P56134 (ATPK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase subunit f, mitochondrial

Gene names

Name:	ATP5J2
Synonyms:	ATP5JL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	94 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L).
Subcellular location	Mitochondrion. Mitochondrion inner membrane.
Sequence similarities	Belongs to the ATPase F chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Alternative splicing
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP catabolic process Inferred from direct assay. Source: GOC mitochondrial ATP synthesis coupled proton transport Inferred by curator. Source: UniProtKB respiratory electron transport chain Traceable author statement. Source: Reactome
Cellular component	mitochondrial proton-transporting ATP synthase complex Inferred from direct assay. Source: UniProtKB proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transmembrane transporter activity Inferred by curator. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P56134-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P56134-2)

The sequence of this isoform differs from the canonical sequence as follows:
     5-10: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 94	93	ATP synthase subunit f, mitochondrial		PRO_0000194824
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.5
Natural variations
	Alternative sequence	5 – 10	6	Missing in isoform 2.		VSP_000437
Experimental info
	Sequence conflict	24	1	G → L in AAH03678. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: D5F0D94273DEF880	FASTA	94	10,918
	10 20 30 40 50 60 MASVGECPAP VPVKDKKLLE VKLGELPSWI LMRDFSPSGI FGAFQRGYYR YYNKYINVKK 70 80 90 GSISGITMVL ACYVLFSYSF SYKHLKHERL RKYH
	Isoform 2 [UniParc]. Checksum: 38072EB09CAC8D65	FASTA	88	10,363
	10 20 30 40 50 60 MASVVPVKDK KLLEVKLGEL PSWILMRDFS PSGIFGAFQR GYYRYYNKYI NVKKGSISGI 70 80 TMVLACYVLF SYSFSYKHLK HERLRKYH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning, and chromosomal localization of a human F1F0-type ATPase subunit f." Lee H.C., Kang Y.J., Park D.S., Lee C.M., Cho W.K., Ahn H.J., Lee M.Y., Hwang M.Y., Jin S.W., Sohn U.I.K. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Thymus.
[2]	"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning." Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed: 9653160] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Umbilical cord blood.
[3]	"F1Fo-ATP synthase complex Fo membrane domain f subunit of Homo sapiens." Guo J.H., Yu L., Dai F.Y., She X.Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[5]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF088918 mRNA. Translation: AAC34895.1. AF047436 mRNA. Translation: AAC39887.1. AY046911 mRNA. Translation: AAL06647.1. BC003678 mRNA. Translation: AAH03678.1.
IPI	IPI00220300. IPI01013118.
RefSeq	NP_001003713.1. NM_001003713.2. NP_004880.1. NM_004889.3.
UniGene	Hs.521056. Hs.656515.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P56134. 16 interactions.
MINT	MINT-1370314.
STRING	P56134.
PTM databases
PhosphoSite	P56134.
Polymorphism databases
DMDM	7404340.
Proteomic databases
PRIDE	P56134.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292475; ENSP00000292475; ENSG00000241468.
GeneID	9551.
KEGG	hsa:9551.
UCSC	uc003uql.1. human. uc003uqm.1. human.
Organism-specific databases
CTD	9551.
GeneCards	GC07M099046.
HGNC	HGNC:848. ATP5J2.
neXtProt	NX_P56134.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20504.
HOVERGEN	HBG002418.
InParanoid	P56134.
OrthoDB	EOG4NVZMX.
PhylomeDB	P56134.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	P56134.
Bgee	P56134.
CleanEx	HS_ATP5J2.
Genevestigator	P56134.
GermOnline	ENSG00000160916. Homo sapiens.
Family and domain databases
InterPro	IPR019344. F1F0-ATPsyn_F_prd. [Graphical view]
KO	K02130.
PANTHER	PTHR13080. F1F0-ATPsyn_F_prd. 1 hit.
Pfam	PF10206. WRW. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35811.

Entry information

Entry name

ATPK_HUMAN

Accession

Primary (citable) accession number: P56134
Secondary accession number(s): O76079, Q96L83, Q9BTI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 108 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.