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Protein

Ribonuclease 3

Gene

rnc

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54MagnesiumUniRule annotation1
Active sitei58UniRule annotation1
Metal bindingi127MagnesiumUniRule annotation1
Active sitei130UniRule annotation1
Metal bindingi130MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:HP_0662
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001804011 – 239Ribonuclease 3Add BLAST239

Proteomic databases

PaxDbiP56118.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiP56118. 3 interactors.
MINTiMINT-159557.
STRINGi85962.HP0662.

Structurei

3D structure databases

ProteinModelPortaliP56118.
SMRiP56118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 141RNase IIIUniRule annotationAdd BLAST124
Domaini168 – 237DRBMUniRule annotationAdd BLAST70

Phylogenomic databases

eggNOGiENOG4108ZBM. Bacteria.
COG0571. LUCA.
KOiK03685.
OMAiLTHKSCK.

Family and domain databases

CDDicd00593. RIBOc. 1 hit.
Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III. 1 hit.
InterProiView protein in InterPro
IPR014720. dsRBD_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
PfamiView protein in Pfam
PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
SMARTiView protein in SMART
SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiView protein in PROSITE
PS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P56118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKRSQNSP YITPNSSYTT LEKALGYSFK DKRLLEQALT HKSCKLALNN
60 70 80 90 100
ERLEFLGDAV LGLVIGELLY HKFYQYDEGK LSKLRASIVS AHGFTKLAKA
110 120 130 140 150
IALQDYLRVS SSEEISNGRE KPSILSSAFE ALMAGVYLEA GLAKVQKIMQ
160 170 180 190 200
NLLNRAYKRL DLEHLFMDYK TALQELTQAQ FCVIPTYQLL KEKGPDHHKE
210 220 230
FEMALYIQDK MYATAKGKSK KEAEQQCAYQ ALQKLKEAK
Length:239
Mass (Da):27,215
Last modified:May 30, 2000 - v2
Checksum:i5FFE8A0F17489BE1
GO

Sequence cautioni

The sequence AAD07725 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07725.1. Different initiation.
PIRiF64602.
RefSeqiNP_207456.1. NC_000915.1.
WP_000977306.1. NC_000915.1.
WP_015056054.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07725; AAD07725; HP_0662.
GeneIDi899029.
KEGGiheo:C694_03425.
hpy:HP0662.
PATRICi20592609. VBIHelPyl33062_0693.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07725.1. Different initiation.
PIRiF64602.
RefSeqiNP_207456.1. NC_000915.1.
WP_000977306.1. NC_000915.1.
WP_015056054.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56118.
SMRiP56118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56118. 3 interactors.
MINTiMINT-159557.
STRINGi85962.HP0662.

Proteomic databases

PaxDbiP56118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07725; AAD07725; HP_0662.
GeneIDi899029.
KEGGiheo:C694_03425.
hpy:HP0662.
PATRICi20592609. VBIHelPyl33062_0693.

Phylogenomic databases

eggNOGiENOG4108ZBM. Bacteria.
COG0571. LUCA.
KOiK03685.
OMAiLTHKSCK.

Family and domain databases

CDDicd00593. RIBOc. 1 hit.
Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III. 1 hit.
InterProiView protein in InterPro
IPR014720. dsRBD_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
PfamiView protein in Pfam
PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
SMARTiView protein in SMART
SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiView protein in PROSITE
PS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNC_HELPY
AccessioniPrimary (citable) accession number: P56118
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: March 15, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.