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P56119

- AROE_HELPY

UniProt

P56119 - AROE_HELPY

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Protein
Shikimate dehydrogenase
Gene
aroE, HP_1249
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Shikimate + NADP+ = 3-dehydroshikimate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei69 – 691Proton acceptor Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi125 – 1295NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
  3. shikimate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciHPY:HP1249-MONOMER.
UniPathwayiUPA00053; UER00087.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate dehydrogenase (EC:1.1.1.25)
Gene namesi
Name:aroE
Ordered Locus Names:HP_1249
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Shikimate dehydrogenaseUniRule annotation
PRO_0000136007Add
BLAST

Proteomic databases

PRIDEiP56119.

PTM databases

PhosSiteiP11041007.

Interactioni

Protein-protein interaction databases

IntActiP56119. 1 interaction.
STRINGi85962.HP1249.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 1210
Helixi18 – 3316
Beta strandi34 – 4310
Beta strandi46 – 483
Helixi50 – 567
Beta strandi59 – 646
Helixi69 – 757
Beta strandi76 – 794
Helixi81 – 855
Beta strandi91 – 955
Beta strandi98 – 1025
Helixi105 – 1128
Beta strandi120 – 1245
Helixi128 – 13912
Beta strandi143 – 1475
Beta strandi149 – 1513
Helixi154 – 1607
Beta strandi163 – 1675
Beta strandi174 – 1785
Helixi183 – 1853
Helixi192 – 20110
Beta strandi203 – 2086
Helixi215 – 2228
Helixi231 – 24515
Turni246 – 2483
Helixi252 – 26211

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PHGX-ray1.57A/B1-263[»]
3PHHX-ray1.42A1-263[»]
3PHIX-ray2.04A/B1-263[»]
3PHJX-ray2.30A/B1-263[»]
4FOOX-ray2.55A/B1-263[»]
4FOSX-ray1.72A1-263[»]
4FPXX-ray2.40A/B1-263[»]
4FQ8X-ray2.07A/B1-263[»]
4FR5X-ray2.20A/B1-263[»]
4FSHX-ray2.85A/B1-263[»]
ProteinModelPortaliP56119.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0169.
KOiK00014.
OMAiASMDSIP.
OrthoDBiEOG64R67G.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00222. Shikimate_DH_AroE.
InterProiIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamiPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00507. aroE. 1 hit.

Sequencei

Sequence statusi: Complete.

P56119-1 [UniParc]FASTAAdd to Basket

« Hide

MKLKSFGVFG NPIKHSKSPL IHNACFLTFQ KELRFLGHYH PILLPLESHI    50
KSEFLHLGLS GANVTLPFKE RAFQVCDKIK GIALECGAVN TLVLENDELV 100
GYNTDALGFY LSLKQKNYQN ALILGAGGSA KALACELKKQ GLQVSVLNRS 150
SRGLDFFQRL GCDCFMEPPK SAFDLIINAT SASLHNELPL NKEVLKGYFK 200
EGKLAYDLAY GFLTPFLSLA KELKTPFQDG KDMLIYQAAL SFEKFSASQI 250
PYSKAFEVMR SVF 263
Length:263
Mass (Da):29,273
Last modified:November 1, 1997 - v1
Checksum:iA34E5BD3E54C4937
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08294.1.
PIRiA64676.
RefSeqiNP_208041.1. NC_000915.1.
YP_006935169.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08294; AAD08294; HP_1249.
GeneIDi13870456.
898819.
KEGGiheo:C694_06455.
hpy:HP1249.
PATRICi20593875. VBIHelPyl33062_1308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08294.1 .
PIRi A64676.
RefSeqi NP_208041.1. NC_000915.1.
YP_006935169.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3PHG X-ray 1.57 A/B 1-263 [» ]
3PHH X-ray 1.42 A 1-263 [» ]
3PHI X-ray 2.04 A/B 1-263 [» ]
3PHJ X-ray 2.30 A/B 1-263 [» ]
4FOO X-ray 2.55 A/B 1-263 [» ]
4FOS X-ray 1.72 A 1-263 [» ]
4FPX X-ray 2.40 A/B 1-263 [» ]
4FQ8 X-ray 2.07 A/B 1-263 [» ]
4FR5 X-ray 2.20 A/B 1-263 [» ]
4FSH X-ray 2.85 A/B 1-263 [» ]
ProteinModelPortali P56119.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P56119. 1 interaction.
STRINGi 85962.HP1249.

PTM databases

PhosSitei P11041007.

Proteomic databases

PRIDEi P56119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08294 ; AAD08294 ; HP_1249 .
GeneIDi 13870456.
898819.
KEGGi heo:C694_06455.
hpy:HP1249.
PATRICi 20593875. VBIHelPyl33062_1308.

Phylogenomic databases

eggNOGi COG0169.
KOi K00014.
OMAi ASMDSIP.
OrthoDBi EOG64R67G.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00087 .
BioCyci HPY:HP1249-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00222. Shikimate_DH_AroE.
InterProi IPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view ]
Pfami PF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00507. aroE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiAROE_HELPY
AccessioniPrimary (citable) accession number: P56119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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