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P56109

- ALF_HELPY

UniProt

P56109 - ALF_HELPY

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Protein
Fructose-bisphosphate aldolase
Gene
fba, HP_0176
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491Glyceraldehyde 3-phosphate By similarity
Active sitei82 – 821Proton donor By similarity
Metal bindingi83 – 831Zinc 1; catalytic By similarity
Metal bindingi104 – 1041Zinc 2 By similarity
Metal bindingi134 – 1341Zinc 2 By similarity
Metal bindingi180 – 1801Zinc 1; catalytic By similarity
Binding sitei181 – 1811Dihydroxyacetone phosphate; via amide nitrogen By similarity
Metal bindingi210 – 2101Zinc 1; catalytic By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fructose 1,6-bisphosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Ordered Locus Names:HP_0176
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Fructose-bisphosphate aldolase
PRO_0000178717Add
BLAST

Proteomic databases

PRIDEiP56109.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi85962.HP0176.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1511
Beta strandi19 – 235
Helixi27 – 4014
Beta strandi44 – 496
Helixi50 – 567
Helixi58 – 7114
Beta strandi77 – 848
Helixi87 – 9610
Beta strandi99 – 1035
Helixi110 – 12617
Beta strandi130 – 1356
Helixi157 – 16711
Beta strandi170 – 1745
Helixi181 – 1833
Beta strandi186 – 1883
Helixi193 – 20311
Beta strandi207 – 2093
Helixi217 – 2259
Helixi238 – 24710
Beta strandi249 – 2546
Helixi256 – 27217
Helixi279 – 30123

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3C4UX-ray1.83A/B1-307[»]
3C52X-ray2.30A/B1-307[»]
3C56X-ray2.30A/B1-307[»]
ProteinModelPortaliP56109.

Miscellaneous databases

EvolutionaryTraceiP56109.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni211 – 2133Dihydroxyacetone phosphate binding By similarity
Regioni253 – 2564Dihydroxyacetone phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
KOiK01624.
OMAiGKMKETY.
OrthoDBiEOG6HXJ7B.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56109-1 [UniParc]FASTAAdd to Basket

« Hide

MLVKGNEILL KAHKEGYGVG AFNFVNFEML NAIFEAGNEE NSPLFIQTSE    50
GAIKYMGIDM AVGMVKTMCE RYPHIPVALH LDHGTTFESC EKAVKAGFTS 100
VMIDASHHAF EENLELTSKV VKMAHNAGVS VEAELGRLMG IEDNISVDEK 150
DAVLVNPKEA EQFVKESQVD YLAPAIGTSH GAFKFKGEPK LDFERLQEVK 200
RLTNIPLVLH GASAIPDNVR KSYLDAGGDL KGSKGVPFEF LQESVKGGIN 250
KVNTDTDLRI AFIAEVRKVA NEDKSQFDLR KFFSPAQLAL KNVVKERMKL 300
LGSANKI 307
Length:307
Mass (Da):33,773
Last modified:November 1, 1997 - v1
Checksum:iADC5696C67C69A45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07246.1.
PIRiH64541.
RefSeqiNP_206975.1. NC_000915.1.
YP_006934099.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07246; AAD07246; HP_0176.
GeneIDi13869355.
900140.
KEGGiheo:C694_00875.
hpy:HP0176.
PATRICi20591573. VBIHelPyl33062_0186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07246.1 .
PIRi H64541.
RefSeqi NP_206975.1. NC_000915.1.
YP_006934099.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3C4U X-ray 1.83 A/B 1-307 [» ]
3C52 X-ray 2.30 A/B 1-307 [» ]
3C56 X-ray 2.30 A/B 1-307 [» ]
ProteinModelPortali P56109.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0176.

Chemistry

BindingDBi P56109.
ChEMBLi CHEMBL1287618.

Proteomic databases

PRIDEi P56109.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07246 ; AAD07246 ; HP_0176 .
GeneIDi 13869355.
900140.
KEGGi heo:C694_00875.
hpy:HP0176.
PATRICi 20591573. VBIHelPyl33062_0186.

Phylogenomic databases

eggNOGi COG0191.
KOi K01624.
OMAi GKMKETY.
OrthoDBi EOG6HXJ7B.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Miscellaneous databases

EvolutionaryTracei P56109.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiALF_HELPY
AccessioniPrimary (citable) accession number: P56109
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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