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P56149 (ASPA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aspartate ammonia-lyase
Short name=Aspartase
EC=4.3.1.1
Gene names
Name:aspA
Ordered Locus Names:HP_0649
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate = fumarate + NH3.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

Ontologies

Keywords
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaspartate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Molecular functionaspartate ammonia-lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Aspartate ammonia-lyase
PRO_0000161342

Regions

Region138 – 1403Substrate binding By similarity

Sites

Binding site991Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P56149 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 60111E869302836A

FASTA46851,981
        10         20         30         40         50         60 
MRIEHDFIGQ MEISDEVYYG IQTLRASENF FITNDKLCSY PVFIKSFAQV KKAATLANVQ 

        70         80         90        100        110        120 
LGLIDEKLKI AICHACDLLI DGKYHDQFIV DMIQGGAGTS TNMNMNEVIA NLALEYMGHQ 

       130        140        150        160        170        180 
KGEYQFCHPN DHVNRSQSTN DAYPSALKIA IYERLSNLVA PMKALRDAFA QKAKEFAHVI 

       190        200        210        220        230        240 
KMGRTQLQDA VPMTLGQEFE TYALMVDRDI EQVLDARNWV RELNLGGTAI GTGINSHPDY 

       250        260        270        280        290        300 
RSLIEKKIQE VTGRPFVMAN NLIEATQSTG AYVQVSGVLK RIAVKLSKVC NDLRLLSSGP 

       310        320        330        340        350        360 
RAGLNEINLP KMQPGSSIMP GKVNPVIPEV VNQVCFAVIG NDLSVALAAE GGQLQLNVFE 

       370        380        390        400        410        420 
PVIAYKLFHS FVILGRAIET LTTKCVEGIT ANEKICHDYV FNSIGIVTAL NPHIGYEKSA 

       430        440        450        460 
MIAKEALKSD RSIYDIALEK KILTKEQLDD IFKPENMLSP HAFKKHKD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000511 Genomic DNA. Translation: AAD07709.1.
PIRA64601.
RefSeqNP_207443.1. NC_000915.1.

3D structure databases

ProteinModelPortalP56149.
SMRP56149. Positions 1-453.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-3567N.
MINTMINT-188059.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID900208.
GenomeReviewsGene locus HP_0649 in contig AE000511_GR.
KEGGhpy:HP0649.
NMPDRfig|85962.1.peg.641.
PATRIC20592583. VBIHelPyl33062_0680.
TIGRHP_0649.

Phylogenomic databases

HOGENOMHBG284369.
OMAEGITANE.
ProtClustDBPRK12273.

Family and domain databases

InterProIPR004708. ApsA.
IPR003031. D_crystallin.
IPR018951. Fumarase_C_C.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR024083. L-Aspartase-like_N.
IPR022761. Lyase1_N.
[Graphical view]
Gene3DG3DSA:1.10.275.10. G3DSA:1.10.275.10. 1 hit.
KOK01744.
PfamPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00839. AspA. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASPA_HELPY
AccessionPrimary (citable) accession number: P56149
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families

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