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P56138

- MNMG_HELPY

UniProt

P56138 - MNMG_HELPY

Protein

tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG

Gene

mnmG

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166FADUniRule annotation
    Nucleotide bindingi270 – 28415NADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tRNA wobble uridine modification Source: InterPro

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciHPY:HP0213-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotation
    Alternative name(s):
    Glucose-inhibited division protein AUniRule annotation
    Gene namesi
    Name:mnmGUniRule annotation
    Synonyms:gidAUniRule annotation
    Ordered Locus Names:HP_0213
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 621621tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGPRO_0000117112Add
    BLAST

    Proteomic databases

    PRIDEiP56138.

    Interactioni

    Subunit structurei

    Homodimer. Heterotetramer of two MnmE and two MnmG subunits.UniRule annotation

    Protein-protein interaction databases

    DIPiDIP-3538N.
    IntActiP56138. 1 interaction.
    MINTiMINT-178352.
    STRINGi85962.HP0213.

    Structurei

    3D structure databases

    ProteinModelPortaliP56138.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0445.
    KOiK03495.
    OMAiTEYYLNG.
    OrthoDBiEOG6W9X6J.

    Family and domain databases

    HAMAPiMF_00129. MnmG_GidA.
    InterProiIPR004416. GidA.
    IPR026904. GidA-assoc_3.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    PF13932. GIDA_assoc_3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00136. gidA. 1 hit.
    PROSITEiPS01280. GIDA_1. 1 hit.
    PS01281. GIDA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56138-1 [UniParc]FASTAAdd to Basket

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    MVKESDILVV GGGHAGIEAS LIAAKMGARV HLITMLIDTI GLASCNPAIG    50
    GLGKGHLTKE VDVLGGAMGI ITDHSGLQYR VLNASKGPAV RGTRAQIDMD 100
    TYRILARNLV LNTPNLSVSQ EMTESLILEN DEVVGVTTNI NNTYRAKKVI 150
    ITTGTFLKGV VHIGEHQNQN GRFGENASNS LALNLRELGF KVDRLKTGTC 200
    PRVAGNSIDF EGLEEHFGDT NPPYFSYKTK DFNPTQLSCF ITYTNPITHQ 250
    IIRDNFHRAP LFSGQIEGIG PRYCPSIEDK INRFSEKERH QLFLEPQTIH 300
    KSEYYINGLS TSLPLDVQEK VIHSIKGLEN ALITRYGYAI EYDFIQPTEL 350
    THTLETKKIK GLYLAGQING TTGYEEAAAQ GLMAGINAVL ALKNQAPFIL 400
    KRNEAYIGVL IDDLITKGTN EPYRMFTSRA EYRLLLREDN TLFRLGEHAY 450
    RLGLMEEDFY KELKKDKQEI QDNLKRLKEY ILTPSKEVLK RLDELDENPI 500
    NDKVDGVSLL ARDSFNAEKM RSFFSFLAPL NERVLEQIKI ECKYNIYIEK 550
    QHENIAKMDS MLKVSIPKGF VFKGIPGLSL EAVEKLEKFR PKSLFEASEI 600
    SGITPANLDV LHLYIHLRKN S 621
    Length:621
    Mass (Da):69,684
    Last modified:November 1, 1997 - v1
    Checksum:iC5C5CE80259E49E8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101V → I in strain: 60190.
    Natural varianti105 – 1051L → F in strain: 60190.
    Natural varianti193 – 1931D → E in strain: 60190.
    Natural varianti220 – 2201T → A in strain: 60190.
    Natural varianti302 – 3021S → N in strain: 60190.
    Natural varianti353 – 3531T → A in strain: 60190.
    Natural varianti379 – 3791A → D in strain: 60190.
    Natural varianti415 – 4151I → V in strain: 60190.
    Natural varianti457 – 4571E → Q in strain: 60190.
    Natural varianti480 – 4812YI → CV in strain: 60190.
    Natural varianti487 – 4882EV → KL in strain: 60190.
    Natural varianti493 – 4931D → N in strain: 60190.
    Natural varianti505 – 5051D → N in strain: 60190.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07281.1.
    AF008565 Genomic DNA. Translation: AAB63296.1.
    PIRiE64546.
    RefSeqiNP_207011.1. NC_000915.1.
    YP_006934138.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07281; AAD07281; HP_0213.
    GeneIDi13869394.
    898934.
    KEGGiheo:C694_01070.
    hpy:HP0213.
    PATRICi20591649. VBIHelPyl33062_0224.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07281.1 .
    AF008565 Genomic DNA. Translation: AAB63296.1 .
    PIRi E64546.
    RefSeqi NP_207011.1. NC_000915.1.
    YP_006934138.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56138.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3538N.
    IntActi P56138. 1 interaction.
    MINTi MINT-178352.
    STRINGi 85962.HP0213.

    Proteomic databases

    PRIDEi P56138.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07281 ; AAD07281 ; HP_0213 .
    GeneIDi 13869394.
    898934.
    KEGGi heo:C694_01070.
    hpy:HP0213.
    PATRICi 20591649. VBIHelPyl33062_0224.

    Phylogenomic databases

    eggNOGi COG0445.
    KOi K03495.
    OMAi TEYYLNG.
    OrthoDBi EOG6W9X6J.

    Enzyme and pathway databases

    BioCyci HPY:HP0213-MONOMER.

    Family and domain databases

    HAMAPi MF_00129. MnmG_GidA.
    InterProi IPR004416. GidA.
    IPR026904. GidA-assoc_3.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    PF13932. GIDA_assoc_3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00136. gidA. 1 hit.
    PROSITEi PS01280. GIDA_1. 1 hit.
    PS01281. GIDA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.
    2. Karita M., Etterbeek M.L., Forsyth M.H., Tummuru M.K.R., Blaser M.J.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 49503 / 60190.

    Entry informationi

    Entry nameiMNMG_HELPY
    AccessioniPrimary (citable) accession number: P56138
    Secondary accession number(s): O32632
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3