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P56119

- AROE_HELPY

UniProt

P56119 - AROE_HELPY

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Protein

Shikimate dehydrogenase

Gene

aroE

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Shikimate + NADP+ = 3-dehydroshikimate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei69 – 691Proton acceptorSequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi125 – 1295NADPBy similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
  3. shikimate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciHPY:HP1249-MONOMER.
UniPathwayiUPA00053; UER00087.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate dehydrogenase (EC:1.1.1.25)
Gene namesi
Name:aroE
Ordered Locus Names:HP_1249
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Shikimate dehydrogenasePRO_0000136007Add
BLAST

Proteomic databases

PRIDEiP56119.

PTM databases

PhosSiteiP11041007.

Interactioni

Protein-protein interaction databases

IntActiP56119. 1 interaction.
STRINGi85962.HP1249.

Structurei

Secondary structure

1
263
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 1210Combined sources
Helixi18 – 3316Combined sources
Beta strandi34 – 4310Combined sources
Beta strandi46 – 483Combined sources
Helixi50 – 567Combined sources
Beta strandi59 – 646Combined sources
Helixi69 – 757Combined sources
Beta strandi76 – 794Combined sources
Helixi81 – 855Combined sources
Beta strandi91 – 955Combined sources
Beta strandi98 – 1025Combined sources
Helixi105 – 1128Combined sources
Beta strandi120 – 1245Combined sources
Helixi128 – 13912Combined sources
Beta strandi143 – 1475Combined sources
Beta strandi149 – 1513Combined sources
Helixi154 – 1607Combined sources
Beta strandi163 – 1675Combined sources
Beta strandi174 – 1785Combined sources
Helixi183 – 1853Combined sources
Helixi192 – 20110Combined sources
Beta strandi203 – 2086Combined sources
Helixi215 – 2228Combined sources
Helixi231 – 24515Combined sources
Turni246 – 2483Combined sources
Helixi252 – 26211Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PHGX-ray1.57A/B1-263[»]
3PHHX-ray1.42A1-263[»]
3PHIX-ray2.04A/B1-263[»]
3PHJX-ray2.30A/B1-263[»]
4FOOX-ray2.55A/B1-263[»]
4FOSX-ray1.72A1-263[»]
4FPXX-ray2.40A/B1-263[»]
4FQ8X-ray2.07A/B1-263[»]
4FR5X-ray2.20A/B1-263[»]
4FSHX-ray2.85A/B1-263[»]
ProteinModelPortaliP56119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0169.
KOiK00014.
OMAiASMDSIP.
OrthoDBiEOG64R67G.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00222. Shikimate_DH_AroE.
InterProiIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamiPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00507. aroE. 1 hit.

Sequencei

Sequence statusi: Complete.

P56119-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLKSFGVFG NPIKHSKSPL IHNACFLTFQ KELRFLGHYH PILLPLESHI
60 70 80 90 100
KSEFLHLGLS GANVTLPFKE RAFQVCDKIK GIALECGAVN TLVLENDELV
110 120 130 140 150
GYNTDALGFY LSLKQKNYQN ALILGAGGSA KALACELKKQ GLQVSVLNRS
160 170 180 190 200
SRGLDFFQRL GCDCFMEPPK SAFDLIINAT SASLHNELPL NKEVLKGYFK
210 220 230 240 250
EGKLAYDLAY GFLTPFLSLA KELKTPFQDG KDMLIYQAAL SFEKFSASQI
260
PYSKAFEVMR SVF
Length:263
Mass (Da):29,273
Last modified:November 1, 1997 - v1
Checksum:iA34E5BD3E54C4937
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08294.1.
PIRiA64676.
RefSeqiNP_208041.1. NC_000915.1.
YP_006935169.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08294; AAD08294; HP_1249.
GeneIDi13870456.
898819.
KEGGiheo:C694_06455.
hpy:HP1249.
PATRICi20593875. VBIHelPyl33062_1308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08294.1 .
PIRi A64676.
RefSeqi NP_208041.1. NC_000915.1.
YP_006935169.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3PHG X-ray 1.57 A/B 1-263 [» ]
3PHH X-ray 1.42 A 1-263 [» ]
3PHI X-ray 2.04 A/B 1-263 [» ]
3PHJ X-ray 2.30 A/B 1-263 [» ]
4FOO X-ray 2.55 A/B 1-263 [» ]
4FOS X-ray 1.72 A 1-263 [» ]
4FPX X-ray 2.40 A/B 1-263 [» ]
4FQ8 X-ray 2.07 A/B 1-263 [» ]
4FR5 X-ray 2.20 A/B 1-263 [» ]
4FSH X-ray 2.85 A/B 1-263 [» ]
ProteinModelPortali P56119.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P56119. 1 interaction.
STRINGi 85962.HP1249.

PTM databases

PhosSitei P11041007.

Proteomic databases

PRIDEi P56119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08294 ; AAD08294 ; HP_1249 .
GeneIDi 13870456.
898819.
KEGGi heo:C694_06455.
hpy:HP1249.
PATRICi 20593875. VBIHelPyl33062_1308.

Phylogenomic databases

eggNOGi COG0169.
KOi K00014.
OMAi ASMDSIP.
OrthoDBi EOG64R67G.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00087 .
BioCyci HPY:HP1249-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00222. Shikimate_DH_AroE.
InterProi IPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view ]
Pfami PF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00507. aroE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiAROE_HELPY
AccessioniPrimary (citable) accession number: P56119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3