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P56110

- G6PD_HELPY

UniProt

P56110 - G6PD_HELPY

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
zwf, HP_1101
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441NADP By similarity
Binding sitei135 – 1351NADP By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei169 – 1691Substrate By similarity
Binding sitei201 – 2011Substrate By similarity
Binding sitei220 – 2201Substrate By similarity
Active sitei225 – 2251Proton acceptor By similarity
Binding sitei311 – 3111Substrate By similarity

GO - Molecular functioni

  1. NADP binding Source: UniProtKB-HAMAP
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciHPY:HP1101-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:HP_1101
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Glucose-6-phosphate 1-dehydrogenaseUniRule annotation
PRO_0000068123Add
BLAST

Proteomic databases

PRIDEiP56110.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP1101.

Structurei

3D structure databases

ProteinModelPortaliP56110.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiWNAAHID.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56110-1 [UniParc]FASTAAdd to Basket

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MLDFDLVLFG ATGDLAMRKL FVSLYEIYTH YGFKNDSRII ASGRKELSNE    50
EFLTLLCEKT QLHSREKGRE FLAHISYLCV RLDNPKDFEE LSKIATKNKP 100
LIFYFSISPS FFATTAQHLA KNALNHANTR LILEKPLGHD LKTCKEIFQS 150
ISVFFKEEQI FRIDHYLGKK GVQNILELRL NNPILNILWD QISAVEICVY 200
ETLGVEERGE FYDKIGALRD MVQNHLLQVL SLIATDLPNN LKDLRKEKIK 250
VLKTLQPPKD FKKQVIRAQY QGYRDENKVH KESQTETFVA IKAFLDTPKF 300
KGVPFYLKHA KKMPHNQASV KIHFNAVNTL EFFLSQDKIT LTLKDHQNPL 350
ILETHNKQEF LRPYAKLLYD AIQNNHNNFA HQLELEASWV FIDTLIEGFM 400
NNATPLYSYE SHHLNESEFL KPLYQ 425
Length:425
Mass (Da):49,541
Last modified:November 1, 1997 - v1
Checksum:iEF5A5C1C5AC7B6DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08144.1.
PIRiE64657.
RefSeqiNP_207892.1. NC_000915.1.
YP_006935016.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08144; AAD08144; HP_1101.
GeneIDi13870294.
899637.
KEGGiheo:C694_05680.
hpy:HP1101.
PATRICi20593541. VBIHelPyl33062_1150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08144.1 .
PIRi E64657.
RefSeqi NP_207892.1. NC_000915.1.
YP_006935016.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56110.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP1101.

Proteomic databases

PRIDEi P56110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08144 ; AAD08144 ; HP_1101 .
GeneIDi 13870294.
899637.
KEGGi heo:C694_05680.
hpy:HP1101.
PATRICi 20593541. VBIHelPyl33062_1150.

Phylogenomic databases

eggNOGi COG0364.
KOi K00036.
OMAi WNAAHID.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci HPY:HP1101-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiG6PD_HELPY
AccessioniPrimary (citable) accession number: P56110
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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