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P56138 (MNMG_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
Alternative name(s):
Glucose-inhibited division protein A
Gene names
Name:mnmG
Synonyms:gidA
Ordered Locus Names:HP_0213
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length621 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34 By similarity. HAMAP-Rule MF_00129

Cofactor

FAD By similarity. HAMAP-Rule MF_00129

Subunit structure

Homodimer By similarity. Heterotetramer of two MnmE and two MnmG subunits By similarity. HAMAP-Rule MF_00129

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00129.

Sequence similarities

Belongs to the MnmG family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
NAD
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtRNA wobble uridine modification

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionflavin adenine dinucleotide binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 621621tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG HAMAP-Rule MF_00129
PRO_0000117112

Regions

Nucleotide binding11 – 166FAD By similarity
Nucleotide binding270 – 28415NAD Potential

Natural variations

Natural variant101V → I in strain: 60190.
Natural variant1051L → F in strain: 60190.
Natural variant1931D → E in strain: 60190.
Natural variant2201T → A in strain: 60190.
Natural variant3021S → N in strain: 60190.
Natural variant3531T → A in strain: 60190.
Natural variant3791A → D in strain: 60190.
Natural variant4151I → V in strain: 60190.
Natural variant4571E → Q in strain: 60190.
Natural variant480 – 4812YI → CV in strain: 60190.
Natural variant487 – 4882EV → KL in strain: 60190.
Natural variant4931D → N in strain: 60190.
Natural variant5051D → N in strain: 60190.

Sequences

Sequence LengthMass (Da)Tools
P56138 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: C5C5CE80259E49E8

FASTA62169,684
        10         20         30         40         50         60 
MVKESDILVV GGGHAGIEAS LIAAKMGARV HLITMLIDTI GLASCNPAIG GLGKGHLTKE 

        70         80         90        100        110        120 
VDVLGGAMGI ITDHSGLQYR VLNASKGPAV RGTRAQIDMD TYRILARNLV LNTPNLSVSQ 

       130        140        150        160        170        180 
EMTESLILEN DEVVGVTTNI NNTYRAKKVI ITTGTFLKGV VHIGEHQNQN GRFGENASNS 

       190        200        210        220        230        240 
LALNLRELGF KVDRLKTGTC PRVAGNSIDF EGLEEHFGDT NPPYFSYKTK DFNPTQLSCF 

       250        260        270        280        290        300 
ITYTNPITHQ IIRDNFHRAP LFSGQIEGIG PRYCPSIEDK INRFSEKERH QLFLEPQTIH 

       310        320        330        340        350        360 
KSEYYINGLS TSLPLDVQEK VIHSIKGLEN ALITRYGYAI EYDFIQPTEL THTLETKKIK 

       370        380        390        400        410        420 
GLYLAGQING TTGYEEAAAQ GLMAGINAVL ALKNQAPFIL KRNEAYIGVL IDDLITKGTN 

       430        440        450        460        470        480 
EPYRMFTSRA EYRLLLREDN TLFRLGEHAY RLGLMEEDFY KELKKDKQEI QDNLKRLKEY 

       490        500        510        520        530        540 
ILTPSKEVLK RLDELDENPI NDKVDGVSLL ARDSFNAEKM RSFFSFLAPL NERVLEQIKI 

       550        560        570        580        590        600 
ECKYNIYIEK QHENIAKMDS MLKVSIPKGF VFKGIPGLSL EAVEKLEKFR PKSLFEASEI 

       610        620 
SGITPANLDV LHLYIHLRKN S 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07281.1.
AF008565 Genomic DNA. Translation: AAB63296.1.
PIRE64546.
RefSeqNP_207011.1. NC_000915.1.
YP_006934138.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56138.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3538N.
IntActP56138. 1 interaction.
MINTMINT-178352.
STRING85962.HP0213.

Proteomic databases

PRIDEP56138.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07281; AAD07281; HP_0213.
GeneID898934.
KEGGheo:C694_01070.
hpy:HP0213.
PATRIC20591649. VBIHelPyl33062_0224.

Phylogenomic databases

eggNOGCOG0445.
KOK03495.
OMATEYYLNG.
OrthoDBEOG6W9X6J.

Enzyme and pathway databases

BioCycHPY:HP0213-MONOMER.

Family and domain databases

HAMAPMF_00129. MnmG_GidA.
InterProIPR004416. GidA.
IPR026904. GidA-assoc_3.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc_3. 1 hit.
[Graphical view]
TIGRFAMsTIGR00136. gidA. 1 hit.
PROSITEPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMNMG_HELPY
AccessionPrimary (citable) accession number: P56138
Secondary accession number(s): O32632
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names