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Protein

tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG

Gene

mnmG

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166FADUniRule annotation
Nucleotide bindingi270 – 28415NADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA wobble uridine modification Source: InterPro
Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciHPY:HP0213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotation
Alternative name(s):
Glucose-inhibited division protein AUniRule annotation
Gene namesi
Name:mnmGUniRule annotation
Synonyms:gidAUniRule annotation
Ordered Locus Names:HP_0213
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGPRO_0000117112Add
BLAST

Proteomic databases

PRIDEiP56138.

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two MnmE and two MnmG subunits.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3538N.
IntActiP56138. 1 interaction.
MINTiMINT-178352.
STRINGi85962.HP0213.

Structurei

3D structure databases

ProteinModelPortaliP56138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0445.
KOiK03495.
OMAiYINGLST.
OrthoDBiEOG6W9X6J.

Family and domain databases

HAMAPiMF_00129. MnmG_GidA.
InterProiIPR004416. GidA.
IPR026904. GidA-assoc_3.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc_3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56138-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKESDILVV GGGHAGIEAS LIAAKMGARV HLITMLIDTI GLASCNPAIG
60 70 80 90 100
GLGKGHLTKE VDVLGGAMGI ITDHSGLQYR VLNASKGPAV RGTRAQIDMD
110 120 130 140 150
TYRILARNLV LNTPNLSVSQ EMTESLILEN DEVVGVTTNI NNTYRAKKVI
160 170 180 190 200
ITTGTFLKGV VHIGEHQNQN GRFGENASNS LALNLRELGF KVDRLKTGTC
210 220 230 240 250
PRVAGNSIDF EGLEEHFGDT NPPYFSYKTK DFNPTQLSCF ITYTNPITHQ
260 270 280 290 300
IIRDNFHRAP LFSGQIEGIG PRYCPSIEDK INRFSEKERH QLFLEPQTIH
310 320 330 340 350
KSEYYINGLS TSLPLDVQEK VIHSIKGLEN ALITRYGYAI EYDFIQPTEL
360 370 380 390 400
THTLETKKIK GLYLAGQING TTGYEEAAAQ GLMAGINAVL ALKNQAPFIL
410 420 430 440 450
KRNEAYIGVL IDDLITKGTN EPYRMFTSRA EYRLLLREDN TLFRLGEHAY
460 470 480 490 500
RLGLMEEDFY KELKKDKQEI QDNLKRLKEY ILTPSKEVLK RLDELDENPI
510 520 530 540 550
NDKVDGVSLL ARDSFNAEKM RSFFSFLAPL NERVLEQIKI ECKYNIYIEK
560 570 580 590 600
QHENIAKMDS MLKVSIPKGF VFKGIPGLSL EAVEKLEKFR PKSLFEASEI
610 620
SGITPANLDV LHLYIHLRKN S
Length:621
Mass (Da):69,684
Last modified:November 1, 1997 - v1
Checksum:iC5C5CE80259E49E8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101V → I in strain: 60190.
Natural varianti105 – 1051L → F in strain: 60190.
Natural varianti193 – 1931D → E in strain: 60190.
Natural varianti220 – 2201T → A in strain: 60190.
Natural varianti302 – 3021S → N in strain: 60190.
Natural varianti353 – 3531T → A in strain: 60190.
Natural varianti379 – 3791A → D in strain: 60190.
Natural varianti415 – 4151I → V in strain: 60190.
Natural varianti457 – 4571E → Q in strain: 60190.
Natural varianti480 – 4812YI → CV in strain: 60190.
Natural varianti487 – 4882EV → KL in strain: 60190.
Natural varianti493 – 4931D → N in strain: 60190.
Natural varianti505 – 5051D → N in strain: 60190.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07281.1.
AF008565 Genomic DNA. Translation: AAB63296.1.
PIRiE64546.
RefSeqiNP_207011.1. NC_000915.1.
YP_006934138.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07281; AAD07281; HP_0213.
GeneIDi898934.
KEGGiheo:C694_01070.
hpy:HP0213.
PATRICi20591649. VBIHelPyl33062_0224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07281.1.
AF008565 Genomic DNA. Translation: AAB63296.1.
PIRiE64546.
RefSeqiNP_207011.1. NC_000915.1.
YP_006934138.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3538N.
IntActiP56138. 1 interaction.
MINTiMINT-178352.
STRINGi85962.HP0213.

Proteomic databases

PRIDEiP56138.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07281; AAD07281; HP_0213.
GeneIDi898934.
KEGGiheo:C694_01070.
hpy:HP0213.
PATRICi20591649. VBIHelPyl33062_0224.

Phylogenomic databases

eggNOGiCOG0445.
KOiK03495.
OMAiYINGLST.
OrthoDBiEOG6W9X6J.

Enzyme and pathway databases

BioCyciHPY:HP0213-MONOMER.

Family and domain databases

HAMAPiMF_00129. MnmG_GidA.
InterProiIPR004416. GidA.
IPR026904. GidA-assoc_3.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc_3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  2. Karita M., Etterbeek M.L., Forsyth M.H., Tummuru M.K.R., Blaser M.J.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 49503 / 60190.

Entry informationi

Entry nameiMNMG_HELPY
AccessioniPrimary (citable) accession number: P56138
Secondary accession number(s): O32632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 29, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.