Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P56133

- PIMT_HELPY

UniProt

P56133 - PIMT_HELPY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei59 – 591By similarity

GO - Molecular functioni

  1. protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPY:HP0363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferase (EC:2.1.1.77)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase
Protein L-isoaspartyl methyltransferase
Protein-beta-aspartate methyltransferase
Short name:
PIMT
Gene namesi
Name:pcm
Ordered Locus Names:HP_0363
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Protein-L-isoaspartate O-methyltransferasePRO_0000111892Add
BLAST

Proteomic databases

PRIDEiP56133.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiP56133. 1 interaction.
STRINGi85962.HP0363.

Structurei

3D structure databases

ProteinModelPortaliP56133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2518.
KOiK00573.
OMAiLMVERQI.
OrthoDBiEOG644ZP2.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
PfamiPF01135. PCMT. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56133-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSIKNHLMC EEINKRFNLH PKVREAMESI EREVFVPAPF KHFAYTLNAL
60 70 80 90 100
SMQAQQYISS PLTVAKMTQY LEIDHVDSVL EIGCGSGYQA AVLSQIFRRV
110 120 130 140 150
FSIERIESLY IEARLRLKTL GLDNVHVKFA DGNKGWEQYA PYDRILFSAC
160 170 180 190 200
AKNIPQALID QLEEGGILVA PIQENNEQVI KRFVKQNNAL RVQKVLEKCL

FVPVVDGVQ
Length:209
Mass (Da):23,868
Last modified:November 1, 1997 - v1
Checksum:i48F060C1C00B50D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07431.1.
PIRiC64565.
RefSeqiNP_207161.1. NC_000915.1.
YP_006934287.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07431; AAD07431; HP_0363.
GeneIDi13869548.
900271.
KEGGiheo:C694_01840.
hpy:HP0363.
PATRICi20591961. VBIHelPyl33062_0375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07431.1 .
PIRi C64565.
RefSeqi NP_207161.1. NC_000915.1.
YP_006934287.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56133.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P56133. 1 interaction.
STRINGi 85962.HP0363.

Proteomic databases

PRIDEi P56133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07431 ; AAD07431 ; HP_0363 .
GeneIDi 13869548.
900271.
KEGGi heo:C694_01840.
hpy:HP0363.
PATRICi 20591961. VBIHelPyl33062_0375.

Phylogenomic databases

eggNOGi COG2518.
KOi K00573.
OMAi LMVERQI.
OrthoDBi EOG644ZP2.

Enzyme and pathway databases

BioCyci HPY:HP0363-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_00090. PIMT.
InterProi IPR000682. PCMT.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR11579. PTHR11579. 1 hit.
Pfami PF01135. PCMT. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00080. pimt. 1 hit.
PROSITEi PS01279. PCMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiPIMT_HELPY
AccessioniPrimary (citable) accession number: P56133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3