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P56128

- SYR_HELPY

UniProt

P56128 - SYR_HELPY

Protein

Arginine--tRNA ligase

Gene

argS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0319-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligase (EC:6.1.1.19)
    Alternative name(s):
    Arginyl-tRNA synthetase
    Short name:
    ArgRS
    Gene namesi
    Name:argS
    Ordered Locus Names:HP_0319
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 541541Arginine--tRNA ligasePRO_0000151565Add
    BLAST

    Proteomic databases

    PRIDEiP56128.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    DIPiDIP-3643N.
    IntActiP56128. 2 interactions.
    MINTiMINT-169291.
    STRINGi85962.HP0319.

    Structurei

    3D structure databases

    ProteinModelPortaliP56128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi119 – 12911"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0018.
    KOiK01887.
    OMAiIRNTIND.
    OrthoDBiEOG6JB13C.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56128-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHTLIKGILE EILEEEVIVE YPKDREHGHY ATPIAFNLAK VFKKSPLAIA    50
    EELALKISTH EKTQGLFDSV VACKGYINFT LSLDFLERFT QKALELKEKF 100
    GSQVKSERSQ KIFLEFVSAN PTGPLHIGHA RGAVFGDSLA KIARFLGHEV 150
    LCEYYVNDMG SQIRLLGLSV WLAYREHVLK ESVTYPEVFY KGEYIIEIAK 200
    KANNDLEPSL LKENEETIIE VLSGYARDLM LLEIKDNLDA LGIHFDSYAS 250
    EKEVFKHKDA VFEQLEKANA LYEKDSKIWL KSSLYQDESD RVLIKEDKSY 300
    TYLAGDIVYH DEKFKQDYTK YINIWGADHH GYIARVKASL EFLGYDSNKL 350
    EVLLAQMVRL LKDNEPYKMS KRAGNFILIK DVVDDVGKDA LRFIFLSKRL 400
    DTHLEFDVNT LKKQDSSNPI YYIHYANSRI HTMLEKSPFS KEEVLQTPLT 450
    NLNAEEKYLL FSALSLPKAI ESSFEEYGLQ KMCEYAKTLA SEFHRFYNAG 500
    KILDTPKAKE LLKICLIVSL SLSNAFKLLG IEIKTKISAR D 541
    Length:541
    Mass (Da):62,077
    Last modified:November 1, 1997 - v1
    Checksum:iDAB18669FD03A866
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07388.1.
    PIRiG64559.
    RefSeqiNP_207117.1. NC_000915.1.
    YP_006934247.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07388; AAD07388; HP_0319.
    GeneIDi13869505.
    900101.
    KEGGiheo:C694_01615.
    hpy:HP0319.
    PATRICi20591869. VBIHelPyl33062_0332.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07388.1 .
    PIRi G64559.
    RefSeqi NP_207117.1. NC_000915.1.
    YP_006934247.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3643N.
    IntActi P56128. 2 interactions.
    MINTi MINT-169291.
    STRINGi 85962.HP0319.

    Proteomic databases

    PRIDEi P56128.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07388 ; AAD07388 ; HP_0319 .
    GeneIDi 13869505.
    900101.
    KEGGi heo:C694_01615.
    hpy:HP0319.
    PATRICi 20591869. VBIHelPyl33062_0332.

    Phylogenomic databases

    eggNOGi COG0018.
    KOi K01887.
    OMAi IRNTIND.
    OrthoDBi EOG6JB13C.

    Enzyme and pathway databases

    BioCyci HPY:HP0319-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiSYR_HELPY
    AccessioniPrimary (citable) accession number: P56128
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3