P56117 (Y190_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein HP_0190

Gene names

Ordered Locus Names:

HP_0190

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Cell membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the phospholipase D family. Cardiolipin synthase subfamily. Contains 2 PLD phosphodiesterase domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 502	502	Uncharacterized protein HP_0190		PRO_0000201290
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Domain	162 – 189	28	PLD phosphodiesterase 1
	Domain	396 – 423	28	PLD phosphodiesterase 2

Sequences

	Sequence		Length	Mass (Da)
	P56117 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C80911F2FB59C714	FASTA	502	58,287
	10 20 30 40 50 60 MKIFLVFLSV FFFNGCFGLV YKTPISSSPI SYDPYTTPIG SLYAEKLKEN PNHSAAILLE 70 80 90 100 110 120 DGFDALLHRV GLIRMSQKSI DMQTYIYKND LSSQVIAKEL LNAANRGVKV RILLDDNGLD 130 140 150 160 170 180 SDFSDIMLLN FHKNIEVKIF NPYYIRNKGL RYFEMLADYE RIKKRMHNKL FIVDNFAVII 190 200 210 220 230 240 GGRNIGDNYF DNDLDTNFLD LDALFFGGVA SKAKESFERY WRFHRSIPVS LLRTHKRLKN 250 260 270 280 290 300 NAKEIAKLHE KIPISAEDKN QFEKKVNDFI DRFQKYQYPI YYGNAIFLAD SPKKIDTPLY 310 320 330 340 350 360 SPIKIAFEKA LKNAKDSVFI ASSYFIPGKK MMKIFKNQIS KGIELNILTN SLSSTDAIVV 370 380 390 400 410 420 YGAWERYRNQ LVRMGANVYE IRNDFFNRQI KGRFSTKHSL HGKTIVFDDN LTLLGSFNID 430 440 450 460 470 480 PRSAYINTES AVLFDNPSFA KRVRLSLKDH AQQSWHLVVY RHRVIWEAVE EGILIHEKTS 490 500 PDTSFFLRLI KEWSKVLPER EL

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07257.1.
PIR	F64543.
RefSeq	NP_206989.1. NC_000915.1.
3D structure databases
ProteinModelPortal	P56117.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	899993.
GenomeReviews	Gene locus HP_0190 in contig AE000511_GR.
KEGG	hpy:HP0190.
NMPDR	fig|85962.1.peg.187.
PATRIC	20591601. VBIHelPyl33062_0200.
TIGR	HP_0190.
Phylogenomic databases
HOGENOM	HBG500321.
OMA	DELREHW.
ProtClustDB	CLSK495909.
Family and domain databases
InterPro	IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
SMART	SM00155. PLDc. 2 hits. [Graphical view]
PROSITE	PS50035. PLD. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y190_HELPY

Accession

Primary (citable) accession number: P56117

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program