Shikimate dehydrogenase - Helicobacter pylori (strain ATCC 700392 / 26695)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	HP_1249

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 263

263

Shikimate dehydrogenase HAMAP MF_00222

PRO_0000136007

Regions

Nucleotide binding

125 – 129

5

NADP By similarity

Sites

Active site

69

1

Proton acceptor Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P56119 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: A34E5BD3E54C4937
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FASTA

263

29,273

        10         20         30         40         50         60 
MKLKSFGVFG NPIKHSKSPL IHNACFLTFQ KELRFLGHYH PILLPLESHI KSEFLHLGLS 

        70         80         90        100        110        120 
GANVTLPFKE RAFQVCDKIK GIALECGAVN TLVLENDELV GYNTDALGFY LSLKQKNYQN 

       130        140        150        160        170        180 
ALILGAGGSA KALACELKKQ GLQVSVLNRS SRGLDFFQRL GCDCFMEPPK SAFDLIINAT 

       190        200        210        220        230        240 
SASLHNELPL NKEVLKGYFK EGKLAYDLAY GFLTPFLSLA KELKTPFQDG KDMLIYQAAL 

       250        260 
SFEKFSASQI PYSKAFEVMR SVF

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References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J.

Venter J.C.
Nature 388:539-547(1997) [PubMed: 9252185] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000511 Genomic DNA. Translation: AAD08294.1.

PIR

A64676.

RefSeq

NP_208041.1. NC_000915.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3PHG	X-ray	1.57	A/B	1-263	[»]
3PHH	X-ray	1.42	A	1-263	[»]
3PHI	X-ray	2.04	A/B	1-263	[»]
3PHJ	X-ray	2.30	A/B	1-263	[»]

ProteinModelPortal

P56119.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

898819.

GenomeReviews

Gene locus HP_1249 in contig AE000511_GR.

KEGG

hpy:HP1249.

NMPDR

fig|85962.1.peg.1237.

PATRIC

20593875. VBIHelPyl33062_1308.

TIGR

HP_1249.

Phylogenomic databases

HOGENOM

HBG553408.

OMA

VVFGNPI.

ProtClustDB

PRK00258.

Family and domain databases

HAMAP

MF_00222. Shikimate_DH_AroE.
[Tree]

InterPro

IPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.

KO

K00014.

Pfam

PF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00507. AroE. 1 hit.

ProtoNet

Search...

Entry information

Entry name

AROE_HELPY

Accession

Primary (citable) accession number: P56119

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families