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P56133 (PIMT_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein-L-isoaspartate O-methyltransferase

EC=2.1.1.77
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase
Protein L-isoaspartyl methyltransferase
Protein-beta-aspartate methyltransferase
Short name=PIMT
Gene names
Name:pcm
Ordered Locus Names:HP_0363
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins By similarity. HAMAP-Rule MF_00090

Catalytic activity

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester. HAMAP-Rule MF_00090

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00090

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00090.

Sequence similarities

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein-L-isoaspartate (D-aspartate) O-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Protein-L-isoaspartate O-methyltransferase HAMAP-Rule MF_00090
PRO_0000111892

Sites

Active site591 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56133 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 48F060C1C00B50D8

FASTA20923,868
        10         20         30         40         50         60 
MNSIKNHLMC EEINKRFNLH PKVREAMESI EREVFVPAPF KHFAYTLNAL SMQAQQYISS 

        70         80         90        100        110        120 
PLTVAKMTQY LEIDHVDSVL EIGCGSGYQA AVLSQIFRRV FSIERIESLY IEARLRLKTL 

       130        140        150        160        170        180 
GLDNVHVKFA DGNKGWEQYA PYDRILFSAC AKNIPQALID QLEEGGILVA PIQENNEQVI 

       190        200 
KRFVKQNNAL RVQKVLEKCL FVPVVDGVQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07431.1.
PIRC64565.
RefSeqNP_207161.1. NC_000915.1.
YP_006934287.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56133.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0363.

Proteomic databases

PRIDEP56133.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07431; AAD07431; HP_0363.
GeneID13869548.
900271.
KEGGheo:C694_01840.
hpy:HP0363.
PATRIC20591961. VBIHelPyl33062_0375.

Phylogenomic databases

eggNOGCOG2518.
KOK00573.
OMAHLMCEEI.
OrthoDBEOG644ZP2.
ProtClustDBPRK00312.

Enzyme and pathway databases

BioCycHPY:HP0363-MONOMER.

Family and domain databases

HAMAPMF_00090. PIMT.
InterProIPR000682. PCMT.
[Graphical view]
PANTHERPTHR11579. PTHR11579. 1 hit.
PfamPF01135. PCMT. 1 hit.
[Graphical view]
TIGRFAMsTIGR00080. pimt. 1 hit.
PROSITEPS01279. PCMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePIMT_HELPY
AccessionPrimary (citable) accession number: P56133
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names