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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511NucleophileUniRule annotation
Binding sitei107 – 1071SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciHPY:HP0361-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Synonyms:hisT
Ordered Locus Names:HP_0361
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242tRNA pseudouridine synthase APRO_0000057390Add
BLAST

Proteomic databases

PRIDEiP56144.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiP56144. 3 interactions.
STRINGi85962.HP0361.

Structurei

3D structure databases

ProteinModelPortaliP56144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0101.
KOiK06173.
OMAiIRTPIMA.
OrthoDBiEOG6Z9B4R.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

Sequencei

Sequence statusi: Complete.

P56144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCFKATIAY DGAYFLGYAK QPNKLGVQDK IEDALNALGI KSVVIAAGRT
60 70 80 90 100
DKGVHANNQV LSFHAPKHWN AAKLFYYLAP KLAPHIVLKK LEEKNFHARF
110 120 130 140 150
DAQKRAYRYL LTKNLKTPFL APYIACGDYG SLDALNTALK QFTGKHDFSM
160 170 180 190 200
FKKEGGATTN PKRTIFNAFA YKTFIIGHEC VVFKIIGDAF LRSSVRLIIQ
210 220 230 240
ACVQYSLEKI TLAEIQAQIH NLKATIRTPI MANGLYLHRV YY
Length:242
Mass (Da):27,312
Last modified:November 1, 1997 - v1
Checksum:i76C4093AC440B78D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07429.1.
PIRiA64565.
RefSeqiNP_207159.1. NC_000915.1.
WP_001203260.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07429; AAD07429; HP_0361.
GeneIDi900091.
KEGGiheo:C694_01830.
hpy:HP0361.
PATRICi20591957. VBIHelPyl33062_0373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07429.1.
PIRiA64565.
RefSeqiNP_207159.1. NC_000915.1.
WP_001203260.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56144. 3 interactions.
STRINGi85962.HP0361.

Proteomic databases

PRIDEiP56144.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07429; AAD07429; HP_0361.
GeneIDi900091.
KEGGiheo:C694_01830.
hpy:HP0361.
PATRICi20591957. VBIHelPyl33062_0373.

Phylogenomic databases

eggNOGiCOG0101.
KOiK06173.
OMAiIRTPIMA.
OrthoDBiEOG6Z9B4R.

Enzyme and pathway databases

BioCyciHPY:HP0361-MONOMER.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiTRUA_HELPY
AccessioniPrimary (citable) accession number: P56144
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 22, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.