P56122 (AROC_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	HP_0663

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 365

365

Chorismate synthase HAMAP MF_00300

PRO_0000140596

Secondary structure

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365

Helix Strand Turn

Details...

Beta strand

6 – 12

7

Beta strand

18 – 26

9

Helix

36 – 46

11

Helix

56 – 59

4

Beta strand

62 – 65

4

Beta strand

67 – 70

4

Beta strand

79 – 84

6

Helix

106 – 113

8

Helix

126 – 145

20

Beta strand

148 – 157

10

Helix

167 – 172

6

Helix

180 – 195

16

Beta strand

202 – 212

11

Turn

224 – 226

3

Helix

229 – 238

10

Beta strand

243 – 248

6

Helix

251 – 256

6

Helix

259 – 262

4

Beta strand

270 – 272

3

Turn

275 – 278

4

Beta strand

289 – 295

7

Beta strand

305 – 309

5

Beta strand

314 – 317

4

Helix

328 – 349

22

Helix

350 – 352

3

Helix

355 – 362

8

Sequences

	Sequence		Length	Mass (Da)
	P56122 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 98ABC708E1909561	FASTA	365	40,100
	10 20 30 40 50 60 MNTLGRFLRL TTFGESHGDV IGGVLDGMPS GIKIDYALLE NEMKRRQGGR NVFITPRKED 70 80 90 100 110 120 DKVEITSGVF EDFSTGTPIG FLIHNQRARS KDYDNIKNLF RPSHADFTYF HKYGIRDFRG 130 140 150 160 170 180 GGRSSARESA IRVAAGAFAK MLLREIGIVC ESGIIEIGGI KAKNYDFNHA LKSEIFALDE 190 200 210 220 230 240 EQEEAQKTAI QNAIKNHDSI GGVALIRARS IKTNQKLPIG LGQGLYAKLD AKIAEAMMGL 250 260 270 280 290 300 NGVKAVEIGK GVESSLLKGS EYNDLMDQKG FLSNRSGGVL GGMSNGEEII VRVHFKPTPS 310 320 330 340 350 360 IFQPQRTIDI NGNECECLLK GRHDPCIAIR GSVVCESLLA LVLADMVLLN LTSKIEYLKT IYNEN

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000511 Genomic DNA. Translation: AAD07726.1.

PIR

G64602.

RefSeq

NP_207457.1. NC_000915.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UM0	X-ray	1.95	A/B/C/D	1-365	[»]
1UMF	X-ray	2.25	A/B/C/D	1-365	[»]

ProteinModelPortal

P56122.

SMR

P56122. Positions 1-365.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-176132.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

898986.

GenomeReviews

Gene locus HP_0663 in contig AE000511_GR.

KEGG

hpy:HP0663.

NMPDR

fig|85962.1.peg.655.

PATRIC

20592611. VBIHelPyl33062_0694.

TIGR

HP_0663.

Phylogenomic databases

HOGENOM

HBG292336.

OMA

SRFTTQR.

ProtClustDB

PRK05382.

Family and domain databases

HAMAP

MF_00300. Chorismate_synth.
[Tree]

InterPro

IPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]

KO

K01736.

PANTHER

PTHR21085. Chorismate_synth. 1 hit.

Pfam

PF01264. Chorismate_synt. 1 hit.
[Graphical view]

PIRSF

PIRSF001456. Chorismate_synth. 1 hit.

SUPFAM

SSF103263. Chorismate_synth. 1 hit.

TIGRFAMs

TIGR00033. AroC. 1 hit.

PROSITE

PS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

AROC_HELPY

Accession

Primary (citable) accession number: P56122

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program