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P56144 (TRUA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA pseudouridine synthase A

EC=5.4.99.12
Alternative name(s):
tRNA pseudouridine(38-40) synthase
tRNA pseudouridylate synthase I
tRNA-uridine isomerase I
Gene names
Name:truA
Synonyms:hisT
Ordered Locus Names:HP_0361
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs By similarity. HAMAP-Rule MF_00171

Catalytic activity

tRNA uridine(38-40) = tRNA pseudouridine(38-40). HAMAP-Rule MF_00171

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00171

Sequence similarities

Belongs to the tRNA pseudouridine synthase TruA family.

Ontologies

Keywords
   Biological processtRNA processing
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtRNA pseudouridine synthesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

pseudouridine synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242tRNA pseudouridine synthase A HAMAP-Rule MF_00171
PRO_0000057390

Sites

Active site511Nucleophile By similarity
Binding site1071Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P56144 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 76C4093AC440B78D

FASTA24227,312
        10         20         30         40         50         60 
MRCFKATIAY DGAYFLGYAK QPNKLGVQDK IEDALNALGI KSVVIAAGRT DKGVHANNQV 

        70         80         90        100        110        120 
LSFHAPKHWN AAKLFYYLAP KLAPHIVLKK LEEKNFHARF DAQKRAYRYL LTKNLKTPFL 

       130        140        150        160        170        180 
APYIACGDYG SLDALNTALK QFTGKHDFSM FKKEGGATTN PKRTIFNAFA YKTFIIGHEC 

       190        200        210        220        230        240 
VVFKIIGDAF LRSSVRLIIQ ACVQYSLEKI TLAEIQAQIH NLKATIRTPI MANGLYLHRV 


YY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07429.1.
PIRA64565.
RefSeqNP_207159.1. NC_000915.1.
YP_006934285.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56144.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0361.

Proteomic databases

PRIDEP56144.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07429; AAD07429; HP_0361.
GeneID13869546.
900091.
KEGGheo:C694_01830.
hpy:HP0361.
PATRIC20591957. VBIHelPyl33062_0373.

Phylogenomic databases

eggNOGCOG0101.
KOK06173.
OMAHYLAPKL.
OrthoDBEOG6Z9B4R.
ProtClustDBPRK00021.

Enzyme and pathway databases

BioCycHPY:HP0361-MONOMER.

Family and domain databases

Gene3D3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPMF_00171. TruA.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERPTHR11142. PTHR11142. 1 hit.
PfamPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMSSF55120. SSF55120. 1 hit.
TIGRFAMsTIGR00071. hisT_truA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRUA_HELPY
AccessionPrimary (citable) accession number: P56144
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names