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P56109

- ALF_HELPY

UniProt

P56109 - ALF_HELPY

Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Cofactori

    Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491Glyceraldehyde 3-phosphateBy similarity
    Active sitei82 – 821Proton donorBy similarity
    Metal bindingi83 – 831Zinc 1; catalyticBy similarity
    Metal bindingi104 – 1041Zinc 2By similarity
    Metal bindingi134 – 1341Zinc 2By similarity
    Metal bindingi180 – 1801Zinc 1; catalyticBy similarity
    Binding sitei181 – 1811Dihydroxyacetone phosphate; via amide nitrogenBy similarity
    Metal bindingi210 – 2101Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fructose 1,6-bisphosphate metabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase (EC:4.1.2.13)
    Short name:
    FBP aldolase
    Short name:
    FBPA
    Alternative name(s):
    Fructose-1,6-bisphosphate aldolase
    Gene namesi
    Name:fba
    Ordered Locus Names:HP_0176
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Fructose-bisphosphate aldolasePRO_0000178717Add
    BLAST

    Proteomic databases

    PRIDEiP56109.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi85962.HP0176.

    Structurei

    Secondary structure

    1
    307
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1511
    Beta strandi19 – 235
    Helixi27 – 4014
    Beta strandi44 – 496
    Helixi50 – 567
    Helixi58 – 7114
    Beta strandi77 – 848
    Helixi87 – 9610
    Beta strandi99 – 1035
    Helixi110 – 12617
    Beta strandi130 – 1356
    Helixi157 – 16711
    Beta strandi170 – 1745
    Helixi181 – 1833
    Beta strandi186 – 1883
    Helixi193 – 20311
    Beta strandi207 – 2093
    Helixi217 – 2259
    Helixi238 – 24710
    Beta strandi249 – 2546
    Helixi256 – 27217
    Helixi279 – 30123

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3C4UX-ray1.83A/B1-307[»]
    3C52X-ray2.30A/B1-307[»]
    3C56X-ray2.30A/B1-307[»]
    ProteinModelPortaliP56109.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP56109.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni211 – 2133Dihydroxyacetone phosphate bindingBy similarity
    Regioni253 – 2564Dihydroxyacetone phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0191.
    KOiK01624.
    OMAiGKMKETY.
    OrthoDBiEOG6HXJ7B.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR011289. Fruc_bis_ald_class-2.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view]
    PfamiPF01116. F_bP_aldolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsiTIGR00167. cbbA. 1 hit.
    TIGR01859. fruc_bis_ald_. 1 hit.
    PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56109-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVKGNEILL KAHKEGYGVG AFNFVNFEML NAIFEAGNEE NSPLFIQTSE    50
    GAIKYMGIDM AVGMVKTMCE RYPHIPVALH LDHGTTFESC EKAVKAGFTS 100
    VMIDASHHAF EENLELTSKV VKMAHNAGVS VEAELGRLMG IEDNISVDEK 150
    DAVLVNPKEA EQFVKESQVD YLAPAIGTSH GAFKFKGEPK LDFERLQEVK 200
    RLTNIPLVLH GASAIPDNVR KSYLDAGGDL KGSKGVPFEF LQESVKGGIN 250
    KVNTDTDLRI AFIAEVRKVA NEDKSQFDLR KFFSPAQLAL KNVVKERMKL 300
    LGSANKI 307
    Length:307
    Mass (Da):33,773
    Last modified:November 1, 1997 - v1
    Checksum:iADC5696C67C69A45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07246.1.
    PIRiH64541.
    RefSeqiNP_206975.1. NC_000915.1.
    YP_006934099.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07246; AAD07246; HP_0176.
    GeneIDi13869355.
    900140.
    KEGGiheo:C694_00875.
    hpy:HP0176.
    PATRICi20591573. VBIHelPyl33062_0186.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07246.1 .
    PIRi H64541.
    RefSeqi NP_206975.1. NC_000915.1.
    YP_006934099.1. NC_018939.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3C4U X-ray 1.83 A/B 1-307 [» ]
    3C52 X-ray 2.30 A/B 1-307 [» ]
    3C56 X-ray 2.30 A/B 1-307 [» ]
    ProteinModelPortali P56109.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0176.

    Chemistry

    BindingDBi P56109.
    ChEMBLi CHEMBL1287618.

    Proteomic databases

    PRIDEi P56109.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07246 ; AAD07246 ; HP_0176 .
    GeneIDi 13869355.
    900140.
    KEGGi heo:C694_00875.
    hpy:HP0176.
    PATRICi 20591573. VBIHelPyl33062_0186.

    Phylogenomic databases

    eggNOGi COG0191.
    KOi K01624.
    OMAi GKMKETY.
    OrthoDBi EOG6HXJ7B.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Miscellaneous databases

    EvolutionaryTracei P56109.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR011289. Fruc_bis_ald_class-2.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view ]
    Pfami PF01116. F_bP_aldolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsi TIGR00167. cbbA. 1 hit.
    TIGR01859. fruc_bis_ald_. 1 hit.
    PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiALF_HELPY
    AccessioniPrimary (citable) accession number: P56109
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3