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P56119

- AROE_HELPY

UniProt

P56119 - AROE_HELPY

Protein

Shikimate dehydrogenase

Gene

aroE

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Shikimate + NADP+ = 3-dehydroshikimate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei69 – 691Proton acceptorSequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi125 – 1295NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway
    3. shikimate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciHPY:HP1249-MONOMER.
    UniPathwayiUPA00053; UER00087.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Shikimate dehydrogenase (EC:1.1.1.25)
    Gene namesi
    Name:aroE
    Ordered Locus Names:HP_1249
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263Shikimate dehydrogenasePRO_0000136007Add
    BLAST

    Proteomic databases

    PRIDEiP56119.

    PTM databases

    PhosSiteiP11041007.

    Interactioni

    Protein-protein interaction databases

    IntActiP56119. 1 interaction.
    STRINGi85962.HP1249.

    Structurei

    Secondary structure

    1
    263
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 1210
    Helixi18 – 3316
    Beta strandi34 – 4310
    Beta strandi46 – 483
    Helixi50 – 567
    Beta strandi59 – 646
    Helixi69 – 757
    Beta strandi76 – 794
    Helixi81 – 855
    Beta strandi91 – 955
    Beta strandi98 – 1025
    Helixi105 – 1128
    Beta strandi120 – 1245
    Helixi128 – 13912
    Beta strandi143 – 1475
    Beta strandi149 – 1513
    Helixi154 – 1607
    Beta strandi163 – 1675
    Beta strandi174 – 1785
    Helixi183 – 1853
    Helixi192 – 20110
    Beta strandi203 – 2086
    Helixi215 – 2228
    Helixi231 – 24515
    Turni246 – 2483
    Helixi252 – 26211

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3PHGX-ray1.57A/B1-263[»]
    3PHHX-ray1.42A1-263[»]
    3PHIX-ray2.04A/B1-263[»]
    3PHJX-ray2.30A/B1-263[»]
    4FOOX-ray2.55A/B1-263[»]
    4FOSX-ray1.72A1-263[»]
    4FPXX-ray2.40A/B1-263[»]
    4FQ8X-ray2.07A/B1-263[»]
    4FR5X-ray2.20A/B1-263[»]
    4FSHX-ray2.85A/B1-263[»]
    ProteinModelPortaliP56119.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the shikimate dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0169.
    KOiK00014.
    OMAiASMDSIP.
    OrthoDBiEOG64R67G.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00222. Shikimate_DH_AroE.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR011342. Shikimate_DH.
    IPR013708. Shikimate_DH-bd_N.
    IPR022893. Shikimate_quinate_DH.
    IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
    [Graphical view]
    PfamiPF01488. Shikimate_DH. 1 hit.
    PF08501. Shikimate_dh_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00507. aroE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P56119-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLKSFGVFG NPIKHSKSPL IHNACFLTFQ KELRFLGHYH PILLPLESHI    50
    KSEFLHLGLS GANVTLPFKE RAFQVCDKIK GIALECGAVN TLVLENDELV 100
    GYNTDALGFY LSLKQKNYQN ALILGAGGSA KALACELKKQ GLQVSVLNRS 150
    SRGLDFFQRL GCDCFMEPPK SAFDLIINAT SASLHNELPL NKEVLKGYFK 200
    EGKLAYDLAY GFLTPFLSLA KELKTPFQDG KDMLIYQAAL SFEKFSASQI 250
    PYSKAFEVMR SVF 263
    Length:263
    Mass (Da):29,273
    Last modified:November 1, 1997 - v1
    Checksum:iA34E5BD3E54C4937
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08294.1.
    PIRiA64676.
    RefSeqiNP_208041.1. NC_000915.1.
    YP_006935169.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08294; AAD08294; HP_1249.
    GeneIDi13870456.
    898819.
    KEGGiheo:C694_06455.
    hpy:HP1249.
    PATRICi20593875. VBIHelPyl33062_1308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08294.1 .
    PIRi A64676.
    RefSeqi NP_208041.1. NC_000915.1.
    YP_006935169.1. NC_018939.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3PHG X-ray 1.57 A/B 1-263 [» ]
    3PHH X-ray 1.42 A 1-263 [» ]
    3PHI X-ray 2.04 A/B 1-263 [» ]
    3PHJ X-ray 2.30 A/B 1-263 [» ]
    4FOO X-ray 2.55 A/B 1-263 [» ]
    4FOS X-ray 1.72 A 1-263 [» ]
    4FPX X-ray 2.40 A/B 1-263 [» ]
    4FQ8 X-ray 2.07 A/B 1-263 [» ]
    4FR5 X-ray 2.20 A/B 1-263 [» ]
    4FSH X-ray 2.85 A/B 1-263 [» ]
    ProteinModelPortali P56119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P56119. 1 interaction.
    STRINGi 85962.HP1249.

    PTM databases

    PhosSitei P11041007.

    Proteomic databases

    PRIDEi P56119.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08294 ; AAD08294 ; HP_1249 .
    GeneIDi 13870456.
    898819.
    KEGGi heo:C694_06455.
    hpy:HP1249.
    PATRICi 20593875. VBIHelPyl33062_1308.

    Phylogenomic databases

    eggNOGi COG0169.
    KOi K00014.
    OMAi ASMDSIP.
    OrthoDBi EOG64R67G.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00087 .
    BioCyci HPY:HP1249-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00222. Shikimate_DH_AroE.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR011342. Shikimate_DH.
    IPR013708. Shikimate_DH-bd_N.
    IPR022893. Shikimate_quinate_DH.
    IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
    [Graphical view ]
    Pfami PF01488. Shikimate_DH. 1 hit.
    PF08501. Shikimate_dh_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00507. aroE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiAROE_HELPY
    AccessioniPrimary (citable) accession number: P56119
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3