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P56109

- ALF_HELPY

UniProt

P56109 - ALF_HELPY

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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491Glyceraldehyde 3-phosphateBy similarity
Active sitei82 – 821Proton donorBy similarity
Metal bindingi83 – 831Zinc 1; catalyticBy similarity
Metal bindingi104 – 1041Zinc 2By similarity
Metal bindingi134 – 1341Zinc 2By similarity
Metal bindingi180 – 1801Zinc 1; catalyticBy similarity
Binding sitei181 – 1811Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi210 – 2101Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fructose 1,6-bisphosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Ordered Locus Names:HP_0176
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Fructose-bisphosphate aldolasePRO_0000178717Add
BLAST

Proteomic databases

PRIDEiP56109.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi85962.HP0176.

Structurei

Secondary structure

1
307
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1511Combined sources
Beta strandi19 – 235Combined sources
Helixi27 – 4014Combined sources
Beta strandi44 – 496Combined sources
Helixi50 – 567Combined sources
Helixi58 – 7114Combined sources
Beta strandi77 – 848Combined sources
Helixi87 – 9610Combined sources
Beta strandi99 – 1035Combined sources
Helixi110 – 12617Combined sources
Beta strandi130 – 1356Combined sources
Helixi157 – 16711Combined sources
Beta strandi170 – 1745Combined sources
Helixi181 – 1833Combined sources
Beta strandi186 – 1883Combined sources
Helixi193 – 20311Combined sources
Beta strandi207 – 2093Combined sources
Helixi217 – 2259Combined sources
Helixi238 – 24710Combined sources
Beta strandi249 – 2546Combined sources
Helixi256 – 27217Combined sources
Helixi279 – 30123Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3C4UX-ray1.83A/B1-307[»]
3C52X-ray2.30A/B1-307[»]
3C56X-ray2.30A/B1-307[»]
ProteinModelPortaliP56109.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56109.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni211 – 2133Dihydroxyacetone phosphate bindingBy similarity
Regioni253 – 2564Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
KOiK01624.
OMAiGKMKETY.
OrthoDBiEOG6HXJ7B.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56109-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVKGNEILL KAHKEGYGVG AFNFVNFEML NAIFEAGNEE NSPLFIQTSE
60 70 80 90 100
GAIKYMGIDM AVGMVKTMCE RYPHIPVALH LDHGTTFESC EKAVKAGFTS
110 120 130 140 150
VMIDASHHAF EENLELTSKV VKMAHNAGVS VEAELGRLMG IEDNISVDEK
160 170 180 190 200
DAVLVNPKEA EQFVKESQVD YLAPAIGTSH GAFKFKGEPK LDFERLQEVK
210 220 230 240 250
RLTNIPLVLH GASAIPDNVR KSYLDAGGDL KGSKGVPFEF LQESVKGGIN
260 270 280 290 300
KVNTDTDLRI AFIAEVRKVA NEDKSQFDLR KFFSPAQLAL KNVVKERMKL

LGSANKI
Length:307
Mass (Da):33,773
Last modified:November 1, 1997 - v1
Checksum:iADC5696C67C69A45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07246.1.
PIRiH64541.
RefSeqiNP_206975.1. NC_000915.1.
YP_006934099.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07246; AAD07246; HP_0176.
GeneIDi13869355.
900140.
KEGGiheo:C694_00875.
hpy:HP0176.
PATRICi20591573. VBIHelPyl33062_0186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07246.1 .
PIRi H64541.
RefSeqi NP_206975.1. NC_000915.1.
YP_006934099.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3C4U X-ray 1.83 A/B 1-307 [» ]
3C52 X-ray 2.30 A/B 1-307 [» ]
3C56 X-ray 2.30 A/B 1-307 [» ]
ProteinModelPortali P56109.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0176.

Chemistry

BindingDBi P56109.
ChEMBLi CHEMBL1287618.

Proteomic databases

PRIDEi P56109.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07246 ; AAD07246 ; HP_0176 .
GeneIDi 13869355.
900140.
KEGGi heo:C694_00875.
hpy:HP0176.
PATRICi 20591573. VBIHelPyl33062_0186.

Phylogenomic databases

eggNOGi COG0191.
KOi K01624.
OMAi GKMKETY.
OrthoDBi EOG6HXJ7B.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Miscellaneous databases

EvolutionaryTracei P56109.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiALF_HELPY
AccessioniPrimary (citable) accession number: P56109
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3