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P56138

- MNMG_HELPY

UniProt

P56138 - MNMG_HELPY

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Protein

tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG

Gene
mnmG, gidA, HP_0213
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34 By similarity.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166FAD By similarity
Nucleotide bindingi270 – 28415NAD Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA wobble uridine modification Source: InterPro
Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciHPY:HP0213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
Alternative name(s):
Glucose-inhibited division protein A
Gene namesi
Name:mnmG
Synonyms:gidA
Ordered Locus Names:HP_0213
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotationPRO_0000117112Add
BLAST

Proteomic databases

PRIDEiP56138.

Interactioni

Subunit structurei

Homodimer By similarity. Heterotetramer of two MnmE and two MnmG subunits By similarity.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3538N.
IntActiP56138. 1 interaction.
MINTiMINT-178352.
STRINGi85962.HP0213.

Structurei

3D structure databases

ProteinModelPortaliP56138.

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family.

Phylogenomic databases

eggNOGiCOG0445.
KOiK03495.
OMAiTEYYLNG.
OrthoDBiEOG6W9X6J.

Family and domain databases

HAMAPiMF_00129. MnmG_GidA.
InterProiIPR004416. GidA.
IPR026904. GidA-assoc_3.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc_3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56138-1 [UniParc]FASTAAdd to Basket

« Hide

MVKESDILVV GGGHAGIEAS LIAAKMGARV HLITMLIDTI GLASCNPAIG    50
GLGKGHLTKE VDVLGGAMGI ITDHSGLQYR VLNASKGPAV RGTRAQIDMD 100
TYRILARNLV LNTPNLSVSQ EMTESLILEN DEVVGVTTNI NNTYRAKKVI 150
ITTGTFLKGV VHIGEHQNQN GRFGENASNS LALNLRELGF KVDRLKTGTC 200
PRVAGNSIDF EGLEEHFGDT NPPYFSYKTK DFNPTQLSCF ITYTNPITHQ 250
IIRDNFHRAP LFSGQIEGIG PRYCPSIEDK INRFSEKERH QLFLEPQTIH 300
KSEYYINGLS TSLPLDVQEK VIHSIKGLEN ALITRYGYAI EYDFIQPTEL 350
THTLETKKIK GLYLAGQING TTGYEEAAAQ GLMAGINAVL ALKNQAPFIL 400
KRNEAYIGVL IDDLITKGTN EPYRMFTSRA EYRLLLREDN TLFRLGEHAY 450
RLGLMEEDFY KELKKDKQEI QDNLKRLKEY ILTPSKEVLK RLDELDENPI 500
NDKVDGVSLL ARDSFNAEKM RSFFSFLAPL NERVLEQIKI ECKYNIYIEK 550
QHENIAKMDS MLKVSIPKGF VFKGIPGLSL EAVEKLEKFR PKSLFEASEI 600
SGITPANLDV LHLYIHLRKN S 621
Length:621
Mass (Da):69,684
Last modified:November 1, 1997 - v1
Checksum:iC5C5CE80259E49E8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101V → I in strain: 60190.
Natural varianti105 – 1051L → F in strain: 60190.
Natural varianti193 – 1931D → E in strain: 60190.
Natural varianti220 – 2201T → A in strain: 60190.
Natural varianti302 – 3021S → N in strain: 60190.
Natural varianti353 – 3531T → A in strain: 60190.
Natural varianti379 – 3791A → D in strain: 60190.
Natural varianti415 – 4151I → V in strain: 60190.
Natural varianti457 – 4571E → Q in strain: 60190.
Natural varianti480 – 4812YI → CV in strain: 60190.
Natural varianti487 – 4882EV → KL in strain: 60190.
Natural varianti493 – 4931D → N in strain: 60190.
Natural varianti505 – 5051D → N in strain: 60190.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07281.1.
AF008565 Genomic DNA. Translation: AAB63296.1.
PIRiE64546.
RefSeqiNP_207011.1. NC_000915.1.
YP_006934138.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07281; AAD07281; HP_0213.
GeneIDi13869394.
898934.
KEGGiheo:C694_01070.
hpy:HP0213.
PATRICi20591649. VBIHelPyl33062_0224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07281.1 .
AF008565 Genomic DNA. Translation: AAB63296.1 .
PIRi E64546.
RefSeqi NP_207011.1. NC_000915.1.
YP_006934138.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56138.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3538N.
IntActi P56138. 1 interaction.
MINTi MINT-178352.
STRINGi 85962.HP0213.

Proteomic databases

PRIDEi P56138.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07281 ; AAD07281 ; HP_0213 .
GeneIDi 13869394.
898934.
KEGGi heo:C694_01070.
hpy:HP0213.
PATRICi 20591649. VBIHelPyl33062_0224.

Phylogenomic databases

eggNOGi COG0445.
KOi K03495.
OMAi TEYYLNG.
OrthoDBi EOG6W9X6J.

Enzyme and pathway databases

BioCyci HPY:HP0213-MONOMER.

Family and domain databases

HAMAPi MF_00129. MnmG_GidA.
InterProi IPR004416. GidA.
IPR026904. GidA-assoc_3.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
PF13932. GIDA_assoc_3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00136. gidA. 1 hit.
PROSITEi PS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  2. Karita M., Etterbeek M.L., Forsyth M.H., Tummuru M.K.R., Blaser M.J.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 49503 / 60190.

Entry informationi

Entry nameiMNMG_HELPY
AccessioniPrimary (citable) accession number: P56138
Secondary accession number(s): O32632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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