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Protein

ATP synthase subunit f, mitochondrial

Gene

Atp5j2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit f, mitochondrial
Gene namesi
Name:Atp5j2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1927558. Atp5j2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 7620HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 8887ATP synthase subunit f, mitochondrialPRO_0000194825Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei3 – 31PhosphoserineBy similarity
Modified residuei16 – 161N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP56135.
MaxQBiP56135.
PaxDbiP56135.
PeptideAtlasiP56135.
PRIDEiP56135.
TopDownProteomicsiP56135.

PTM databases

iPTMnetiP56135.
PhosphoSiteiP56135.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038690.
ExpressionAtlasiP56135. baseline and differential.
GenevisibleiP56135. MM.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi208283. 1 interaction.
IntActiP56135. 2 interactions.
MINTiMINT-1843047.
STRINGi10090.ENSMUSP00000125504.

Structurei

3D structure databases

ProteinModelPortaliP56135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase F chain family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4092. Eukaryota.
ENOG4111PBN. LUCA.
GeneTreeiENSGT00510000046986.
HOGENOMiHOG000034215.
HOVERGENiHBG002418.
InParanoidiP56135.
KOiK02130.
OMAiFYMINYT.
OrthoDBiEOG091G12MW.
PhylomeDBiP56135.
TreeFamiTF342865.

Family and domain databases

InterProiIPR019344. F1F0-ATPsyn_F_prd.
[Graphical view]
PANTHERiPTHR13080. PTHR13080. 1 hit.
PfamiPF10206. WRW. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56135-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLVPLKEK KLMEVKLGEL PSWIMMRDFT PSGIAGAFRR GYDRYYNKYI
60 70 80
NVRKGSISGI SMVLAAYVVF SYCISYKELK HERRRKYH
Length:88
Mass (Da):10,344
Last modified:January 23, 2007 - v3
Checksum:i89526C72EC436E48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030192 mRNA. Translation: BAA92756.1.
AK002519 mRNA. Translation: BAB22157.1.
AK003235 mRNA. Translation: BAB22660.1.
AK003817 mRNA. Translation: BAB23014.1.
AK013130 mRNA. Translation: BAB28667.1.
AK151737 mRNA. Translation: BAE30651.1.
AK168095 mRNA. Translation: BAE40067.1.
BC029226 mRNA. Translation: AAH29226.1.
CCDSiCCDS39385.1.
RefSeqiNP_065607.1. NM_020582.2.
UniGeneiMm.133551.

Genome annotation databases

EnsembliENSMUST00000161741; ENSMUSP00000125504; ENSMUSG00000038690.
GeneIDi57423.
KEGGimmu:57423.
UCSCiuc009amk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030192 mRNA. Translation: BAA92756.1.
AK002519 mRNA. Translation: BAB22157.1.
AK003235 mRNA. Translation: BAB22660.1.
AK003817 mRNA. Translation: BAB23014.1.
AK013130 mRNA. Translation: BAB28667.1.
AK151737 mRNA. Translation: BAE30651.1.
AK168095 mRNA. Translation: BAE40067.1.
BC029226 mRNA. Translation: AAH29226.1.
CCDSiCCDS39385.1.
RefSeqiNP_065607.1. NM_020582.2.
UniGeneiMm.133551.

3D structure databases

ProteinModelPortaliP56135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208283. 1 interaction.
IntActiP56135. 2 interactions.
MINTiMINT-1843047.
STRINGi10090.ENSMUSP00000125504.

PTM databases

iPTMnetiP56135.
PhosphoSiteiP56135.

Proteomic databases

EPDiP56135.
MaxQBiP56135.
PaxDbiP56135.
PeptideAtlasiP56135.
PRIDEiP56135.
TopDownProteomicsiP56135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000161741; ENSMUSP00000125504; ENSMUSG00000038690.
GeneIDi57423.
KEGGimmu:57423.
UCSCiuc009amk.1. mouse.

Organism-specific databases

CTDi9551.
MGIiMGI:1927558. Atp5j2.

Phylogenomic databases

eggNOGiKOG4092. Eukaryota.
ENOG4111PBN. LUCA.
GeneTreeiENSGT00510000046986.
HOGENOMiHOG000034215.
HOVERGENiHBG002418.
InParanoidiP56135.
KOiK02130.
OMAiFYMINYT.
OrthoDBiEOG091G12MW.
PhylomeDBiP56135.
TreeFamiTF342865.

Enzyme and pathway databases

ReactomeiR-MMU-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

PROiP56135.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038690.
ExpressionAtlasiP56135. baseline and differential.
GenevisibleiP56135. MM.

Family and domain databases

InterProiIPR019344. F1F0-ATPsyn_F_prd.
[Graphical view]
PANTHERiPTHR13080. PTHR13080. 1 hit.
PfamiPF10206. WRW. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPK_MOUSE
AccessioniPrimary (citable) accession number: P56135
Secondary accession number(s): Q3THX9, Q9JMF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.