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P56128 (SYR_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:HP_0319
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length541 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 541541Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151565

Regions

Motif119 – 12911"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
P56128 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: DAB18669FD03A866

FASTA54162,077
        10         20         30         40         50         60 
MHTLIKGILE EILEEEVIVE YPKDREHGHY ATPIAFNLAK VFKKSPLAIA EELALKISTH 

        70         80         90        100        110        120 
EKTQGLFDSV VACKGYINFT LSLDFLERFT QKALELKEKF GSQVKSERSQ KIFLEFVSAN 

       130        140        150        160        170        180 
PTGPLHIGHA RGAVFGDSLA KIARFLGHEV LCEYYVNDMG SQIRLLGLSV WLAYREHVLK 

       190        200        210        220        230        240 
ESVTYPEVFY KGEYIIEIAK KANNDLEPSL LKENEETIIE VLSGYARDLM LLEIKDNLDA 

       250        260        270        280        290        300 
LGIHFDSYAS EKEVFKHKDA VFEQLEKANA LYEKDSKIWL KSSLYQDESD RVLIKEDKSY 

       310        320        330        340        350        360 
TYLAGDIVYH DEKFKQDYTK YINIWGADHH GYIARVKASL EFLGYDSNKL EVLLAQMVRL 

       370        380        390        400        410        420 
LKDNEPYKMS KRAGNFILIK DVVDDVGKDA LRFIFLSKRL DTHLEFDVNT LKKQDSSNPI 

       430        440        450        460        470        480 
YYIHYANSRI HTMLEKSPFS KEEVLQTPLT NLNAEEKYLL FSALSLPKAI ESSFEEYGLQ 

       490        500        510        520        530        540 
KMCEYAKTLA SEFHRFYNAG KILDTPKAKE LLKICLIVSL SLSNAFKLLG IEIKTKISAR 


D 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07388.1.
PIRG64559.
RefSeqNP_207117.1. NC_000915.1.
YP_006934247.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56128.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3643N.
IntActP56128. 2 interactions.
MINTMINT-169291.
STRING85962.HP0319.

Proteomic databases

PRIDEP56128.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07388; AAD07388; HP_0319.
GeneID900101.
KEGGheo:C694_01615.
hpy:HP0319.
PATRIC20591869. VBIHelPyl33062_0332.

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMAIRNTIND.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycHPY:HP0319-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_HELPY
AccessionPrimary (citable) accession number: P56128
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries