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P56115

- GSA_HELPY

UniProt

P56115 - GSA_HELPY

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

Cofactori

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciHPY:HP0306-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:HP_0306
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000120414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiP56115.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

DIPiDIP-3347N.
IntActiP56115. 4 interactions.
MINTiMINT-175701.
STRINGi85962.HP0306.

Structurei

3D structure databases

ProteinModelPortaliP56115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
KOiK01845.
OMAiLMAHIAP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56115-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELLHSINDF NEAKQVIAGG VNSPVRAFKS VKGTPPFILK GKGAYLYDVD
60 70 80 90 100
NNHYIDFVQS WGPLIFGHAD EEIEENIINA LKKGTSFGAP TELETTLAKE
110 120 130 140 150
IISCYEGLDK VRLVSSGTEA TMSAIRLARA YSQKDDLIKF EGCYHGHSDS
160 170 180 190 200
LLVKAGSGCA TFGSPSSLGV PNDFSKHTLV ARYNDLNSTE ECFKKGNVGC
210 220 230 240 250
VIIEPIAGNM GLVPAQKEFL LGLKALCEKY QAVLILDEVM SGFRASLSGS
260 270 280 290 300
QEFYGVVPDL VTFGKVIGAG LPLACFGGRA EIMDLLSPIG SVYQAGTLSG
310 320 330 340 350
NPLAVCAGLS ALYKIKRDKT LYTRLDALAI RLTQGLQKSA QNYNIALETL
360 370 380 390 400
NMGSMFGFFF NENAVHDFDD ALKSDTEMFA KFHQKMLFKG VYLACSSFET
410 420 430
GFICEPMTEE MIDLTIAKAD ESFDEIIKGV
Length:430
Mass (Da):46,727
Last modified:November 1, 1997 - v1
Checksum:i246AC6B4096949F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07374.1.
PIRiB64558.
RefSeqiNP_207104.1. NC_000915.1.
YP_006934233.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07374; AAD07374; HP_0306.
GeneIDi13869491.
900188.
KEGGiheo:C694_01545.
hpy:HP0306.
PATRICi20591839. VBIHelPyl33062_0317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07374.1 .
PIRi B64558.
RefSeqi NP_207104.1. NC_000915.1.
YP_006934233.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56115.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3347N.
IntActi P56115. 4 interactions.
MINTi MINT-175701.
STRINGi 85962.HP0306.

Proteomic databases

PRIDEi P56115.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07374 ; AAD07374 ; HP_0306 .
GeneIDi 13869491.
900188.
KEGGi heo:C694_01545.
hpy:HP0306.
PATRICi 20591839. VBIHelPyl33062_0317.

Phylogenomic databases

eggNOGi COG0001.
KOi K01845.
OMAi LMAHIAP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci HPY:HP0306-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiGSA_HELPY
AccessioniPrimary (citable) accession number: P56115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3