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P56110

- G6PD_HELPY

UniProt

P56110 - G6PD_HELPY

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441NADPUniRule annotation
Binding sitei135 – 1351NADPUniRule annotation
Binding sitei165 – 1651SubstrateUniRule annotation
Binding sitei169 – 1691SubstrateUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation
Binding sitei220 – 2201SubstrateUniRule annotation
Active sitei225 – 2251Proton acceptorUniRule annotation
Binding sitei311 – 3111SubstrateUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciHPY:HP1101-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:HP_1101
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Glucose-6-phosphate 1-dehydrogenasePRO_0000068123Add
BLAST

Proteomic databases

PRIDEiP56110.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP1101.

Structurei

3D structure databases

ProteinModelPortaliP56110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiWNAAHID.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56110-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDFDLVLFG ATGDLAMRKL FVSLYEIYTH YGFKNDSRII ASGRKELSNE
60 70 80 90 100
EFLTLLCEKT QLHSREKGRE FLAHISYLCV RLDNPKDFEE LSKIATKNKP
110 120 130 140 150
LIFYFSISPS FFATTAQHLA KNALNHANTR LILEKPLGHD LKTCKEIFQS
160 170 180 190 200
ISVFFKEEQI FRIDHYLGKK GVQNILELRL NNPILNILWD QISAVEICVY
210 220 230 240 250
ETLGVEERGE FYDKIGALRD MVQNHLLQVL SLIATDLPNN LKDLRKEKIK
260 270 280 290 300
VLKTLQPPKD FKKQVIRAQY QGYRDENKVH KESQTETFVA IKAFLDTPKF
310 320 330 340 350
KGVPFYLKHA KKMPHNQASV KIHFNAVNTL EFFLSQDKIT LTLKDHQNPL
360 370 380 390 400
ILETHNKQEF LRPYAKLLYD AIQNNHNNFA HQLELEASWV FIDTLIEGFM
410 420
NNATPLYSYE SHHLNESEFL KPLYQ
Length:425
Mass (Da):49,541
Last modified:November 1, 1997 - v1
Checksum:iEF5A5C1C5AC7B6DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08144.1.
PIRiE64657.
RefSeqiNP_207892.1. NC_000915.1.
YP_006935016.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08144; AAD08144; HP_1101.
GeneIDi13870294.
899637.
KEGGiheo:C694_05680.
hpy:HP1101.
PATRICi20593541. VBIHelPyl33062_1150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08144.1 .
PIRi E64657.
RefSeqi NP_207892.1. NC_000915.1.
YP_006935016.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56110.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP1101.

Proteomic databases

PRIDEi P56110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08144 ; AAD08144 ; HP_1101 .
GeneIDi 13870294.
899637.
KEGGi heo:C694_05680.
hpy:HP1101.
PATRICi 20593541. VBIHelPyl33062_1150.

Phylogenomic databases

eggNOGi COG0364.
KOi K00036.
OMAi WNAAHID.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci HPY:HP1101-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiG6PD_HELPY
AccessioniPrimary (citable) accession number: P56110
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 1, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3