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Protein

Aspartate ammonia-lyase

Gene

aspA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate = fumarate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciHPY:HP0649-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate ammonia-lyase (EC:4.3.1.1)
Short name:
Aspartase
Gene namesi
Name:aspA
Ordered Locus Names:HP_0649
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001613421 – 468Aspartate ammonia-lyaseAdd BLAST468

Proteomic databases

PaxDbiP56149
PRIDEiP56149

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

DIPiDIP-3567N
IntActiP56149, 2 interactors
MINTiP56149
STRINGi85962.HP0649

Structurei

3D structure databases

ProteinModelPortaliP56149
SMRiP56149
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 140Substrate bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IJ0 Bacteria
COG1027 LUCA
KOiK01744
OMAiEICENYV

Family and domain databases

Gene3Di1.10.275.10, 1 hit
InterProiView protein in InterPro
IPR004708 ApsA
IPR024083 Fumarase/histidase_N
IPR018951 Fumarase_C_C
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PfamiView protein in Pfam
PF10415 FumaraseC_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00839 aspA, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

P56149-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIEHDFIGQ MEISDEVYYG IQTLRASENF FITNDKLCSY PVFIKSFAQV
60 70 80 90 100
KKAATLANVQ LGLIDEKLKI AICHACDLLI DGKYHDQFIV DMIQGGAGTS
110 120 130 140 150
TNMNMNEVIA NLALEYMGHQ KGEYQFCHPN DHVNRSQSTN DAYPSALKIA
160 170 180 190 200
IYERLSNLVA PMKALRDAFA QKAKEFAHVI KMGRTQLQDA VPMTLGQEFE
210 220 230 240 250
TYALMVDRDI EQVLDARNWV RELNLGGTAI GTGINSHPDY RSLIEKKIQE
260 270 280 290 300
VTGRPFVMAN NLIEATQSTG AYVQVSGVLK RIAVKLSKVC NDLRLLSSGP
310 320 330 340 350
RAGLNEINLP KMQPGSSIMP GKVNPVIPEV VNQVCFAVIG NDLSVALAAE
360 370 380 390 400
GGQLQLNVFE PVIAYKLFHS FVILGRAIET LTTKCVEGIT ANEKICHDYV
410 420 430 440 450
FNSIGIVTAL NPHIGYEKSA MIAKEALKSD RSIYDIALEK KILTKEQLDD
460
IFKPENMLSP HAFKKHKD
Length:468
Mass (Da):51,981
Last modified:November 1, 1997 - v1
Checksum:i60111E869302836A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07709.1
PIRiA64601
RefSeqiNP_207443.1, NC_000915.1
WP_001217520.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD07709; AAD07709; HP_0649
GeneIDi900208
KEGGiheo:C694_03355
hpy:HP0649
PATRICifig|85962.47.peg.699

Similar proteinsi

Entry informationi

Entry nameiASPA_HELPY
AccessioniPrimary (citable) accession number: P56149
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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