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Beta strandi14 – 21Combined sources8
Beta strandi26 – 31Combined sources6
Turni33 – 35Combined sources3
Beta strandi38 – 43Combined sources6
Beta strandi45 – 47Combined sources3
Beta strandi51 – 56Combined sources6
Beta strandi69 – 72Combined sources4
Beta strandi83 – 96Combined sources14
Beta strandi99 – 108Combined sources10
Turni110 – 112Combined sources3
Turni115 – 118Combined sources4
Helixi122 – 124Combined sources3
Helixi127 – 139Combined sources13
Turni140 – 143Combined sources4
Beta strandi144 – 146Combined sources3
Beta strandi149 – 156Combined sources8
Helixi157 – 171Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YGZX-ray2.60A/B/C/D/E/F1-173[»]
2BQXX-ray1.90A1-173[»]
2BQYX-ray2.30A1-173[»]
ProteinModelPortaliP56153.
SMRiP56153.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56153.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
KOiK01507.
OMAiAVYYPAN.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLEKLEVSH DADSLCVVIE ISKHSNIKYE LDKESGALMV DRVLYGAQNY
60 70 80 90 100
PANYGFVPNT LGSDGDPVDA LVLSDVAFQA GSVVKARLVG VLNMEDESGM
110 120 130 140 150
DEKLIALPID KIDPTHSYVK DIDDLSKHTL DKIKHFFETY KDLEPNKWVK
160 170
VKGFENKESA IKVLEKAIKA YQG
Length:173
Mass (Da):19,272
Last modified:November 1, 1997 - v1
Checksum:i23A51C685A6EC7F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY153259 Genomic DNA. Translation: AAN74434.1.
AE000511 Genomic DNA. Translation: AAD07684.1.
PIRiD64597.
RefSeqiNP_207414.1. NC_000915.1.
WP_001047373.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07684; AAD07684; HP_0620.
GeneIDi898984.
KEGGiheo:C694_03210.
hpy:HP0620.
PATRICi20592521. VBIHelPyl33062_0649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY153259 Genomic DNA. Translation: AAN74434.1.
AE000511 Genomic DNA. Translation: AAD07684.1.
PIRiD64597.
RefSeqiNP_207414.1. NC_000915.1.
WP_001047373.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YGZX-ray2.60A/B/C/D/E/F1-173[»]
2BQXX-ray1.90A1-173[»]
2BQYX-ray2.30A1-173[»]
ProteinModelPortaliP56153.
SMRiP56153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3464N.
IntActiP56153. 2 interactors.
MINTiMINT-163881.
STRINGi85962.HP0620.

Proteomic databases

PaxDbiP56153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07684; AAD07684; HP_0620.
GeneIDi898984.
KEGGiheo:C694_03210.
hpy:HP0620.
PATRICi20592521. VBIHelPyl33062_0649.

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
KOiK01507.
OMAiAVYYPAN.

Enzyme and pathway databases

BioCyciHPY:HP0620-MONOMER.
BRENDAi3.6.1.1. 2604.

Miscellaneous databases

EvolutionaryTraceiP56153.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPYR_HELPY
AccessioniPrimary (citable) accession number: P56153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.