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P56133

- PIMT_HELPY

UniProt

P56133 - PIMT_HELPY

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Protein
Protein-L-isoaspartate O-methyltransferase
Gene
pcm, HP_0363
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei59 – 591 By similarity

GO - Molecular functioni

  1. protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPY:HP0363-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferase (EC:2.1.1.77)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase
Protein L-isoaspartyl methyltransferase
Protein-beta-aspartate methyltransferase
Short name:
PIMT
Gene namesi
Name:pcm
Ordered Locus Names:HP_0363
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Protein-L-isoaspartate O-methyltransferaseUniRule annotation
PRO_0000111892Add
BLAST

Proteomic databases

PRIDEiP56133.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiP56133. 1 interaction.
STRINGi85962.HP0363.

Structurei

3D structure databases

ProteinModelPortaliP56133.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2518.
KOiK00573.
OMAiLMVERQI.
OrthoDBiEOG644ZP2.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
PfamiPF01135. PCMT. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56133-1 [UniParc]FASTAAdd to Basket

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MNSIKNHLMC EEINKRFNLH PKVREAMESI EREVFVPAPF KHFAYTLNAL    50
SMQAQQYISS PLTVAKMTQY LEIDHVDSVL EIGCGSGYQA AVLSQIFRRV 100
FSIERIESLY IEARLRLKTL GLDNVHVKFA DGNKGWEQYA PYDRILFSAC 150
AKNIPQALID QLEEGGILVA PIQENNEQVI KRFVKQNNAL RVQKVLEKCL 200
FVPVVDGVQ 209
Length:209
Mass (Da):23,868
Last modified:November 1, 1997 - v1
Checksum:i48F060C1C00B50D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07431.1.
PIRiC64565.
RefSeqiNP_207161.1. NC_000915.1.
YP_006934287.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07431; AAD07431; HP_0363.
GeneIDi13869548.
900271.
KEGGiheo:C694_01840.
hpy:HP0363.
PATRICi20591961. VBIHelPyl33062_0375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07431.1 .
PIRi C64565.
RefSeqi NP_207161.1. NC_000915.1.
YP_006934287.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56133.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P56133. 1 interaction.
STRINGi 85962.HP0363.

Proteomic databases

PRIDEi P56133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07431 ; AAD07431 ; HP_0363 .
GeneIDi 13869548.
900271.
KEGGi heo:C694_01840.
hpy:HP0363.
PATRICi 20591961. VBIHelPyl33062_0375.

Phylogenomic databases

eggNOGi COG2518.
KOi K00573.
OMAi LMVERQI.
OrthoDBi EOG644ZP2.

Enzyme and pathway databases

BioCyci HPY:HP0363-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_00090. PIMT.
InterProi IPR000682. PCMT.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR11579. PTHR11579. 1 hit.
Pfami PF01135. PCMT. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00080. pimt. 1 hit.
PROSITEi PS01279. PCMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiPIMT_HELPY
AccessioniPrimary (citable) accession number: P56133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi