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Protein

Ribonuclease R

Gene

rnr

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciHPY:HP1248-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease RUniRule annotation (EC:3.1.13.1UniRule annotation)
Short name:
RNase RUniRule annotation
Alternative name(s):
VacB protein homolog
Gene namesi
Name:rnrUniRule annotation
Synonyms:vacB
Ordered Locus Names:HP_1248
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001664041 – 644Ribonuclease RAdd BLAST644

Proteomic databases

PaxDbiP56123.

Interactioni

Protein-protein interaction databases

DIPiDIP-3252N.
IntActiP56123. 11 interactors.
MINTiMINT-159708.
STRINGi85962.HP1248.

Structurei

3D structure databases

ProteinModelPortaliP56123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini573 – 644S1 motifUniRule annotationAdd BLAST72

Sequence similaritiesi

Belongs to the RNR ribonuclease family. RNase R subfamily.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C40. Bacteria.
COG0557. LUCA.
KOiK12573.
OMAiYRTHKEP.

Family and domain databases

HAMAPiMF_01895. RNase_R. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022966. RNase_II/R_CS.
IPR011805. RNase_R.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS01175. RIBONUCLEASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGFLRSLFF GVKKIPKPFA PLVEKGVLKE ALELKKDRYF LKEGFDIGKV
60 70 80 90 100
EKVKDKAFFI SLAKNYPKDP LIKNLPPSFK TDALILCQIE CSKKRPIAFF
110 120 130 140 150
KAALLNADHT MIAYLAKKNN QIVAIPFKEP FKKPVSLKHS QKSLLELPRH
160 170 180 190 200
CVVKIDTKKR EISEILGALE DPLIDENLSL SLFDRVKDFS KDCLNLAQHY
210 220 230 240 250
AQLKASDFKD RINYSHIPFI TIDPKDAKDF DDAIFYDQEK RVLFVAVADV
260 270 280 290 300
SEFVPKHSSL DKEARVRGFS VYFPNSVYPM LPLSLSQGAC SLKAFEKRLA
310 320 330 340 350
LVYEIPLDNL KNARLSQGVI EVRANCTYEE INHFLSANQS SLDKDLQQSL
360 370 380 390 400
LGFLEMALKL KKERLKKGFN FNSFENKLYL NKEGRIEKIE TEKESDAHTL
410 420 430 440 450
IEEAMLLANQ SSARLLDEHF HNKGIYRTHK EPSLEQQKRL YDKLFDYEIV
460 470 480 490 500
RPKNMGFFPF LEHALKIAKE KSIEREVSRL IIKSQNLALY SPLQESHFGL
510 520 530 540 550
GFASYTHFTS PIRRYSDLAL HRLLKELLFY QAKGCSYLLE ETPELCAELN
560 570 580 590 600
ALQKKAALIE RDFIKRKFAR LALELLEKEF LGVVLEVKDW VVVGLKEFIG
610 620 630 640
LKVLVKTNKV FKPLEKVRVT ITHADLILGQ VRGEITERIK EHVS
Length:644
Mass (Da):74,163
Last modified:November 1, 1997 - v1
Checksum:i960C62605A041EE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08293.1.
PIRiH64675.
RefSeqiNP_208040.1. NC_000915.1.
WP_001161318.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08293; AAD08293; HP_1248.
GeneIDi898781.
KEGGiheo:C694_06450.
hpy:HP1248.
PATRICi20593873. VBIHelPyl33062_1307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08293.1.
PIRiH64675.
RefSeqiNP_208040.1. NC_000915.1.
WP_001161318.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3252N.
IntActiP56123. 11 interactors.
MINTiMINT-159708.
STRINGi85962.HP1248.

Proteomic databases

PaxDbiP56123.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08293; AAD08293; HP_1248.
GeneIDi898781.
KEGGiheo:C694_06450.
hpy:HP1248.
PATRICi20593873. VBIHelPyl33062_1307.

Phylogenomic databases

eggNOGiENOG4105C40. Bacteria.
COG0557. LUCA.
KOiK12573.
OMAiYRTHKEP.

Enzyme and pathway databases

BioCyciHPY:HP1248-MONOMER.

Family and domain databases

HAMAPiMF_01895. RNase_R. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022966. RNase_II/R_CS.
IPR011805. RNase_R.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS01175. RIBONUCLEASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNR_HELPY
AccessioniPrimary (citable) accession number: P56123
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.