P56112 (Y175_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative peptidyl-prolyl cis-trans isomerase HP_0175
Short name=PPIase HP_0175
EC=5.2.1.8

Alternative name(s):
Rotamase HP_0175

Gene names

Ordered Locus Names:

HP_0175

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Sequence similarities	Contains 1 PpiC domain.

Ontologies

Keywords
Domain	Signal
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 299	278	Putative peptidyl-prolyl cis-trans isomerase HP_0175		PRO_0000025547
Regions
	Domain	154 – 253	100	PpiC

Sequences

	Sequence		Length	Mass (Da)
	P56112 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: E65F3F2F94B11F5A	FASTA	299	34,031
	10 20 30 40 50 60 MKKNILNLAL VGALSTSFLM AKPAHNANNA THNTKKTTDS SAGVLATVDG RPITKSDFDM 70 80 90 100 110 120 IKQRNPNFDF DKLKEKEKEA LIDQAIRTAL VENEAKTEKL DSTPEFKAMM EAVKKQALVE 130 140 150 160 170 180 FWAKKQAEEV KKVQIPEKEM QDFYNANKDQ LFVKQEAHAR HILVKTEDEA KRIISEIDKQ 190 200 210 220 230 240 PKAKKEAKFI ELANRDTIDP NSKNAQNGGD LGKFQKNQMA PDFSKAAFAL TPGDYTKTPV 250 260 270 280 290 KTEFGYHIIY LISKDSPVTY TYEQAKPTIK GMLQEKLFQE RMNQRIEELR KHAKIVINK

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07245.1.
PIR	G64541.
RefSeq	NP_206974.1. NC_000915.1.
3D structure databases
ProteinModelPortal	P56112.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3058N.
MINT	MINT-164726.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	899149.
GenomeReviews	Gene locus HP_0175 in contig AE000511_GR.
KEGG	hpy:HP0175.
NMPDR	fig|85962.1.peg.172.
PATRIC	20591571. VBIHelPyl33062_0185.
TIGR	HP_0175.
Phylogenomic databases
HOGENOM	HBG712792.
OMA	ELANRDT.
ProtClustDB	CLSK495901.
Family and domain databases
InterPro	IPR000297. PPIase_PpiC. IPR023058. PPIase_PpiC_CS. [Graphical view]
KO	K01802.
Pfam	PF00639. Rotamase. 1 hit. [Graphical view]
PROSITE	PS01096. PPIC_PPIASE_1. 1 hit. PS50198. PPIC_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y175_HELPY

Accession

Primary (citable) accession number: P56112

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program