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Reviewed, UniProtKB/Swiss-Prot P56110 (G6PD_HELPY)

Last modified June 16, 2009. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49
Gene names
Name: zwf
Ordered Locus Names: HP_1101
OrganismHelicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]
Taxonomic identifier210 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglucose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionbinding

Inferred from electronic annotation. Source: InterPro

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Glucose-6-phosphate 1-dehydrogenase
PRO_0000068123

Sites

Active site2251Proton acceptor By similarity
Binding site121NADP By similarity
Binding site441NADP By similarity
Binding site1651Substrate By similarity
Binding site1691Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P56110-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: EF5A5C1C5AC7B6DB

FASTA42549,541
        10         20         30         40         50         60 
MLDFDLVLFG ATGDLAMRKL FVSLYEIYTH YGFKNDSRII ASGRKELSNE EFLTLLCEKT 

        70         80         90        100        110        120 
QLHSREKGRE FLAHISYLCV RLDNPKDFEE LSKIATKNKP LIFYFSISPS FFATTAQHLA 

       130        140        150        160        170        180 
KNALNHANTR LILEKPLGHD LKTCKEIFQS ISVFFKEEQI FRIDHYLGKK GVQNILELRL 

       190        200        210        220        230        240 
NNPILNILWD QISAVEICVY ETLGVEERGE FYDKIGALRD MVQNHLLQVL SLIATDLPNN 

       250        260        270        280        290        300 
LKDLRKEKIK VLKTLQPPKD FKKQVIRAQY QGYRDENKVH KESQTETFVA IKAFLDTPKF 

       310        320        330        340        350        360 
KGVPFYLKHA KKMPHNQASV KIHFNAVNTL EFFLSQDKIT LTLKDHQNPL ILETHNKQEF 

       370        380        390        400        410        420 
LRPYAKLLYD AIQNNHNNFA HQLELEASWV FIDTLIEGFM NNATPLYSYE SHHLNESEFL 


KPLYQ 

« Hide

Cross-references

Sequence databases

AE000511 Genomic DNA. Translation: AAD08144.1.
PIRE64657.
RefSeqNP_207892.1.

3D structure databases

HSSPHSSP built from PDB template 1DPG based on UniProtKB P11411.
ModBaseSearch...

Genome annotation databases

GeneID899637.
GenomeReviewsGene locus HP_1101 in contig AE000511_GR.
KEGGhpy:HP1101.
NMPDRfig|85962.1.peg.1088.
TIGRHP_1101.

Phylogenomic databases

HOGENOMP56110.
OMAP56110. TAMEAPA.

Enzyme and pathway databases

BRENDA1.1.1.49. 1131.

Family and domain databases

InterProIPR001282. Glc-6-P_DH.
IPR019796. Glc-6-P_DH_AS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR23429. G6PDH. 1 hit.
PfamPF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
ProDomPD001129. G6PD. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_HELPY
AccessionPrimary (citable) accession number: P56110
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents