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P56118 (RNC_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:HP_0662
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence caution

The sequence AAD07725.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000180401

Regions

Domain18 – 141124RNase III
Domain168 – 23770DRBM

Sites

Active site581 Potential
Active site1301 By similarity
Metal binding541Magnesium By similarity
Metal binding1271Magnesium By similarity
Metal binding1301Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P56118 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 5FFE8A0F17489BE1

FASTA23927,215
        10         20         30         40         50         60 
MKNKRSQNSP YITPNSSYTT LEKALGYSFK DKRLLEQALT HKSCKLALNN ERLEFLGDAV 

        70         80         90        100        110        120 
LGLVIGELLY HKFYQYDEGK LSKLRASIVS AHGFTKLAKA IALQDYLRVS SSEEISNGRE 

       130        140        150        160        170        180 
KPSILSSAFE ALMAGVYLEA GLAKVQKIMQ NLLNRAYKRL DLEHLFMDYK TALQELTQAQ 

       190        200        210        220        230 
FCVIPTYQLL KEKGPDHHKE FEMALYIQDK MYATAKGKSK KEAEQQCAYQ ALQKLKEAK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07725.1. Different initiation.
PIRF64602.
RefSeqNP_207456.1. NC_000915.1.
YP_006934587.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56118.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP56118. 3 interactions.
MINTMINT-159557.
STRING85962.HP0662.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07725; AAD07725; HP_0662.
GeneID899029.
KEGGheo:C694_03425.
hpy:HP0662.
PATRIC20592609. VBIHelPyl33062_0693.

Phylogenomic databases

eggNOGCOG0571.
KOK03685.
OMATFKDQEL.
OrthoDBEOG6T1WVS.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_HELPY
AccessionPrimary (citable) accession number: P56118
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names