P56110 (G6PD_HELPY) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 85.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Glucose-6-phosphate 1-dehydrogenase Short name=G6PD EC=1.1.1.49 | ||||
| Gene names |
| ||||
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP] | ||||
| Taxonomic identifier | 85962 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › ![]() |
Protein attributes
| Sequence length | 425 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. |
| Pathway | |
| Sequence similarities | Belongs to the glucose-6-phosphate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism Glucose metabolism |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-UniPathway |
| Molecular_function | NADP binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 425 | 425 | Glucose-6-phosphate 1-dehydrogenase | PRO_0000068123 | |||||
Sites | |||||||||
| Active site | 225 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 12 | 1 | NADP By similarity | ||||||
| Binding site | 44 | 1 | NADP By similarity | ||||||
| Binding site | 165 | 1 | Substrate By similarity | ||||||
| Binding site | 169 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. Venter J.C.Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE000511 Genomic DNA. Translation: AAD08144.1. |
| PIR | E64657. |
| RefSeq | NP_207892.1. NC_000915.1. YP_006935016.1. NC_018939.1. |
3D structure databases | |
| ProteinModelPortal | P56110. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 85962.HP1101. |
Proteomic databases | |
| PRIDE | P56110. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAD08144; AAD08144; HP_1101. |
| GeneID | 13870294. 899637. |
| KEGG | heo:C694_05680. hpy:HP1101. |
| PATRIC | 20593541. VBIHelPyl33062_1150. |
Phylogenomic databases | |
| eggNOG | COG0364. |
| KO | K00036. |
| OMA | ENFSDEA. |
| ProtClustDB | PRK05722. |
Enzyme and pathway databases | |
| UniPathway | UPA00115; UER00408. |
Family and domain databases | |
| Gene3D | 3.40.50.720. 1 hit. |
| InterPro | IPR001282. G6P_DH. IPR019796. G6P_DH_AS. IPR022675. G6P_DH_C. IPR022674. G6P_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| PANTHER | PTHR23429. PTHR23429. 1 hit. |
| Pfam | PF02781. G6PD_C. 2 hits. PF00479. G6PD_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000110. G6PD. 1 hit. |
| PRINTS | PR00079. G6PDHDRGNASE. |
| PROSITE | PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | G6PD_HELPY | ||||||||
| Accession | Primary (citable) accession number: P56110 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Helicobacter pylori Helicobacter pylori (strain 26695): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
