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Protein

ATP synthase subunit f, mitochondrial

Gene

Atp5j2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit f, mitochondrial
Gene namesi
Name:Atp5j2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1927558 Atp5j2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 76HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001948252 – 88ATP synthase subunit f, mitochondrialAdd BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei16N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP56135
MaxQBiP56135
PaxDbiP56135
PeptideAtlasiP56135
PRIDEiP56135
TopDownProteomicsiP56135

PTM databases

iPTMnetiP56135
PhosphoSitePlusiP56135
SwissPalmiP56135

Expressioni

Gene expression databases

BgeeiENSMUSG00000038690
ExpressionAtlasiP56135 baseline and differential
GenevisibleiP56135 MM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi208283, 3 interactors
CORUMiP56135
IntActiP56135, 2 interactors
MINTiP56135
STRINGi10090.ENSMUSP00000125504

Structurei

3D structure databases

ProteinModelPortaliP56135
SMRiP56135
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase F chain family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4092 Eukaryota
ENOG4111PBN LUCA
GeneTreeiENSGT00510000046986
HOGENOMiHOG000034215
HOVERGENiHBG002418
InParanoidiP56135
KOiK02130
OMAiHKYVQPK
OrthoDBiEOG091G12MW
PhylomeDBiP56135
TreeFamiTF342865

Family and domain databases

InterProiView protein in InterPro
IPR019344 F1F0-ATPsyn_F_prd
PANTHERiPTHR13080 PTHR13080, 1 hit
PfamiView protein in Pfam
PF10206 WRW, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56135-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLVPLKEK KLMEVKLGEL PSWIMMRDFT PSGIAGAFRR GYDRYYNKYI
60 70 80
NVRKGSISGI SMVLAAYVVF SYCISYKELK HERRRKYH
Length:88
Mass (Da):10,344
Last modified:January 23, 2007 - v3
Checksum:i89526C72EC436E48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030192 mRNA Translation: BAA92756.1
AK002519 mRNA Translation: BAB22157.1
AK003235 mRNA Translation: BAB22660.1
AK003817 mRNA Translation: BAB23014.1
AK013130 mRNA Translation: BAB28667.1
AK151737 mRNA Translation: BAE30651.1
AK168095 mRNA Translation: BAE40067.1
BC029226 mRNA Translation: AAH29226.1
CCDSiCCDS39385.1
RefSeqiNP_065607.1, NM_020582.2
UniGeneiMm.133551

Genome annotation databases

EnsembliENSMUST00000161741; ENSMUSP00000125504; ENSMUSG00000038690
GeneIDi57423
KEGGimmu:57423
UCSCiuc009amk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiATPK_MOUSE
AccessioniPrimary (citable) accession number: P56135
Secondary accession number(s): Q3THX9, Q9JMF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health