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Protein

Aspartate ammonia-lyase

Gene

aspA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate = fumarate + NH3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciHPY:HP0649-MONOMER.
RETL1328306-WGS:GSTH-6215-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate ammonia-lyase (EC:4.3.1.1)
Short name:
Aspartase
Gene namesi
Name:aspA
Ordered Locus Names:HP_0649
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Aspartate ammonia-lyasePRO_0000161342Add
BLAST

Proteomic databases

PaxDbiP56149.
PRIDEiP56149.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

DIPiDIP-3567N.
IntActiP56149. 2 interactions.
MINTiMINT-188059.
STRINGi85962.HP0649.

Structurei

3D structure databases

ProteinModelPortaliP56149.
SMRiP56149. Positions 1-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni138 – 1403Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IJ0. Bacteria.
COG1027. LUCA.
KOiK01744.
OMAiEICENYV.
OrthoDBiEOG6V1M4M.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56149-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIEHDFIGQ MEISDEVYYG IQTLRASENF FITNDKLCSY PVFIKSFAQV
60 70 80 90 100
KKAATLANVQ LGLIDEKLKI AICHACDLLI DGKYHDQFIV DMIQGGAGTS
110 120 130 140 150
TNMNMNEVIA NLALEYMGHQ KGEYQFCHPN DHVNRSQSTN DAYPSALKIA
160 170 180 190 200
IYERLSNLVA PMKALRDAFA QKAKEFAHVI KMGRTQLQDA VPMTLGQEFE
210 220 230 240 250
TYALMVDRDI EQVLDARNWV RELNLGGTAI GTGINSHPDY RSLIEKKIQE
260 270 280 290 300
VTGRPFVMAN NLIEATQSTG AYVQVSGVLK RIAVKLSKVC NDLRLLSSGP
310 320 330 340 350
RAGLNEINLP KMQPGSSIMP GKVNPVIPEV VNQVCFAVIG NDLSVALAAE
360 370 380 390 400
GGQLQLNVFE PVIAYKLFHS FVILGRAIET LTTKCVEGIT ANEKICHDYV
410 420 430 440 450
FNSIGIVTAL NPHIGYEKSA MIAKEALKSD RSIYDIALEK KILTKEQLDD
460
IFKPENMLSP HAFKKHKD
Length:468
Mass (Da):51,981
Last modified:November 1, 1997 - v1
Checksum:i60111E869302836A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07709.1.
PIRiA64601.
RefSeqiNP_207443.1. NC_000915.1.
WP_001217520.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07709; AAD07709; HP_0649.
GeneIDi900208.
KEGGiheo:C694_03355.
hpy:HP0649.
PATRICi20592583. VBIHelPyl33062_0680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07709.1.
PIRiA64601.
RefSeqiNP_207443.1. NC_000915.1.
WP_001217520.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56149.
SMRiP56149. Positions 1-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3567N.
IntActiP56149. 2 interactions.
MINTiMINT-188059.
STRINGi85962.HP0649.

Proteomic databases

PaxDbiP56149.
PRIDEiP56149.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07709; AAD07709; HP_0649.
GeneIDi900208.
KEGGiheo:C694_03355.
hpy:HP0649.
PATRICi20592583. VBIHelPyl33062_0680.

Phylogenomic databases

eggNOGiENOG4108IJ0. Bacteria.
COG1027. LUCA.
KOiK01744.
OMAiEICENYV.
OrthoDBiEOG6V1M4M.

Enzyme and pathway databases

BioCyciHPY:HP0649-MONOMER.
RETL1328306-WGS:GSTH-6215-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiASPA_HELPY
AccessioniPrimary (citable) accession number: P56149
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 11, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.