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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28SubstrateUniRule annotation1
Binding sitei42SubstrateUniRule annotation1
Binding sitei54SubstrateUniRule annotation1
Metal bindingi64Magnesium 1UniRule annotation1
Metal bindingi69Magnesium 1UniRule annotation1
Metal bindingi69Magnesium 2UniRule annotation1
Metal bindingi101Magnesium 1UniRule annotation1
Binding sitei140SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0620-MONOMER
BRENDAi3.6.1.1 2604

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaUniRule annotation
Ordered Locus Names:HP_0620
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375011 – 173Inorganic pyrophosphataseAdd BLAST173

Proteomic databases

PaxDbiP56153

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3464N
IntActiP56153, 2 interactors
MINTiP56153
STRINGi85962.HP0620

Structurei

Secondary structure

1173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Beta strandi14 – 21Combined sources8
Beta strandi26 – 31Combined sources6
Turni33 – 35Combined sources3
Beta strandi38 – 43Combined sources6
Beta strandi45 – 47Combined sources3
Beta strandi51 – 56Combined sources6
Beta strandi69 – 72Combined sources4
Beta strandi83 – 96Combined sources14
Beta strandi99 – 108Combined sources10
Turni110 – 112Combined sources3
Turni115 – 118Combined sources4
Helixi122 – 124Combined sources3
Helixi127 – 139Combined sources13
Turni140 – 143Combined sources4
Beta strandi144 – 146Combined sources3
Beta strandi149 – 156Combined sources8
Helixi157 – 171Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YGZX-ray2.60A/B/C/D/E/F1-173[»]
2BQXX-ray1.90A1-173[»]
2BQYX-ray2.30A1-173[»]
ProteinModelPortaliP56153
SMRiP56153
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56153

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F0N Bacteria
COG0221 LUCA
KOiK01507
OMAiDEPTFPG

Family and domain databases

CDDicd00412 pyrophosphatase, 1 hit
Gene3Di3.90.80.10, 1 hit
HAMAPiMF_00209 Inorganic_PPase, 1 hit
InterProiView protein in InterPro
IPR008162 Pyrophosphatase
IPR036649 Pyrophosphatase_sf
PANTHERiPTHR10286 PTHR10286, 1 hit
PfamiView protein in Pfam
PF00719 Pyrophosphatase, 1 hit
SUPFAMiSSF50324 SSF50324, 1 hit
PROSITEiView protein in PROSITE
PS00387 PPASE, 1 hit

Sequencei

Sequence statusi: Complete.

P56153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLEKLEVSH DADSLCVVIE ISKHSNIKYE LDKESGALMV DRVLYGAQNY
60 70 80 90 100
PANYGFVPNT LGSDGDPVDA LVLSDVAFQA GSVVKARLVG VLNMEDESGM
110 120 130 140 150
DEKLIALPID KIDPTHSYVK DIDDLSKHTL DKIKHFFETY KDLEPNKWVK
160 170
VKGFENKESA IKVLEKAIKA YQG
Length:173
Mass (Da):19,272
Last modified:November 1, 1997 - v1
Checksum:i23A51C685A6EC7F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY153259 Genomic DNA Translation: AAN74434.1
AE000511 Genomic DNA Translation: AAD07684.1
PIRiD64597
RefSeqiNP_207414.1, NC_000915.1
WP_001047373.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD07684; AAD07684; HP_0620
GeneIDi898984
KEGGiheo:C694_03210
hpy:HP0620
PATRICifig|85962.47.peg.669

Similar proteinsi

Entry informationi

Entry nameiIPYR_HELPY
AccessioniPrimary (citable) accession number: P56153
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health