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P56133

- PIMT_HELPY

UniProt

P56133 - PIMT_HELPY

Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei59 – 591By similarity

    GO - Molecular functioni

    1. protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protein repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciHPY:HP0363-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-L-isoaspartate O-methyltransferase (EC:2.1.1.77)
    Alternative name(s):
    L-isoaspartyl protein carboxyl methyltransferase
    Protein L-isoaspartyl methyltransferase
    Protein-beta-aspartate methyltransferase
    Short name:
    PIMT
    Gene namesi
    Name:pcm
    Ordered Locus Names:HP_0363
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Protein-L-isoaspartate O-methyltransferasePRO_0000111892Add
    BLAST

    Proteomic databases

    PRIDEiP56133.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    IntActiP56133. 1 interaction.
    STRINGi85962.HP0363.

    Structurei

    3D structure databases

    ProteinModelPortaliP56133.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2518.
    KOiK00573.
    OMAiLMVERQI.
    OrthoDBiEOG644ZP2.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_00090. PIMT.
    InterProiIPR000682. PCMT.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR11579. PTHR11579. 1 hit.
    PfamiPF01135. PCMT. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00080. pimt. 1 hit.
    PROSITEiPS01279. PCMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56133-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSIKNHLMC EEINKRFNLH PKVREAMESI EREVFVPAPF KHFAYTLNAL    50
    SMQAQQYISS PLTVAKMTQY LEIDHVDSVL EIGCGSGYQA AVLSQIFRRV 100
    FSIERIESLY IEARLRLKTL GLDNVHVKFA DGNKGWEQYA PYDRILFSAC 150
    AKNIPQALID QLEEGGILVA PIQENNEQVI KRFVKQNNAL RVQKVLEKCL 200
    FVPVVDGVQ 209
    Length:209
    Mass (Da):23,868
    Last modified:November 1, 1997 - v1
    Checksum:i48F060C1C00B50D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07431.1.
    PIRiC64565.
    RefSeqiNP_207161.1. NC_000915.1.
    YP_006934287.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07431; AAD07431; HP_0363.
    GeneIDi13869548.
    900271.
    KEGGiheo:C694_01840.
    hpy:HP0363.
    PATRICi20591961. VBIHelPyl33062_0375.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07431.1 .
    PIRi C64565.
    RefSeqi NP_207161.1. NC_000915.1.
    YP_006934287.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56133.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P56133. 1 interaction.
    STRINGi 85962.HP0363.

    Proteomic databases

    PRIDEi P56133.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07431 ; AAD07431 ; HP_0363 .
    GeneIDi 13869548.
    900271.
    KEGGi heo:C694_01840.
    hpy:HP0363.
    PATRICi 20591961. VBIHelPyl33062_0375.

    Phylogenomic databases

    eggNOGi COG2518.
    KOi K00573.
    OMAi LMVERQI.
    OrthoDBi EOG644ZP2.

    Enzyme and pathway databases

    BioCyci HPY:HP0363-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_00090. PIMT.
    InterProi IPR000682. PCMT.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR11579. PTHR11579. 1 hit.
    Pfami PF01135. PCMT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00080. pimt. 1 hit.
    PROSITEi PS01279. PCMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiPIMT_HELPY
    AccessioniPrimary (citable) accession number: P56133
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3